Mutagenetix > Incidental Mutation

Incidental Mutation 'R6455:Fat2'

519561

Institutional Source

Beutler Lab

Gene Symbol

Fat2

Ensembl Gene

ENSMUSG00000055333

Gene Name

FAT atypical cadherin 2

Synonyms

mKIAA0811, LOC245827, Fath2, EMI2

MMRRC Submission

044591-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6455 (G1)

Quality Score

161.009

Status

Validated

Chromosome

Chromosomal Location

55250609-55336564 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 55270457 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 3149 (Q3149L)

Ref Sequence

ENSEMBL: ENSMUSP00000104492 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068853] [ENSMUST00000108864]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000068853
AA Change: Q3149L

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000067556
Gene: ENSMUSG00000055333
AA Change: Q3149L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000108864
AA Change: Q3149L

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000104492
Gene: ENSMUSG00000055333
AA Change: Q3149L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.6%
20x: 92.7%

Validation Efficiency

96% (70/73)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are healthy, fertile and overtly normal, with no apparent defects in the development of red blood cells or platelets. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9230110F15Rik	T	A	9: 35,844,055 (GRCm38)	K3*	probably null	Het
A430078G23Rik	A	T	8: 3,388,753 (GRCm38)	Y370F	probably benign	Het
Abca1	T	C	4: 53,042,376 (GRCm38)	R1899G	probably damaging	Het
Abca6	C	T	11: 110,241,581 (GRCm38)	G296D	probably damaging	Het
Abcb5	A	T	12: 118,890,549 (GRCm38)		probably null	Het
Adam28	T	G	14: 68,633,208 (GRCm38)	T339P	probably damaging	Het
Adcy10	C	G	1: 165,518,374 (GRCm38)	Q331E	probably damaging	Het
Aldh1a2	A	T	9: 71,252,914 (GRCm38)		probably null	Het
Alms1	T	A	6: 85,696,657 (GRCm38)	I3078N	probably damaging	Het
Amtn	A	T	5: 88,380,280 (GRCm38)	N71Y	probably damaging	Het
Arid4a	T	C	12: 71,075,088 (GRCm38)	S748P	probably benign	Het
Atp2b1	C	A	10: 99,016,980 (GRCm38)	Q108K	possibly damaging	Het
Bcdin3d	T	C	15: 99,470,949 (GRCm38)	D123G	probably benign	Het
Capn15	A	G	17: 25,965,436 (GRCm38)	S24P	probably damaging	Het
Cc2d2a	T	A	5: 43,739,412 (GRCm38)	S1550R	possibly damaging	Het
Ccdc7a	C	T	8: 128,832,610 (GRCm38)	V1174M	probably damaging	Het
Cd22	T	A	7: 30,876,153 (GRCm38)	I155F	probably damaging	Het
Ceacam3	T	C	7: 17,161,938 (GRCm38)	I611T	possibly damaging	Het
Chrna1	C	T	2: 73,566,836 (GRCm38)	D370N	possibly damaging	Het
Diexf	G	T	1: 193,128,376 (GRCm38)	D106E	probably benign	Het
Dlg2	C	A	7: 92,444,508 (GRCm38)		probably null	Het
Dll4	A	T	2: 119,333,795 (GRCm38)		probably null	Het
Eif5b	T	C	1: 38,019,027 (GRCm38)	S137P	probably benign	Het
Epn2	A	T	11: 61,533,641 (GRCm38)	M250K	probably damaging	Het
Fbxl13	G	A	5: 21,556,814 (GRCm38)	S341F	probably benign	Het
