Incidental Mutation 'R6404:Slco6c1'
ID 518878
Institutional Source Beutler Lab
Gene Symbol Slco6c1
Ensembl Gene ENSMUSG00000026331
Gene Name solute carrier organic anion transporter family, member 6c1
Synonyms 4933404A18Rik
MMRRC Submission 044549-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6404 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 96986763-97056026 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 97046330 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 251 (Y251C)
Ref Sequence ENSEMBL: ENSMUSP00000140791 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027569] [ENSMUST00000189547]
AlphaFold Q8C0X7
Predicted Effect probably damaging
Transcript: ENSMUST00000027569
AA Change: Y268C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027569
Gene: ENSMUSG00000026331
AA Change: Y268C

DomainStartEndE-ValueType
low complexity region 44 55 N/A INTRINSIC
Pfam:OATP 95 654 3e-101 PFAM
Pfam:MFS_1 207 474 6.5e-14 PFAM
Pfam:Kazal_2 497 538 7.4e-10 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000189547
AA Change: Y251C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000140791
Gene: ENSMUSG00000026331
AA Change: Y251C

DomainStartEndE-ValueType
low complexity region 44 55 N/A INTRINSIC
Pfam:OATP 93 197 7.4e-12 PFAM
Pfam:MFS_1 99 457 2.2e-15 PFAM
Pfam:OATP 192 638 2.5e-64 PFAM
Pfam:Kazal_2 480 521 2.1e-8 PFAM
Meta Mutation Damage Score 0.7062 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.4%
Validation Efficiency 98% (40/41)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,484,892 (GRCm39) D1540G probably benign Het
Adamts7 A T 9: 90,062,509 (GRCm39) probably null Het
Apol10a C A 15: 77,373,241 (GRCm39) F292L probably benign Het
Atp13a4 A T 16: 29,290,719 (GRCm39) Y243* probably null Het
Cc2d2a A G 5: 43,861,416 (GRCm39) N660D possibly damaging Het
Ccdc57 T C 11: 120,785,538 (GRCm39) T466A probably benign Het
Ccdc74a A T 16: 17,467,889 (GRCm39) N249Y possibly damaging Het
Cd3e T A 9: 44,912,426 (GRCm39) E106V probably damaging Het
Col4a1 G T 8: 11,257,409 (GRCm39) probably null Het
Csmd2 T C 4: 128,415,743 (GRCm39) Y2691H possibly damaging Het
Dmxl2 T C 9: 54,282,820 (GRCm39) R2786G probably damaging Het
Dpyd A G 3: 119,059,606 (GRCm39) T768A probably benign Het
Endou T A 15: 97,610,012 (GRCm39) Q428L probably damaging Het
Fam13c T C 10: 70,284,646 (GRCm39) probably null Het
Fhip1b G A 7: 105,034,198 (GRCm39) R478* probably null Het
Frmd5 G A 2: 121,379,699 (GRCm39) R70* probably null Het
Fsip2 A G 2: 82,820,430 (GRCm39) T5388A possibly damaging Het
Gm4131 T A 14: 62,718,598 (GRCm39) R3* probably null Het
Habp4 A G 13: 64,330,000 (GRCm39) T302A possibly damaging Het
Ift81 A T 5: 122,749,069 (GRCm39) D27E probably damaging Het
Iqcf3 T C 9: 106,430,083 (GRCm39) I107V probably benign Het
Iqgap2 A G 13: 95,865,985 (GRCm39) I298T probably benign Het
Lilrb4b A G 10: 51,361,825 (GRCm39) D199G probably damaging Het
