Mutagenetix > Incidental Mutation

Incidental Mutation 'R6512:Slc22a26'

519976

Institutional Source

Beutler Lab

Gene Symbol

Slc22a26

Ensembl Gene

ENSMUSG00000053303

Gene Name

solute carrier family 22 (organic cation transporter), member 26

Synonyms

BC014805

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R6512 (G1)

Quality Score

167.009

Status

Not validated

Chromosome

Chromosomal Location

7781041-7802667 bp(-) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

T to C at 7802500 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000113607 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065634] [ENSMUST00000120522]

AlphaFold

Q91WJ2

Predicted Effect

probably benign
Transcript: ENSMUST00000065634

SMART Domains

Protein: ENSMUSP00000064809
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	96	528	1.1e-23	PFAM
Pfam:MFS_1	124	370	7.8e-17	PFAM
Pfam:MFS_1	350	547	2.1e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000120522

SMART Domains

Protein: ENSMUSP00000113607
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	94	527	4.9e-23	PFAM
Pfam:MFS_1	124	358	1.2e-15	PFAM
Pfam:MFS_1	349	547	2.4e-12	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 93.9%

Validation Efficiency

100% (39/39)

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700122O11Rik	A	G	17: 48,036,863	S211P	possibly damaging	Het
Abcb11	T	C	2: 69,282,652	T674A	probably benign	Het
Acad11	G	T	9: 104,095,559	E484*	probably null	Het
Ankhd1	A	T	18: 36,591,456	D389V	probably damaging	Het
Asic4	T	A	1: 75,473,043	L439*	probably null	Het
Atp13a2	A	G	4: 141,003,218	T808A	probably damaging	Het
Capn13	C	A	17: 73,382,990	V9L	probably benign	Het
Chst11	A	G	10: 83,191,468	Y243C	probably damaging	Het
Ctdp1	A	T	18: 80,451,263	W308R	probably damaging	Het
Dnttip2	A	G	3: 122,275,523	E129G	possibly damaging	Het
Dock5	A	G	14: 67,824,648	S424P	possibly damaging	Het
Ebf1	C	T	11: 44,992,341	H469Y	probably damaging	Het
Efhc1	A	T	1: 20,960,349	N169Y	probably damaging	Het
Elmo1	T	C	13: 20,373,161	L424P	probably damaging	Het
Ighv1-59	A	G	12: 115,335,383	V16A	probably damaging	Het
Kcnc1	T	G	7: 46,427,397	C208G	probably damaging	Het
Kif13b	A	T	14: 64,744,874		probably null	Het
Lilra6	T	A	7: 3,914,388	N203Y	probably benign	Het
Mkl1	T	C	15: 81,013,716	T787A	probably benign	Het
Myh8	A	T	11: 67,289,662	K575*	probably null	Het
Nedd1	C	T	10: 92,691,875	A486T	probably benign	Het
Olfr170	A	T	16: 19,606,359	L103H	probably damaging	Het
Phrf1	T	C	7: 141,260,396	I1168T	possibly damaging	Het
Pla2g12a	T	A	3: 129,888,957	H59Q	probably benign	Het
Ralbp1	A	G	17: 65,861,275	V345A	probably damaging	Het
Ryr3	C	T	2: 112,867,378	V894M	possibly damaging	Het
Sec24b	T	A	3: 130,041,297	Y84F	probably damaging	Het
Smc1b	C	T	15: 85,092,031	R825Q	probably benign	Het
Spats1	C	T	17: 45,452,673		probably null	Het
Tbk1	T	A	10: 121,578,621	N63Y	probably damaging	Het
Tbl1xr1	C	T	3: 22,140,534		probably benign	Het
Top2b	T	A	14: 16,409,854	D840E	possibly damaging	Het
Trpc3	T	A	3: 36,662,758	Y377F	possibly damaging	Het
Uba6	C	T	5: 86,124,403	R778K	probably benign	Het
Vmn2r101	A	T	17: 19,588,884	I92F	probably damaging	Het
Vmn2r106	C	T	17: 20,268,463	C558Y	probably damaging	Het
Vmn2r70	G	T	7: 85,566,097	F76L	probably benign	Het
Vwa3b	A	G	1: 37,063,642		probably benign	Het
Zfp407	T	A	18: 84,560,349	T880S	probably damaging	Het
Zfp64	C	A	2: 168,894,077	G560V	probably benign	Het

Other mutations in Slc22a26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Slc22a26	APN	19	7782836	missense	probably damaging	0.99
IGL00338:Slc22a26	APN	19	7782975	missense	probably benign	0.25
IGL00736:Slc22a26	APN	19	7790162	missense	possibly damaging	0.50
IGL01085:Slc22a26	APN	19	7790099	missense	probably benign	0.02
IGL01581:Slc22a26	APN	19	7802184	missense	probably benign	0.15
IGL02502:Slc22a26	APN	19	7790760	critical splice donor site	probably null
IGL02658:Slc22a26	APN	19	7788248	missense	probably benign	0.25
IGL02936:Slc22a26	APN	19	7791105	missense	probably damaging	0.99
IGL03162:Slc22a26	APN	19	7802101	missense	probably benign	0.00
R0034:Slc22a26	UTSW	19	7802253	missense	probably benign	0.03
R0633:Slc22a26	UTSW	19	7788210	critical splice donor site	probably null
R0676:Slc22a26	UTSW	19	7796144	splice site	probably benign
R2156:Slc22a26	UTSW	19	7802115	missense	probably damaging	1.00
R4043:Slc22a26	UTSW	19	7788329	critical splice acceptor site	probably null
R4781:Slc22a26	UTSW	19	7790135	missense	probably benign	0.34
R4896:Slc22a26	UTSW	19	7791054	missense	probably benign	0.14
R4999:Slc22a26	UTSW	19	7802181	missense	probably damaging	1.00
R5125:Slc22a26	UTSW	19	7790175	missense	possibly damaging	0.62
R5178:Slc22a26	UTSW	19	7790175	missense	possibly damaging	0.62
R6161:Slc22a26	UTSW	19	7786447	missense	possibly damaging	0.50
R6494:Slc22a26	UTSW	19	7802286	missense	probably damaging	1.00
R6724:Slc22a26	UTSW	19	7802361	missense	probably benign	0.14
R7323:Slc22a26	UTSW	19	7790894	missense	probably damaging	0.97
R7375:Slc22a26	UTSW	19	7783144	splice site	probably null
R7558:Slc22a26	UTSW	19	7785286	missense	possibly damaging	0.94
R7634:Slc22a26	UTSW	19	7802587	splice site	probably null
R8772:Slc22a26	UTSW	19	7790112	missense	probably benign	0.27
R8905:Slc22a26	UTSW	19	7782966	missense	probably damaging	0.97
R8937:Slc22a26	UTSW	19	7791025	splice site	probably benign
R9059:Slc22a26	UTSW	19	7785194	missense	probably benign	0.01
R9659:Slc22a26	UTSW	19	7786433	missense	probably benign	0.02
R9788:Slc22a26	UTSW	19	7786433	missense	probably benign	0.02

Predicted Primers

Posted On

2018-06-06