Mutagenetix > Incidental Mutation

Incidental Mutation 'R6501:Zfp758'

519751

Institutional Source

Beutler Lab

Gene Symbol

Zfp758

Ensembl Gene

ENSMUSG00000044501

Gene Name

zinc finger protein 758

Synonyms

MMRRC Submission

044633-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R6501 (G1)

Quality Score

184.009

Status

Not validated

Chromosome

Chromosomal Location

22580434-22596262 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to G at 22590978 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000121288 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072477] [ENSMUST00000088765] [ENSMUST00000121315] [ENSMUST00000149699]

AlphaFold

E9QAA1

Predicted Effect

probably benign
Transcript: ENSMUST00000072477

SMART Domains

Protein: ENSMUSP00000072298
Gene: ENSMUSG00000044501

Domain	Start	End	E-Value	Type
KRAB	13	73	1.55e-20	SMART
ZnF_C2H2	177	199	6.92e0	SMART
ZnF_C2H2	205	227	6.32e-3	SMART
ZnF_C2H2	233	255	1.2e-3	SMART
ZnF_C2H2	261	283	9.08e-4	SMART
ZnF_C2H2	289	311	6.08e-5	SMART
ZnF_C2H2	317	339	1.03e-2	SMART
ZnF_C2H2	345	367	2.24e-3	SMART
ZnF_C2H2	373	395	3.21e-4	SMART
ZnF_C2H2	401	423	6.32e-3	SMART
ZnF_C2H2	429	451	2.24e-3	SMART
ZnF_C2H2	457	479	5.14e-3	SMART
ZnF_C2H2	485	507	1.04e-3	SMART
ZnF_C2H2	513	535	4.4e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000088765

SMART Domains

Protein: ENSMUSP00000086143
Gene: ENSMUSG00000044501

Domain	Start	End	E-Value	Type
KRAB	13	73	1.55e-20	SMART
ZnF_C2H2	177	199	6.92e0	SMART
ZnF_C2H2	205	227	6.32e-3	SMART
ZnF_C2H2	233	255	1.2e-3	SMART
ZnF_C2H2	261	283	9.08e-4	SMART
ZnF_C2H2	289	311	6.08e-5	SMART
ZnF_C2H2	317	339	1.03e-2	SMART
ZnF_C2H2	345	367	2.24e-3	SMART
ZnF_C2H2	373	395	3.21e-4	SMART
ZnF_C2H2	401	423	6.32e-3	SMART
ZnF_C2H2	429	451	2.24e-3	SMART
ZnF_C2H2	457	479	5.14e-3	SMART
ZnF_C2H2	485	507	1.04e-3	SMART
ZnF_C2H2	513	535	4.4e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000121315

SMART Domains

Protein: ENSMUSP00000113532
Gene: ENSMUSG00000044501

Domain	Start	End	E-Value	Type
KRAB	13	73	1.55e-20	SMART
ZnF_C2H2	177	199	6.92e0	SMART
ZnF_C2H2	205	227	6.32e-3	SMART
ZnF_C2H2	233	255	1.2e-3	SMART
ZnF_C2H2	261	283	9.08e-4	SMART
ZnF_C2H2	289	311	6.08e-5	SMART
ZnF_C2H2	317	339	1.03e-2	SMART
ZnF_C2H2	345	367	2.24e-3	SMART
ZnF_C2H2	373	395	3.21e-4	SMART
ZnF_C2H2	401	423	6.32e-3	SMART
ZnF_C2H2	429	451	2.24e-3	SMART
ZnF_C2H2	457	479	5.14e-3	SMART
ZnF_C2H2	485	507	1.04e-3	SMART
ZnF_C2H2	513	535	4.4e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000149699