Gm15922	T	A	7: 3,738,931 (GRCm38)	Y150F	probably benign	Het
Gm5141	A	T	13: 62,774,783 (GRCm38)	C191S	probably damaging	Het
Gm5150	C	T	3: 15,990,651 (GRCm38)	G137S	probably damaging	Het
Gm5346	T	A	8: 43,626,152 (GRCm38)	H345L	probably damaging	Het
Gpr75	C	T	11: 30,891,529 (GRCm38)	R145W	probably damaging	Het
Heatr5b	G	A	17: 78,753,073 (GRCm38)	H2058Y	probably benign	Het
Ina	G	A	19: 47,023,561 (GRCm38)	E473K	probably benign	Het
Irx6	T	C	8: 92,676,072 (GRCm38)	S22P	probably benign	Het
Itpr1	T	A	6: 108,417,972 (GRCm38)	M32K	probably damaging	Het
Jmjd1c	T	A	10: 67,226,016 (GRCm38)	S1383T	probably benign	Het
Lclat1	T	A	17: 73,161,833 (GRCm38)	S3T	probably damaging	Het
Llgl1	G	A	11: 60,709,660 (GRCm38)	V612M	probably damaging	Het
Mios	A	G	6: 8,231,239 (GRCm38)	R708G	probably benign	Het
Mphosph8	T	C	14: 56,688,486 (GRCm38)	L636P	probably damaging	Het
Mrgpra2b	T	A	7: 47,464,145 (GRCm38)	N254Y	probably damaging	Het
Myo7a	C	T	7: 98,073,167 (GRCm38)	V1184M	probably benign	Het
Myog	G	A	1: 134,290,488 (GRCm38)	D145N	probably benign	Het
Nat10	T	A	2: 103,739,886 (GRCm38)	I371F	possibly damaging	Het
Neb	A	T	2: 52,167,644 (GRCm38)	Y229*	probably null	Het
Nlrp6	T	A	7: 140,927,509 (GRCm38)	I896K	possibly damaging	Het
Olfr235	T	C	19: 12,268,706 (GRCm38)	S159P	probably damaging	Het
Olfr551	G	A	7: 102,588,671 (GRCm38)	A24V	probably benign	Het
Olfr740	A	T	14: 50,453,585 (GRCm38)	I178L	possibly damaging	Het
Pcdhgc5	A	C	18: 37,821,248 (GRCm38)	E525A	probably damaging	Het
Pkd2	C	A	5: 104,459,924 (GRCm38)	D96E	probably benign	Het
Prtg	A	G	9: 72,907,856 (GRCm38)	D1022G	probably damaging	Het
Ptpn13	T	C	5: 103,541,284 (GRCm38)	M981T	probably benign	Het
Rc3h2	C	A	2: 37,409,470 (GRCm38)	A183S	probably damaging	Het
Rorb	A	T	19: 18,960,492 (GRCm38)	I270N	probably damaging	Het
Rpgrip1	C	T	14: 52,141,189 (GRCm38)	R524W	probably damaging	Het
Slc25a10	T	C	11: 120,495,205 (GRCm38)	V124A	probably damaging	Het
Slc40a1	T	A	1: 45,918,947 (GRCm38)	I109F	probably damaging	Het
Spen	G	A	4: 141,475,509 (GRCm38)	R1936W	probably damaging	Het
St6gal2	T	A	17: 55,482,513 (GRCm38)	Y183N	probably benign	Het
Svil	A	G	18: 5,056,629 (GRCm38)	K588E	possibly damaging	Het
Tas2r122	C	T	6: 132,711,663 (GRCm38)	W89*	probably null	Het
Tbxas1	T	A	6: 38,952,145 (GRCm38)		probably benign	Het
Tia1	T	A	6: 86,420,378 (GRCm38)	I111N	probably damaging	Het
Tlr9	T	A	9: 106,223,999 (GRCm38)	L163H	probably damaging	Het
Tnn	C	T	1: 160,114,719 (GRCm38)	V806M	probably damaging	Het
Traf5	G	A	1: 191,999,926 (GRCm38)	A318V	probably benign	Het
Ttc3	T	A	16: 94,418,623 (GRCm38)	M1K	probably null	Het
Vmn1r192	T	A	13: 22,187,830 (GRCm38)	R73S	probably benign	Het
Vmn1r71	T	C	7: 10,748,404 (GRCm38)	Y53C	probably benign	Het
Vmn2r34	T	A	7: 7,683,583 (GRCm38)	N372Y	probably damaging	Het
Wbp2	A	T	11: 116,079,753 (GRCm38)	S229R	probably damaging	Het
Wdr18	C	T	10: 79,965,281 (GRCm38)	T176I	probably damaging	Het

