Incidental Mutation 'IGL01099:Olfr894'
ID51914
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr894
Ensembl Gene ENSMUSG00000070311
Gene Nameolfactory receptor 894
SynonymsGA_x6K02T2PVTD-31898993-31899934, MOR170-5
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #IGL01099
Quality Score
Status
Chromosome9
Chromosomal Location38218055-38221706 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 38219743 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 307 (S307P)
Ref Sequence ENSEMBL: ENSMUSP00000091389 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093866] [ENSMUST00000212992]
Predicted Effect probably benign
Transcript: ENSMUST00000093866
AA Change: S307P

PolyPhen 2 Score 0.181 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000091389
Gene: ENSMUSG00000070311
AA Change: S307P

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 8.8e-47 PFAM
Pfam:7tm_1 44 293 1.1e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212992
AA Change: S304P

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933425L06Rik A T 13: 105,109,360 H143L probably benign Het
Abca8a G A 11: 110,074,205 probably benign Het
Adam28 A G 14: 68,637,329 probably null Het
Adcy10 A G 1: 165,539,842 I560M probably benign Het
Alpl G A 4: 137,743,313 probably benign Het
Ank1 G A 8: 23,108,249 G753D probably damaging Het
Arhgef28 A T 13: 97,953,972 probably benign Het
Bmp7 A T 2: 172,875,262 C329S probably damaging Het
Capn13 T C 17: 73,351,509 D188G probably damaging Het
Car10 G A 11: 93,578,690 E164K possibly damaging Het
Cfhr1 T A 1: 139,547,759 probably benign Het
Col11a1 C T 3: 114,112,041 R562* probably null Het
Colec12 C T 18: 9,848,826 R335C probably damaging Het
Cyb561d2 C T 9: 107,540,289 probably null Het
D430042O09Rik T A 7: 125,865,320 H1286Q probably damaging Het
Epb41l3 A G 17: 69,210,193 D72G possibly damaging Het
Etl4 T C 2: 20,807,111 L1335P probably benign Het
F5 T G 1: 164,194,334 N1459K probably damaging Het
Fam161a T C 11: 23,015,894 probably benign Het
Flnc G A 6: 29,433,618 V54M probably damaging Het
Fndc3b T C 3: 27,463,817 I607V probably benign Het
Fscb A G 12: 64,472,101 S864P unknown Het
Glod4 T A 11: 76,239,550 K36* probably null Het
Gm6619 G A 6: 131,490,430 R86Q possibly damaging Het
Gm7052 T C 17: 22,039,725 probably benign Het
Gyg A T 3: 20,151,047 M119K probably benign Het
Ifit2 A T 19: 34,573,302 I81F probably damaging Het
Insr T C 8: 3,258,682 Y118C probably damaging Het
Kcnh3 T C 15: 99,239,736 S771P probably benign Het
Kndc1 C A 7: 139,920,784 H688Q probably damaging Het
Mybpc2 A G 7: 44,516,167 C330R probably damaging Het
Naa50 A T 16: 44,156,469 N23I probably damaging Het
Olfr544 T A 7: 102,484,478 D214V probably damaging Het
Olfr76 A G 19: 12,119,876 S279P probably damaging Het
Olfr912 T C 9: 38,582,077 S267P probably benign Het
Pfkp A T 13: 6,603,390 probably benign Het
Phlda2 G A 7: 143,502,139 probably null Het
Plxnd1 C A 6: 115,969,945 V823L probably benign Het
Ppil2 T A 16: 17,091,212 M368L probably damaging Het
Prpf40a T A 2: 53,141,835 H794L probably benign Het
Ripor2 A T 13: 24,701,207 H436L probably benign Het
Rnf138 T A 18: 21,020,913 C159S possibly damaging Het
Scn7a A T 2: 66,684,238 V1064D probably damaging Het
Slc12a2 T A 18: 57,906,020 C557* probably null Het
Slc1a6 T C 10: 78,788,997 S79P possibly damaging Het
Snapin G A 3: 90,490,602 probably benign Het
Tdp1 A T 12: 99,915,445 probably benign Het
Tigar G T 6: 127,088,145 A180E probably benign Het
Trav6-2 A T 14: 52,667,665 T48S probably benign Het
Ttn A G 2: 76,728,432 Y29702H probably damaging Het
Ush1c A G 7: 46,205,262 S689P probably damaging Het
Vmn1r40 A T 6: 89,714,596 I132F probably damaging Het
Vmn1r85 T A 7: 13,084,534 K228* probably null Het
Wdr33 C A 18: 31,906,789 probably benign Het
Ybx2 A T 11: 69,940,730 Q136L probably damaging Het
Other mutations in Olfr894
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01772:Olfr894 APN 9 38219609 missense probably damaging 0.97
IGL02253:Olfr894 APN 9 38219735 missense probably benign 0.01
IGL02279:Olfr894 APN 9 38219093 missense probably benign 0.00
IGL03031:Olfr894 APN 9 38219065 missense probably damaging 0.99
IGL03163:Olfr894 APN 9 38219414 missense probably benign 0.00
R0417:Olfr894 UTSW 9 38219455 missense probably benign 0.01
R0458:Olfr894 UTSW 9 38219048 missense probably damaging 0.97
R1498:Olfr894 UTSW 9 38219380 missense probably damaging 1.00
R1765:Olfr894 UTSW 9 38219252 missense probably benign 0.01
R2020:Olfr894 UTSW 9 38219432 missense possibly damaging 0.47
R2282:Olfr894 UTSW 9 38218828 missense probably benign 0.01
R3928:Olfr894 UTSW 9 38218835 start codon destroyed probably null 0.63
R4716:Olfr894 UTSW 9 38219418 missense probably damaging 0.99
R4911:Olfr894 UTSW 9 38219096 missense probably damaging 0.99
R5148:Olfr894 UTSW 9 38219021 missense probably benign 0.01
R7677:Olfr894 UTSW 9 38219028 missense probably damaging 1.00
R7971:Olfr894 UTSW 9 38219547 missense probably benign 0.00
R8219:Olfr894 UTSW 9 38219372 missense probably damaging 0.98
X0050:Olfr894 UTSW 9 38219150 missense probably benign 0.00
Posted On2013-06-21