Incidental Mutation 'R6449:Ano10'
ID 519302
Institutional Source Beutler Lab
Gene Symbol Ano10
Ensembl Gene ENSMUSG00000037949
Gene Name anoctamin 10
Synonyms Tmem16k
MMRRC Submission 044585-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R6449 (G1)
Quality Score 125.008
Status Validated
Chromosome 9
Chromosomal Location 122004940-122123489 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 122030754 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149278 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042546] [ENSMUST00000214283] [ENSMUST00000214409] [ENSMUST00000214507] [ENSMUST00000216081]
AlphaFold Q8BH79
Predicted Effect probably benign
Transcript: ENSMUST00000042546
SMART Domains Protein: ENSMUSP00000045214
Gene: ENSMUSG00000037949

DomainStartEndE-ValueType
Pfam:Anoctamin 200 628 2.2e-115 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214283
Predicted Effect probably benign
Transcript: ENSMUST00000214409
Predicted Effect unknown
Transcript: ENSMUST00000214507
AA Change: D474G
Predicted Effect probably benign
Transcript: ENSMUST00000216081
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.6%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to inhibit anion conductance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a knock-out allele fail to exhibit calcium-activated chloride ion secretion in the jejunum. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik C T 7: 41,275,298 (GRCm39) Q334* probably null Het
Aadacl2fm2 A T 3: 59,652,972 (GRCm39) D137V probably damaging Het
Adam28 T C 14: 68,868,116 (GRCm39) T410A probably benign Het
Bmpr2 T A 1: 59,906,596 (GRCm39) V563E probably damaging Het
Ccdc47 A G 11: 106,095,811 (GRCm39) L295P probably damaging Het
Cdhr1 T C 14: 36,812,554 (GRCm39) T210A probably benign Het
Col16a1 G A 4: 129,960,486 (GRCm39) A408T unknown Het
Csnk1g2 A G 10: 80,475,906 (GRCm39) K415R probably damaging Het
Cyp2c29 G T 19: 39,279,311 (GRCm39) A103S probably benign Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Homo
Dsg1b A T 18: 20,527,498 (GRCm39) I210F possibly damaging Het
Fhod1 T A 8: 106,056,869 (GRCm39) D1002V probably damaging Het
Gm5592 G A 7: 40,938,010 (GRCm39) V431I probably benign Het
Gtpbp4 A T 13: 9,040,773 (GRCm39) C174* probably null Het
Il2ra A G 2: 11,685,173 (GRCm39) K170E probably benign Het
Itch T C 2: 155,005,315 (GRCm39) probably benign Het
Jazf1 A C 6: 52,754,640 (GRCm39) D145E probably damaging Het
Kank2 G T 9: 21,691,858 (GRCm39) A469E possibly damaging Het
Kirrel3 A G 9: 34,902,269 (GRCm39) I125V probably benign Het
Klra9 G T 6: 130,155,995 (GRCm39) Y253* probably null Het
Krtap27-1 C T 16: 88,467,941 (GRCm39) S201N probably benign Het
Map3k20 T C 2: 72,228,758 (GRCm39) S326P probably damaging Het
Mkks C A 2: 136,716,206 (GRCm39) V565F probably damaging Het
Ntaq1 T G 15: 58,013,994 (GRCm39) probably null Het
Or5c1 A G 2: 37,221,837 (GRCm39) D26G possibly damaging Het
Or5k8 A T 16: 58,644,889 (GRCm39) I61N probably damaging Het
Or5w11 T C 2: 87,459,493 (GRCm39) S229P possibly damaging Het
Pacsin3 A T 2: 91,090,514 (GRCm39) probably null Het
Pdcd7 A G 9: 65,264,057 (GRCm39) E434G probably damaging Het
Plekhb2 T C 1: 34,903,564 (GRCm39) F102L probably benign Het
Ppp1r9a A G 6: 5,057,458 (GRCm39) D191G probably benign Het
Psmd3 A G 11: 98,576,466 (GRCm39) T123A probably benign Het