SMART Domains

Protein: ENSMUSP00000121288
Gene: ENSMUSG00000044501

Domain	Start	End	E-Value	Type
KRAB	45	105	1.55e-20	SMART
ZnF_C2H2	209	231	6.92e0	SMART
ZnF_C2H2	237	259	6.32e-3	SMART
ZnF_C2H2	265	287	1.2e-3	SMART
ZnF_C2H2	293	315	9.08e-4	SMART
ZnF_C2H2	321	343	6.08e-5	SMART
ZnF_C2H2	349	371	1.03e-2	SMART
ZnF_C2H2	377	399	2.24e-3	SMART
ZnF_C2H2	405	427	3.21e-4	SMART
ZnF_C2H2	433	455	6.32e-3	SMART
ZnF_C2H2	461	483	2.24e-3	SMART
ZnF_C2H2	489	511	5.14e-3	SMART
ZnF_C2H2	517	539	1.04e-3	SMART
ZnF_C2H2	545	567	4.4e-2	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 94.1%

Validation Efficiency

100% (48/48)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd8	A	T	8: 71,914,165 (GRCm39)	C154*	probably null	Het
Ada	A	G	2: 163,570,108 (GRCm39)		probably null	Het
Birc6	G	A	17: 74,886,276 (GRCm39)	V535I	probably damaging	Het
Bptf	T	C	11: 106,968,509 (GRCm39)	N1058S	probably null	Het
Cdadc1	C	T	14: 59,823,898 (GRCm39)	C198Y	probably benign	Het
Chrna7	G	A	7: 62,755,863 (GRCm39)	R228C	probably damaging	Het
Cts6	T	C	13: 61,344,149 (GRCm39)	N301S	probably damaging	Het
Cts8	T	A	13: 61,398,756 (GRCm39)	D250V	probably damaging	Het
Cyp26a1	G	T	19: 37,687,518 (GRCm39)	R235L	possibly damaging	Het
Disc1	A	T	8: 125,944,844 (GRCm39)	M598L	probably benign	Het
Ear6	T	A	14: 52,091,681 (GRCm39)	V76D	possibly damaging	Het
Grifin	A	G	5: 140,549,036 (GRCm39)	*145R	probably null	Het
Htr2b	T	G	1: 86,038,363 (GRCm39)	E11A	probably damaging	Het
Krtap4-9	T	A	11: 99,676,255 (GRCm39)		probably benign	Het
Larp4b	A	C	13: 9,218,829 (GRCm39)	H522P	probably damaging	Het
Macf1	A	T	4: 123,363,425 (GRCm39)		probably null	Het
Mdfic	T	C	6: 15,770,516 (GRCm39)	L174P	possibly damaging	Het
Mmp17	A	G	5: 129,683,469 (GRCm39)	E535G	probably benign	Het
Nfxl1	A	T	5: 72,685,852 (GRCm39)		probably null	Het
Nynrin	A	T	14: 56,100,989 (GRCm39)	T260S	probably benign	Het
Or4k44	C	T	2: 111,368,124 (GRCm39)	G170D	probably damaging	Het
Or7e168	A	T	9: 19,720,271 (GRCm39)	Y219F	possibly damaging	Het
Or8b1c	A	T	9: 38,384,585 (GRCm39)	I181F	possibly damaging	Het
Pbx1	G	T	1: 168,037,103 (GRCm39)	D109E	probably damaging	Het
Pde4d	A	T	13: 109,253,476 (GRCm39)	H101L	probably benign	Het
Pdlim3	T	C	8: 46,361,639 (GRCm39)	I155T	possibly damaging	Het
Plekha5	T	A	6: 140,471,655 (GRCm39)	Y26*	probably null	Het
Prpf6	T	A	2: 181,263,713 (GRCm39)	L191*	probably null	Het
Rabl6	A	G	2: 25,492,459 (GRCm39)	V80A	possibly damaging	Het
Rp1	T	C	1: 4,381,503 (GRCm39)		probably benign	Het
Sec14l1	A	G	11: 117,047,676 (GRCm39)	S698G	probably damaging	Het
Skic2	A	G	17: 35,063,412 (GRCm39)	S622P	possibly damaging	Het
Slc19a1	G	A	10: 76,885,440 (GRCm39)	G447S	probably benign	Het
Slc2a6	A	T	2: 26,913,143 (GRCm39)	Y383*	probably null	Het
Slc9a9	C	A	9: 94,818,424 (GRCm39)	Q273K	probably benign	Het
Spint2	A	G	7: 28,963,131 (GRCm39)	Y56H	probably damaging	Het
Sspo	T	A	6: 48,472,146 (GRCm39)	M123K	possibly damaging	Het
Syne2	A	G	12: 76,074,621 (GRCm39)		probably null	Het
Trdn	A	C	10: 33,342,450 (GRCm39)	K619N	probably benign	Het
Ttll13	A	G	7: 79,899,924 (GRCm39)	T119A	possibly damaging	Het
Ttn	T	C	2: 76,615,990 (GRCm39)	Y8324C	probably damaging	Het
Ttn	T	C	2: 76,728,602 (GRCm39)		probably benign	Het
Vav2	A	G	2: 27,186,231 (GRCm39)	L208P	probably damaging	Het
Vmn1r179	A	G	7: 23,628,342 (GRCm39)	I178V	probably benign	Het
Vmn1r210	T	C	13: 23,011,705 (GRCm39)	M194V	possibly damaging	Het
Vmn2r103	A	T	17: 20,032,166 (GRCm39)	T647S	probably benign	Het
Wdr49	T	A	3: 75,246,765 (GRCm39)	H289L	probably benign	Het
Wnk2	T	G	13: 49,300,159 (GRCm39)	K184Q	probably damaging	Het

