Mutagenetix > Incidental Mutations

Incidental Mutation 'R6501:Zfp758'

519751

Institutional Source

Beutler Lab

Gene Symbol

Zfp758

Ensembl Gene

ENSMUSG00000044501

Gene Name

zinc finger protein 758

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R6501 (G1)

Quality Score

184.009

Status

Not validated

Chromosome

Chromosomal Location

22361453-22377281 bp(+) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

A to G at 22371997 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000121288 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072477] [ENSMUST00000088765] [ENSMUST00000121315] [ENSMUST00000149699]

Predicted Effect

probably benign
Transcript: ENSMUST00000072477

SMART Domains

Protein: ENSMUSP00000072298
Gene: ENSMUSG00000044501

Domain	Start	End	E-Value	Type
KRAB	13	73	1.55e-20	SMART
ZnF_C2H2	177	199	6.92e0	SMART
ZnF_C2H2	205	227	6.32e-3	SMART
ZnF_C2H2	233	255	1.2e-3	SMART
ZnF_C2H2	261	283	9.08e-4	SMART
ZnF_C2H2	289	311	6.08e-5	SMART
ZnF_C2H2	317	339	1.03e-2	SMART
ZnF_C2H2	345	367	2.24e-3	SMART
ZnF_C2H2	373	395	3.21e-4	SMART
ZnF_C2H2	401	423	6.32e-3	SMART
ZnF_C2H2	429	451	2.24e-3	SMART
ZnF_C2H2	457	479	5.14e-3	SMART
ZnF_C2H2	485	507	1.04e-3	SMART
ZnF_C2H2	513	535	4.4e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000088765

SMART Domains

Protein: ENSMUSP00000086143
Gene: ENSMUSG00000044501

Domain	Start	End	E-Value	Type
KRAB	13	73	1.55e-20	SMART
ZnF_C2H2	177	199	6.92e0	SMART
ZnF_C2H2	205	227	6.32e-3	SMART
ZnF_C2H2	233	255	1.2e-3	SMART
ZnF_C2H2	261	283	9.08e-4	SMART
ZnF_C2H2	289	311	6.08e-5	SMART
ZnF_C2H2	317	339	1.03e-2	SMART
ZnF_C2H2	345	367	2.24e-3	SMART
ZnF_C2H2	373	395	3.21e-4	SMART
ZnF_C2H2	401	423	6.32e-3	SMART
ZnF_C2H2	429	451	2.24e-3	SMART
ZnF_C2H2	457	479	5.14e-3	SMART
ZnF_C2H2	485	507	1.04e-3	SMART
ZnF_C2H2	513	535	4.4e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000121315

SMART Domains

Protein: ENSMUSP00000113532
Gene: ENSMUSG00000044501

Domain	Start	End	E-Value	Type
KRAB	13	73	1.55e-20	SMART
ZnF_C2H2	177	199	6.92e0	SMART
ZnF_C2H2	205	227	6.32e-3	SMART
ZnF_C2H2	233	255	1.2e-3	SMART
ZnF_C2H2	261	283	9.08e-4	SMART
ZnF_C2H2	289	311	6.08e-5	SMART
ZnF_C2H2	317	339	1.03e-2	SMART
ZnF_C2H2	345	367	2.24e-3	SMART
ZnF_C2H2	373	395	3.21e-4	SMART
ZnF_C2H2	401	423	6.32e-3	SMART
ZnF_C2H2	429	451	2.24e-3	SMART
ZnF_C2H2	457	479	5.14e-3	SMART
ZnF_C2H2	485	507	1.04e-3	SMART
ZnF_C2H2	513	535	4.4e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000149699

SMART Domains

Protein: ENSMUSP00000121288
Gene: ENSMUSG00000044501

Domain	Start	End	E-Value	Type
KRAB	45	105	1.55e-20	SMART
ZnF_C2H2	209	231	6.92e0	SMART
ZnF_C2H2	237	259	6.32e-3	SMART
ZnF_C2H2	265	287	1.2e-3	SMART
ZnF_C2H2	293	315	9.08e-4	SMART
ZnF_C2H2	321	343	6.08e-5	SMART
ZnF_C2H2	349	371	1.03e-2	SMART
ZnF_C2H2	377	399	2.24e-3	SMART
ZnF_C2H2	405	427	3.21e-4	SMART
ZnF_C2H2	433	455	6.32e-3	SMART
ZnF_C2H2	461	483	2.24e-3	SMART
ZnF_C2H2	489	511	5.14e-3	SMART
ZnF_C2H2	517	539	1.04e-3	SMART
ZnF_C2H2	545	567	4.4e-2	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 94.1%