Other mutations in Fat2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00720:Fat2	APN	11	55,311,244 (GRCm38)	missense	probably benign
IGL00897:Fat2	APN	11	55,289,252 (GRCm38)	missense	probably damaging	0.99
IGL01161:Fat2	APN	11	55,284,191 (GRCm38)	missense	probably benign
IGL01306:Fat2	APN	11	55,310,872 (GRCm38)	missense	probably benign	0.28
IGL01393:Fat2	APN	11	55,269,309 (GRCm38)	missense	probably benign	0.00
IGL01529:Fat2	APN	11	55,282,156 (GRCm38)	missense	probably damaging	1.00
IGL01530:Fat2	APN	11	55,283,387 (GRCm38)	missense	probably benign	0.42
IGL01555:Fat2	APN	11	55,278,930 (GRCm38)	missense	probably damaging	0.99
IGL01758:Fat2	APN	11	55,296,209 (GRCm38)	missense	probably damaging	1.00
IGL01768:Fat2	APN	11	55,262,568 (GRCm38)	missense	probably damaging	1.00
IGL01939:Fat2	APN	11	55,283,980 (GRCm38)	missense	probably benign	0.01
IGL01941:Fat2	APN	11	55,312,005 (GRCm38)	missense	probably benign	0.01
IGL01967:Fat2	APN	11	55,311,823 (GRCm38)	missense	probably damaging	1.00
IGL01978:Fat2	APN	11	55,270,146 (GRCm38)	missense	probably benign	0.34
IGL01998:Fat2	APN	11	55,296,195 (GRCm38)	missense	probably benign	0.00
IGL02001:Fat2	APN	11	55,312,245 (GRCm38)	start codon destroyed	probably null	0.89
IGL02004:Fat2	APN	11	55,282,840 (GRCm38)	missense	probably damaging	1.00
IGL02103:Fat2	APN	11	55,289,296 (GRCm38)	missense	probably damaging	0.96
IGL02131:Fat2	APN	11	55,309,042 (GRCm38)	missense	probably damaging	1.00
IGL02155:Fat2	APN	11	55,262,419 (GRCm38)	missense	probably benign	0.00
IGL02223:Fat2	APN	11	55,273,129 (GRCm38)	missense	probably benign	0.01
IGL02231:Fat2	APN	11	55,281,092 (GRCm38)	missense	probably damaging	0.98
IGL02312:Fat2	APN	11	55,270,259 (GRCm38)	missense	probably damaging	1.00
IGL02476:Fat2	APN	11	55,311,124 (GRCm38)	missense	probably damaging	1.00
IGL02539:Fat2	APN	11	55,281,793 (GRCm38)	missense	probably damaging	1.00
IGL02553:Fat2	APN	11	55,311,283 (GRCm38)	missense	probably damaging	1.00
IGL02645:Fat2	APN	11	55,282,828 (GRCm38)	missense	probably damaging	1.00
IGL02664:Fat2	APN	11	55,311,096 (GRCm38)	missense	probably damaging	1.00
IGL02708:Fat2	APN	11	55,282,385 (GRCm38)	missense	probably damaging	0.99
IGL02883:Fat2	APN	11	55,256,618 (GRCm38)	missense	probably benign	0.16
IGL02894:Fat2	APN	11	55,256,653 (GRCm38)	missense	probably damaging	1.00
IGL02975:Fat2	APN	11	55,270,194 (GRCm38)	missense	probably benign	0.00
IGL03085:Fat2	APN	11	55,283,246 (GRCm38)	missense	probably benign	0.09
IGL03106:Fat2	APN	11	55,311,901 (GRCm38)	missense	probably benign	0.45
IGL03132:Fat2	APN	11	55,253,920 (GRCm38)	missense	probably benign	0.25
IGL03133:Fat2	APN	11	55,286,043 (GRCm38)	missense	probably benign	0.01
IGL03194:Fat2	APN	11	55,310,995 (GRCm38)	missense	probably benign	0.02
IGL03266:Fat2	APN	11	55,284,029 (GRCm38)	missense	possibly damaging	0.62
IGL03290:Fat2	APN	11	55,256,219 (GRCm38)	missense	probably benign	0.33
IGL03291:Fat2	APN	11	55,262,595 (GRCm38)	missense	probably benign
IGL03325:Fat2	APN	11	55,282,342 (GRCm38)	missense	probably damaging	1.00
IGL03345:Fat2	APN	11	55,282,361 (GRCm38)	missense	probably damaging	1.00
IGL03371:Fat2	APN	11	55,311,164 (GRCm38)	missense	probably benign	0.10
ANU23:Fat2	UTSW	11	55,310,872 (GRCm38)	missense	probably benign	0.28
BB001:Fat2	UTSW	11	55,262,787 (GRCm38)	missense	probably benign	0.03
BB011:Fat2	UTSW	11	55,262,787 (GRCm38)	missense	probably benign	0.03
P0040:Fat2	UTSW	11	55,282,213 (GRCm38)	missense	possibly damaging	0.89
PIT4504001:Fat2	UTSW	11	55,256,110 (GRCm38)	missense	possibly damaging	0.68
R0008:Fat2	UTSW	11	55,311,249 (GRCm38)	missense	probably damaging	1.00
