Mutagenetix > Incidental Mutation

Incidental Mutation 'R6446:Vmn2r108'

519209

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r108

Ensembl Gene

ENSMUSG00000091805

Gene Name

vomeronasal 2, receptor 108

Synonyms

EG627805

MMRRC Submission

044583-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

R6446 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20682635-20701498 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 20692609 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 82 (Y82*)

Ref Sequence

ENSEMBL: ENSMUSP00000130373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167314]

AlphaFold

E9PYS0

Predicted Effect

probably null
Transcript: ENSMUST00000167314
AA Change: Y82*

SMART Domains

Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: Y82*

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	6e-33	PFAM
Pfam:NCD3G	510	563	9.2e-22	PFAM
Pfam:7tm_3	593	831	2.2e-51	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 93.9%

Validation Efficiency

97% (36/37)

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp13a3	A	G	16: 30,180,687 (GRCm39)	L114P	probably benign	Het
Blm	GCCTCCTCCTCCTCCTCCTCCTCCTCCTCC	GCCTCCTCCTCCTCCTCCTCCTCCTCC	7: 80,162,652 (GRCm39)		probably benign	Het
Catsperg1	T	C	7: 28,905,992 (GRCm39)	I196V	probably benign	Het
Cbx2	T	A	11: 118,918,752 (GRCm39)	S106T	probably benign	Het
Ccar2	T	A	14: 70,380,518 (GRCm39)	E354V	probably benign	Het
Ccr1	A	G	9: 123,764,143 (GRCm39)	I129T	probably damaging	Het
Cdkl2	T	A	5: 92,181,076 (GRCm39)	I188F	probably damaging	Het
Cep350	T	C	1: 155,737,900 (GRCm39)	N2648D	probably benign	Het
Chtf18	A	G	17: 25,940,218 (GRCm39)	S658P	probably benign	Het
Csnka2ip	G	A	16: 64,299,744 (GRCm39)	Q207*	probably null	Het
Dennd5a	A	G	7: 109,493,873 (GRCm39)	L1253P	probably damaging	Het
Dennd6a	T	A	14: 26,350,689 (GRCm39)	I374K	probably damaging	Het
Dut	T	C	2: 125,092,939 (GRCm39)		probably null	Het
Gcm1	T	C	9: 77,967,065 (GRCm39)	Y95H	probably benign	Het
Grid2	A	T	6: 64,322,577 (GRCm39)	I526F	probably damaging	Het
Hectd4	T	A	5: 121,472,438 (GRCm39)	Y2725N	possibly damaging	Het
Helq	A	T	5: 100,916,250 (GRCm39)	N907K	possibly damaging	Het
Hpse	G	A	5: 100,843,435 (GRCm39)	Q246*	probably null	Het
Iigp1c	A	G	18: 60,378,840 (GRCm39)	D125G	probably damaging	Het
Kcnj15	C	T	16: 95,097,118 (GRCm39)	H247Y	probably benign	Het
Kif27	C	A	13: 58,493,530 (GRCm39)	V138F	probably damaging	Het
Map7	T	G	10: 20,153,979 (GRCm39)	D698E	unknown	Het
Mtmr11	A	T	3: 96,078,504 (GRCm39)	S687C	probably benign	Het
Ncbp2	CGTCTGGATG	CG	16: 31,775,161 (GRCm39)		probably null	Het
Nup210l	G	A	3: 90,079,375 (GRCm39)	G953E	probably damaging	Het
Or14c45	T	A	7: 86,176,310 (GRCm39)	I115N	possibly damaging	Het
Piezo2	G	T	18: 63,219,678 (GRCm39)	P792T	probably damaging	Het
Pld3	T	C	7: 27,237,156 (GRCm39)	D241G	probably damaging	Het
Prss35	G	T	9: 86,637,706 (GRCm39)	V159F	probably damaging	Het
Rimbp3	A	T	16: 17,030,793 (GRCm39)	M1406L	probably benign	Het
Serpina3g	T	C	12: 104,205,341 (GRCm39)	F27L	probably damaging	Het
Setd1b	G	A	5: 123,299,862 (GRCm39)		probably benign	Het
Sh3glb1	T	C	3: 144,411,366 (GRCm39)	K13E	probably damaging	Het
Slc29a1	A	T	17: 45,900,171 (GRCm39)	I217N	possibly damaging	Het
Spag17	A	T	3: 100,010,448 (GRCm39)	T1981S	probably benign	Het
Svil	A	C	18: 5,057,323 (GRCm39)	E590D	probably benign	Het
Synm	A	G	7: 67,384,714 (GRCm39)	S541P	probably damaging	Het

