Incidental Mutation 'R6456:Vmn2r125'
ID |
520168 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r125
|
Ensembl Gene |
ENSMUSG00000096042 |
Gene Name |
vomeronasal 2, receptor 125 |
Synonyms |
Gm20782 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.078)
|
Stock # |
R6456 (G1)
|
Quality Score |
84.0076 |
Status
|
Not validated
|
Chromosome |
4 |
Chromosomal Location |
156696567-156708037 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 156703357 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Serine
at position 245
(N245S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000094556
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096794]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000096794
AA Change: N245S
PolyPhen 2
Score 0.406 (Sensitivity: 0.89; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000094556 Gene: ENSMUSG00000096042 AA Change: N245S
Domain | Start | End | E-Value | Type |
Pfam:ANF_receptor
|
9 |
355 |
7e-32 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.4%
- 20x: 91.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 51 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca13 |
A |
T |
11: 9,240,474 (GRCm39) |
H779L |
possibly damaging |
Het |
Abca7 |
T |
C |
10: 79,850,984 (GRCm39) |
V2097A |
probably null |
Het |
Adam8 |
A |
G |
7: 139,566,701 (GRCm39) |
S524P |
possibly damaging |
Het |
Anapc2 |
T |
C |
2: 25,170,207 (GRCm39) |
M575T |
probably damaging |
Het |
Arhgap42 |
T |
A |
9: 9,005,823 (GRCm39) |
I736L |
probably benign |
Het |
AU040320 |
A |
G |
4: 126,736,284 (GRCm39) |
N789S |
probably benign |
Het |
Bmi1 |
A |
G |
2: 18,687,058 (GRCm39) |
Y46C |
probably damaging |
Het |
Brd10 |
G |
A |
19: 29,693,914 (GRCm39) |
P1860S |
possibly damaging |
Het |
Ccdc125 |
T |
C |
13: 100,832,817 (GRCm39) |
S465P |
possibly damaging |
Het |
Cd180 |
C |
T |
13: 102,839,344 (GRCm39) |
L76F |
probably damaging |
Het |
Cep135 |
T |
C |
5: 76,739,571 (GRCm39) |
|
probably benign |
Het |
Col6a5 |
G |
A |
9: 105,822,676 (GRCm39) |
T227I |
unknown |
Het |
Cyp4a29 |
G |
T |
4: 115,108,381 (GRCm39) |
M368I |
probably benign |
Het |
Ddx28 |
T |
A |
8: 106,737,000 (GRCm39) |
I353F |
possibly damaging |
Het |
Dhx40 |
G |
A |
11: 86,675,800 (GRCm39) |
T198M |
probably damaging |
Het |
Dnai4 |
A |
C |
4: 102,906,746 (GRCm39) |
M689R |
probably benign |
Het |
Dync2i2 |
T |
C |
2: 29,922,779 (GRCm39) |
S323G |
probably benign |
Het |
Fat4 |
G |
A |
3: 39,038,128 (GRCm39) |
V3927M |
possibly damaging |
Het |
Garin1b |
A |
G |
6: 29,334,045 (GRCm39) |
N299S |
probably benign |
Het |
Gm10226 |
G |
T |
17: 21,910,932 (GRCm39) |
G56* |
probably null |
Het |
H2-T15 |
A |
T |
17: 36,367,502 (GRCm39) |
Y279N |
probably damaging |
Het |
Itsn2 |
T |
G |
12: 4,679,923 (GRCm39) |
|
probably benign |
Het |
Lrrc8a |
A |
G |
2: 30,145,486 (GRCm39) |
D100G |
probably benign |
Het |
Madd |
T |
C |
2: 91,008,536 (GRCm39) |
H122R |
probably benign |
Het |
Mfsd4b3-ps |
C |
G |
10: 39,823,316 (GRCm39) |
V315L |
probably benign |
