Incidental Mutation 'IGL01145:Layn'
ID52011
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Layn
Ensembl Gene ENSMUSG00000060594
Gene Namelayilin
SynonymsLOC244864, E030012M19Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.080) question?
Stock #IGL01145
Quality Score
Status
Chromosome9
Chromosomal Location51054640-51077094 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 51074046 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 62 (T62I)
Ref Sequence ENSEMBL: ENSMUSP00000149794 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098782] [ENSMUST00000214452] [ENSMUST00000214993] [ENSMUST00000217212]
Predicted Effect probably benign
Transcript: ENSMUST00000098782
AA Change: T70I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000096379
Gene: ENSMUSG00000060594
AA Change: T70I

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
CLECT 41 185 6.18e-25 SMART
transmembrane domain 237 259 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214090
Predicted Effect probably benign
Transcript: ENSMUST00000214452
Predicted Effect probably benign
Transcript: ENSMUST00000214993
AA Change: T62I

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216453
Predicted Effect probably benign
Transcript: ENSMUST00000217212
AA Change: T70I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A C 7: 79,099,282 D1267A probably damaging Het
AI314180 A C 4: 58,811,501 D1467E probably null Het
Ankrd44 A G 1: 54,762,259 probably null Het
Arap3 T C 18: 37,989,179 M619V probably benign Het
C8b A T 4: 104,780,580 Y83F probably benign Het
Capn15 A G 17: 25,963,050 V595A probably damaging Het
Cbx1 A T 11: 96,801,566 D93V probably benign Het
Cyp2c66 G T 19: 39,170,961 E285D probably benign Het
Dkk4 T A 8: 22,625,386 V84D probably damaging Het
Dnah17 T A 11: 118,047,173 I3343F possibly damaging Het
Dus3l T C 17: 56,767,627 probably benign Het
Eif6 A G 2: 155,826,435 probably benign Het
Eya3 A G 4: 132,709,995 I389V probably damaging Het
Gm5868 A T 5: 72,586,204 probably null Het
Gm5916 A T 9: 36,120,702 D95E unknown Het
Gucy2d T A 7: 98,449,963 S329T probably benign Het
Hook3 C T 8: 26,059,344 M157I probably benign Het
Iapp C A 6: 142,303,364 R48S probably damaging Het
Ints11 A G 4: 155,885,126 Y153C probably damaging Het
Llgl2 A G 11: 115,853,805 H876R probably benign Het
Lrp4 T C 2: 91,487,051 I840T probably damaging Het
Myo9a T A 9: 59,855,375 F796L probably benign Het
Naip1 A G 13: 100,409,121 S1300P probably benign Het
Nfat5 T A 8: 107,367,215 I602N probably damaging Het
Omt2a T C 9: 78,312,956 M64V probably benign Het
Pcnx T C 12: 81,992,035 S2025P probably damaging Het
Pemt A G 11: 59,983,467 L62P probably damaging Het
Polrmt A G 10: 79,741,137 V399A probably benign Het
Rasgrp4 T C 7: 29,151,473 S77P possibly damaging Het
Rrm2b G A 15: 37,944,560 P111L probably damaging Het
Thap12 A G 7: 98,712,903 *121W probably null Het
Tnik A G 3: 28,604,167 probably benign Het
Trio G A 15: 27,818,167 probably benign Het
Zfhx4 A G 3: 5,245,347 E930G probably damaging Het
Zfp335 G T 2: 164,907,502 T299K probably benign Het
Other mutations in Layn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00921:Layn APN 9 51057408 missense probably damaging 1.00
IGL02006:Layn APN 9 51057291 intron probably benign
IGL02226:Layn APN 9 51074017 missense probably damaging 1.00
PIT4677001:Layn UTSW 9 51057411 missense probably damaging 0.98
R1464:Layn UTSW 9 51057586 missense probably damaging 1.00
R1464:Layn UTSW 9 51057586 missense probably damaging 1.00
R1775:Layn UTSW 9 51059533 missense probably benign 0.03
R2156:Layn UTSW 9 51057397 missense probably benign
R3732:Layn UTSW 9 51059544 missense probably damaging 1.00
R3732:Layn UTSW 9 51059544 missense probably damaging 1.00
R3733:Layn UTSW 9 51059544 missense probably damaging 1.00
R3757:Layn UTSW 9 51059556 missense probably benign 0.11
R4840:Layn UTSW 9 51057382 missense probably damaging 1.00
R5792:Layn UTSW 9 51068161 missense probably damaging 1.00
R7185:Layn UTSW 9 51073873 missense possibly damaging 0.58
R7216:Layn UTSW 9 51077052 start gained probably benign
R7404:Layn UTSW 9 51057370 missense possibly damaging 0.94
Posted On2013-06-21