Other mutations in Zfp758

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01550:Zfp758	APN	17	22,594,021 (GRCm39)	missense	probably damaging	1.00
R1034:Zfp758	UTSW	17	22,594,740 (GRCm39)	nonsense	probably null
R1187:Zfp758	UTSW	17	22,594,171 (GRCm39)	missense	probably benign	0.23
R1733:Zfp758	UTSW	17	22,594,830 (GRCm39)	missense	probably damaging	1.00
R1847:Zfp758	UTSW	17	22,594,204 (GRCm39)	missense	probably benign	0.19
R1927:Zfp758	UTSW	17	22,594,823 (GRCm39)	missense	probably damaging	0.99
R1934:Zfp758	UTSW	17	22,592,633 (GRCm39)	missense	probably damaging	0.99
R2113:Zfp758	UTSW	17	22,580,626 (GRCm39)	missense	probably benign	0.10
R2132:Zfp758	UTSW	17	22,594,951 (GRCm39)	missense	probably damaging	1.00
R5134:Zfp758	UTSW	17	22,594,386 (GRCm39)	missense	probably damaging	1.00
R5274:Zfp758	UTSW	17	22,594,836 (GRCm39)	missense	probably benign	0.31
R5303:Zfp758	UTSW	17	22,593,842 (GRCm39)	missense	probably benign	0.05
R5394:Zfp758	UTSW	17	22,591,049 (GRCm39)	missense	probably damaging	0.99
R5813:Zfp758	UTSW	17	22,594,796 (GRCm39)	missense	probably damaging	1.00
R6017:Zfp758	UTSW	17	22,592,712 (GRCm39)	missense	probably damaging	1.00
R6411:Zfp758	UTSW	17	22,594,075 (GRCm39)	missense	possibly damaging	0.85
R6805:Zfp758	UTSW	17	22,580,650 (GRCm39)	missense	probably benign	0.00
R7076:Zfp758	UTSW	17	22,594,137 (GRCm39)	missense	probably benign	0.11
R7147:Zfp758	UTSW	17	22,594,981 (GRCm39)	missense	possibly damaging	0.75
R7170:Zfp758	UTSW	17	22,594,116 (GRCm39)	nonsense	probably null
R7572:Zfp758	UTSW	17	22,593,872 (GRCm39)	missense	possibly damaging	0.61
R7593:Zfp758	UTSW	17	22,593,939 (GRCm39)	missense	probably damaging	0.98
R7699:Zfp758	UTSW	17	22,594,646 (GRCm39)	nonsense	probably null
R7858:Zfp758	UTSW	17	22,594,359 (GRCm39)	missense	probably benign	0.02
R9377:Zfp758	UTSW	17	22,593,925 (GRCm39)	missense	probably benign	0.35
R9717:Zfp758	UTSW	17	22,593,829 (GRCm39)	missense	possibly damaging	0.48

Predicted Primers

Posted On

2018-06-06