Other mutations in Vmn2r108

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Vmn2r108	APN	17	20,682,774 (GRCm39)	missense	probably damaging	0.98
IGL01143:Vmn2r108	APN	17	20,682,727 (GRCm39)	missense	possibly damaging	0.82
IGL01311:Vmn2r108	APN	17	20,682,939 (GRCm39)	nonsense	probably null
IGL01411:Vmn2r108	APN	17	20,691,282 (GRCm39)	missense	probably benign	0.01
IGL01414:Vmn2r108	APN	17	20,691,942 (GRCm39)	missense	probably benign	0.00
IGL01536:Vmn2r108	APN	17	20,683,543 (GRCm39)	missense	probably damaging	1.00
IGL01748:Vmn2r108	APN	17	20,683,476 (GRCm39)	missense	probably benign	0.03
IGL01769:Vmn2r108	APN	17	20,691,280 (GRCm39)	missense	probably benign	0.02
IGL02022:Vmn2r108	APN	17	20,691,987 (GRCm39)	missense	possibly damaging	0.77
IGL02041:Vmn2r108	APN	17	20,683,398 (GRCm39)	missense	probably damaging	1.00
IGL02049:Vmn2r108	APN	17	20,691,608 (GRCm39)	missense	probably benign	0.00
IGL02344:Vmn2r108	APN	17	20,689,405 (GRCm39)	missense	probably damaging	1.00
IGL02939:Vmn2r108	APN	17	20,691,545 (GRCm39)	missense	probably benign	0.05
IGL03202:Vmn2r108	APN	17	20,691,319 (GRCm39)	nonsense	probably null
PIT4498001:Vmn2r108	UTSW	17	20,683,279 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r108	UTSW	17	20,691,897 (GRCm39)	missense	probably benign	0.07
R0505:Vmn2r108	UTSW	17	20,683,096 (GRCm39)	missense	possibly damaging	0.77
R0833:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0836:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0943:Vmn2r108	UTSW	17	20,691,397 (GRCm39)	nonsense	probably null
R1411:Vmn2r108	UTSW	17	20,683,107 (GRCm39)	missense	probably damaging	0.98
R1442:Vmn2r108	UTSW	17	20,692,623 (GRCm39)	nonsense	probably null
R1587:Vmn2r108	UTSW	17	20,692,383 (GRCm39)	missense	probably damaging	1.00
R1751:Vmn2r108	UTSW	17	20,682,786 (GRCm39)	missense	probably damaging	1.00
R1773:Vmn2r108	UTSW	17	20,689,335 (GRCm39)	missense	probably damaging	1.00
R2021:Vmn2r108	UTSW	17	20,691,252 (GRCm39)	missense	probably benign	0.00
R2159:Vmn2r108	UTSW	17	20,689,363 (GRCm39)	missense	probably benign	0.41
R2224:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2226:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2517:Vmn2r108	UTSW	17	20,692,577 (GRCm39)	missense	probably damaging	1.00
R3710:Vmn2r108	UTSW	17	20,682,932 (GRCm39)	missense	probably benign
R4470:Vmn2r108	UTSW	17	20,682,990 (GRCm39)	missense	probably damaging	1.00
R4686:Vmn2r108	UTSW	17	20,691,636 (GRCm39)	missense	probably damaging	0.99
R4729:Vmn2r108	UTSW	17	20,692,632 (GRCm39)	missense	probably damaging	0.99
R4799:Vmn2r108	UTSW	17	20,682,891 (GRCm39)	missense	probably damaging	1.00
R4993:Vmn2r108	UTSW	17	20,701,449 (GRCm39)	missense	probably benign	0.04
R5088:Vmn2r108	UTSW	17	20,690,454 (GRCm39)	missense	possibly damaging	0.46
R5213:Vmn2r108	UTSW	17	20,691,755 (GRCm39)	missense	probably benign	0.00
R5289:Vmn2r108	UTSW	17	20,691,866 (GRCm39)	missense	probably damaging	1.00
