Mutagenetix > Incidental Mutation

Incidental Mutation 'R6511:Vmn1r158'

519913

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r158

Ensembl Gene

ENSMUSG00000094700

Gene Name

vomeronasal 1 receptor 158

Synonyms

Gm16455

MMRRC Submission

Accession Numbers

Is this an essential gene?

Possibly essential (E-score: 0.687) question?

Stock #

R6511 (G1)

Quality Score

177.009

Status

Validated

Chromosome

Chromosomal Location

22789859-22790782 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22790691 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Arginine at position 31 (K31R)

Ref Sequence

ENSEMBL: ENSMUSP00000133990 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000174643]

AlphaFold

G3UY92

Predicted Effect

probably benign
Transcript: ENSMUST00000174643
AA Change: K31R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000133990
Gene: ENSMUSG00000094700
AA Change: K31R

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	2.9e-15	PFAM
Pfam:7tm_1	39	290	5.5e-9	PFAM
Pfam:V1R	41	298	3.2e-17	PFAM

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.5%

Validation Efficiency

100% (39/39)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc5	G	A	16: 20,376,594	H718Y	probably damaging	Het
Abcc8	G	A	7: 46,150,861	T499I	possibly damaging	Het
Azin2	C	A	4: 128,934,466	R316L	probably damaging	Het
Cep85l	C	T	10: 53,278,092	V702I	probably benign	Het
Cfap69	A	T	5: 5,617,220	C442S	probably damaging	Het
Commd3	G	A	2: 18,674,839	G148R	probably benign	Het
Cyfip2	T	C	11: 46,196,308	T1252A	probably benign	Het
Cyp4a30b	A	T	4: 115,456,708	D162V	probably damaging	Het
Exoc3l	G	T	8: 105,293,255	T346K	probably benign	Het
Gas8	T	C	8: 123,524,157	V123A	probably benign	Het
Gm8890	A	G	5: 11,257,308	Y51C	probably benign	Het
Hmcn2	T	G	2: 31,356,342	D774E	possibly damaging	Het
Itga1	G	T	13: 114,992,501	S540R	probably damaging	Het
Itpr2	T	C	6: 146,329,727	N1145S	probably damaging	Het
Kcnc2	C	T	10: 112,462,067		probably benign	Het
Lrp5	G	A	19: 3,652,296	R174W	probably damaging	Het
Lrrn4	T	G	2: 132,870,326	S526R	probably benign	Het
Map3k6	G	A	4: 133,248,078	R708H	probably damaging	Het
Mefv	T	C	16: 3,715,946	T154A	probably benign	Het
Mkl2	T	A	16: 13,379,850	S66R	probably damaging	Het
Mtif2	G	T	11: 29,536,949	A320S	possibly damaging	Het
Nos2	A	G	11: 78,955,464		probably null	Het
Olfr1006	A	G	2: 85,674,840	S104P	possibly damaging	Het
Olfr725	A	G	14: 50,034,809	L198P	probably damaging	Het
Pip5k1c	T	C	10: 81,310,817	Y44H	probably damaging	Het
Ppp1r13b	T	C	12: 111,831,567	E972G	probably damaging	Het
Prdm12	T	C	2: 31,640,309	S71P	probably damaging	Het
Prkag2	G	T	5: 25,100,288		probably benign	Het
Ptprb	T	C	10: 116,346,820	L1467P	probably damaging	Het
Rnf43	G	A	11: 87,732,163	V697I	probably benign	Het
Rpl7	C	A	1: 16,103,665	A12S	probably benign	Het
Slc25a54	T	G	3: 109,094,256	I120S	possibly damaging	Het
Slc41a2	T	C	10: 83,283,788	H370R	probably damaging	Het
Sv2c	C	T	13: 96,048,525	V215I	probably benign	Het
Synpo2l	T	C	14: 20,662,450	E34G	probably damaging	Het
Tubgcp5	T	A	7: 55,817,392	C703*	probably null	Het
Vmn2r106	C	T	17: 20,268,463	C558Y	probably damaging	Het
Zfp2	A	T	11: 50,900,407	C270S	probably damaging	Het

Other mutations in Vmn1r158

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01147:Vmn1r158	APN	7	22790779	missense	probably benign	0.01
R1173:Vmn1r158	UTSW	7	22790445	missense	probably benign	0.19
R1574:Vmn1r158	UTSW	7	22790347	missense	probably damaging	1.00
R1574:Vmn1r158	UTSW	7	22790347	missense	probably damaging	1.00
R1725:Vmn1r158	UTSW	7	22790647	missense	probably benign	0.08
R1777:Vmn1r158	UTSW	7	22790430	missense	probably damaging	1.00
R1813:Vmn1r158	UTSW	7	22790718	missense	probably damaging	1.00
R1896:Vmn1r158	UTSW	7	22790718	missense	probably damaging	1.00
R2077:Vmn1r158	UTSW	7	22790390	missense	probably benign	0.03
R3749:Vmn1r158	UTSW	7	22790214	missense	probably damaging	1.00
R4872:Vmn1r158	UTSW	7	22790754	missense	possibly damaging	0.94
R5238:Vmn1r158	UTSW	7	22790374	missense	probably benign
R6500:Vmn1r158	UTSW	7	22790653	missense	possibly damaging	0.89
R6581:Vmn1r158	UTSW	7	22790040	missense	possibly damaging	0.69
R6751:Vmn1r158	UTSW	7	22789881	missense	probably damaging	0.96
R7168:Vmn1r158	UTSW	7	22790676	missense	possibly damaging	0.82
R7337:Vmn1r158	UTSW	7	22790224	missense	probably benign	0.00
R7747:Vmn1r158	UTSW	7	22790300	missense	probably benign	0.15
R7902:Vmn1r158	UTSW	7	22790008	missense	possibly damaging	0.67
R8328:Vmn1r158	UTSW	7	22790062	missense	probably damaging	1.00
R8400:Vmn1r158	UTSW	7	22789880	nonsense	probably null
R8809:Vmn1r158	UTSW	7	22790350	missense	probably damaging	0.97
R9227:Vmn1r158	UTSW	7	22790044	missense	probably benign	0.02
R9468:Vmn1r158	UTSW	7	22790463	missense	probably damaging	1.00
Z1177:Vmn1r158	UTSW	7	22790458	missense	possibly damaging	0.46

Predicted Primers

PCR Primer
(F):5'- TTGTGCTTCTTGCCACCAGG -3'
(R):5'- CTCAAATCAATTGGTAAGTGTGGAC -3'

Sequencing Primer
(F):5'- GAGTTTTGGGAGCAAAAGC -3'
(R):5'- ATCAATTGGTAAGTGTGGACAATAG -3'

Posted On

2018-06-06