Incidental Mutation 'R6511:Vmn1r158'
ID |
519913 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r158
|
Ensembl Gene |
ENSMUSG00000094700 |
Gene Name |
vomeronasal 1 receptor 158 |
Synonyms |
Gm16455 |
MMRRC Submission |
044639-MU
|
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.653)
|
Stock # |
R6511 (G1)
|
Quality Score |
177.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
22489284-22490207 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 22490116 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Arginine
at position 31
(K31R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000133990
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000174643]
|
AlphaFold |
G3UY92 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000174643
AA Change: K31R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
SMART Domains |
Protein: ENSMUSP00000133990 Gene: ENSMUSG00000094700 AA Change: K31R
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
8 |
298 |
2.9e-15 |
PFAM |
Pfam:7tm_1
|
39 |
290 |
5.5e-9 |
PFAM |
Pfam:V1R
|
41 |
298 |
3.2e-17 |
PFAM |
|
Meta Mutation Damage Score |
0.0846 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 97.9%
- 20x: 93.5%
|
Validation Efficiency |
100% (39/39) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 38 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc5 |
G |
A |
16: 20,195,344 (GRCm39) |
H718Y |
probably damaging |
Het |
Abcc8 |
G |
A |
7: 45,800,285 (GRCm39) |
T499I |
possibly damaging |
Het |
Azin2 |
C |
A |
4: 128,828,259 (GRCm39) |
R316L |
probably damaging |
Het |
Cep85l |
C |
T |
10: 53,154,188 (GRCm39) |
V702I |
probably benign |
Het |
Cfap69 |
A |
T |
5: 5,667,220 (GRCm39) |
C442S |
probably damaging |
Het |
Commd3 |
G |
A |
2: 18,679,650 (GRCm39) |
G148R |
probably benign |
Het |
Cyfip2 |
T |
C |
11: 46,087,135 (GRCm39) |
T1252A |
probably benign |
Het |
Cyp4a30b |
A |
T |
4: 115,313,905 (GRCm39) |
D162V |
probably damaging |
Het |
Exoc3l |
G |
T |
8: 106,019,887 (GRCm39) |
T346K |
probably benign |
Het |
Gas8 |
T |
C |
8: 124,250,896 (GRCm39) |
V123A |
probably benign |
Het |
Hmcn2 |
T |
G |
2: 31,246,354 (GRCm39) |
D774E |
possibly damaging |
Het |
Itga1 |
G |
T |
13: 115,129,037 (GRCm39) |
S540R |
probably damaging |
Het |
Itpr2 |
T |
C |
6: 146,231,225 (GRCm39) |
N1145S |
probably damaging |
Het |
Kcnc2 |
C |
T |
10: 112,297,972 (GRCm39) |
|
probably benign |
Het |
Lrp5 |
G |
A |
19: 3,702,296 (GRCm39) |
R174W |
probably damaging |
Het |
Lrrn4 |
T |
G |
2: 132,712,246 (GRCm39) |
S526R |
probably benign |
Het |
Map3k6 |
G |
A |
4: 132,975,389 (GRCm39) |
R708H |
probably damaging |
Het |
Mefv |
T |
C |
16: 3,533,810 (GRCm39) |
T154A |
probably benign |
Het |
Mrtfb |
T |
A |
16: 13,197,714 (GRCm39) |
S66R |
probably damaging |
Het |
Mtif2 |
G |
T |
11: 29,486,949 (GRCm39) |
A320S |
possibly damaging |
Het |
Nos2 |
A |
G |
11: 78,846,290 (GRCm39) |
|
probably null |
Het |
Or4k15b |
A |
G |
14: 50,272,266 (GRCm39) |
L198P |
probably damaging |
Het |
Or9g4 |
A |
G |
2: 85,505,184 (GRCm39) |
S104P |
possibly damaging |
Het |
Pip5k1c |
T |
C |
10: 81,146,651 (GRCm39) |
Y44H |
probably damaging |
Het |
Ppp1r13b |
T |
C |
12: 111,798,001 (GRCm39) |
E972G |
probably damaging |
Het |
Prdm12 |
T |
C |
2: 31,530,321 (GRCm39) |
S71P |
probably damaging |
Het |
Prkag2 |
G |
T |
5: 25,305,286 (GRCm39) |
|
probably benign |
Het |
Ptprb |
T |
C |
10: 116,182,725 (GRCm39) |
L1467P |