Lsm8 C T 6: 18,848,739 (GRCm39) S3F possibly damaging Het
Meox1 T C 11: 101,769,482 (GRCm39) E238G probably benign Het
Naip1 A T 13: 100,559,727 (GRCm39) D1092E probably benign Het
Neb T C 2: 52,097,737 (GRCm39) Y901C probably damaging Het
Nfat5 A G 8: 108,097,220 (GRCm39) M121V probably benign Het
Notch2 G A 3: 97,989,314 (GRCm39) G278D probably damaging Het
Or4c121 T C 2: 89,023,906 (GRCm39) I157M probably damaging Het
Pbld2 T A 10: 62,890,107 (GRCm39) S172T probably damaging Het
Pla2g7 T A 17: 43,905,688 (GRCm39) Y83N probably damaging Het
Plxnb1 A T 9: 108,945,705 (GRCm39) I2079F probably damaging Het
Rara T C 11: 98,851,839 (GRCm39) F17L probably benign Het
Skint5 G A 4: 113,799,806 (GRCm39) T121I probably damaging Het
Slmap T A 14: 26,143,566 (GRCm39) probably null Het
Uba2 A T 7: 33,853,985 (GRCm39) L319Q probably damaging Het
Vmn2r96 A T 17: 18,817,793 (GRCm39) I457F probably damaging Het
Zfp57 A T 17: 37,320,716 (GRCm39) H190L probably damaging Het
Zfp738 A G 13: 67,819,179 (GRCm39) S271P possibly damaging Het
Zp2 A T 7: 119,734,765 (GRCm39) H474Q possibly damaging Het
Other mutations in Slco6c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00547:Slco6c1 APN 1 97,015,674 (GRCm39) missense probably benign 0.00
IGL00571:Slco6c1 APN 1 97,015,676 (GRCm39) missense probably benign 0.04
IGL01483:Slco6c1 APN 1 97,055,832 (GRCm39) missense probably benign
IGL01543:Slco6c1 APN 1 97,053,553 (GRCm39) missense possibly damaging 0.95
IGL01860:Slco6c1 APN 1 97,003,548 (GRCm39) splice site probably benign
IGL03106:Slco6c1 APN 1 96,993,748 (GRCm39) splice site probably benign
R0087:Slco6c1 UTSW 1 97,046,303 (GRCm39) missense probably benign 0.00
R0543:Slco6c1 UTSW 1 97,055,623 (GRCm39) missense probably damaging 0.99
R0674:Slco6c1 UTSW 1 97,032,498 (GRCm39) splice site probably benign
R0826:Slco6c1 UTSW 1 97,055,826 (GRCm39) missense probably benign 0.00
R0928:Slco6c1 UTSW 1 97,032,573 (GRCm39) missense possibly damaging 0.88
R0969:Slco6c1 UTSW 1 97,047,685 (GRCm39) missense probably benign 0.05
R1366:Slco6c1 UTSW 1 97,055,928 (GRCm39) start gained probably null
R1559:Slco6c1 UTSW 1 97,026,223 (GRCm39) missense probably damaging 1.00
R1594:Slco6c1 UTSW 1 96,990,163 (GRCm39) missense probably benign 0.36
R1901:Slco6c1 UTSW 1 97,000,707 (GRCm39) missense probably damaging 0.98
R2005:Slco6c1 UTSW 1 97,009,214 (GRCm39) missense probably damaging 0.99
R2101:Slco6c1 UTSW 1 97,000,595 (GRCm39) nonsense probably null
R2102:Slco6c1 UTSW 1 97,055,656 (GRCm39) missense probably benign 0.02
R2120:Slco6c1 UTSW 1 96,993,808 (GRCm39) missense possibly damaging 0.57
R2135:Slco6c1 UTSW 1 97,032,542 (GRCm39) missense probably benign 0.01
R2295:Slco6c1 UTSW 1 97,053,473 (GRCm39) missense probably damaging 1.00
R2437:Slco6c1 UTSW 1 96,990,201 (GRCm39) missense probably benign 0.22
R4004:Slco6c1 UTSW 1 97,003,610 (GRCm39) missense probably damaging 1.00
R4133:Slco6c1 UTSW 1 97,009,218 (GRCm39) missense probably benign 0.02