R0008:Fat2	UTSW	11	55,311,249 (GRCm38)	missense	probably damaging	1.00
R0012:Fat2	UTSW	11	55,262,871 (GRCm38)	missense	probably benign	0.16
R0012:Fat2	UTSW	11	55,262,871 (GRCm38)	missense	probably benign	0.16
R0048:Fat2	UTSW	11	55,310,039 (GRCm38)	missense	probably benign	0.00
R0048:Fat2	UTSW	11	55,310,039 (GRCm38)	missense	probably benign	0.00
R0098:Fat2	UTSW	11	55,298,605 (GRCm38)	missense	probably damaging	0.98
R0124:Fat2	UTSW	11	55,283,678 (GRCm38)	missense	probably damaging	0.98
R0127:Fat2	UTSW	11	55,289,286 (GRCm38)	missense	probably benign	0.01
R0130:Fat2	UTSW	11	55,252,118 (GRCm38)	missense	probably benign	0.26
R0131:Fat2	UTSW	11	55,273,211 (GRCm38)	missense	probably benign
R0158:Fat2	UTSW	11	55,296,185 (GRCm38)	missense	probably benign	0.00
R0184:Fat2	UTSW	11	55,296,288 (GRCm38)	missense	probably damaging	1.00
R0367:Fat2	UTSW	11	55,292,093 (GRCm38)	splice site	probably benign
R0384:Fat2	UTSW	11	55,269,465 (GRCm38)	missense	possibly damaging	0.81
R0390:Fat2	UTSW	11	55,310,777 (GRCm38)	missense	probably damaging	0.99
R0403:Fat2	UTSW	11	55,270,349 (GRCm38)	missense	probably benign	0.42
R0416:Fat2	UTSW	11	55,284,134 (GRCm38)	missense	possibly damaging	0.94
R0437:Fat2	UTSW	11	55,282,799 (GRCm38)	missense	probably benign	0.02
R0463:Fat2	UTSW	11	55,262,829 (GRCm38)	missense	probably damaging	1.00
R0497:Fat2	UTSW	11	55,283,402 (GRCm38)	missense	probably benign	0.03
R0617:Fat2	UTSW	11	55,311,843 (GRCm38)	missense	possibly damaging	0.60
R0622:Fat2	UTSW	11	55,283,128 (GRCm38)	missense	probably damaging	1.00
R0675:Fat2	UTSW	11	55,309,209 (GRCm38)	missense	probably damaging	0.97
R0811:Fat2	UTSW	11	55,253,633 (GRCm38)	missense	possibly damaging	0.75
R0812:Fat2	UTSW	11	55,253,633 (GRCm38)	missense	possibly damaging	0.75
R0869:Fat2	UTSW	11	55,311,775 (GRCm38)	missense	probably benign	0.08
R0870:Fat2	UTSW	11	55,311,775 (GRCm38)	missense	probably benign	0.08
R0899:Fat2	UTSW	11	55,256,225 (GRCm38)	missense	probably damaging	1.00
R1278:Fat2	UTSW	11	55,268,179 (GRCm38)	missense	probably damaging	1.00
R1383:Fat2	UTSW	11	55,310,773 (GRCm38)	missense	probably benign
R1428:Fat2	UTSW	11	55,296,087 (GRCm38)	missense	probably damaging	1.00
R1438:Fat2	UTSW	11	55,287,811 (GRCm38)	missense	probably damaging	1.00
R1495:Fat2	UTSW	11	55,262,673 (GRCm38)	missense	probably benign
R1506:Fat2	UTSW	11	55,284,264 (GRCm38)	missense	probably benign
R1547:Fat2	UTSW	11	55,252,255 (GRCm38)	missense	probably benign	0.01
R1554:Fat2	UTSW	11	55,253,664 (GRCm38)	missense	probably benign	0.01
R1562:Fat2	UTSW	11	55,309,974 (GRCm38)	missense	probably damaging	1.00
R1588:Fat2	UTSW	11	55,283,404 (GRCm38)	missense	probably damaging	1.00
R1592:Fat2	UTSW	11	55,291,870 (GRCm38)	splice site	probably null
R1601:Fat2	UTSW	11	55,282,010 (GRCm38)	missense	probably benign	0.01
R1610:Fat2	UTSW	11	55,278,924 (GRCm38)	missense	probably damaging	1.00
R1634:Fat2	UTSW	11	55,284,719 (GRCm38)	missense	probably benign
R1634:Fat2	UTSW	11	55,267,684 (GRCm38)	missense	probably damaging	1.00
R1644:Fat2	UTSW	11	55,296,181 (GRCm38)	missense	possibly damaging	0.94
R1644:Fat2	UTSW	11	55,287,783 (GRCm38)	missense	possibly damaging	0.91
R1691:Fat2	UTSW	11	55,311,852 (GRCm38)	missense	probably damaging	0.99
R1734:Fat2	UTSW	11	55,281,371 (GRCm38)	missense	probably benign	0.00
R1748:Fat2	UTSW	11	55,256,647 (GRCm38)	missense	probably damaging	0.97
R1771:Fat2	UTSW	11	55,310,865 (GRCm38)	missense	probably benign	0.01
R1800:Fat2	UTSW	11	55,283,892 (GRCm38)	missense	probably damaging	1.00
R1807:Fat2	UTSW	11	55,289,259 (GRCm38)	missense	probably damaging	1.00
R1823:Fat2	UTSW	11	55,256,780 (GRCm38)	missense	probably benign	0.29
