Incidental Mutation 'R6452:Cetn3'
ID 519435
Institutional Source Beutler Lab
Gene Symbol Cetn3
Ensembl Gene ENSMUSG00000021537
Gene Name centrin 3
Synonyms MmCEN3
MMRRC Submission 044588-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.581) question?
Stock # R6452 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 81931196-81945274 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 81932797 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 19 (R19*)
Ref Sequence ENSEMBL: ENSMUSP00000022009 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022009] [ENSMUST00000223793] [ENSMUST00000224433] [ENSMUST00000224574] [ENSMUST00000226007]
AlphaFold O35648
Predicted Effect probably null
Transcript: ENSMUST00000022009
AA Change: R19*
SMART Domains Protein: ENSMUSP00000022009
Gene: ENSMUSG00000021537
AA Change: R19*

DomainStartEndE-ValueType
EFh 29 57 3.82e-7 SMART
EFh 65 93 1.87e0 SMART
EFh 102 130 2.33e-2 SMART
EFh 138 166 1.26e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181520
Predicted Effect probably benign
Transcript: ENSMUST00000223793
Predicted Effect probably benign
Transcript: ENSMUST00000224433
Predicted Effect probably benign
Transcript: ENSMUST00000224574
Predicted Effect probably benign
Transcript: ENSMUST00000224705
Predicted Effect probably benign
Transcript: ENSMUST00000226007
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 93.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110070M22Rik A G 13: 119,624,651 (GRCm39) probably benign Het
Alox12e A T 11: 70,210,831 (GRCm39) V296E probably damaging Het
Bmal2 G A 6: 146,724,705 (GRCm39) E400K probably benign Het
Ccdc171 A G 4: 83,782,527 (GRCm39) D1273G probably damaging Het
Chd6 G T 2: 160,807,418 (GRCm39) P1932H possibly damaging Het
Cimip1 C A 2: 173,369,700 (GRCm39) F71L probably benign Het
Cyp2d34 A T 15: 82,500,290 (GRCm39) I483N probably benign Het
Dglucy T C 12: 100,801,468 (GRCm39) V71A possibly damaging Het
Dhx35 A G 2: 158,673,607 (GRCm39) E346G probably damaging Het
Dnajc14 A G 10: 128,643,359 (GRCm39) E427G probably damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Fasn G T 11: 120,706,237 (GRCm39) Q1036K probably damaging Het
Fermt3 A T 19: 6,992,105 (GRCm39) F92I probably benign Het
Filip1l C A 16: 57,327,163 (GRCm39) D64E possibly damaging Het
Fnbp1l A G 3: 122,338,198 (GRCm39) F491S probably damaging Het
Fzd2 T G 11: 102,495,811 (GRCm39) V85G probably damaging Het
Gjd4 G A 18: 9,280,457 (GRCm39) T207M possibly damaging Het
Gm32742 T C 9: 51,057,490 (GRCm39) E1096G probably damaging Het
Itgb3 T A 11: 104,524,290 (GRCm39) L142* probably null Het
Kctd21 T A 7: 96,996,869 (GRCm39) I114N probably benign Het
Klra4 G T 6: 130,042,329 (GRCm39) probably null Het
Larp4b T C 13: 9,197,503 (GRCm39) V240A probably damaging Het
Lrriq4 T C 3: 30,709,882 (GRCm39) S409P probably damaging Het
Magel2 A G 7: 62,030,132 (GRCm39) E1012G unknown Het
Mmp24 A T 2: 155,657,673 (GRCm39) D521V possibly damaging Het
Mocos A G 18: 24,828,998 (GRCm39) I768V probably benign Het
Mprip A T 11: 59,643,609 (GRCm39) E553V probably damaging Het
Myh8 A T 11: 67,183,275 (GRCm39) Y718F probably benign Het
Myh8 A T 11: 67,196,565 (GRCm39) I1762F possibly damaging Het
Myo7a C T 7: 97,722,374 (GRCm39) V1184M probably benign Het
Neb A T 2: 52,069,495 (GRCm39) D5775E probably benign Het
Or10h5 T C 17: 33,434,919 (GRCm39) N133S probably benign Het
Or5p66 A G 7: 107,886,100 (GRCm39) S78P probably damaging Het
Pramel19 T C 4: 101,798,640 (GRCm39) Y204H probably benign Het
Prl8a2 T C 13: 27,536,780 (GRCm39) I134T probably benign Het
Qrich2 G A 11: 116,346,714 (GRCm39) T1370I probably benign Het
Rabgap1l A G 1: 160,281,331 (GRCm39) L630P probably damaging Het
Ranbp2 G T 10: 58,313,979 (GRCm39) L1566F probably benign Het
Rnf43 T A 11: 87,623,079 (GRCm39) W727R probably damaging Het
Rundc3b A T 5: 8,629,175 (GRCm39) probably null Het
Samm50 T G 15: 84,088,298 (GRCm39) probably benign Het
Sema4f G A 6: 82,894,643 (GRCm39) A476V probably benign Het
Slc4a4 A G 5: 89,376,839 (GRCm39) N1031S probably benign Het
Slc4a9 A G 18: 36,664,512 (GRCm39) Y390C probably damaging Het
Slco6d1 C A 1: 98,348,937 (GRCm39) Q3K probably benign Het
Smim1 T C 4: 154,108,071 (GRCm39) probably benign Het
Spg7 A G 8: 123,806,162 (GRCm39) K291E possibly damaging Het
Sppl2c A T 11: 104,079,017 (GRCm39) T606S probably benign Het
Tex15 A G 8: 34,062,844 (GRCm39) D758G probably damaging Het
Tigd5 A T 15: 75,783,287 (GRCm39) R550* probably null Het
Tlcd3a G T 11: 76,097,972 (GRCm39) G60* probably null Het
Tnrc18 A C 5: 142,712,767 (GRCm39) L2594R probably damaging Het
Vezf1 A G 11: 87,972,496 (GRCm39) T468A possibly damaging Het
Vmn1r210 T A 13: 23,011,840 (GRCm39) I149F probably damaging Het
Vmn2r96 A C 17: 18,804,117 (GRCm39) T264P probably benign Het
Zfp217 C G 2: 169,961,214 (GRCm39) S371T probably benign Het
Zfp442 G A 2: 150,250,028 (GRCm39) H568Y probably damaging Het
Zfp53 A C 17: 21,729,875 (GRCm39) H636P probably damaging Het
Zscan4d C T 7: 10,895,999 (GRCm39) C457Y probably damaging Het
Other mutations in Cetn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01804:Cetn3 APN 13 81,932,779 (GRCm39) nonsense probably null
R1982:Cetn3 UTSW 13 81,932,816 (GRCm39) missense probably damaging 1.00
R4879:Cetn3 UTSW 13 81,940,268 (GRCm39) unclassified probably benign
R6169:Cetn3 UTSW 13 81,940,097 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGTCCAAAATCAAGTCTATTCTG -3'
(R):5'- CTCACAGTTCCGAGACAAGC -3'

Sequencing Primer
(F):5'- AATAATATGTATGGTGTTTTCGGTGC -3'
(R):5'- GTTCCGAGACAAGCTTCTAAAATAG -3'
Posted On 2018-05-24