Incidental Mutation 'R6454:Or9g19'
ID 519452
Institutional Source Beutler Lab
Gene Symbol Or9g19
Ensembl Gene ENSMUSG00000053287
Gene Name olfactory receptor family 9 subfamily G member 19
Synonyms Olfr1013, MOR213-2, GA_x6K02T2Q125-47248551-47249468
MMRRC Submission 044590-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # R6454 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85600147-85601064 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85600717 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 191 (K191E)
Ref Sequence ENSEMBL: ENSMUSP00000150201 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065626] [ENSMUST00000213453] [ENSMUST00000216397]
AlphaFold Q7TR96
Predicted Effect probably benign
Transcript: ENSMUST00000065626
AA Change: K191E

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000068173
Gene: ENSMUSG00000053287
AA Change: K191E

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 3.3e-50 PFAM
Pfam:7tm_1 40 289 1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213453
Predicted Effect probably benign
Transcript: ENSMUST00000216397
AA Change: K191E

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
Meta Mutation Damage Score 0.0955 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.1%
Validation Efficiency 100% (63/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l G T 8: 44,079,845 (GRCm39) N126K probably damaging Het
Arid2 C T 15: 96,270,294 (GRCm39) T1469I probably benign Het
Atp12a A G 14: 56,608,290 (GRCm39) T93A probably benign Het
Atp8a2 A T 14: 60,245,948 (GRCm39) probably null Het
Casz1 A T 4: 149,035,952 (GRCm39) I1405F probably damaging Het
Chrnb3 T C 8: 27,883,403 (GRCm39) S100P probably damaging Het
Creld2 T A 15: 88,707,274 (GRCm39) C197* probably null Het
Csmd1 A T 8: 15,971,150 (GRCm39) F3055Y probably damaging Het
Dnah11 T A 12: 117,880,590 (GRCm39) E3843D probably benign Het
Dnah14 T C 1: 181,611,270 (GRCm39) S3799P probably damaging Het
Dpp9 A T 17: 56,513,808 (GRCm39) L102Q probably damaging Het
Eipr1 T G 12: 28,914,761 (GRCm39) I305S probably damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Faf1 G T 4: 109,699,531 (GRCm39) A359S probably benign Het
Fam13b A G 18: 34,590,715 (GRCm39) probably null Het
Gm14496 A T 2: 181,638,015 (GRCm39) N363I probably damaging Het
Grm8 T G 6: 27,363,775 (GRCm39) H580P possibly damaging Het
Itih5 T C 2: 10,245,479 (GRCm39) F523L probably benign Het
Klhl1 A T 14: 96,517,527 (GRCm39) M383K possibly damaging Het
Lgi4 A T 7: 30,759,557 (GRCm39) T38S probably benign Het
Myh13 T A 11: 67,241,191 (GRCm39) M856K probably benign Het
Myo7a C T 7: 97,722,374 (GRCm39) V1184M probably benign Het
Nlrp9c G A 7: 26,085,199 (GRCm39) R127C possibly damaging Het
Notch2 T C 3: 98,044,722 (GRCm39) I1548T possibly damaging Het
Nphs2 T A 1: 156,146,337 (GRCm39) H179Q probably damaging Het
Nup153 T C 13: 46,863,136 (GRCm39) probably null Het
Nup50l T G 6: 96,142,609 (GRCm39) H145P possibly damaging Het
Odf2l C A 3: 144,859,181 (GRCm39) Q517K possibly damaging Het
Omd A T 13: 49,743,345 (GRCm39) I132F probably damaging Het
Or10d1b A G 9: 39,613,130 (GRCm39) *312Q probably null Het
Or4a81 T C 2: 89,619,522 (GRCm39) Y58C probably damaging Het