R1848:Fat2	UTSW	11	55,311,558 (GRCm38)	missense	probably damaging	1.00
R1866:Fat2	UTSW	11	55,292,014 (GRCm38)	missense	probably benign	0.00
R1899:Fat2	UTSW	11	55,262,178 (GRCm38)	missense	probably benign
R1954:Fat2	UTSW	11	55,311,084 (GRCm38)	missense	probably benign	0.06
R2010:Fat2	UTSW	11	55,253,827 (GRCm38)	missense	probably damaging	0.99
R2011:Fat2	UTSW	11	55,282,757 (GRCm38)	missense	probably damaging	1.00
R2057:Fat2	UTSW	11	55,281,860 (GRCm38)	missense	possibly damaging	0.60
R2081:Fat2	UTSW	11	55,309,677 (GRCm38)	missense	possibly damaging	0.94
R2106:Fat2	UTSW	11	55,256,564 (GRCm38)	missense	probably benign	0.00
R2165:Fat2	UTSW	11	55,303,716 (GRCm38)	missense	probably benign	0.00
R2176:Fat2	UTSW	11	55,267,575 (GRCm38)	critical splice donor site	probably null
R2284:Fat2	UTSW	11	55,282,360 (GRCm38)	missense	probably damaging	1.00
R2338:Fat2	UTSW	11	55,311,901 (GRCm38)	missense	possibly damaging	0.93
R2340:Fat2	UTSW	11	55,270,096 (GRCm38)	missense	possibly damaging	0.90
R2427:Fat2	UTSW	11	55,310,812 (GRCm38)	missense	probably benign	0.15
R2444:Fat2	UTSW	11	55,281,973 (GRCm38)	missense	probably damaging	1.00
R2858:Fat2	UTSW	11	55,283,773 (GRCm38)	missense	possibly damaging	0.94
R2882:Fat2	UTSW	11	55,311,305 (GRCm38)	missense	probably damaging	0.96
R3029:Fat2	UTSW	11	55,284,709 (GRCm38)	missense	probably damaging	1.00
R3085:Fat2	UTSW	11	55,252,171 (GRCm38)	missense	possibly damaging	0.79
R3121:Fat2	UTSW	11	55,311,796 (GRCm38)	missense	probably damaging	1.00
R3418:Fat2	UTSW	11	55,278,998 (GRCm38)	missense	probably benign	0.01
R3500:Fat2	UTSW	11	55,260,516 (GRCm38)	missense	probably damaging	0.99
R3607:Fat2	UTSW	11	55,281,685 (GRCm38)	missense	probably damaging	1.00
R3611:Fat2	UTSW	11	55,312,069 (GRCm38)	missense	probably benign
R3620:Fat2	UTSW	11	55,256,695 (GRCm38)	missense	probably damaging	0.97
R3688:Fat2	UTSW	11	55,281,101 (GRCm38)	missense	probably damaging	0.99
R3704:Fat2	UTSW	11	55,309,650 (GRCm38)	missense	probably damaging	1.00
R3784:Fat2	UTSW	11	55,256,186 (GRCm38)	missense	probably benign
R3889:Fat2	UTSW	11	55,281,763 (GRCm38)	missense	probably damaging	1.00
R3951:Fat2	UTSW	11	55,296,382 (GRCm38)	missense	probably benign	0.00
R4211:Fat2	UTSW	11	55,283,984 (GRCm38)	missense	probably damaging	1.00
R4249:Fat2	UTSW	11	55,284,301 (GRCm38)	missense	probably damaging	0.98
R4406:Fat2	UTSW	11	55,262,268 (GRCm38)	missense	probably benign	0.00
R4433:Fat2	UTSW	11	55,309,640 (GRCm38)	missense	possibly damaging	0.91
R4436:Fat2	UTSW	11	55,296,198 (GRCm38)	missense	probably damaging	1.00
R4498:Fat2	UTSW	11	55,270,097 (GRCm38)	missense	possibly damaging	0.90
R4560:Fat2	UTSW	11	55,265,951 (GRCm38)	missense	possibly damaging	0.89
R4594:Fat2	UTSW	11	55,284,752 (GRCm38)	missense	possibly damaging	0.78
R4663:Fat2	UTSW	11	55,296,213 (GRCm38)	nonsense	probably null
R4669:Fat2	UTSW	11	55,311,615 (GRCm38)	missense	probably benign	0.01
R4696:Fat2	UTSW	11	55,285,015 (GRCm38)	missense	probably benign	0.00
R4734:Fat2	UTSW	11	55,311,468 (GRCm38)	missense	probably benign	0.01
R4749:Fat2	UTSW	11	55,311,468 (GRCm38)	missense	probably benign	0.01
R4765:Fat2	UTSW	11	55,281,187 (GRCm38)	missense	probably damaging	1.00
R4803:Fat2	UTSW	11	55,285,060 (GRCm38)	missense	probably benign	0.03
R4805:Fat2	UTSW	11	55,283,979 (GRCm38)	missense	probably benign	0.01
R4822:Fat2	UTSW	11	55,311,318 (GRCm38)	missense	probably benign	0.02
R4840:Fat2	UTSW	11	55,279,018 (GRCm38)	missense	probably benign	0.21
R4849:Fat2	UTSW	11	55,310,637 (GRCm38)	missense	probably damaging	1.00
R4943:Fat2	UTSW	11	55,279,033 (GRCm38)	missense	probably benign	0.00
R4993:Fat2	UTSW	11	55,283,092 (GRCm38)	missense	probably damaging	0.99