R4643:Slco6c1 UTSW 1 96,990,149 (GRCm39) missense probably benign 0.00
R4786:Slco6c1 UTSW 1 97,015,720 (GRCm39) missense probably benign 0.04
R4942:Slco6c1 UTSW 1 97,009,049 (GRCm39) missense probably damaging 1.00
R5485:Slco6c1 UTSW 1 97,053,481 (GRCm39) missense probably damaging 1.00
R5573:Slco6c1 UTSW 1 97,055,656 (GRCm39) missense probably benign 0.00
R5810:Slco6c1 UTSW 1 97,003,598 (GRCm39) missense probably damaging 1.00
R6033:Slco6c1 UTSW 1 97,009,041 (GRCm39) splice site probably null
R6033:Slco6c1 UTSW 1 97,009,041 (GRCm39) splice site probably null
R6191:Slco6c1 UTSW 1 96,993,808 (GRCm39) missense possibly damaging 0.57
R6197:Slco6c1 UTSW 1 97,000,518 (GRCm39) critical splice donor site probably null
R6286:Slco6c1 UTSW 1 97,053,445 (GRCm39) missense possibly damaging 0.90
R6430:Slco6c1 UTSW 1 97,003,699 (GRCm39) missense probably benign 0.43
R6492:Slco6c1 UTSW 1 97,053,538 (GRCm39) missense probably damaging 0.99
R6649:Slco6c1 UTSW 1 97,053,436 (GRCm39) missense probably benign 0.44
R6940:Slco6c1 UTSW 1 97,000,626 (GRCm39) missense possibly damaging 0.80
R7138:Slco6c1 UTSW 1 97,047,706 (GRCm39) missense possibly damaging 0.95
R7213:Slco6c1 UTSW 1 97,055,671 (GRCm39) missense probably benign
R7234:Slco6c1 UTSW 1 97,053,466 (GRCm39) missense probably benign 0.06
R7320:Slco6c1 UTSW 1 97,055,887 (GRCm39) missense possibly damaging 0.83
R7375:Slco6c1 UTSW 1 97,009,146 (GRCm39) missense possibly damaging 0.58
R7383:Slco6c1 UTSW 1 97,003,608 (GRCm39) nonsense probably null
R7422:Slco6c1 UTSW 1 97,009,207 (GRCm39) missense probably benign 0.17
R7491:Slco6c1 UTSW 1 97,055,579 (GRCm39) missense probably benign 0.32
R7561:Slco6c1 UTSW 1 97,000,691 (GRCm39) missense probably damaging 1.00
R7890:Slco6c1 UTSW 1 96,990,192 (GRCm39) missense possibly damaging 0.59
R8115:Slco6c1 UTSW 1 97,000,686 (GRCm39) missense probably damaging 1.00
R8409:Slco6c1 UTSW 1 97,003,663 (GRCm39) missense probably damaging 0.99
R8422:Slco6c1 UTSW 1 97,053,508 (GRCm39) missense probably damaging 1.00
R8824:Slco6c1 UTSW 1 97,055,884 (GRCm39) missense possibly damaging 0.84
R8905:Slco6c1 UTSW 1 97,053,391 (GRCm39) missense possibly damaging 0.68
R9183:Slco6c1 UTSW 1 96,996,775 (GRCm39) critical splice acceptor site probably null
R9300:Slco6c1 UTSW 1 96,993,809 (GRCm39) missense probably benign 0.37
R9359:Slco6c1 UTSW 1 96,990,248 (GRCm39) missense possibly damaging 0.94
R9374:Slco6c1 UTSW 1 97,055,827 (GRCm39) missense probably benign 0.00
R9403:Slco6c1 UTSW 1 96,990,248 (GRCm39) missense possibly damaging 0.94
R9499:Slco6c1 UTSW 1 97,055,827 (GRCm39) missense probably benign 0.00
R9551:Slco6c1 UTSW 1 97,055,827 (GRCm39) missense probably benign 0.00
R9674:Slco6c1 UTSW 1 97,047,565 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCCTAGGTATACAACATCATGTG -3'
(R):5'- CTGGAAGTATTTACAATTACCTCTCTT -3'

Sequencing Primer
(F):5'- CATCATGTGAGTAGGAAGGTAGCTTG -3'
(R):5'- CATCTTTCCTCTGTCAAGTACTA -3'
Posted On 2018-05-24