Incidental Mutation 'R6442:Sapcd2'
ID 519040
Institutional Source Beutler Lab
Gene Symbol Sapcd2
Ensembl Gene ENSMUSG00000026955
Gene Name suppressor APC domain containing 2
Synonyms 2010317E24Rik, 6030458L21Rik, ang
MMRRC Submission 044580-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.343) question?
Stock # R6442 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 25262333-25268225 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to A at 25266134 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000109932 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028329] [ENSMUST00000100323] [ENSMUST00000114293]
AlphaFold Q9D818
Predicted Effect probably benign
Transcript: ENSMUST00000028329
SMART Domains Protein: ENSMUSP00000028329
Gene: ENSMUSG00000026955

DomainStartEndE-ValueType
low complexity region 197 212 N/A INTRINSIC
low complexity region 236 250 N/A INTRINSIC
Pfam:Suppressor_APC 257 340 1.6e-34 PFAM
low complexity region 348 362 N/A INTRINSIC
coiled coil region 374 415 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000100323
AA Change: M328K
SMART Domains Protein: ENSMUSP00000097898
Gene: ENSMUSG00000026955
AA Change: M328K

DomainStartEndE-ValueType
low complexity region 202 216 N/A INTRINSIC
Pfam:Suppressor_APC 224 305 2.2e-32 PFAM
low complexity region 385 392 N/A INTRINSIC
coiled coil region 403 436 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000114293
SMART Domains Protein: ENSMUSP00000109932
Gene: ENSMUSG00000026955

DomainStartEndE-ValueType
low complexity region 202 216 N/A INTRINSIC
Pfam:Suppressor_APC 223 306 1.4e-34 PFAM
low complexity region 314 328 N/A INTRINSIC
coiled coil region 340 381 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129214
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132539
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137171
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155310
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 93.9%
Validation Efficiency 100% (36/36)
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene display an apparently normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp9a T C 2: 168,491,481 (GRCm39) T695A probably benign Het
Btla A G 16: 45,044,821 (GRCm39) N36D probably benign Het
Btla T C 16: 45,070,713 (GRCm39) V224A possibly damaging Het
Cep126 T C 9: 8,100,564 (GRCm39) N657D probably benign Het
Cops3 T A 11: 59,718,780 (GRCm39) K171N probably benign Het
Crocc2 A G 1: 93,112,775 (GRCm39) R193G probably benign Het
Dis3l T C 9: 64,214,837 (GRCm39) I911V probably benign Het
Dpp6 G A 5: 27,923,507 (GRCm39) probably null Het
Efcab5 A T 11: 76,996,260 (GRCm39) Y1100* probably null Het
Fcgbpl1 C T 7: 27,843,611 (GRCm39) T833I possibly damaging Het
Galnt10 A G 11: 57,656,448 (GRCm39) T211A probably benign Het
Gdf9 A G 11: 53,324,515 (GRCm39) T95A probably benign Het
Gm826 T A 2: 160,169,328 (GRCm39) probably benign Het
Hsd17b6 C T 10: 127,829,636 (GRCm39) probably null Het
Hyal4 A G 6: 24,765,849 (GRCm39) N401S probably benign Het
Itga8 C T 2: 12,234,954 (GRCm39) V435I probably benign Het
Nr1h5 G A 3: 102,848,427 (GRCm39) P418L probably damaging Het
Or3a4 G A 11: 73,945,505 (GRCm39) R27W probably benign Het
Or4f15 G A 2: 111,813,874 (GRCm39) P182S probably damaging Het
Or4n4 T G 14: 50,518,826 (GRCm39) K295Q probably damaging Het
Or6c214 C A 10: 129,591,277 (GRCm39) G14V probably damaging Het
Or9i14 T C 19: 13,792,992 (GRCm39) probably benign Het
Prdm11 G A 2: 92,805,990 (GRCm39) A320V probably benign Het
Ptpn5 T C 7: 46,732,831 (GRCm39) probably null Het
Reln T A 5: 22,137,774 (GRCm39) I2473L probably benign Het
Rmnd5a A T 6: 71,371,659 (GRCm39) C180* probably null Het
Rsrc1 C T 3: 66,901,982 (GRCm39) P44L unknown Het
Sec24b A G 3: 129,790,350 (GRCm39) L462S probably damaging Het
Slc26a9 A T 1: 131,686,555 (GRCm39) Y425F possibly damaging Het
Sult1b1 T C 5: 87,682,912 (GRCm39) D11G probably benign Het
Tgs1 T A 4: 3,604,760 (GRCm39) Y727* probably null Het
Tmem80 T C 7: 140,915,839 (GRCm39) V83A probably benign Het
Ttn T C 2: 76,551,978 (GRCm39) T31220A probably benign Het
Usp46 A T 5: 74,177,377 (GRCm39) D167E probably benign Het
Vmn2r67 T A 7: 84,805,046 (GRCm39) D22V possibly damaging Het
Zswim5 C A 4: 116,808,202 (GRCm39) P262Q probably damaging Het
Other mutations in Sapcd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01337:Sapcd2 APN 2 25,266,491 (GRCm39) makesense probably null
R1596:Sapcd2 UTSW 2 25,266,422 (GRCm39) missense probably damaging 1.00
R3815:Sapcd2 UTSW 2 25,263,518 (GRCm39) intron probably benign
R4826:Sapcd2 UTSW 2 25,262,768 (GRCm39) missense probably benign 0.09
R4926:Sapcd2 UTSW 2 25,263,578 (GRCm39) splice site probably null
R6794:Sapcd2 UTSW 2 25,266,379 (GRCm39) missense probably damaging 1.00
R7090:Sapcd2 UTSW 2 25,266,091 (GRCm39) missense probably benign 0.00
R7659:Sapcd2 UTSW 2 25,265,978 (GRCm39) critical splice acceptor site probably null
R7744:Sapcd2 UTSW 2 25,263,508 (GRCm39) missense unknown
R9697:Sapcd2 UTSW 2 25,262,925 (GRCm39) nonsense probably null
R9728:Sapcd2 UTSW 2 25,262,669 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAACAGGTGTGCCAGGTTC -3'
(R):5'- TGCTTGATGAGTGCAGACTTC -3'

Sequencing Primer
(F):5'- AGGTTCCGGGACTTCCTCATG -3'
(R):5'- TATCAGTCACCTCCTGGGCAG -3'
Posted On 2018-05-24