Incidental Mutation 'R6513:Or10ak14'
ID 519994
Institutional Source Beutler Lab
Gene Symbol Or10ak14
Ensembl Gene ENSMUSG00000095218
Gene Name olfactory receptor family 10 subfamily AK member 14
Synonyms GA_x6K02T2QD9B-18795136-18796077, MOR259-4P, MOR259-9, Olfr1338, MOR259-4P, Olfr1524-ps1
MMRRC Submission 044640-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.778) question?
Stock # R6513 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 118610386-118614155 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 118611224 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 172 (C172*)
Ref Sequence ENSEMBL: ENSMUSP00000149843 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084315] [ENSMUST00000214922] [ENSMUST00000216559]
AlphaFold A0A1L1SSB4
Predicted Effect probably null
Transcript: ENSMUST00000084315
AA Change: C170*
SMART Domains Protein: ENSMUSP00000092427
Gene: ENSMUSG00000095218
AA Change: C170*

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 3.3e-55 PFAM
Pfam:7TM_GPCR_Srsx 36 306 1e-8 PFAM
Pfam:7tm_1 42 291 1.8e-26 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000214922
AA Change: C172*
Predicted Effect probably null
Transcript: ENSMUST00000216559
AA Change: C172*
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.4%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik T C 16: 90,852,654 (GRCm39) S161G probably benign Het
Ankfy1 G A 11: 72,621,308 (GRCm39) R198Q possibly damaging Het
Ankrd11 A G 8: 123,616,919 (GRCm39) V2290A probably benign Het
Aox4 A G 1: 58,252,212 (GRCm39) N29S probably benign Het
Arhgap17 T C 7: 122,891,379 (GRCm39) R592G possibly damaging Het
Caap1 A T 4: 94,389,640 (GRCm39) D231E possibly damaging Het
Cabp1 T A 5: 115,307,193 (GRCm39) M165L possibly damaging Het
Calhm4 T A 10: 33,917,630 (GRCm39) R274* probably null Het
Cep72 A T 13: 74,206,582 (GRCm39) L73H probably damaging Het
Cfap74 A G 4: 155,525,743 (GRCm39) S731G probably null Het
Dsc2 T C 18: 20,179,295 (GRCm39) I258V probably benign Het
Dsg1c T G 18: 20,407,687 (GRCm39) N344K probably benign Het
Enah A G 1: 181,841,920 (GRCm39) probably benign Het
Fbn1 T A 2: 125,225,591 (GRCm39) S554C probably damaging Het
Fkrp C A 7: 16,545,037 (GRCm39) R275L possibly damaging Het
Gbp4 C T 5: 105,270,986 (GRCm39) G215D possibly damaging Het
Gli2 G A 1: 118,783,284 (GRCm39) L239F probably damaging Het
Gpr146 A G 5: 139,378,573 (GRCm39) D125G probably damaging Het
Hectd4 C A 5: 121,494,259 (GRCm39) probably null Het
Invs G A 4: 48,397,534 (GRCm39) V370I possibly damaging Het
Kdm2b A G 5: 123,018,302 (GRCm39) V1040A probably damaging Het
Kidins220 T A 12: 25,088,434 (GRCm39) V1059D possibly damaging Het
Kif26a T A 12: 112,141,926 (GRCm39) S727T probably damaging Het
Kifbp T C 10: 62,410,813 (GRCm39) probably null Het
Klk1b27 A G 7: 43,705,169 (GRCm39) H112R probably benign Het
Krt72 T G 15: 101,685,187 (GRCm39) probably null Het
Lactb C T 9: 66,878,172 (GRCm39) R219H probably damaging Het
Lrig2 A T 3: 104,373,045 (GRCm39) I612N probably damaging Het
Meaf6 A C 4: 124,983,697 (GRCm39) N51T probably damaging Het
Mtap A G 4: 89,066,498 (GRCm39) T36A possibly damaging Het
Myo3a G A 2: 22,412,143 (GRCm39) G713S probably damaging Het
Nr4a3 C T 4: 48,083,255 (GRCm39) T596I probably damaging Het
Or4f14 C G 2: 111,743,228 (GRCm39) G16R possibly damaging Het
Pam A G 1: 97,765,752 (GRCm39) V759A possibly damaging Het
Pcare T A 17: 72,051,701 (GRCm39) E1217V probably damaging Het
Pds5a T A 5: 65,772,944 (GRCm39) I1220F probably benign Het
Phldb2 T A 16: 45,568,240 (GRCm39) M1222L possibly damaging Het
Phospho1 C T 11: 95,721,513 (GRCm39) A61V possibly damaging Het
Pnpla7 G A 2: 24,906,550 (GRCm39) V638I possibly damaging Het
