Mutagenetix > Incidental Mutation

Incidental Mutation 'R6501:Vmn2r103'

519750

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R6501 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 19811904 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 647 (T647S)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: T647S

PolyPhen 2 Score 0.287 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: T647S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 94.1%

Validation Efficiency

100% (48/48)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd8	A	T	8: 71,461,521	C154*	probably null	Het
Ada	A	G	2: 163,728,188		probably null	Het
Birc6	G	A	17: 74,579,281	V535I	probably damaging	Het
Bptf	T	C	11: 107,077,683	N1058S	probably null	Het
Cdadc1	C	T	14: 59,586,449	C198Y	probably benign	Het
Chrna7	G	A	7: 63,106,115	R228C	probably damaging	Het
Cts6	T	C	13: 61,196,335	N301S	probably damaging	Het
Cts8	T	A	13: 61,250,942	D250V	probably damaging	Het
Cyp26a1	G	T	19: 37,699,070	R235L	possibly damaging	Het
Disc1	A	T	8: 125,218,105	M598L	probably benign	Het
Ear6	T	A	14: 51,854,224	V76D	possibly damaging	Het
Grifin	A	G	5: 140,563,281	*145R	probably null	Het
Htr2b	T	G	1: 86,110,641	E11A	probably damaging	Het
Krtap4-9	T	A	11: 99,785,429		probably benign	Het
Larp4b	A	C	13: 9,168,793	H522P	probably damaging	Het
Macf1	A	T	4: 123,469,632		probably null	Het
Mdfic	T	C	6: 15,770,517	L174P	possibly damaging	Het
Mmp17	A	G	5: 129,606,405	E535G	probably benign	Het
Nfxl1	A	T	5: 72,528,509		probably null	Het
Nynrin	A	T	14: 55,863,532	T260S	probably benign	Het
Olfr1294	C	T	2: 111,537,779	G170D	probably damaging	Het
Olfr859	A	T	9: 19,808,975	Y219F	possibly damaging	Het
Olfr905	A	T	9: 38,473,289	I181F	possibly damaging	Het
Pbx1	G	T	1: 168,209,534	D109E	probably damaging	Het
Pde4d	A	T	13: 109,116,942	H101L	probably benign	Het
Pdlim3	T	C	8: 45,908,602	I155T	possibly damaging	Het
Plekha5	T	A	6: 140,525,929	Y26*	probably null	Het
Prpf6	T	A	2: 181,621,920	L191*	probably null	Het
Rabl6	A	G	2: 25,602,447	V80A	possibly damaging	Het
Rp1	T	C	1: 4,311,280		probably benign	Het
Sec14l1	A	G	11: 117,156,850	S698G	probably damaging	Het
Skiv2l	A	G	17: 34,844,436	S622P	possibly damaging	Het
Slc19a1	G	A	10: 77,049,606	G447S	probably benign	Het
Slc2a6	A	T	2: 27,023,131	Y383*	probably null	Het
Slc9a9	C	A	9: 94,936,371	Q273K	probably benign	Het
Spint2	A	G	7: 29,263,706	Y56H	probably damaging	Het
Sspo	T	A	6: 48,495,212	M123K	possibly damaging	Het
Syne2	A	G	12: 76,027,847		probably null	Het
Trdn	A	C	10: 33,466,454	K619N	probably benign	Het
Ttll13	A	G	7: 80,250,176	T119A	possibly damaging	Het
Ttn	T	C	2: 76,785,646	Y8324C	probably damaging	Het
Ttn	T	C	2: 76,898,258		probably benign	Het
Vav2	A	G	2: 27,296,219	L208P	probably damaging	Het
Vmn1r179	A	G	7: 23,928,917	I178V	probably benign	Het
Vmn1r210	T	C	13: 22,827,535	M194V	possibly damaging	Het
Wdr49	T	A	3: 75,339,458	H289L	probably benign	Het
Wnk2	T	G	13: 49,146,683	K184Q	probably damaging	Het
Zfp758	A	G	17: 22,371,997		probably benign	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19793497	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19811796	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19811943	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19812384	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19811896	missense	possibly damaging	0.54
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- GTGATCTTTCTTGCCTATGAAGACC -3'
(R):5'- GCTGGATCAGGGTGCATATAG -3'

Sequencing Primer
(F):5'- GATGACTCTAGCCAGCGTAG -3'
(R):5'- ATAGGAATGATGTAGTTTGGACCCC -3'

Posted On

2018-06-06