Incidental Mutation 'IGL01100:Ip6k2'
ID 51919
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ip6k2
Ensembl Gene ENSMUSG00000032599
Gene Name inositol hexaphosphate kinase 2
Synonyms Ihpk2, 1500005N04Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01100
Quality Score
Status
Chromosome 9
Chromosomal Location 108660995-108683536 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 108682943 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Isoleucine at position 305 (S305I)
Ref Sequence ENSEMBL: ENSMUSP00000141605 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035218] [ENSMUST00000085018] [ENSMUST00000193560] [ENSMUST00000194819] [ENSMUST00000195323]
AlphaFold Q80V72
Predicted Effect probably benign
Transcript: ENSMUST00000035218
SMART Domains Protein: ENSMUSP00000035218
Gene: ENSMUSG00000032598

DomainStartEndE-ValueType
SH3 1 57 2.21e-9 SMART
low complexity region 162 179 N/A INTRINSIC
low complexity region 200 215 N/A INTRINSIC
low complexity region 230 240 N/A INTRINSIC
low complexity region 249 271 N/A INTRINSIC
low complexity region 288 298 N/A INTRINSIC
Pfam:DUF2013 539 675 5e-36 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000085018
AA Change: S351I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000082091
Gene: ENSMUSG00000032599
AA Change: S351I

DomainStartEndE-ValueType
Pfam:IPK 225 440 2.7e-64 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000193560
AA Change: S305I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141605
Gene: ENSMUSG00000032599
AA Change: S305I

DomainStartEndE-ValueType
Pfam:IPK 179 394 1.6e-61 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000194819
SMART Domains Protein: ENSMUSP00000141702
Gene: ENSMUSG00000032598

DomainStartEndE-ValueType
SH3 1 52 3.3e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000195323
SMART Domains Protein: ENSMUSP00000141728
Gene: ENSMUSG00000032598

DomainStartEndE-ValueType
SH3 1 57 1.4e-11 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a null allele are resistant to radiation-induced mortality and show increased double-strand DNA break repair and incidence of induced aerodigestive tract carcinomas. Homozygotes for another null allele show increased B cell viability after radiation or neocarzinostatin treatment. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T G 11: 9,224,673 (GRCm39) probably null Het
Abca8a C T 11: 109,949,249 (GRCm39) probably null Het
Acad11 A G 9: 103,953,607 (GRCm39) T32A probably damaging Het
Ak7 T A 12: 105,679,833 (GRCm39) N122K probably benign Het
Arrb1 A T 7: 99,236,420 (GRCm39) probably null Het
Csde1 C A 3: 102,947,841 (GRCm39) R132S possibly damaging Het
Emilin1 A G 5: 31,075,748 (GRCm39) H663R probably benign Het
Etaa1 A G 11: 17,902,576 (GRCm39) probably null Het
Fat3 A T 9: 16,286,524 (GRCm39) F1000I probably damaging Het
Foxj2 T C 6: 122,805,350 (GRCm39) L74P probably damaging Het
Gas6 C T 8: 13,525,118 (GRCm39) V289M probably benign Het
Gm10801 A T 2: 98,494,328 (GRCm39) Y135F probably benign Het
Ihh C T 1: 74,985,601 (GRCm39) A295T probably damaging Het
Kcnk2 A G 1: 189,072,133 (GRCm39) V65A probably damaging Het
Kif26b G A 1: 178,744,809 (GRCm39) C1635Y probably benign Het
Klhdc4 G A 8: 122,548,582 (GRCm39) Q44* probably null Het
Madd C A 2: 90,988,385 (GRCm39) R1216L probably damaging Het
Myo15a T A 11: 60,401,984 (GRCm39) C3076S probably damaging Het
Or1l4 A T 2: 37,091,652 (GRCm39) H133L possibly damaging Het
Or52e18 T A 7: 104,609,202 (GRCm39) I246F probably benign Het
Polq C A 16: 36,881,474 (GRCm39) P934T probably benign Het
Prkaa1 A T 15: 5,203,799 (GRCm39) K227M probably damaging Het
Psap G A 10: 60,135,708 (GRCm39) G388S probably benign Het
Repin1 A G 6: 48,573,839 (GRCm39) E200G probably damaging Het
Samd9l C A 6: 3,375,863 (GRCm39) S466I possibly damaging Het
Slc5a3 A G 16: 91,876,110 (GRCm39) probably benign Het
Smg9 G A 7: 24,116,376 (GRCm39) V314M probably damaging Het
Tktl1 G A X: 73,244,232 (GRCm39) R352H probably benign Het
Ube2z A G 11: 95,953,849 (GRCm39) V123A probably damaging Het
Vmn1r176 A T 7: 23,535,049 (GRCm39) F35I probably benign Het
Zdhhc18 A T 4: 133,340,269 (GRCm39) Y293N probably damaging Het
Other mutations in Ip6k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01585:Ip6k2 APN 9 108,673,512 (GRCm39) missense probably damaging 1.00
IGL02377:Ip6k2 APN 9 108,681,798 (GRCm39) missense probably damaging 1.00
IGL02831:Ip6k2 APN 9 108,681,733 (GRCm39) unclassified probably benign
banting UTSW 9 108,682,847 (GRCm39) missense probably benign 0.07
R0310:Ip6k2 UTSW 9 108,676,432 (GRCm39) splice site probably benign
R0541:Ip6k2 UTSW 9 108,681,826 (GRCm39) missense probably damaging 1.00
R2378:Ip6k2 UTSW 9 108,673,500 (GRCm39) splice site probably null
R4119:Ip6k2 UTSW 9 108,682,847 (GRCm39) missense probably benign 0.07
R4120:Ip6k2 UTSW 9 108,682,847 (GRCm39) missense probably benign 0.07
R4165:Ip6k2 UTSW 9 108,682,847 (GRCm39) missense probably benign 0.07
R4231:Ip6k2 UTSW 9 108,682,847 (GRCm39) missense probably benign 0.07
R4232:Ip6k2 UTSW 9 108,682,847 (GRCm39) missense probably benign 0.07
R4235:Ip6k2 UTSW 9 108,682,847 (GRCm39) missense probably benign 0.07
R4236:Ip6k2 UTSW 9 108,682,847 (GRCm39) missense probably benign 0.07
R4327:Ip6k2 UTSW 9 108,682,847 (GRCm39) missense probably benign 0.07
R4328:Ip6k2 UTSW 9 108,682,847 (GRCm39) missense probably benign 0.07
R5019:Ip6k2 UTSW 9 108,674,945 (GRCm39) intron probably benign
R5466:Ip6k2 UTSW 9 108,675,661 (GRCm39) missense probably damaging 1.00
R6017:Ip6k2 UTSW 9 108,674,466 (GRCm39) missense probably benign 0.01
R6688:Ip6k2 UTSW 9 108,683,210 (GRCm39) missense probably benign 0.00
R6971:Ip6k2 UTSW 9 108,674,510 (GRCm39) intron probably benign
R7150:Ip6k2 UTSW 9 108,673,930 (GRCm39) missense unknown
R8007:Ip6k2 UTSW 9 108,682,955 (GRCm39) missense probably benign 0.15
R8826:Ip6k2 UTSW 9 108,675,379 (GRCm39) critical splice donor site probably null
R9039:Ip6k2 UTSW 9 108,681,807 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21