R5097:Fat2	UTSW	11	55,310,704 (GRCm38)	missense	probably damaging	1.00
R5104:Fat2	UTSW	11	55,278,988 (GRCm38)	missense	possibly damaging	0.93
R5115:Fat2	UTSW	11	55,296,333 (GRCm38)	missense	probably damaging	1.00
R5213:Fat2	UTSW	11	55,253,832 (GRCm38)	missense	probably benign	0.00
R5254:Fat2	UTSW	11	55,281,175 (GRCm38)	missense	probably damaging	1.00
R5269:Fat2	UTSW	11	55,287,878 (GRCm38)	missense	probably benign	0.00
R5288:Fat2	UTSW	11	55,267,656 (GRCm38)	missense	probably benign	0.00
R5355:Fat2	UTSW	11	55,282,166 (GRCm38)	missense	probably damaging	1.00
R5375:Fat2	UTSW	11	55,262,820 (GRCm38)	missense	probably benign	0.00
R5379:Fat2	UTSW	11	55,303,941 (GRCm38)	missense	probably damaging	0.99
R5411:Fat2	UTSW	11	55,252,226 (GRCm38)	missense	probably benign	0.23
R5416:Fat2	UTSW	11	55,303,688 (GRCm38)	missense	possibly damaging	0.77
R5480:Fat2	UTSW	11	55,310,086 (GRCm38)	missense	probably damaging	0.99
R5486:Fat2	UTSW	11	55,253,681 (GRCm38)	missense	probably benign	0.00
R5526:Fat2	UTSW	11	55,269,361 (GRCm38)	missense	possibly damaging	0.90
R5532:Fat2	UTSW	11	55,262,337 (GRCm38)	missense	probably damaging	1.00
R5583:Fat2	UTSW	11	55,253,889 (GRCm38)	missense	probably benign	0.00
R5588:Fat2	UTSW	11	55,282,277 (GRCm38)	missense	probably damaging	1.00
R5598:Fat2	UTSW	11	55,281,130 (GRCm38)	missense	probably damaging	1.00
R5636:Fat2	UTSW	11	55,282,481 (GRCm38)	missense	probably damaging	1.00
R5653:Fat2	UTSW	11	55,310,316 (GRCm38)	missense	probably damaging	1.00
R5657:Fat2	UTSW	11	55,310,681 (GRCm38)	nonsense	probably null
R5660:Fat2	UTSW	11	55,284,176 (GRCm38)	missense	probably benign	0.00
R5752:Fat2	UTSW	11	55,289,237 (GRCm38)	missense	possibly damaging	0.48
R5757:Fat2	UTSW	11	55,252,346 (GRCm38)	missense	probably damaging	1.00
R5792:Fat2	UTSW	11	55,262,325 (GRCm38)	missense	possibly damaging	0.77
R5872:Fat2	UTSW	11	55,270,382 (GRCm38)	missense	probably damaging	1.00
R5933:Fat2	UTSW	11	55,284,051 (GRCm38)	missense	probably damaging	1.00
R6030:Fat2	UTSW	11	55,310,303 (GRCm38)	nonsense	probably null
R6030:Fat2	UTSW	11	55,310,303 (GRCm38)	nonsense	probably null
R6032:Fat2	UTSW	11	55,253,934 (GRCm38)	missense	probably damaging	1.00
R6032:Fat2	UTSW	11	55,253,934 (GRCm38)	missense	probably damaging	1.00
R6221:Fat2	UTSW	11	55,296,072 (GRCm38)	critical splice donor site	probably null
R6253:Fat2	UTSW	11	55,296,271 (GRCm38)	missense	probably damaging	1.00
R6257:Fat2	UTSW	11	55,262,581 (GRCm38)	missense	probably benign
R6307:Fat2	UTSW	11	55,281,280 (GRCm38)	missense	possibly damaging	0.63
R6450:Fat2	UTSW	11	55,289,310 (GRCm38)	missense	probably damaging	0.97
R6453:Fat2	UTSW	11	55,282,216 (GRCm38)	missense	probably benign	0.29
R6483:Fat2	UTSW	11	55,296,345 (GRCm38)	missense	probably damaging	1.00
R6504:Fat2	UTSW	11	55,262,397 (GRCm38)	missense	probably benign	0.00
R6520:Fat2	UTSW	11	55,284,988 (GRCm38)	missense	probably damaging	0.99
R6525:Fat2	UTSW	11	55,283,800 (GRCm38)	missense	probably damaging	1.00
R6617:Fat2	UTSW	11	55,296,105 (GRCm38)	missense	probably benign	0.01
R6652:Fat2	UTSW	11	55,252,262 (GRCm38)	missense	probably benign
R6679:Fat2	UTSW	11	55,309,305 (GRCm38)	missense	probably damaging	1.00
R6680:Fat2	UTSW	11	55,310,858 (GRCm38)	nonsense	probably null
R6762:Fat2	UTSW	11	55,253,482 (GRCm38)	splice site	probably null
R6810:Fat2	UTSW	11	55,282,241 (GRCm38)	missense	possibly damaging	0.88
R6818:Fat2	UTSW	11	55,309,341 (GRCm38)	missense	probably benign	0.31
R6919:Fat2	UTSW	11	55,282,771 (GRCm38)	missense	possibly damaging	0.68
R6939:Fat2	UTSW	11	55,252,474 (GRCm38)	nonsense	probably null
R6941:Fat2	UTSW	11	55,262,088 (GRCm38)	missense	probably benign