Het |
Mki67 |
C |
G |
7: 135,301,204 (GRCm39) |
A1277P |
possibly damaging |
Het |
Nlrp9b |
T |
A |
7: 19,782,703 (GRCm39) |
N872K |
probably damaging |
Het |
Npas1 |
T |
C |
7: 16,195,851 (GRCm39) |
T274A |
probably benign |
Het |
Nrm |
A |
T |
17: 36,176,292 (GRCm39) |
|
probably null |
Het |
Or10j2 |
A |
T |
1: 173,098,105 (GRCm39) |
D121V |
probably damaging |
Het |
Pdilt |
T |
A |
7: 119,099,706 (GRCm39) |
L187F |
probably damaging |
Het |
Pkdcc |
T |
C |
17: 83,527,548 (GRCm39) |
I242T |
probably damaging |
Het |
Plch2 |
C |
A |
4: 155,077,459 (GRCm39) |
D535Y |
probably damaging |
Het |
Pmpca |
T |
A |
2: 26,285,179 (GRCm39) |
I468N |
probably damaging |
Het |
Prpf4 |
T |
C |
4: 62,332,869 (GRCm39) |
|
probably null |
Het |
Rcc1 |
A |
G |
4: 132,061,427 (GRCm39) |
S361P |
probably benign |
Het |
Rigi |
T |
A |
4: 40,213,838 (GRCm39) |
N607Y |
possibly damaging |
Het |
Rnf213 |
A |
G |
11: 119,350,792 (GRCm39) |
I3876V |
probably benign |
Het |
Sall2 |
T |
A |
14: 52,551,050 (GRCm39) |
Q715L |
probably damaging |
Het |
Sall2 |
G |
A |
14: 52,551,051 (GRCm39) |
Q713* |
probably null |
Het |
Sin3a |
A |
G |
9: 57,020,985 (GRCm39) |
S1004G |
possibly damaging |
Het |
Sltm |
C |
T |
9: 70,450,269 (GRCm39) |
T23M |
probably damaging |
Het |
Spata31e2 |
T |
A |
1: 26,724,250 (GRCm39) |
H310L |
probably damaging |
Het |
Sspo |
A |
G |
6: 48,428,740 (GRCm39) |
E385G |
probably benign |
Het |
Syne3 |
G |
T |
12: 104,906,963 (GRCm39) |
R775S |
possibly damaging |
Het |
Szt2 |
A |
T |
4: 118,233,894 (GRCm39) |
|
probably benign |
Het |
Tlk2 |
T |
C |
11: 105,112,099 (GRCm39) |
S151P |
probably benign |
Het |
Trabd2b |
C |
T |
4: 114,443,757 (GRCm39) |
R305C |
probably damaging |
Het |
Ttc21b |
T |
C |
2: 66,018,675 (GRCm39) |
Q1244R |
probably damaging |
Het |
Wdr64 |
G |
A |
1: 175,613,175 (GRCm39) |
|
probably null |
Het |
Wdr70 |
G |
A |
15: 7,915,118 (GRCm39) |
T550M |
possibly damaging |
Het |
|
Other mutations in Vmn2r125 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00990:Vmn2r125
|
APN |
4 |
156,703,194 (GRCm39) |
missense |
probably benign |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
IGL00990:Vmn2r125
|
APN |
4 |
156,703,332 (GRCm39) |
missense |
probably benign |
0.16 |
IGL00990:Vmn2r125
|
APN |
4 |
156,703,521 (GRCm39) |
missense |
probably benign |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,678 (GRCm39) |
missense |
probably benign |
0.00 |
IGL00990:Vmn2r125
|
APN |
4 |
156,703,261 (GRCm39) |
missense |
probably benign |
0.01 |
IGL00990:Vmn2r125
|
APN |
4 |
156,703,195 (GRCm39) |
missense |
probably benign |
0.35 |
IGL01018:Vmn2r125
|
APN |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01018:Vmn2r125
|
APN |
4 |
156,703,332 (GRCm39) |
missense |
probably benign |
0.16 |
IGL01018:Vmn2r125
|
APN |
4 |
156,703,521 (GRCm39) |
missense |
probably benign |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,195 (GRCm39) |
missense |
probably benign |
0.35 |
IGL01018:Vmn2r125
|
APN |
4 |
156,703,194 (GRCm39) |
