Incidental Mutation 'R6511:Vmn1r158'
ID 519913
Institutional Source Beutler Lab
Gene Symbol Vmn1r158
Ensembl Gene ENSMUSG00000094700
Gene Name vomeronasal 1 receptor 158
Synonyms Gm16455
MMRRC Submission 044639-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.653) question?
Stock # R6511 (G1)
Quality Score 177.009
Status Validated
Chromosome 7
Chromosomal Location 22489284-22490207 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 22490116 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 31 (K31R)
Ref Sequence ENSEMBL: ENSMUSP00000133990 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000174643]
AlphaFold G3UY92
Predicted Effect probably benign
Transcript: ENSMUST00000174643
AA Change: K31R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000133990
Gene: ENSMUSG00000094700
AA Change: K31R

DomainStartEndE-ValueType
Pfam:TAS2R 8 298 2.9e-15 PFAM
Pfam:7tm_1 39 290 5.5e-9 PFAM
Pfam:V1R 41 298 3.2e-17 PFAM
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.5%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 G A 16: 20,195,344 (GRCm39) H718Y probably damaging Het
Abcc8 G A 7: 45,800,285 (GRCm39) T499I possibly damaging Het
Azin2 C A 4: 128,828,259 (GRCm39) R316L probably damaging Het
Cep85l C T 10: 53,154,188 (GRCm39) V702I probably benign Het
Cfap69 A T 5: 5,667,220 (GRCm39) C442S probably damaging Het
Commd3 G A 2: 18,679,650 (GRCm39) G148R probably benign Het
Cyfip2 T C 11: 46,087,135 (GRCm39) T1252A probably benign Het
Cyp4a30b A T 4: 115,313,905 (GRCm39) D162V probably damaging Het
Exoc3l G T 8: 106,019,887 (GRCm39) T346K probably benign Het
Gas8 T C 8: 124,250,896 (GRCm39) V123A probably benign Het
Hmcn2 T G 2: 31,246,354 (GRCm39) D774E possibly damaging Het
Itga1 G T 13: 115,129,037 (GRCm39) S540R probably damaging Het
Itpr2 T C 6: 146,231,225 (GRCm39) N1145S probably damaging Het
Kcnc2 C T 10: 112,297,972 (GRCm39) probably benign Het
Lrp5 G A 19: 3,702,296 (GRCm39) R174W probably damaging Het
Lrrn4 T G 2: 132,712,246 (GRCm39) S526R probably benign Het
Map3k6 G A 4: 132,975,389 (GRCm39) R708H probably damaging Het
Mefv T C 16: 3,533,810 (GRCm39) T154A probably benign Het
Mrtfb T A 16: 13,197,714 (GRCm39) S66R probably damaging Het
Mtif2 G T 11: 29,486,949 (GRCm39) A320S possibly damaging Het
Nos2 A G 11: 78,846,290 (GRCm39) probably null Het
Or4k15b A G 14: 50,272,266 (GRCm39) L198P probably damaging Het
Or9g4 A G 2: 85,505,184 (GRCm39) S104P possibly damaging Het
Pip5k1c T C 10: 81,146,651 (GRCm39) Y44H probably damaging Het
Ppp1r13b T C 12: 111,798,001 (GRCm39) E972G probably damaging Het
Prdm12 T C 2: 31,530,321 (GRCm39) S71P probably damaging Het
Prkag2 G T 5: 25,305,286 (GRCm39) probably benign Het
Ptprb T C 10: 116,182,725 (GRCm39) L1467P probably damaging Het
Rnf43 G A 11: 87,622,989 (GRCm39) V697I probably benign Het
Rpl7 C A 1: 16,173,889 (GRCm39) A12S probably benign Het
Slc25a54 T G 3: 109,001,572 (GRCm39) I120S possibly damaging Het
Slc41a2 T C 10: 83,119,652 (GRCm39) H370R probably damaging Het
Speer1d A G 5: 11,307,275 (GRCm39) Y51C probably benign Het
Sv2c C T 13: 96,185,033 (GRCm39) V215I probably benign Het
Synpo2l T C 14: 20,712,518 (GRCm39) E34G probably damaging Het
Tubgcp5 T A 7: 55,467,140 (GRCm39) C703* probably null Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Zfp2 A T 11: 50,791,234 (GRCm39) C270S probably damaging Het
Other mutations in Vmn1r158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01147:Vmn1r158 APN 7 22,490,204 (GRCm39) missense probably benign 0.01
R1173:Vmn1r158 UTSW 7 22,489,870 (GRCm39) missense probably benign 0.19
R1574:Vmn1r158 UTSW 7 22,489,772 (GRCm39) missense probably damaging 1.00
R1574:Vmn1r158 UTSW 7 22,489,772 (GRCm39) missense probably damaging 1.00
R1725:Vmn1r158 UTSW 7 22,490,072 (GRCm39) missense probably benign 0.08
R1777:Vmn1r158 UTSW 7 22,489,855 (GRCm39) missense probably damaging 1.00
R1813:Vmn1r158 UTSW 7 22,490,143 (GRCm39) missense probably damaging 1.00
R1896:Vmn1r158 UTSW 7 22,490,143 (GRCm39) missense probably damaging 1.00
R2077:Vmn1r158 UTSW 7 22,489,815 (GRCm39) missense probably benign 0.03
R3749:Vmn1r158 UTSW 7 22,489,639 (GRCm39) missense probably damaging 1.00
R4872:Vmn1r158 UTSW 7 22,490,179 (GRCm39) missense possibly damaging 0.94
R5238:Vmn1r158 UTSW 7 22,489,799 (GRCm39) missense probably benign
R6500:Vmn1r158 UTSW 7 22,490,078 (GRCm39) missense possibly damaging 0.89
R6581:Vmn1r158 UTSW 7 22,489,465 (GRCm39) missense possibly damaging 0.69
R6751:Vmn1r158 UTSW 7 22,489,306 (GRCm39) missense probably damaging 0.96
R7168:Vmn1r158 UTSW 7 22,490,101 (GRCm39) missense possibly damaging 0.82
R7337:Vmn1r158 UTSW 7 22,489,649 (GRCm39) missense probably benign 0.00
R7747:Vmn1r158 UTSW 7 22,489,725 (GRCm39) missense probably benign 0.15
R7902:Vmn1r158 UTSW 7 22,489,433 (GRCm39) missense possibly damaging 0.67
R8328:Vmn1r158 UTSW 7 22,489,487 (GRCm39) missense probably damaging 1.00
R8400:Vmn1r158 UTSW 7 22,489,305 (GRCm39) nonsense probably null
R8809:Vmn1r158 UTSW 7 22,489,775 (GRCm39) missense probably damaging 0.97
R9227:Vmn1r158 UTSW 7 22,489,469 (GRCm39) missense probably benign 0.02
R9468:Vmn1r158 UTSW 7 22,489,888 (GRCm39) missense probably damaging 1.00
R9702:Vmn1r158 UTSW 7 22,490,065 (GRCm39) missense probably benign 0.00
R9719:Vmn1r158 UTSW 7 22,489,331 (GRCm39) missense possibly damaging 0.95
Z1177:Vmn1r158 UTSW 7 22,489,883 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- TTGTGCTTCTTGCCACCAGG -3'
(R):5'- CTCAAATCAATTGGTAAGTGTGGAC -3'

Sequencing Primer
(F):5'- GAGTTTTGGGAGCAAAAGC -3'
(R):5'- ATCAATTGGTAAGTGTGGACAATAG -3'
Posted On 2018-06-06