Incidental Mutation 'IGL01137:Gsta4'
ID 51994
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gsta4
Ensembl Gene ENSMUSG00000032348
Gene Name glutathione S-transferase, alpha 4
Synonyms GST 5.7, mGsta4
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01137
Quality Score
Status
Chromosome 9
Chromosomal Location 78099248-78116631 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78113204 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 95 (Y95H)
Ref Sequence ENSEMBL: ENSMUSP00000034903 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034903] [ENSMUST00000213215]
AlphaFold P24472
PDB Structure CRYSTAL STRUCTURE OF MGSTA4-4 IN COMPLEX WITH GSH CONJUGATE OF 4-HYDROXYNONENAL IN ONE SUBUNIT AND GSH IN THE OTHER: EVIDENCE OF SIGNALING ACROSS DIMER INTERFACE IN MGSTA4-4 [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF MURINE ALPHA-CLASS GSTA4-4 [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000034903
AA Change: Y95H

PolyPhen 2 Score 0.627 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000034903
Gene: ENSMUSG00000032348
AA Change: Y95H

DomainStartEndE-ValueType
Pfam:GST_N 5 77 1.2e-19 PFAM
Pfam:GST_C 99 192 5.2e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213215
AA Change: Y95H

PolyPhen 2 Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene display increased sensitivity to oxidative stress, increased alanine and aspartate transaminase levels, increased susceptibility to bacterial infection, reduced litter size, and impaired glucose tolerance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 C A 15: 94,292,492 (GRCm39) probably null Het
Ankrd11 T C 8: 123,611,075 (GRCm39) T2583A probably damaging Het
Anxa7 G A 14: 20,506,648 (GRCm39) Q431* probably null Het
Asb15 T A 6: 24,556,521 (GRCm39) D5E probably benign Het
Bex1 C A X: 135,115,243 (GRCm39) D29Y probably damaging Het
Cadm2 G A 16: 66,612,238 (GRCm39) T108I probably damaging Het
Cecr2 T G 6: 120,738,989 (GRCm39) L1211V probably damaging Het
Cntn2 T C 1: 132,449,035 (GRCm39) probably benign Het
Ctrc C A 4: 141,566,065 (GRCm39) V198L possibly damaging Het
Cyp2g1 A G 7: 26,513,684 (GRCm39) S208G possibly damaging Het
Ddx46 T A 13: 55,817,530 (GRCm39) Y718* probably null Het
Dlec1 T C 9: 118,966,379 (GRCm39) I1116T probably damaging Het
Dnajc13 A G 9: 104,037,689 (GRCm39) Y2177H probably benign Het
Dpp6 T C 5: 27,919,486 (GRCm39) F661S probably damaging Het
Dpy19l2 G A 9: 24,569,858 (GRCm39) T365I possibly damaging Het
Flot2 T C 11: 77,940,333 (GRCm39) Y27H probably damaging Het
Kir3dl1 A G X: 135,427,360 (GRCm39) T192A probably damaging Het
Llgl1 T A 11: 60,600,825 (GRCm39) N640K probably benign Het
Lrch1 C T 14: 74,994,532 (GRCm39) V691M probably damaging Het
Myh9 T C 15: 77,653,742 (GRCm39) D1302G probably benign Het
Myo18a T G 11: 77,718,655 (GRCm39) F935V probably damaging Het
Mypn T C 10: 62,988,633 (GRCm39) E464G probably benign Het
Or52l1 A G 7: 104,829,695 (GRCm39) V290A probably benign Het
Or5ac25 A C 16: 59,182,335 (GRCm39) M82R probably benign Het
Or5b101 A T 19: 13,005,394 (GRCm39) F100I possibly damaging Het
Or8k38 A T 2: 86,488,055 (GRCm39) I249N possibly damaging Het
R3hdm1 C T 1: 128,109,612 (GRCm39) R39C probably damaging Het
Rps3a3 A T 13: 108,807,666 (GRCm39) probably benign Het
Sec24b C T 3: 129,801,093 (GRCm39) S401N probably benign Het
Slc22a22 C A 15: 57,117,674 (GRCm39) G289V probably damaging Het
Stk33 T C 7: 108,928,775 (GRCm39) I246V probably benign Het
Tedc1 C T 12: 113,126,808 (GRCm39) R357* probably null Het
Timmdc1 A T 16: 38,338,747 (GRCm39) H114Q probably benign Het
Tlcd2 T C 11: 75,360,337 (GRCm39) Y127H probably damaging Het
Tnfrsf11a G A 1: 105,737,147 (GRCm39) D85N possibly damaging Het
Trbc2 T C 6: 41,524,751 (GRCm39) probably benign Het
Unc13b G A 4: 43,091,291 (GRCm39) R39H probably damaging Het
Vwa8 T C 14: 79,341,087 (GRCm39) L1521P probably damaging Het
Zbtb17 T A 4: 141,193,678 (GRCm39) C607* probably null Het
Other mutations in Gsta4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02442:Gsta4 APN 9 78,116,447 (GRCm39) missense probably benign
IGL03088:Gsta4 APN 9 78,113,345 (GRCm39) unclassified probably benign
R1668:Gsta4 UTSW 9 78,111,570 (GRCm39) missense probably benign 0.00
R1766:Gsta4 UTSW 9 78,111,611 (GRCm39) nonsense probably null
R4578:Gsta4 UTSW 9 78,113,302 (GRCm39) missense probably benign 0.12
R6654:Gsta4 UTSW 9 78,116,381 (GRCm39) missense probably damaging 0.98
R8190:Gsta4 UTSW 9 78,105,654 (GRCm39) missense possibly damaging 0.80
R8825:Gsta4 UTSW 9 78,116,121 (GRCm39) unclassified probably benign
R9181:Gsta4 UTSW 9 78,105,597 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21