R5290:Vmn2r108	UTSW	17	20,691,665 (GRCm39)	missense	probably benign	0.00
R5713:Vmn2r108	UTSW	17	20,691,290 (GRCm39)	missense	probably damaging	1.00
R5753:Vmn2r108	UTSW	17	20,683,179 (GRCm39)	missense	probably damaging	0.99
R5792:Vmn2r108	UTSW	17	20,683,398 (GRCm39)	missense	probably damaging	0.99
R5798:Vmn2r108	UTSW	17	20,692,545 (GRCm39)	missense	probably benign	0.39
R5897:Vmn2r108	UTSW	17	20,691,580 (GRCm39)	missense	probably benign	0.01
R6018:Vmn2r108	UTSW	17	20,683,268 (GRCm39)	missense	possibly damaging	0.83
R6093:Vmn2r108	UTSW	17	20,701,402 (GRCm39)	missense	probably benign	0.00
R6156:Vmn2r108	UTSW	17	20,692,447 (GRCm39)	missense	probably benign	0.03
R6199:Vmn2r108	UTSW	17	20,682,644 (GRCm39)	missense	probably benign	0.01
R6259:Vmn2r108	UTSW	17	20,683,371 (GRCm39)	missense	possibly damaging	0.95
R6309:Vmn2r108	UTSW	17	20,691,660 (GRCm39)	missense	probably damaging	0.98
R6324:Vmn2r108	UTSW	17	20,691,977 (GRCm39)	nonsense	probably null
R6364:Vmn2r108	UTSW	17	20,691,260 (GRCm39)	missense	probably benign	0.00
R6541:Vmn2r108	UTSW	17	20,701,480 (GRCm39)	missense	probably benign	0.02
R7025:Vmn2r108	UTSW	17	20,691,345 (GRCm39)	missense	possibly damaging	0.67
R7063:Vmn2r108	UTSW	17	20,701,410 (GRCm39)	missense	probably damaging	1.00
R7092:Vmn2r108	UTSW	17	20,701,338 (GRCm39)	missense	probably benign	0.10
R7096:Vmn2r108	UTSW	17	20,682,762 (GRCm39)	missense	probably damaging	1.00
R7203:Vmn2r108	UTSW	17	20,683,038 (GRCm39)	missense	probably benign	0.12
R7458:Vmn2r108	UTSW	17	20,692,532 (GRCm39)	missense	probably benign	0.17
R7619:Vmn2r108	UTSW	17	20,692,457 (GRCm39)	missense	probably benign	0.02
R7841:Vmn2r108	UTSW	17	20,690,305 (GRCm39)	critical splice donor site	probably null
R7944:Vmn2r108	UTSW	17	20,691,890 (GRCm39)	missense	probably damaging	0.99
R8048:Vmn2r108	UTSW	17	20,691,762 (GRCm39)	missense	probably benign	0.29
R8213:Vmn2r108	UTSW	17	20,690,350 (GRCm39)	missense	probably benign	0.03
R8218:Vmn2r108	UTSW	17	20,683,465 (GRCm39)	missense	probably damaging	1.00
R8507:Vmn2r108	UTSW	17	20,683,195 (GRCm39)	nonsense	probably null
R8708:Vmn2r108	UTSW	17	20,682,687 (GRCm39)	missense	probably damaging	0.98
R8845:Vmn2r108	UTSW	17	20,691,361 (GRCm39)	missense	probably benign	0.03
R9030:Vmn2r108	UTSW	17	20,690,312 (GRCm39)	missense	probably benign	0.01
R9226:Vmn2r108	UTSW	17	20,691,330 (GRCm39)	missense	probably benign
R9278:Vmn2r108	UTSW	17	20,692,561 (GRCm39)	missense	probably benign	0.11
X0022:Vmn2r108	UTSW	17	20,691,371 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r108	UTSW	17	20,691,375 (GRCm39)	missense	probably benign	0.01
Z1177:Vmn2r108	UTSW	17	20,691,219 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TGTTCCTGTGAGAGCAGTAGC -3'
(R):5'- GCCAAGATCAAGGTATCAAAAGATC -3'

Sequencing Primer
(F):5'- TCCTGTGAGAGCAGTAGCAAAATTAC -3'
(R):5'- CTTGCCAAACTTTAACATATTTACCC -3'

Posted On

2018-05-24