Pramel34 C A 5: 93,785,391 (GRCm39) probably null Het
Ptf1a T A 2: 19,451,848 (GRCm39) D282E probably damaging Het
Ptgs2 A T 1: 149,975,879 (GRCm39) probably benign Het
Racgap1 T C 15: 99,522,156 (GRCm39) R471G probably damaging Het
Rptn T C 3: 93,303,419 (GRCm39) S251P possibly damaging Het
Shcbp1 T C 8: 4,794,507 (GRCm39) M429V probably benign Het
Shprh T C 10: 11,062,637 (GRCm39) L1248P probably damaging Het
Son T C 16: 91,456,835 (GRCm39) probably benign Het
Sppl3 T C 5: 115,233,995 (GRCm39) L355P probably damaging Het
Tbc1d31 A T 15: 57,818,778 (GRCm39) R794W probably damaging Het
Telo2 T C 17: 25,320,386 (GRCm39) Y766C probably damaging Het
Tfr2 A G 5: 137,572,793 (GRCm39) probably null Het
Tle4 T C 19: 14,429,056 (GRCm39) D722G probably damaging Het
Tprg1l A G 4: 154,243,862 (GRCm39) V98A probably benign Het
Trak1 C T 9: 121,272,822 (GRCm39) R237C probably benign Het
Vmn2r113 T C 17: 23,177,715 (GRCm39) I833T probably damaging Het
Vmn2r118 T A 17: 55,915,093 (GRCm39) S518C probably damaging Het
Vmn2r49 A G 7: 9,710,524 (GRCm39) I736T probably damaging Het
Wdr38 T A 2: 38,889,970 (GRCm39) probably null Het
Wee2 A G 6: 40,429,553 (GRCm39) E180G probably benign Het
Zbtb1 T C 12: 76,432,604 (GRCm39) S197P possibly damaging Het
Zc3h7a T C 16: 10,976,629 (GRCm39) probably null Het
Zfp516 T A 18: 82,973,835 (GRCm39) L11Q probably damaging Het
Zfp623 G A 15: 75,819,317 (GRCm39) R91H probably benign Het
Zkscan7 G A 9: 122,725,170 (GRCm39) R713Q probably benign Het
Other mutations in Or10ak14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01092:Or10ak14 APN 4 118,610,959 (GRCm39) missense possibly damaging 0.78
IGL02726:Or10ak14 APN 4 118,610,961 (GRCm39) missense probably benign 0.00
IGL02928:Or10ak14 APN 4 118,611,697 (GRCm39) missense probably damaging 1.00
IGL03102:Or10ak14 APN 4 118,611,131 (GRCm39) missense probably benign 0.00
R0062:Or10ak14 UTSW 4 118,611,100 (GRCm39) missense probably benign 0.00
R0062:Or10ak14 UTSW 4 118,611,100 (GRCm39) missense probably benign 0.00
R0299:Or10ak14 UTSW 4 118,611,732 (GRCm39) start codon destroyed probably null 0.82
R0501:Or10ak14 UTSW 4 118,611,027 (GRCm39) missense probably benign 0.00
R1301:Or10ak14 UTSW 4 118,610,816 (GRCm39) missense probably benign
R1719:Or10ak14 UTSW 4 118,610,797 (GRCm39) missense possibly damaging 0.78
R2327:Or10ak14 UTSW 4 118,611,331 (GRCm39) missense probably benign 0.13
R3110:Or10ak14 UTSW 4 118,611,421 (GRCm39) missense probably damaging 0.99
R3112:Or10ak14 UTSW 4 118,611,421 (GRCm39) missense probably damaging 0.99
R4582:Or10ak14 UTSW 4 118,611,090 (GRCm39) missense probably damaging 1.00
R4615:Or10ak14 UTSW 4 118,611,334 (GRCm39) missense probably benign 0.34
R5640:Or10ak14 UTSW 4 118,610,986 (GRCm39) missense probably benign 0.07
R6889:Or10ak14 UTSW 4 118,611,504 (GRCm39) missense probably damaging 0.99
R7157:Or10ak14 UTSW 4 118,611,615 (GRCm39) missense possibly damaging 0.93
R7168:Or10ak14 UTSW 4 118,611,048 (GRCm39) missense probably damaging 0.98
R7378:Or10ak14 UTSW 4 118,611,372 (GRCm39) missense possibly damaging 0.74
R7451:Or10ak14 UTSW 4 118,610,884 (GRCm39) missense probably benign 0.03
R7770:Or10ak14 UTSW 4 118,611,254 (GRCm39) missense probably benign 0.04
R7847:Or10ak14 UTSW 4 118,611,565 (GRCm39) missense possibly damaging 0.79
R8839:Or10ak14 UTSW 4 118,611,411 (GRCm39) missense probably damaging 0.99
R8942:Or10ak14 UTSW 4 118,611,594 (GRCm39) missense possibly damaging 0.94
R9274:Or10ak14 UTSW 4 118,610,883 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GAGAATTGCCTTGGTAATGTGAATG -3'
(R):5'- CAGACCATCTCCTTTGCTGG -3'

Sequencing Primer
(F):5'- CCTTGGTAATGTGAATGTAGGAAGCC -3'
(R):5'- CTGCAGATGTATATGTTCAGTGCCC -3'
Posted On 2018-06-06