Incidental Mutation 'IGL01132:Olfr859'
ID51980
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr859
Ensembl Gene ENSMUSG00000095448
Gene Nameolfactory receptor 859
SynonymsMOR146-3, GA_x6K02T2PVTD-13548326-13549255, MOR146-10_p
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.150) question?
Stock #IGL01132
Quality Score
Status
Chromosome9
Chromosomal Location19804906-19817626 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 19808654 bp
ZygosityHeterozygous
Amino Acid Change Serine to Asparagine at position 112 (S112N)
Ref Sequence ENSEMBL: ENSMUSP00000151076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086480] [ENSMUST00000212540] [ENSMUST00000217280]
Predicted Effect probably damaging
Transcript: ENSMUST00000086480
AA Change: S112N

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000083669
Gene: ENSMUSG00000095448
AA Change: S112N

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.2e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2e-7 PFAM
Pfam:7tm_1 41 290 3.9e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212540
AA Change: S112N

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000217280
AA Change: S112N

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,950,275 V124I probably damaging Het
Adcy6 T C 15: 98,597,851 N619S probably benign Het
Adgrf5 G T 17: 43,422,509 D75Y possibly damaging Het
Aldh1a7 T C 19: 20,727,040 H30R possibly damaging Het
Birc6 T C 17: 74,603,060 S1483P probably damaging Het
Cd209e T C 8: 3,851,274 T127A probably benign Het
Clmn T A 12: 104,774,551 probably null Het
Dcc A T 18: 71,682,174 Y376* probably null Het
Dscaml1 C T 9: 45,752,328 R1950* probably null Het
Eml2 A T 7: 19,200,539 S388C probably damaging Het
Ext2 C T 2: 93,791,073 M370I probably benign Het
Foxo1 C T 3: 52,345,159 R248W probably damaging Het
Gan T A 8: 117,196,444 probably benign Het
Klra1 A T 6: 130,364,274 C245* probably null Het
Myh10 A T 11: 68,768,268 M491L possibly damaging Het
Myrf A G 19: 10,223,205 Y343H probably damaging Het
Olfr1084 A T 2: 86,639,166 C181S probably benign Het
Olfr790 T C 10: 129,501,646 V254A probably damaging Het
Oplah C T 15: 76,300,957 S852N probably benign Het
Prag1 T C 8: 36,146,357 V1021A probably damaging Het
Rassf4 C T 6: 116,659,607 probably benign Het
Sf3b3 T C 8: 110,842,781 I102V probably benign Het
Slc27a4 T C 2: 29,804,302 I46T probably benign Het
Slc5a12 T C 2: 110,597,822 V74A probably damaging Het
St5 A G 7: 109,570,005 probably null Het
Tas2r134 G T 2: 51,627,659 C50F probably damaging Het
Tcte1 G T 17: 45,539,862 A355S possibly damaging Het
Other mutations in Olfr859
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00156:Olfr859 APN 9 19808396 missense probably benign 0.09
IGL00897:Olfr859 APN 9 19808621 missense probably damaging 0.97
IGL01768:Olfr859 APN 9 19809160 missense possibly damaging 0.57
IGL02302:Olfr859 APN 9 19808685 missense probably damaging 0.97
IGL02377:Olfr859 APN 9 19809047 missense probably damaging 0.99
IGL02972:Olfr859 APN 9 19808942 missense probably damaging 0.97
R0139:Olfr859 UTSW 9 19808869 missense probably damaging 0.99
R0367:Olfr859 UTSW 9 19808543 missense probably damaging 0.99
R0521:Olfr859 UTSW 9 19808860 missense probably benign 0.00
R1196:Olfr859 UTSW 9 19808632 missense probably benign 0.00
R3742:Olfr859 UTSW 9 19808899 missense probably benign 0.44
R5567:Olfr859 UTSW 9 19808378 missense probably damaging 0.99
R6499:Olfr859 UTSW 9 19808551 missense probably benign
R6501:Olfr859 UTSW 9 19808975 missense possibly damaging 0.95
R6560:Olfr859 UTSW 9 19809116 missense probably benign
R7291:Olfr859 UTSW 9 19808648 missense possibly damaging 0.71
R7623:Olfr859 UTSW 9 19808929 missense possibly damaging 0.93
R7627:Olfr859 UTSW 9 19808651 missense probably damaging 0.99
Z1177:Olfr859 UTSW 9 19808534 missense probably damaging 1.00
Posted On2013-06-21