R7023:Fat2	UTSW	11	55,310,502 (GRCm38)	missense	probably benign	0.00
R7027:Fat2	UTSW	11	55,269,433 (GRCm38)	missense	probably benign	0.03
R7027:Fat2	UTSW	11	55,281,851 (GRCm38)	nonsense	probably null
R7095:Fat2	UTSW	11	55,311,331 (GRCm38)	missense	probably damaging	1.00
R7102:Fat2	UTSW	11	55,283,434 (GRCm38)	missense	probably damaging	1.00
R7116:Fat2	UTSW	11	55,282,336 (GRCm38)	missense	probably damaging	1.00
R7117:Fat2	UTSW	11	55,281,262 (GRCm38)	missense	probably damaging	1.00
R7167:Fat2	UTSW	11	55,285,001 (GRCm38)	missense	possibly damaging	0.48
R7213:Fat2	UTSW	11	55,281,045 (GRCm38)	nonsense	probably null
R7246:Fat2	UTSW	11	55,296,382 (GRCm38)	missense	probably benign	0.00
R7252:Fat2	UTSW	11	55,311,262 (GRCm38)	missense	probably damaging	0.98
R7266:Fat2	UTSW	11	55,285,030 (GRCm38)	missense	probably damaging	0.99
R7316:Fat2	UTSW	11	55,286,067 (GRCm38)	missense	probably damaging	1.00
R7326:Fat2	UTSW	11	55,282,304 (GRCm38)	missense	probably damaging	0.99
R7355:Fat2	UTSW	11	55,256,551 (GRCm38)	missense	probably benign	0.00
R7431:Fat2	UTSW	11	55,309,101 (GRCm38)	missense	probably damaging	1.00
R7459:Fat2	UTSW	11	55,303,919 (GRCm38)	missense	probably damaging	1.00
R7460:Fat2	UTSW	11	55,278,963 (GRCm38)	missense	probably damaging	1.00
R7466:Fat2	UTSW	11	55,310,432 (GRCm38)	missense	probably damaging	1.00
R7475:Fat2	UTSW	11	55,303,653 (GRCm38)	missense	probably benign	0.31
R7678:Fat2	UTSW	11	55,282,330 (GRCm38)	missense	probably damaging	0.99
R7689:Fat2	UTSW	11	55,309,840 (GRCm38)	missense	probably damaging	1.00
R7704:Fat2	UTSW	11	55,284,347 (GRCm38)	missense	probably benign	0.03
R7710:Fat2	UTSW	11	55,310,763 (GRCm38)	missense	probably benign	0.35
R7724:Fat2	UTSW	11	55,284,796 (GRCm38)	missense	probably damaging	1.00
R7731:Fat2	UTSW	11	55,310,706 (GRCm38)	missense	probably damaging	1.00
R7739:Fat2	UTSW	11	55,281,131 (GRCm38)	nonsense	probably null
R7757:Fat2	UTSW	11	55,311,421 (GRCm38)	missense	probably benign	0.00
R7876:Fat2	UTSW	11	55,311,220 (GRCm38)	missense	probably benign	0.01
R7883:Fat2	UTSW	11	55,253,364 (GRCm38)	splice site	probably null
R7924:Fat2	UTSW	11	55,262,787 (GRCm38)	missense	probably benign	0.03
R7936:Fat2	UTSW	11	55,310,167 (GRCm38)	missense	probably benign
R7936:Fat2	UTSW	11	55,311,160 (GRCm38)	nonsense	probably null
R7938:Fat2	UTSW	11	55,273,096 (GRCm38)	missense	probably damaging	1.00
R7947:Fat2	UTSW	11	55,287,734 (GRCm38)	missense	probably damaging	1.00
R8049:Fat2	UTSW	11	55,312,066 (GRCm38)	missense	probably benign	0.13
R8094:Fat2	UTSW	11	55,296,139 (GRCm38)	missense	probably benign	0.06
R8157:Fat2	UTSW	11	55,252,084 (GRCm38)	missense	possibly damaging	0.90
R8170:Fat2	UTSW	11	55,270,455 (GRCm38)	missense	probably damaging	1.00
R8172:Fat2	UTSW	11	55,287,812 (GRCm38)	missense	probably damaging	1.00
R8182:Fat2	UTSW	11	55,284,397 (GRCm38)	missense	possibly damaging	0.51
R8188:Fat2	UTSW	11	55,273,171 (GRCm38)	missense	probably damaging	0.98
R8204:Fat2	UTSW	11	55,284,610 (GRCm38)	missense	probably benign	0.02
R8211:Fat2	UTSW	11	55,312,209 (GRCm38)	missense	possibly damaging	0.92
R8255:Fat2	UTSW	11	55,270,275 (GRCm38)	missense	probably benign	0.19
R8263:Fat2	UTSW	11	55,284,136 (GRCm38)	missense	probably benign
R8269:Fat2	UTSW	11	55,282,709 (GRCm38)	missense	possibly damaging	0.48
R8443:Fat2	UTSW	11	55,311,709 (GRCm38)	missense	probably damaging	1.00
R8465:Fat2	UTSW	11	55,256,704 (GRCm38)	missense	possibly damaging	0.61
R8480:Fat2	UTSW	11	55,282,968 (GRCm38)	missense	possibly damaging	0.61
R8511:Fat2	UTSW	11	55,309,237 (GRCm38)	missense	probably damaging	0.99
R8680:Fat2	UTSW	11	55,253,866 (GRCm38)	missense	probably benign