Or5b12 T A 19: 12,897,395 (GRCm39) N93Y probably benign Het
Otog A G 7: 45,955,241 (GRCm39) N544D probably damaging Het
Ovol3 A G 7: 29,934,800 (GRCm39) Y29H probably damaging Het
Papolb T C 5: 142,515,353 (GRCm39) K97E possibly damaging Het
Pcdhb19 G T 18: 37,632,322 (GRCm39) V706L probably benign Het
Pira1 C G 7: 3,740,319 (GRCm39) A301P probably damaging Het
Plekhm1 G A 11: 103,268,208 (GRCm39) R588C probably damaging Het
Pnpla6 G T 8: 3,587,986 (GRCm39) V1062L probably damaging Het
Ppp1r9a T A 6: 4,905,827 (GRCm39) F127L probably damaging Het
Rigi T A 4: 40,220,456 (GRCm39) I476F probably damaging Het
Rnf5 A C 17: 34,821,283 (GRCm39) C47W probably damaging Het
Sbno1 A T 5: 124,538,910 (GRCm39) M517K probably damaging Het
Slc44a5 C T 3: 153,948,796 (GRCm39) T188M probably benign Het
Smco1 A G 16: 32,092,041 (GRCm39) T40A possibly damaging Het
Speer4f2 A T 5: 17,579,431 (GRCm39) I77F probably damaging Het
Spem2 A G 11: 69,708,254 (GRCm39) L237P probably damaging Het
Spg7 A G 8: 123,806,162 (GRCm39) K291E possibly damaging Het
Tent5b A G 4: 133,207,720 (GRCm39) D37G probably damaging Het
Tiam2 A T 17: 3,488,938 (GRCm39) T749S probably benign Het
Tln1 T C 4: 43,533,866 (GRCm39) K2291E probably damaging Het
Tm6sf1 A G 7: 81,525,801 (GRCm39) M294V probably damaging Het
Tmem35b T C 4: 127,022,811 (GRCm39) *138R probably null Het
Tpst1 A G 5: 130,130,892 (GRCm39) K121E possibly damaging Het
Tsc22d2 T A 3: 58,323,261 (GRCm39) V51D possibly damaging Het
Tshr C A 12: 91,505,323 (GRCm39) Q754K probably benign Het
Ttc38 T A 15: 85,723,023 (GRCm39) M157K probably damaging Het
Ube2g2 T G 10: 77,470,580 (GRCm39) probably benign Het
Ugt2b37 T G 5: 87,388,836 (GRCm39) D459A probably damaging Het
Usp35 A T 7: 96,960,851 (GRCm39) Y858* probably null Het
Usp35 A T 7: 96,960,767 (GRCm39) N886K probably damaging Het
Wdr33 T C 18: 31,963,028 (GRCm39) V125A possibly damaging Het
Xpnpep1 G A 19: 52,986,310 (GRCm39) T506I possibly damaging Het
Other mutations in Or9g19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01944:Or9g19 APN 2 85,600,384 (GRCm39) missense probably damaging 0.99
R0523:Or9g19 UTSW 2 85,600,273 (GRCm39) missense probably benign
R0939:Or9g19 UTSW 2 85,600,997 (GRCm39) nonsense probably null
R1400:Or9g19 UTSW 2 85,600,477 (GRCm39) missense possibly damaging 0.87
R1710:Or9g19 UTSW 2 85,600,199 (GRCm39) missense probably benign 0.32
R2150:Or9g19 UTSW 2 85,600,342 (GRCm39) missense probably damaging 1.00
R2428:Or9g19 UTSW 2 85,600,322 (GRCm39) missense probably damaging 1.00
R4730:Or9g19 UTSW 2 85,600,405 (GRCm39) nonsense probably null
R5101:Or9g19 UTSW 2 85,600,268 (GRCm39) missense probably damaging 0.97
R5632:Or9g19 UTSW 2 85,600,613 (GRCm39) missense probably benign
R5849:Or9g19 UTSW 2 85,600,768 (GRCm39) missense probably benign 0.00
R6175:Or9g19 UTSW 2 85,600,652 (GRCm39) missense probably benign 0.07
R8032:Or9g19 UTSW 2 85,600,210 (GRCm39) missense probably benign
R8750:Or9g19 UTSW 2 85,600,307 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGACCGCTATGTGGCTATTTC -3'
(R):5'- GCCATAGTACAAGGTCACAGAG -3'

Sequencing Primer
(F):5'- GACCGCTATGTGGCTATTTCAAAGC -3'
(R):5'- CCATAGTACAAGGTCACAGAGATGAG -3'
Posted On 2018-05-24