Incidental Mutation 'R6439:Igfbp5'
ID 518923
Institutional Source Beutler Lab
Gene Symbol Igfbp5
Ensembl Gene ENSMUSG00000026185
Gene Name insulin-like growth factor binding protein 5
Synonyms IGFBP-5, IGFBP-5P
MMRRC Submission 044577-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.134) question?
Stock # R6439 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 72897224-72914024 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to C at 72902300 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000027377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027377]
AlphaFold Q07079
Predicted Effect probably null
Transcript: ENSMUST00000027377
SMART Domains Protein: ENSMUSP00000027377
Gene: ENSMUSG00000026185

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IB 24 101 1.44e-38 SMART
TY 215 266 3.41e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137339
Meta Mutation Damage Score 0.9485 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.5%
Validation Efficiency 100% (35/35)
MGI Phenotype PHENOTYPE: Mice homozygous for one knock-out allele exhibit normal body weight and normal glucose homeostasis relative to wild-type controls. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130401M01Rik T C 15: 57,895,444 (GRCm39) D18G probably null Het
A530064D06Rik A G 17: 48,473,653 (GRCm39) V88A probably damaging Het
Abhd6 T C 14: 8,055,589 (GRCm38) L272P probably damaging Het
Adam25 C T 8: 41,207,627 (GRCm39) R298C possibly damaging Het
Adam34l T C 8: 44,078,988 (GRCm39) N412S probably damaging Het
Afap1l2 T C 19: 56,916,818 (GRCm39) N219D possibly damaging Het
Brd3 A G 2: 27,353,938 (GRCm39) F58S probably damaging Het
Ceacam3 G A 7: 16,892,253 (GRCm39) R332H possibly damaging Het
Cfap57 C A 4: 118,446,172 (GRCm39) probably null Het
Chd2 A G 7: 73,130,154 (GRCm39) F834L probably damaging Het
Crocc2 A G 1: 93,111,126 (GRCm39) K140E possibly damaging Het
Fam117b A G 1: 60,020,731 (GRCm39) T534A probably benign Het
Fchsd1 C T 18: 38,102,487 (GRCm39) V14I probably damaging Het
Grid2ip A T 5: 143,359,257 (GRCm39) E291V probably damaging Het
Hbp1 A G 12: 31,987,720 (GRCm39) L146S probably damaging Het
Hr A G 14: 70,799,276 (GRCm39) D616G possibly damaging Het
Jak2 C T 19: 29,287,022 (GRCm39) probably null Het
Mpl T C 4: 118,305,750 (GRCm39) D425G probably damaging Het
Ms4a4c T C 19: 11,398,676 (GRCm39) S165P probably benign Het
Mycbp2 A G 14: 103,392,911 (GRCm39) S3217P probably benign Het
Nfatc3 T A 8: 106,810,502 (GRCm39) L426* probably null Het
Or4f47 T C 2: 111,972,509 (GRCm39) V73A probably benign Het
Or5ak24 T C 2: 85,261,068 (GRCm39) Y35C probably damaging Het
Or7a42 T A 10: 78,791,818 (GRCm39) Y260N probably damaging Het
Phf1 G T 17: 27,155,586 (GRCm39) V384L probably benign Het
Rangap1 T C 15: 81,596,336 (GRCm39) T259A probably benign Het
Rec8 A G 14: 55,856,076 (GRCm39) N6S possibly damaging Het
Rmdn2 G A 17: 79,934,971 (GRCm39) probably benign Het
Scin T C 12: 40,118,945 (GRCm39) Y617C probably damaging Het
Ttc13 T C 8: 125,400,221 (GRCm39) S744G probably benign Het
Ttc14 T C 3: 33,862,968 (GRCm39) probably benign Het
Uggt1 T C 1: 36,214,032 (GRCm39) E219G possibly damaging Het
Vmn1r183 A G 7: 23,754,704 (GRCm39) D169G possibly damaging Het
Vmn1r72 A T 7: 11,413,064 (GRCm39) probably null Het
Zfp326 T G 5: 106,036,584 (GRCm39) M76R probably null Het
Other mutations in Igfbp5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02380:Igfbp5 APN 1 72,903,108 (GRCm39) nonsense probably null
R1450:Igfbp5 UTSW 1 72,913,048 (GRCm39) missense probably benign 0.06
R1928:Igfbp5 UTSW 1 72,913,184 (GRCm39) missense probably damaging 1.00
R2209:Igfbp5 UTSW 1 72,913,096 (GRCm39) missense possibly damaging 0.65
R4648:Igfbp5 UTSW 1 72,903,222 (GRCm39) missense probably benign 0.01
R6021:Igfbp5 UTSW 1 72,902,363 (GRCm39) missense possibly damaging 0.74
R6752:Igfbp5 UTSW 1 72,903,068 (GRCm39) missense probably damaging 1.00
R9619:Igfbp5 UTSW 1 72,901,543 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- CAGGCGAAGTTTAACACGGGTC -3'
(R):5'- ACACATGAGCCATCAGAGGG -3'

Sequencing Primer
(F):5'- CCCAGGGGCTTTAAATAGCTG -3'
(R):5'- GCACCGCTGAGTGGTTTC -3'
Posted On 2018-05-24