Ptprq C T 10: 107,541,444 (GRCm39) V361M probably benign Het
Raver2 A G 4: 100,990,869 (GRCm39) D414G probably benign Het
Rnf123 G A 9: 107,933,252 (GRCm39) H1162Y probably benign Het
Sema4f A G 6: 82,894,851 (GRCm39) V448A probably benign Het
Tcf12 A T 9: 71,775,550 (GRCm39) M400K probably damaging Het
Tcl1b2 G T 12: 105,119,261 (GRCm39) E50* probably null Het
Thada A C 17: 84,736,601 (GRCm39) D893E probably benign Het
Trim24 G A 6: 37,880,587 (GRCm39) probably null Het
Ttll5 T C 12: 86,071,050 (GRCm39) S1308P probably benign Het
Ubtfl1 T A 9: 18,320,925 (GRCm39) I151N possibly damaging Het
Vmn2r70 A T 7: 85,214,157 (GRCm39) F332I probably damaging Het
Zfhx4 A G 3: 5,307,488 (GRCm39) D238G probably damaging Het
Zfp639 A G 3: 32,573,810 (GRCm39) H145R possibly damaging Het
Other mutations in Ano10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00545:Ano10 APN 9 122,090,422 (GRCm39) missense possibly damaging 0.96
IGL00886:Ano10 APN 9 122,100,390 (GRCm39) missense probably benign 0.01
IGL00932:Ano10 APN 9 122,080,297 (GRCm39) nonsense probably null
IGL01613:Ano10 APN 9 122,088,606 (GRCm39) missense possibly damaging 0.75
IGL02109:Ano10 APN 9 122,090,408 (GRCm39) missense probably damaging 1.00
IGL02397:Ano10 APN 9 122,090,458 (GRCm39) missense probably damaging 1.00
IGL02512:Ano10 APN 9 122,101,540 (GRCm39) missense possibly damaging 0.50
IGL03216:Ano10 APN 9 122,086,127 (GRCm39) missense probably damaging 1.00
arna UTSW 9 122,088,630 (GRCm39) missense possibly damaging 0.77
R0624:Ano10 UTSW 9 122,088,661 (GRCm39) splice site probably benign
R1669:Ano10 UTSW 9 122,086,249 (GRCm39) missense possibly damaging 0.94
R1801:Ano10 UTSW 9 122,082,096 (GRCm39) missense probably damaging 1.00
R2511:Ano10 UTSW 9 122,088,011 (GRCm39) missense probably damaging 0.99
R3836:Ano10 UTSW 9 122,092,829 (GRCm39) missense possibly damaging 0.58
R4027:Ano10 UTSW 9 122,081,994 (GRCm39) splice site probably benign
R4151:Ano10 UTSW 9 122,090,601 (GRCm39) nonsense probably null
R4590:Ano10 UTSW 9 122,086,231 (GRCm39) missense probably benign 0.22
R4651:Ano10 UTSW 9 122,090,181 (GRCm39) nonsense probably null
R4652:Ano10 UTSW 9 122,090,181 (GRCm39) nonsense probably null
R4676:Ano10 UTSW 9 122,092,853 (GRCm39) missense probably damaging 0.98
R5026:Ano10 UTSW 9 122,101,625 (GRCm39) nonsense probably null
R5281:Ano10 UTSW 9 122,090,552 (GRCm39) missense probably damaging 1.00
R5401:Ano10 UTSW 9 122,090,356 (GRCm39) missense probably damaging 1.00
R6269:Ano10 UTSW 9 122,090,308 (GRCm39) missense probably damaging 0.99
R6702:Ano10 UTSW 9 122,088,630 (GRCm39) missense possibly damaging 0.77
R7010:Ano10 UTSW 9 122,082,190 (GRCm39) missense probably damaging 1.00
R7384:Ano10 UTSW 9 122,005,409 (GRCm39) missense unknown
R7584:Ano10 UTSW 9 122,104,597 (GRCm39) missense probably benign
R8849:Ano10 UTSW 9 122,090,510 (GRCm39) missense probably benign 0.00
R8980:Ano10 UTSW 9 122,090,558 (GRCm39) missense probably benign 0.00
R9328:Ano10 UTSW 9 122,090,168 (GRCm39) missense possibly damaging 0.66
R9653:Ano10 UTSW 9 122,080,221 (GRCm39) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- TTGGAATCCTGCTCACTGG -3'
(R):5'- TGGCTCTGAAGTTCATACTCGC -3'

Sequencing Primer
(F):5'- CCCAGTGCTTCTATATAAGGCATGG -3'
(R):5'- GGCTCTGAAGTTCATACTCGCATTTG -3'
Posted On 2018-05-24