Incidental Mutation 'R6456:Vmn2r125'
ID 520168
Institutional Source Beutler Lab
Gene Symbol Vmn2r125
Ensembl Gene ENSMUSG00000096042
Gene Name vomeronasal 2, receptor 125
Synonyms Gm20782
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R6456 (G1)
Quality Score 84.0076
Status Not validated
Chromosome 4
Chromosomal Location 156696567-156708037 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 156703357 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 245 (N245S)
Ref Sequence ENSEMBL: ENSMUSP00000094556 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096794]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000096794
AA Change: N245S

PolyPhen 2 Score 0.406 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000094556
Gene: ENSMUSG00000096042
AA Change: N245S

DomainStartEndE-ValueType
Pfam:ANF_receptor 9 355 7e-32 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 91.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,240,474 (GRCm39) H779L possibly damaging Het
Abca7 T C 10: 79,850,984 (GRCm39) V2097A probably null Het
Adam8 A G 7: 139,566,701 (GRCm39) S524P possibly damaging Het
Anapc2 T C 2: 25,170,207 (GRCm39) M575T probably damaging Het
Arhgap42 T A 9: 9,005,823 (GRCm39) I736L probably benign Het
AU040320 A G 4: 126,736,284 (GRCm39) N789S probably benign Het
Bmi1 A G 2: 18,687,058 (GRCm39) Y46C probably damaging Het
Brd10 G A 19: 29,693,914 (GRCm39) P1860S possibly damaging Het
Ccdc125 T C 13: 100,832,817 (GRCm39) S465P possibly damaging Het
Cd180 C T 13: 102,839,344 (GRCm39) L76F probably damaging Het
Cep135 T C 5: 76,739,571 (GRCm39) probably benign Het
Col6a5 G A 9: 105,822,676 (GRCm39) T227I unknown Het
Cyp4a29 G T 4: 115,108,381 (GRCm39) M368I probably benign Het
Ddx28 T A 8: 106,737,000 (GRCm39) I353F possibly damaging Het
Dhx40 G A 11: 86,675,800 (GRCm39) T198M probably damaging Het
Dnai4 A C 4: 102,906,746 (GRCm39) M689R probably benign Het
Dync2i2 T C 2: 29,922,779 (GRCm39) S323G probably benign Het
Fat4 G A 3: 39,038,128 (GRCm39) V3927M possibly damaging Het
Garin1b A G 6: 29,334,045 (GRCm39) N299S probably benign Het
Gm10226 G T 17: 21,910,932 (GRCm39) G56* probably null Het
H2-T15 A T 17: 36,367,502 (GRCm39) Y279N probably damaging Het
Itsn2 T G 12: 4,679,923 (GRCm39) probably benign Het
Lrrc8a A G 2: 30,145,486 (GRCm39) D100G probably benign Het
Madd T C 2: 91,008,536 (GRCm39) H122R probably benign Het
Mfsd4b3-ps C G 10: 39,823,316 (GRCm39) V315L probably benign Het
Mki67 C G 7: 135,301,204 (GRCm39) A1277P possibly damaging Het
Nlrp9b T A 7: 19,782,703 (GRCm39) N872K probably damaging Het
Npas1 T C 7: 16,195,851 (GRCm39) T274A probably benign Het
Nrm A T 17: 36,176,292 (GRCm39) probably null Het
Or10j2 A T 1: 173,098,105 (GRCm39) D121V probably damaging Het
Pdilt T A 7: 119,099,706 (GRCm39) L187F probably damaging Het
Pkdcc T C 17: 83,527,548 (GRCm39) I242T probably damaging Het
Plch2 C A 4: 155,077,459 (GRCm39) D535Y probably damaging Het
Pmpca T A 2: 26,285,179 (GRCm39) I468N probably damaging Het
Prpf4 T C 4: 62,332,869 (GRCm39) probably null Het
Rcc1 A G 4: 132,061,427 (GRCm39) S361P probably benign Het
Rigi T A 4: 40,213,838 (GRCm39) N607Y possibly damaging Het
Rnf213 A G 11: 119,350,792 (GRCm39) I3876V probably benign Het
Sall2 T A 14: 52,551,050 (GRCm39) Q715L probably damaging Het
Sall2 G A 14: 52,551,051 (GRCm39) Q713* probably null Het
Sin3a A G 9: 57,020,985 (GRCm39) S1004G possibly damaging Het
Sltm C T 9: 70,450,269 (GRCm39) T23M probably damaging Het
Spata31e2 T A 1: 26,724,250 (GRCm39) H310L probably damaging Het
Sspo A G 6: 48,428,740 (GRCm39) E385G probably benign Het
Syne3 G T 12: 104,906,963 (GRCm39) R775S possibly damaging Het
Szt2 A T 4: 118,233,894 (GRCm39) probably benign Het
Tlk2 T C 11: 105,112,099 (GRCm39) S151P probably benign Het