Validation Efficiency

100% (48/48)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd8	A	T	8: 71,461,521	C154*	probably null	Het
Ada	A	G	2: 163,728,188		probably null	Het
Birc6	G	A	17: 74,579,281	V535I	probably damaging	Het
Bptf	T	C	11: 107,077,683	N1058S	probably null	Het
Cdadc1	C	T	14: 59,586,449	C198Y	probably benign	Het
Chrna7	G	A	7: 63,106,115	R228C	probably damaging	Het
Cts6	T	C	13: 61,196,335	N301S	probably damaging	Het
Cts8	T	A	13: 61,250,942	D250V	probably damaging	Het
Cyp26a1	G	T	19: 37,699,070	R235L	possibly damaging	Het
Disc1	A	T	8: 125,218,105	M598L	probably benign	Het
Ear6	T	A	14: 51,854,224	V76D	possibly damaging	Het
Grifin	A	G	5: 140,563,281	*145R	probably null	Het
Htr2b	T	G	1: 86,110,641	E11A	probably damaging	Het
Krtap4-9	T	A	11: 99,785,429		probably benign	Het
Larp4b	A	C	13: 9,168,793	H522P	probably damaging	Het
Macf1	A	T	4: 123,469,632		probably null	Het
Mdfic	T	C	6: 15,770,517	L174P	possibly damaging	Het
Mmp17	A	G	5: 129,606,405	E535G	probably benign	Het
Nfxl1	A	T	5: 72,528,509		probably null	Het
Nynrin	A	T	14: 55,863,532	T260S	probably benign	Het
Olfr1294	C	T	2: 111,537,779	G170D	probably damaging	Het
Olfr859	A	T	9: 19,808,975	Y219F	possibly damaging	Het
Olfr905	A	T	9: 38,473,289	I181F	possibly damaging	Het
Pbx1	G	T	1: 168,209,534	D109E	probably damaging	Het
Pde4d	A	T	13: 109,116,942	H101L	probably benign	Het
Pdlim3	T	C	8: 45,908,602	I155T	possibly damaging	Het
Plekha5	T	A	6: 140,525,929	Y26*	probably null	Het
Prpf6	T	A	2: 181,621,920	L191*	probably null	Het
Rabl6	A	G	2: 25,602,447	V80A	possibly damaging	Het
Rp1	T	C	1: 4,311,280		probably benign	Het
Sec14l1	A	G	11: 117,156,850	S698G	probably damaging	Het
Skiv2l	A	G	17: 34,844,436	S622P	possibly damaging	Het
Slc19a1	G	A	10: 77,049,606	G447S	probably benign	Het
Slc2a6	A	T	2: 27,023,131	Y383*	probably null	Het
Slc9a9	C	A	9: 94,936,371	Q273K	probably benign	Het
Spint2	A	G	7: 29,263,706	Y56H	probably damaging	Het
Sspo	T	A	6: 48,495,212	M123K	possibly damaging	Het
Syne2	A	G	12: 76,027,847		probably null	Het
Trdn	A	C	10: 33,466,454	K619N	probably benign	Het
Ttll13	A	G	7: 80,250,176	T119A	possibly damaging	Het
Ttn	T	C	2: 76,785,646	Y8324C	probably damaging	Het
Ttn	T	C	2: 76,898,258		probably benign	Het
Vav2	A	G	2: 27,296,219	L208P	probably damaging	Het
Vmn1r179	A	G	7: 23,928,917	I178V	probably benign	Het
Vmn1r210	T	C	13: 22,827,535	M194V	possibly damaging	Het
Vmn2r103	A	T	17: 19,811,904	T647S	probably benign	Het
Wdr49	T	A	3: 75,339,458	H289L	probably benign	Het
Wnk2	T	G	13: 49,146,683	K184Q	probably damaging	Het

Other mutations in Zfp758

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01550:Zfp758	APN	17	22375040	missense	probably damaging	1.00
R1034:Zfp758	UTSW	17	22375759	nonsense	probably null
R1187:Zfp758	UTSW	17	22375190	missense	probably benign	0.23
R1733:Zfp758	UTSW	17	22375849	missense	probably damaging	1.00
R1847:Zfp758	UTSW	17	22375223	missense	probably benign	0.19
R1927:Zfp758	UTSW	17	22375842	missense	probably damaging	0.99
R1934:Zfp758	UTSW	17	22373652	missense	probably damaging	0.99
R2113:Zfp758	UTSW	17	22361645	missense	probably benign	0.10
R2132:Zfp758	UTSW	17	22375970	missense	probably damaging	1.00
R5134:Zfp758	UTSW	17	22375405	missense	probably damaging	1.00
R5274:Zfp758	UTSW	17	22375855	missense	probably benign	0.31
R5303:Zfp758	UTSW	17	22374861	missense	probably benign	0.05
R5394:Zfp758	UTSW	17	22372068	missense	probably damaging	0.99
R5813:Zfp758	UTSW	17	22375815	missense	probably damaging	1.00
R6017:Zfp758	UTSW	17	22373731	missense	probably damaging	1.00
R6411:Zfp758	UTSW	17	22375094	missense	possibly damaging	0.85
R6805:Zfp758	UTSW	17	22361669	missense	probably benign	0.00
R7076:Zfp758	UTSW	17	22375156	missense	probably benign	0.11
R7147:Zfp758	UTSW	17	22376000	missense	possibly damaging	0.75
R7170:Zfp758	UTSW	17	22375135	nonsense	probably null
R7572:Zfp758	UTSW	17	22374891	missense	possibly damaging	0.61
R7593:Zfp758	UTSW	17	22374958	missense	probably damaging	0.98

Predicted Primers

Posted On

2018-06-06