Incidental Mutation 'IGL01110:Olfr150'
ID51940
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr150
Ensembl Gene ENSMUSG00000094353
Gene Nameolfactory receptor 150
SynonymsGA_x6K02T2PVTD-33434302-33435240, MOR171-18, M93
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.125) question?
Stock #IGL01110
Quality Score
Status
Chromosome9
Chromosomal Location39730978-39738456 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 39737397 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 194 (V194A)
Ref Sequence ENSEMBL: ENSMUSP00000150024 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078557] [ENSMUST00000217257]
Predicted Effect probably benign
Transcript: ENSMUST00000078557
AA Change: V194A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000077635
Gene: ENSMUSG00000094353
AA Change: V194A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.7e-50 PFAM
Pfam:7tm_1 41 290 1.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217257
AA Change: V194A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bbs1 G A 19: 4,892,925 S479L possibly damaging Het
Capn6 G T X: 143,807,250 P385H probably damaging Het
Cavin1 C A 11: 100,970,474 probably benign Het
Cdh9 A G 15: 16,855,926 D684G possibly damaging Het
Dlgap5 A G 14: 47,394,326 probably benign Het
Doc2g A G 19: 4,006,577 E321G probably damaging Het
Eef1akmt1 A C 14: 57,549,790 F210V probably damaging Het
Eya1 A G 1: 14,283,130 S65P probably damaging Het
Gpx8 C T 13: 113,045,684 V72I probably benign Het
Gria1 A G 11: 57,289,381 E650G probably damaging Het
Hic1 A T 11: 75,165,519 L848Q possibly damaging Het
Mmp1b C T 9: 7,384,921 D243N probably benign Het
Mov10l1 G T 15: 89,021,257 V872L probably benign Het
Olfr1099 C T 2: 86,958,921 C179Y possibly damaging Het
Otof A G 5: 30,461,725 F25S probably damaging Het
Patj A C 4: 98,413,024 N182T probably damaging Het
Pik3r6 G A 11: 68,528,826 probably null Het
Ppil6 G A 10: 41,498,410 V96I probably benign Het
Sardh T A 2: 27,215,113 Q666L probably benign Het
Tasp1 A G 2: 139,977,618 S222P probably damaging Het
Tln2 G T 9: 67,250,582 C1158* probably null Het
Zfp707 T A 15: 75,975,195 C292S probably damaging Het
Zfp956 A G 6: 47,963,412 E235G probably benign Het
Other mutations in Olfr150
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00228:Olfr150 APN 9 39737499 missense probably damaging 1.00
IGL01343:Olfr150 APN 9 39737715 missense probably damaging 0.99
IGL01942:Olfr150 APN 9 39737666 missense possibly damaging 0.90
IGL02044:Olfr150 APN 9 39736974 missense possibly damaging 0.94
PIT4486001:Olfr150 UTSW 9 39737239 nonsense probably null
R1178:Olfr150 UTSW 9 39737346 missense probably damaging 1.00
R1451:Olfr150 UTSW 9 39737316 missense probably benign 0.00
R1672:Olfr150 UTSW 9 39737196 missense probably damaging 1.00
R1916:Olfr150 UTSW 9 39737622 missense probably benign 0.06
R2095:Olfr150 UTSW 9 39737261 missense probably damaging 0.98
R2116:Olfr150 UTSW 9 39737304 missense probably damaging 0.98
R4183:Olfr150 UTSW 9 39737048 missense probably benign 0.01
R4259:Olfr150 UTSW 9 39737703 missense probably damaging 1.00
R4590:Olfr150 UTSW 9 39736850 missense probably damaging 1.00
R5188:Olfr150 UTSW 9 39737235 missense probably benign 0.00
R6158:Olfr150 UTSW 9 39737076 missense probably benign
R6361:Olfr150 UTSW 9 39737672 missense probably damaging 1.00
R6807:Olfr150 UTSW 9 39737618 nonsense probably null
R6977:Olfr150 UTSW 9 39737034 missense probably benign 0.01
R7412:Olfr150 UTSW 9 39737126 missense probably benign 0.24
R8755:Olfr150 UTSW 9 39737490 missense probably damaging 1.00
Posted On2013-06-21