probably damaging |
Het |
Rnf43 |
G |
A |
11: 87,622,989 (GRCm39) |
V697I |
probably benign |
Het |
Rpl7 |
C |
A |
1: 16,173,889 (GRCm39) |
A12S |
probably benign |
Het |
Slc25a54 |
T |
G |
3: 109,001,572 (GRCm39) |
I120S |
possibly damaging |
Het |
Slc41a2 |
T |
C |
10: 83,119,652 (GRCm39) |
H370R |
probably damaging |
Het |
Speer1d |
A |
G |
5: 11,307,275 (GRCm39) |
Y51C |
probably benign |
Het |
Sv2c |
C |
T |
13: 96,185,033 (GRCm39) |
V215I |
probably benign |
Het |
Synpo2l |
T |
C |
14: 20,712,518 (GRCm39) |
E34G |
probably damaging |
Het |
Tubgcp5 |
T |
A |
7: 55,467,140 (GRCm39) |
C703* |
probably null |
Het |
Vmn2r106 |
C |
T |
17: 20,488,725 (GRCm39) |
C558Y |
probably damaging |
Het |
Zfp2 |
A |
T |
11: 50,791,234 (GRCm39) |
C270S |
probably damaging |
Het |
|
Other mutations in Vmn1r158 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01147:Vmn1r158
|
APN |
7 |
22,490,204 (GRCm39) |
missense |
probably benign |
0.01 |
R1173:Vmn1r158
|
UTSW |
7 |
22,489,870 (GRCm39) |
missense |
probably benign |
0.19 |
R1574:Vmn1r158
|
UTSW |
7 |
22,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
R1574:Vmn1r158
|
UTSW |
7 |
22,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
R1725:Vmn1r158
|
UTSW |
7 |
22,490,072 (GRCm39) |
missense |
probably benign |
0.08 |
R1777:Vmn1r158
|
UTSW |
7 |
22,489,855 (GRCm39) |
missense |
probably damaging |
1.00 |
R1813:Vmn1r158
|
UTSW |
7 |
22,490,143 (GRCm39) |
missense |
probably damaging |
1.00 |
R1896:Vmn1r158
|
UTSW |
7 |
22,490,143 (GRCm39) |
missense |
probably damaging |
1.00 |
R2077:Vmn1r158
|
UTSW |
7 |
22,489,815 (GRCm39) |
missense |
probably benign |
0.03 |
R3749:Vmn1r158
|
UTSW |
7 |
22,489,639 (GRCm39) |
missense |
probably damaging |
1.00 |
R4872:Vmn1r158
|
UTSW |
7 |
22,490,179 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5238:Vmn1r158
|
UTSW |
7 |
22,489,799 (GRCm39) |
missense |
probably benign |
|
R6500:Vmn1r158
|
UTSW |
7 |
22,490,078 (GRCm39) |
missense |
possibly damaging |
0.89 |
R6581:Vmn1r158
|
UTSW |
7 |
22,489,465 (GRCm39) |
missense |
possibly damaging |
0.69 |
R6751:Vmn1r158
|
UTSW |
7 |
22,489,306 (GRCm39) |
missense |
probably damaging |
0.96 |
R7168:Vmn1r158
|
UTSW |
7 |
22,490,101 (GRCm39) |
missense |
possibly damaging |
0.82 |
R7337:Vmn1r158
|
UTSW |
7 |
22,489,649 (GRCm39) |
missense |
probably benign |
0.00 |
R7747:Vmn1r158
|
UTSW |
7 |
22,489,725 (GRCm39) |
missense |
probably benign |
0.15 |
R7902:Vmn1r158
|
UTSW |
7 |
22,489,433 (GRCm39) |
missense |
possibly damaging |
0.67 |
R8328:Vmn1r158
|
UTSW |
7 |
22,489,487 (GRCm39) |
missense |
probably damaging |
1.00 |
R8400:Vmn1r158
|
UTSW |
7 |
22,489,305 (GRCm39) |
nonsense |
probably null |
|
R8809:Vmn1r158
|
UTSW |
7 |
22,489,775 (GRCm39) |
missense |
probably damaging |
0.97 |
R9227:Vmn1r158
|
UTSW |
7 |
22,489,469 (GRCm39) |
missense |
probably benign |
0.02 |
R9468:Vmn1r158
|
UTSW |
7 |
22,489,888 (GRCm39) |
missense |
probably damaging |
1.00 |
R9702:Vmn1r158
|
UTSW |
7 |
22,490,065 (GRCm39) |
missense |
probably benign |
0.00 |
R9719:Vmn1r158
|
UTSW |
7 |
22,489,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
Z1177:Vmn1r158
|
UTSW |
7 |
22,489,883 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
Predicted Primers |
PCR Primer
(F):5'- TTGTGCTTCTTGCCACCAGG -3'
(R):5'- CTCAAATCAATTGGTAAGTGTGGAC -3'
Sequencing Primer
(F):5'- GAGTTTTGGGAGCAAAAGC -3'
(R):5'- ATCAATTGGTAAGTGTGGACAATAG -3'
|
Posted On |
2018-06-06 |