R8704:Fat2	UTSW	11	55,281,311 (GRCm38)	missense	probably damaging	1.00
R8711:Fat2	UTSW	11	55,268,303 (GRCm38)	missense	probably benign	0.22
R8724:Fat2	UTSW	11	55,282,960 (GRCm38)	missense	probably damaging	1.00
R8788:Fat2	UTSW	11	55,281,103 (GRCm38)	missense	possibly damaging	0.90
R8802:Fat2	UTSW	11	55,282,924 (GRCm38)	missense	possibly damaging	0.95
R8902:Fat2	UTSW	11	55,310,070 (GRCm38)	missense	probably damaging	1.00
R8940:Fat2	UTSW	11	55,256,810 (GRCm38)	missense	possibly damaging	0.48
R8956:Fat2	UTSW	11	55,282,903 (GRCm38)	missense	probably damaging	1.00
R9035:Fat2	UTSW	11	55,303,721 (GRCm38)	missense	probably damaging	0.99
R9100:Fat2	UTSW	11	55,262,521 (GRCm38)	missense	probably damaging	1.00
R9132:Fat2	UTSW	11	55,298,610 (GRCm38)	missense	possibly damaging	0.88
R9173:Fat2	UTSW	11	55,278,937 (GRCm38)	missense	probably damaging	1.00
R9241:Fat2	UTSW	11	55,256,740 (GRCm38)	missense	probably benign	0.00
R9253:Fat2	UTSW	11	55,310,571 (GRCm38)	missense	probably damaging	1.00
R9280:Fat2	UTSW	11	55,310,697 (GRCm38)	missense	probably benign	0.36
R9351:Fat2	UTSW	11	55,281,301 (GRCm38)	missense	probably damaging	1.00
R9369:Fat2	UTSW	11	55,310,688 (GRCm38)	missense	possibly damaging	0.67
R9404:Fat2	UTSW	11	55,253,522 (GRCm38)	critical splice donor site	probably null
R9431:Fat2	UTSW	11	55,252,012 (GRCm38)	missense	probably damaging	1.00
R9484:Fat2	UTSW	11	55,309,926 (GRCm38)	missense	probably damaging	0.99
R9509:Fat2	UTSW	11	55,309,887 (GRCm38)	missense	possibly damaging	0.51
R9514:Fat2	UTSW	11	55,284,982 (GRCm38)	missense	probably damaging	0.98
R9606:Fat2	UTSW	11	55,289,267 (GRCm38)	missense	probably damaging	1.00
R9630:Fat2	UTSW	11	55,256,779 (GRCm38)	missense	probably benign	0.29
R9727:Fat2	UTSW	11	55,268,311 (GRCm38)	missense	probably damaging	1.00
R9736:Fat2	UTSW	11	55,303,925 (GRCm38)	missense	probably damaging	1.00
X0010:Fat2	UTSW	11	55,252,260 (GRCm38)	missense	probably benign	0.00
X0011:Fat2	UTSW	11	55,310,431 (GRCm38)	missense	probably damaging	0.98
X0018:Fat2	UTSW	11	55,296,210 (GRCm38)	missense	probably damaging	1.00
X0028:Fat2	UTSW	11	55,309,414 (GRCm38)	missense	possibly damaging	0.84
X0067:Fat2	UTSW	11	55,283,234 (GRCm38)	missense	possibly damaging	0.48
Z1176:Fat2	UTSW	11	55,284,991 (GRCm38)	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55,282,795 (GRCm38)	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55,310,121 (GRCm38)	missense	probably damaging	0.96
Z1176:Fat2	UTSW	11	55,303,700 (GRCm38)	missense	probably damaging	1.00
Z1177:Fat2	UTSW	11	55,278,966 (GRCm38)	nonsense	probably null
Z1186:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1186:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1187:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1187:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1188:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1188:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1189:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1189:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1190:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1190:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1191:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1191:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null
Z1192:Fat2	UTSW	11	55,309,799 (GRCm38)	missense	probably benign
Z1192:Fat2	UTSW	11	55,308,970 (GRCm38)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- ATGGAGACTGTAACAGTGCCC -3'
(R):5'- ATAGGTGCATAGGAAGTTGCCAAC -3'

Sequencing Primer
(F):5'- ACTGTAACAGTGCCCAGTGTG -3'
(R):5'- GCCAACTAGTTTGTGAATGAGCCC -3'

Posted On

2018-05-24