Incidental Mutation 'R6445:Ikzf4'
ID 519167
Institutional Source Beutler Lab
Gene Symbol Ikzf4
Ensembl Gene ENSMUSG00000002578
Gene Name IKAROS family zinc finger 4
Synonyms Zfpn1a4, A630026H08Rik, Eos
MMRRC Submission 044388-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6445 (G1)
Quality Score 146.008
Status Not validated
Chromosome 10
Chromosomal Location 128466712-128505227 bp(-) (GRCm39)
Type of Mutation splice site (86 bp from exon)
DNA Base Change (assembly) C to A at 128472424 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152234 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000133342] [ENSMUST00000221150] [ENSMUST00000222067] [ENSMUST00000223162]
AlphaFold Q8C208
Predicted Effect probably null
Transcript: ENSMUST00000133342
SMART Domains Protein: ENSMUSP00000114404
Gene: ENSMUSG00000002578

DomainStartEndE-ValueType
ZnF_C2H2 159 181 7.67e-2 SMART
ZnF_C2H2 187 209 1.72e-4 SMART
ZnF_C2H2 215 237 1.72e-4 SMART
ZnF_C2H2 248 271 1.18e-2 SMART
low complexity region 423 436 N/A INTRINSIC
low complexity region 475 484 N/A INTRINSIC
ZnF_C2H2 531 553 7.49e0 SMART
ZnF_C2H2 559 583 3.52e-1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000221150
Predicted Effect probably null
Transcript: ENSMUST00000222067
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222899
Predicted Effect probably benign
Transcript: ENSMUST00000222901
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223145
Predicted Effect probably benign
Transcript: ENSMUST00000223162
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.7%
  • 10x: 98.2%
  • 20x: 93.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
BC061237 C A 14: 44,738,731 (GRCm39) D43E probably benign Het
Cdh22 T C 2: 165,012,612 (GRCm39) I158V probably damaging Het
Cntrl A G 2: 35,052,860 (GRCm39) I1676V probably benign Het
Crem T C 18: 3,309,671 (GRCm39) Y18C probably benign Het
Cyp2b9 A G 7: 25,886,412 (GRCm39) I146V probably benign Het
Efcab14 C A 4: 115,613,668 (GRCm39) H205Q possibly damaging Het
Efcab6 T C 15: 83,752,558 (GRCm39) Y1437C probably damaging Het
Gm3055 T A 10: 81,945,506 (GRCm39) N375K possibly damaging Het
Gm36864 A T 7: 43,886,842 (GRCm39) Q245L possibly damaging Het
Gna11 A T 10: 81,369,167 (GRCm39) I132N probably damaging Het
Il9r C T 11: 32,141,000 (GRCm39) G346D possibly damaging Het
Krt71 C T 15: 101,648,775 (GRCm39) R190Q probably benign Het
Mfsd8 T C 3: 40,791,553 (GRCm39) I54V probably damaging Het
Nktr G T 9: 121,577,480 (GRCm39) probably benign Het
Or51f23c-ps1 T C 7: 102,431,465 (GRCm39) S261P probably benign Het
Or5ac17 A T 16: 59,036,472 (GRCm39) F168Y probably damaging Het
Peli2 T C 14: 48,493,905 (GRCm39) S376P possibly damaging Het
Pik3r2 C T 8: 71,224,670 (GRCm39) A202T probably benign Het
Pms1 A T 1: 53,231,353 (GRCm39) I832K possibly damaging Het
Reln T C 5: 22,124,212 (GRCm39) K2765E probably benign Het
Rp1 A T 1: 4,296,840 (GRCm39) N744K unknown Het
Smcr8 T C 11: 60,669,841 (GRCm39) Y330H possibly damaging Het
Sned1 A T 1: 93,211,318 (GRCm39) R281S possibly damaging Het
Synm A G 7: 67,383,393 (GRCm39) V1423A probably benign Het
Syt10 G A 15: 89,698,471 (GRCm39) T291I probably damaging Het
Ttn T C 2: 76,744,880 (GRCm39) probably benign Het
Wdr3 T C 3: 100,063,719 (GRCm39) T186A possibly damaging Het
Zfp451 A C 1: 33,812,092 (GRCm39) D874E probably damaging Het
Other mutations in Ikzf4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Ikzf4 APN 10 128,470,416 (GRCm39) missense probably benign 0.00
IGL01649:Ikzf4 APN 10 128,471,689 (GRCm39) missense probably damaging 1.00
IGL02261:Ikzf4 APN 10 128,472,591 (GRCm39) missense possibly damaging 0.50
IGL02315:Ikzf4 APN 10 128,470,014 (GRCm39) missense probably damaging 1.00
R0099:Ikzf4 UTSW 10 128,470,066 (GRCm39) missense probably damaging 0.97
R0200:Ikzf4 UTSW 10 128,470,545 (GRCm39) missense probably damaging 0.96
R0365:Ikzf4 UTSW 10 128,470,276 (GRCm39) missense probably benign
R0376:Ikzf4 UTSW 10 128,468,625 (GRCm39) missense probably benign
R0456:Ikzf4 UTSW 10 128,471,677 (GRCm39) missense probably damaging 0.98
R0536:Ikzf4 UTSW 10 128,477,118 (GRCm39) missense probably benign 0.09
R1731:Ikzf4 UTSW 10 128,470,401 (GRCm39) missense probably benign 0.03
R2017:Ikzf4 UTSW 10 128,470,026 (GRCm39) missense probably damaging 1.00
R4158:Ikzf4 UTSW 10 128,479,605 (GRCm39) intron probably benign
R4160:Ikzf4 UTSW 10 128,479,605 (GRCm39) intron probably benign
R4623:Ikzf4 UTSW 10 128,476,988 (GRCm39) missense probably damaging 1.00
R4789:Ikzf4 UTSW 10 128,468,575 (GRCm39) missense probably benign 0.00
R5008:Ikzf4 UTSW 10 128,477,119 (GRCm39) missense probably benign 0.03
R5432:Ikzf4 UTSW 10 128,470,047 (GRCm39) missense probably damaging 1.00
R6091:Ikzf4 UTSW 10 128,470,542 (GRCm39) missense probably benign 0.15
R7204:Ikzf4 UTSW 10 128,479,759 (GRCm39) missense possibly damaging 0.64
R7219:Ikzf4 UTSW 10 128,470,252 (GRCm39) missense possibly damaging 0.64
R7239:Ikzf4 UTSW 10 128,477,113 (GRCm39) missense probably damaging 1.00
R7485:Ikzf4 UTSW 10 128,468,451 (GRCm39) missense unknown
R7710:Ikzf4 UTSW 10 128,468,610 (GRCm39) missense possibly damaging 0.46
R7988:Ikzf4 UTSW 10 128,470,324 (GRCm39) missense probably damaging 1.00
R9127:Ikzf4 UTSW 10 128,468,487 (GRCm39) missense unknown
R9352:Ikzf4 UTSW 10 128,472,623 (GRCm39) missense probably benign 0.22
Z1176:Ikzf4 UTSW 10 128,470,099 (GRCm39) missense possibly damaging 0.69
Z1177:Ikzf4 UTSW 10 128,478,509 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- TGCCAAGAATCATCGTACATGTC -3'
(R):5'- AACAGCAAAGTACCCTGGAG -3'

Sequencing Primer
(F):5'- GAATCATCGTACATGTCCAGCC -3'
(R):5'- AGTACCCTGGAGGAGCAC -3'
Posted On 2018-05-24