Incidental Mutation 'R6511:Or4k15b'
ID 519931
Institutional Source Beutler Lab
Gene Symbol Or4k15b
Ensembl Gene ENSMUSG00000068437
Gene Name olfactory receptor family 4 subfamily K member 15B
Synonyms GA_x6K02T2PMLR-5725741-5724776, MOR246-7_p, Olfr725, MOR246-3
MMRRC Submission 044639-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R6511 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 50271771-50277832 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50272266 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 198 (L198P)
Ref Sequence ENSEMBL: ENSMUSP00000145828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089844] [ENSMUST00000206920]
AlphaFold Q05A45
Predicted Effect probably damaging
Transcript: ENSMUST00000089844
AA Change: L198P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000087282
Gene: ENSMUSG00000068437
AA Change: L198P

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 4.7e-46 PFAM
Pfam:7TM_GPCR_Srsx 36 282 1.8e-7 PFAM
Pfam:7tm_1 41 287 5.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000206920
AA Change: L198P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.5%
Validation Efficiency 100% (39/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 G A 16: 20,195,344 (GRCm39) H718Y probably damaging Het
Abcc8 G A 7: 45,800,285 (GRCm39) T499I possibly damaging Het
Azin2 C A 4: 128,828,259 (GRCm39) R316L probably damaging Het
Cep85l C T 10: 53,154,188 (GRCm39) V702I probably benign Het
Cfap69 A T 5: 5,667,220 (GRCm39) C442S probably damaging Het
Commd3 G A 2: 18,679,650 (GRCm39) G148R probably benign Het
Cyfip2 T C 11: 46,087,135 (GRCm39) T1252A probably benign Het
Cyp4a30b A T 4: 115,313,905 (GRCm39) D162V probably damaging Het
Exoc3l G T 8: 106,019,887 (GRCm39) T346K probably benign Het
Gas8 T C 8: 124,250,896 (GRCm39) V123A probably benign Het
Hmcn2 T G 2: 31,246,354 (GRCm39) D774E possibly damaging Het
Itga1 G T 13: 115,129,037 (GRCm39) S540R probably damaging Het
Itpr2 T C 6: 146,231,225 (GRCm39) N1145S probably damaging Het
Kcnc2 C T 10: 112,297,972 (GRCm39) probably benign Het
Lrp5 G A 19: 3,702,296 (GRCm39) R174W probably damaging Het
Lrrn4 T G 2: 132,712,246 (GRCm39) S526R probably benign Het
Map3k6 G A 4: 132,975,389 (GRCm39) R708H probably damaging Het
Mefv T C 16: 3,533,810 (GRCm39) T154A probably benign Het
Mrtfb T A 16: 13,197,714 (GRCm39) S66R probably damaging Het
Mtif2 G T 11: 29,486,949 (GRCm39) A320S possibly damaging Het
Nos2 A G 11: 78,846,290 (GRCm39) probably null Het
Or9g4 A G 2: 85,505,184 (GRCm39) S104P possibly damaging Het
Pip5k1c T C 10: 81,146,651 (GRCm39) Y44H probably damaging Het
Ppp1r13b T C 12: 111,798,001 (GRCm39) E972G probably damaging Het
Prdm12 T C 2: 31,530,321 (GRCm39) S71P probably damaging Het
Prkag2 G T 5: 25,305,286 (GRCm39) probably benign Het
Ptprb T C 10: 116,182,725 (GRCm39) L1467P probably damaging Het
Rnf43 G A 11: 87,622,989 (GRCm39) V697I probably benign Het
Rpl7 C A 1: 16,173,889 (GRCm39) A12S probably benign Het
Slc25a54 T G 3: 109,001,572 (GRCm39) I120S possibly damaging Het
Slc41a2 T C 10: 83,119,652 (GRCm39) H370R probably damaging Het
Speer1d A G 5: 11,307,275 (GRCm39) Y51C probably benign Het
Sv2c C T 13: 96,185,033 (GRCm39) V215I probably benign Het
Synpo2l T C 14: 20,712,518 (GRCm39) E34G probably damaging Het
Tubgcp5 T A 7: 55,467,140 (GRCm39) C703* probably null Het
Vmn1r158 T C 7: 22,490,116 (GRCm39) K31R probably benign Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Zfp2 A T 11: 50,791,234 (GRCm39) C270S probably damaging Het
Other mutations in Or4k15b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01116:Or4k15b APN 14 50,272,507 (GRCm39) missense probably benign 0.29
IGL01412:Or4k15b APN 14 50,272,770 (GRCm39) missense probably benign
IGL03241:Or4k15b APN 14 50,272,525 (GRCm39) missense possibly damaging 0.70
IGL03268:Or4k15b APN 14 50,272,024 (GRCm39) missense probably damaging 0.98
IGL03348:Or4k15b APN 14 50,272,212 (GRCm39) missense probably benign 0.00
R0358:Or4k15b UTSW 14 50,272,743 (GRCm39) missense probably damaging 0.97
R0577:Or4k15b UTSW 14 50,272,249 (GRCm39) missense probably damaging 1.00
R2094:Or4k15b UTSW 14 50,272,171 (GRCm39) missense probably damaging 1.00
R2424:Or4k15b UTSW 14 50,272,281 (GRCm39) missense probably damaging 1.00
R3421:Or4k15b UTSW 14 50,271,997 (GRCm39) missense possibly damaging 0.66
R3422:Or4k15b UTSW 14 50,271,997 (GRCm39) missense possibly damaging 0.66
R4436:Or4k15b UTSW 14 50,272,287 (GRCm39) missense probably damaging 1.00
R4437:Or4k15b UTSW 14 50,272,287 (GRCm39) missense probably damaging 1.00
R4438:Or4k15b UTSW 14 50,272,287 (GRCm39) missense probably damaging 1.00
R4684:Or4k15b UTSW 14 50,272,287 (GRCm39) missense probably damaging 1.00
R4717:Or4k15b UTSW 14 50,272,821 (GRCm39) missense probably damaging 0.98
R5253:Or4k15b UTSW 14 50,272,745 (GRCm39) missense possibly damaging 0.91
R5254:Or4k15b UTSW 14 50,272,135 (GRCm39) missense possibly damaging 0.60
R5641:Or4k15b UTSW 14 50,272,746 (GRCm39) missense probably benign 0.04
R5881:Or4k15b UTSW 14 50,272,444 (GRCm39) missense probably benign 0.00
R5906:Or4k15b UTSW 14 50,272,306 (GRCm39) missense probably benign 0.05
R7837:Or4k15b UTSW 14 50,272,033 (GRCm39) missense probably damaging 1.00
R7980:Or4k15b UTSW 14 50,272,252 (GRCm39) missense probably damaging 1.00
R8118:Or4k15b UTSW 14 50,272,608 (GRCm39) missense probably benign 0.13
R8942:Or4k15b UTSW 14 50,272,602 (GRCm39) missense probably damaging 1.00
R9084:Or4k15b UTSW 14 50,271,916 (GRCm39) missense probably benign
R9797:Or4k15b UTSW 14 50,272,224 (GRCm39) missense probably benign 0.19
X0062:Or4k15b UTSW 14 50,272,317 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGGACTTTGTCAACTGAATAGCC -3'
(R):5'- ATCATGAGTCGCCGTGTGTG -3'

Sequencing Primer
(F):5'- CCATTAAAGGGCCATGCATAG -3'
(R):5'- AGTCGCCGTGTGTGTATCACTC -3'
Posted On 2018-06-06