Trabd2b C T 4: 114,443,757 (GRCm39) R305C probably damaging Het
Ttc21b T C 2: 66,018,675 (GRCm39) Q1244R probably damaging Het
Wdr64 G A 1: 175,613,175 (GRCm39) probably null Het
Wdr70 G A 15: 7,915,118 (GRCm39) T550M possibly damaging Het
Other mutations in Vmn2r125
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Vmn2r125 APN 4 156,703,194 (GRCm39) missense probably benign
IGL00990:Vmn2r125 APN 4 156,703,333 (GRCm39) missense probably benign 0.06
IGL00990:Vmn2r125 APN 4 156,703,332 (GRCm39) missense probably benign 0.16
IGL00990:Vmn2r125 APN 4 156,703,521 (GRCm39) missense probably benign
IGL00990:Vmn2r125 APN 4 156,703,678 (GRCm39) missense probably benign 0.00
IGL00990:Vmn2r125 APN 4 156,703,261 (GRCm39) missense probably benign 0.01
IGL00990:Vmn2r125 APN 4 156,703,195 (GRCm39) missense probably benign 0.35
IGL01018:Vmn2r125 APN 4 156,703,333 (GRCm39) missense probably benign 0.06
IGL01018:Vmn2r125 APN 4 156,703,332 (GRCm39) missense probably benign 0.16
IGL01018:Vmn2r125 APN 4 156,703,521 (GRCm39) missense probably benign
IGL01018:Vmn2r125 APN 4 156,703,195 (GRCm39) missense probably benign 0.35
IGL01018:Vmn2r125 APN 4 156,703,194 (GRCm39) missense probably benign
IGL01018:Vmn2r125 APN 4 156,703,140 (GRCm39) missense probably damaging 1.00
IGL01018:Vmn2r125 APN 4 156,702,907 (GRCm39) splice site probably benign
IGL02644:Vmn2r125 APN 4 156,703,294 (GRCm39) missense probably benign 0.01
IGL03144:Vmn2r125 APN 4 156,702,314 (GRCm39) missense possibly damaging 0.76
BB013:Vmn2r125 UTSW 4 156,702,988 (GRCm39) missense probably damaging 1.00
FR4342:Vmn2r125 UTSW 4 156,703,260 (GRCm39) missense probably benign 0.01
R0408:Vmn2r125 UTSW 4 156,703,153 (GRCm39) missense probably damaging 0.99
R0785:Vmn2r125 UTSW 4 156,703,396 (GRCm39) missense probably benign
R1185:Vmn2r125 UTSW 4 156,703,396 (GRCm39) missense probably benign
R1185:Vmn2r125 UTSW 4 156,703,396 (GRCm39) missense probably benign
R1530:Vmn2r125 UTSW 4 156,703,447 (GRCm39) missense probably damaging 1.00
R1698:Vmn2r125 UTSW 4 156,703,333 (GRCm39) missense probably benign 0.06
R1780:Vmn2r125 UTSW 4 156,703,668 (GRCm39) missense probably damaging 1.00
R1977:Vmn2r125 UTSW 4 156,707,162 (GRCm39) splice site probably null
R2917:Vmn2r125 UTSW 4 156,703,564 (GRCm39) missense probably benign 0.01
R3428:Vmn2r125 UTSW 4 156,702,436 (GRCm39) missense probably benign 0.34
R3712:Vmn2r125 UTSW 4 156,702,419 (GRCm39) nonsense probably null
R4274:Vmn2r125 UTSW 4 156,702,382 (GRCm39) missense probably benign 0.00
R4575:Vmn2r125 UTSW 4 156,702,272 (GRCm39) missense probably null 0.30
R4707:Vmn2r125 UTSW 4 156,702,276 (GRCm39) missense probably damaging 1.00
R5229:Vmn2r125 UTSW 4 156,703,333 (GRCm39) missense probably benign 0.06
R5504:Vmn2r125 UTSW 4 156,703,456 (GRCm39) missense possibly damaging 0.81
R5587:Vmn2r125 UTSW 4 156,702,433 (GRCm39) missense probably damaging 1.00
R5987:Vmn2r125 UTSW 4 156,702,292 (GRCm39) missense probably damaging 1.00
R6037:Vmn2r125 UTSW 4 156,703,396 (GRCm39) missense probably benign
R6183:Vmn2r125 UTSW 4 156,702,364 (GRCm39) missense probably damaging 0.97
R7342:Vmn2r125 UTSW 4 156,703,138 (GRCm39) missense probably damaging 1.00
R7926:Vmn2r125 UTSW 4 156,702,988 (GRCm39) missense probably damaging 1.00
R8113:Vmn2r125 UTSW 4 156,703,642 (GRCm39) missense probably damaging 1.00
R8191:Vmn2r125 UTSW 4 156,703,709 (GRCm39) missense probably damaging 1.00
R8272:Vmn2r125 UTSW 4 156,702,373 (GRCm39) missense probably damaging 1.00
R8962:Vmn2r125 UTSW 4 156,703,186 (GRCm39) missense possibly damaging 0.50
R9187:Vmn2r125 UTSW 4 156,703,554 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCAGATATACATGACAAGGGCTAC -3'
(R):5'- AGTGCTGTCCATTGCAATGTG -3'

Sequencing Primer
(F):5'- GACAAGGGCTACAATATATGATCAAC -3'
(R):5'- GTGTTGTTGAATGTAAAATGACCC -3'
Posted On 2018-06-06