Mutagenetix > Incidental Mutations

Incidental Mutation 'R6439:Vmn1r183'

518935

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r183

Ensembl Gene

ENSMUSG00000066723

Gene Name

vomeronasal 1 receptor 183

Synonyms

LOC209824, V1rd15

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

R6439 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

24054774-24055691 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 24055279 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 169 (D169G)

Ref Sequence

ENSEMBL: ENSMUSP00000083176 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086012]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000086012
AA Change: D169G

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000083176
Gene: ENSMUSG00000066723
AA Change: D169G

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	297	5.6e-15	PFAM
Pfam:7tm_1	31	285	1.4e-9	PFAM
Pfam:V1R	41	296	2.5e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000205855

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 94.5%

Validation Efficiency

100% (35/35)

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9130401M01Rik	T	C	15: 58,032,048	D18G	probably null	Het
A530064D06Rik	A	G	17: 48,166,485	V88A	probably damaging	Het
Abhd6	T	C	14: 8,055,589	L272P	probably damaging	Het
Adam25	C	T	8: 40,754,590	R298C	possibly damaging	Het
Afap1l2	T	C	19: 56,928,386	N219D	possibly damaging	Het
Brd3	A	G	2: 27,463,926	F58S	probably damaging	Het
Ceacam3	G	A	7: 17,158,328	R332H	possibly damaging	Het
Cfap57	C	A	4: 118,588,975		probably null	Het
Chd2	A	G	7: 73,480,406	F834L	probably damaging	Het
Crocc2	A	G	1: 93,183,404	K140E	possibly damaging	Het
Fam117b	A	G	1: 59,981,572	T534A	probably benign	Het
Fchsd1	C	T	18: 37,969,434	V14I	probably damaging	Het
Gm5346	T	C	8: 43,625,951	N412S	probably damaging	Het
Grid2ip	A	T	5: 143,373,502	E291V	probably damaging	Het
Hbp1	A	G	12: 31,937,721	L146S	probably damaging	Het
Hr	A	G	14: 70,561,836	D616G	possibly damaging	Het
Igfbp5	A	C	1: 72,863,141		probably null	Het
Jak2	C	T	19: 29,309,622		probably null	Het
Mpl	T	C	4: 118,448,553	D425G	probably damaging	Het
Ms4a4c	T	C	19: 11,421,312	S165P	probably benign	Het
Mycbp2	A	G	14: 103,155,475	S3217P	probably benign	Het
Nfatc3	T	A	8: 106,083,870	L426*	probably null	Het
Olfr1317	T	C	2: 112,142,164	V73A	probably benign	Het
Olfr8	T	A	10: 78,955,984	Y260N	probably damaging	Het
Olfr994	T	C	2: 85,430,724	Y35C	probably damaging	Het
Phf1	G	T	17: 26,936,612	V384L	probably benign	Het
Rangap1	T	C	15: 81,712,135	T259A	probably benign	Het
Rec8	A	G	14: 55,618,619	N6S	possibly damaging	Het
Rmdn2	G	A	17: 79,627,542		probably benign	Het
Scin	T	C	12: 40,068,946	Y617C	probably damaging	Het
Ttc13	T	C	8: 124,673,482	S744G	probably benign	Het
Ttc14	T	C	3: 33,808,819		probably benign	Het
Uggt1	T	C	1: 36,174,951	E219G	possibly damaging	Het
Vmn1r72	A	T	7: 11,679,137		probably null	Het
Zfp326	T	G	5: 105,888,718	M76R	probably null	Het

Other mutations in Vmn1r183

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00987:Vmn1r183	APN	7	24055224	missense	probably damaging	1.00
IGL01813:Vmn1r183	APN	7	24055560	missense	probably benign	0.19
IGL03377:Vmn1r183	APN	7	24055392	missense	possibly damaging	0.70
PIT4791001:Vmn1r183	UTSW	7	24054841	missense	probably damaging	0.99
R0463:Vmn1r183	UTSW	7	24055501	missense	probably damaging	1.00
R0616:Vmn1r183	UTSW	7	24054825	missense	probably benign	0.03
R0666:Vmn1r183	UTSW	7	24055176	missense	probably benign
R3928:Vmn1r183	UTSW	7	24055572	missense	probably damaging	0.98
R4425:Vmn1r183	UTSW	7	24055548	missense	probably benign	0.00
R4767:Vmn1r183	UTSW	7	24055106	frame shift	probably null
R4835:Vmn1r183	UTSW	7	24055139	missense	probably benign	0.07
R5267:Vmn1r183	UTSW	7	24055546	missense	possibly damaging	0.90
R5693:Vmn1r183	UTSW	7	24054802	missense	possibly damaging	0.94
R6291:Vmn1r183	UTSW	7	24055557	missense	possibly damaging	0.70
R7073:Vmn1r183	UTSW	7	24055501	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGTTCCACCTGTGTCCTGAG -3'
(R):5'- TTGGTTGCTCTGGACTCAGC -3'

Sequencing Primer
(F):5'- ACCTGTGTCCTGAGTATCCATCAG -3'
(R):5'- TGGACTCAGCTTGGCCTCTG -3'

Posted On

2018-05-24