Incidental Mutation 'IGL01151:Fbxw26'
ID52017
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw26
Ensembl Gene ENSMUSG00000059547
Gene NameF-box and WD-40 domain protein 26
SynonymsGm5163
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01151
Quality Score
Status
Chromosome9
Chromosomal Location109717566-109746089 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 109721780 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 393 (V393A)
Ref Sequence ENSEMBL: ENSMUSP00000071811 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071917]
Predicted Effect possibly damaging
Transcript: ENSMUST00000071917
AA Change: V393A

PolyPhen 2 Score 0.505 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: V393A

DomainStartEndE-ValueType
FBOX 5 45 2.54e-6 SMART
SCOP:d1tbga_ 128 249 1e-5 SMART
Blast:WD40 137 176 4e-7 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 T C 13: 81,405,399 Q5452R probably benign Het
Ankrd42 A G 7: 92,605,200 probably benign Het
Camk2g T C 14: 20,765,959 D157G probably damaging Het
Cd55b A T 1: 130,422,906 V18E possibly damaging Het
Ep300 T A 15: 81,623,472 probably benign Het
Fkbp4 T C 6: 128,435,791 T59A probably benign Het
Gbp5 T C 3: 142,500,594 L13P probably damaging Het
Gpr161 G T 1: 165,321,509 L482F probably damaging Het
Il6st T A 13: 112,493,651 S344T probably benign Het
Itpr3 T G 17: 27,091,529 F429V probably damaging Het
Kbtbd11 G T 8: 15,029,176 D592Y probably damaging Het
Magi3 C A 3: 104,051,374 G465V probably damaging Het
Naip6 T A 13: 100,299,093 Y974F probably benign Het
Nek1 A G 8: 61,020,077 Y169C probably damaging Het
Nos1ap A T 1: 170,589,276 I30N probably damaging Het
Obox5 T C 7: 15,758,591 I157T possibly damaging Het
Olfr1130 A T 2: 87,607,979 D197V probably damaging Het
Pcdhb10 T A 18: 37,412,195 I108N probably damaging Het
Pgf A G 12: 85,171,736 L80P probably damaging Het
Rpgrip1l A G 8: 91,275,149 L459P probably damaging Het
Slc9a1 A T 4: 133,411,989 I173F probably damaging Het
Taf15 T C 11: 83,487,371 S146P possibly damaging Het
Tedc1 C T 12: 113,163,188 R357* probably null Het
Thumpd1 C T 7: 119,718,195 R161Q probably damaging Het
Tjp2 A G 19: 24,138,810 I5T possibly damaging Het
Umod A G 7: 119,477,219 V108A possibly damaging Het
Usp38 A T 8: 81,013,840 S199R probably damaging Het
Vmn2r73 T A 7: 85,857,878 Y742F probably damaging Het
Other mutations in Fbxw26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00589:Fbxw26 APN 9 109717948 utr 3 prime probably benign
IGL01072:Fbxw26 APN 9 109723837 missense probably damaging 1.00
IGL01394:Fbxw26 APN 9 109717989 missense probably benign 0.00
IGL01432:Fbxw26 APN 9 109717975 missense probably benign 0.32
IGL02559:Fbxw26 APN 9 109722164 missense probably benign 0.34
IGL02981:Fbxw26 APN 9 109744794 missense probably benign 0.09
IGL03370:Fbxw26 APN 9 109746019 missense probably damaging 1.00
R0023:Fbxw26 UTSW 9 109718011 missense probably benign 0.01
R0087:Fbxw26 UTSW 9 109724938 missense probably benign
R0369:Fbxw26 UTSW 9 109723712 critical splice donor site probably null
R0446:Fbxw26 UTSW 9 109743720 missense probably benign 0.03
R1844:Fbxw26 UTSW 9 109724878 missense probably benign 0.42
R1891:Fbxw26 UTSW 9 109722164 missense probably benign 0.34
R2042:Fbxw26 UTSW 9 109732704 missense probably damaging 1.00
R3615:Fbxw26 UTSW 9 109743760 nonsense probably null
R3616:Fbxw26 UTSW 9 109743760 nonsense probably null
R4659:Fbxw26 UTSW 9 109744871 missense probably damaging 0.97
R4785:Fbxw26 UTSW 9 109724800 missense possibly damaging 0.50
R4898:Fbxw26 UTSW 9 109717969 missense possibly damaging 0.95
R5791:Fbxw26 UTSW 9 109745153 missense probably damaging 1.00
R5818:Fbxw26 UTSW 9 109732566 missense probably benign
R5921:Fbxw26 UTSW 9 109746018 missense probably damaging 1.00
R5983:Fbxw26 UTSW 9 109717965 missense possibly damaging 0.49
R6145:Fbxw26 UTSW 9 109732623 missense probably benign 0.09
R6209:Fbxw26 UTSW 9 109717965 missense possibly damaging 0.49
R6412:Fbxw26 UTSW 9 109732647 missense probably damaging 0.97
R6842:Fbxw26 UTSW 9 109724920 missense probably damaging 1.00
R7228:Fbxw26 UTSW 9 109724944 missense possibly damaging 0.93
X0020:Fbxw26 UTSW 9 109732632 missense probably damaging 1.00
Posted On2013-06-21