missense |
probably benign |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,140 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01018:Vmn2r125
|
APN |
4 |
156,702,907 (GRCm39) |
splice site |
probably benign |
|
IGL02644:Vmn2r125
|
APN |
4 |
156,703,294 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03144:Vmn2r125
|
APN |
4 |
156,702,314 (GRCm39) |
missense |
possibly damaging |
0.76 |
BB013:Vmn2r125
|
UTSW |
4 |
156,702,988 (GRCm39) |
missense |
probably damaging |
1.00 |
FR4342:Vmn2r125
|
UTSW |
4 |
156,703,260 (GRCm39) |
missense |
probably benign |
0.01 |
R0408:Vmn2r125
|
UTSW |
4 |
156,703,153 (GRCm39) |
missense |
probably damaging |
0.99 |
R0785:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
R1185:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
R1185:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
R1530:Vmn2r125
|
UTSW |
4 |
156,703,447 (GRCm39) |
missense |
probably damaging |
1.00 |
R1698:Vmn2r125
|
UTSW |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
R1780:Vmn2r125
|
UTSW |
4 |
156,703,668 (GRCm39) |
missense |
probably damaging |
1.00 |
R1977:Vmn2r125
|
UTSW |
4 |
156,707,162 (GRCm39) |
splice site |
probably null |
|
R2917:Vmn2r125
|
UTSW |
4 |
156,703,564 (GRCm39) |
missense |
probably benign |
0.01 |
R3428:Vmn2r125
|
UTSW |
4 |
156,702,436 (GRCm39) |
missense |
probably benign |
0.34 |
R3712:Vmn2r125
|
UTSW |
4 |
156,702,419 (GRCm39) |
nonsense |
probably null |
|
R4274:Vmn2r125
|
UTSW |
4 |
156,702,382 (GRCm39) |
missense |
probably benign |
0.00 |
R4575:Vmn2r125
|
UTSW |
4 |
156,702,272 (GRCm39) |
missense |
probably null |
0.30 |
R4707:Vmn2r125
|
UTSW |
4 |
156,702,276 (GRCm39) |
missense |
probably damaging |
1.00 |
R5229:Vmn2r125
|
UTSW |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
R5504:Vmn2r125
|
UTSW |
4 |
156,703,456 (GRCm39) |
missense |
possibly damaging |
0.81 |
R5587:Vmn2r125
|
UTSW |
4 |
156,702,433 (GRCm39) |
missense |
probably damaging |
1.00 |
R5987:Vmn2r125
|
UTSW |
4 |
156,702,292 (GRCm39) |
missense |
probably damaging |
1.00 |
R6037:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
R6183:Vmn2r125
|
UTSW |
4 |
156,702,364 (GRCm39) |
missense |
probably damaging |
0.97 |
R7342:Vmn2r125
|
UTSW |
4 |
156,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
R7926:Vmn2r125
|
UTSW |
4 |
156,702,988 (GRCm39) |
missense |
probably damaging |
1.00 |
R8113:Vmn2r125
|
UTSW |
4 |
156,703,642 (GRCm39) |
missense |
probably damaging |
1.00 |
R8191:Vmn2r125
|
UTSW |
4 |
156,703,709 (GRCm39) |
missense |
probably damaging |
1.00 |
R8272:Vmn2r125
|
UTSW |
4 |
156,702,373 (GRCm39) |
missense |
probably damaging |
1.00 |
R8962:Vmn2r125
|
UTSW |
4 |
156,703,186 (GRCm39) |
missense |
possibly damaging |
0.50 |
R9187:Vmn2r125
|
UTSW |
4 |
156,703,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGCAGATATACATGACAAGGGCTAC -3'
(R):5'- AGTGCTGTCCATTGCAATGTG -3'
Sequencing Primer
(F):5'- GACAAGGGCTACAATATATGATCAAC -3'
(R):5'- GTGTTGTTGAATGTAAAATGACCC -3'
|
Posted On |
2018-06-06 |