Incidental Mutation 'R6533:Ceacam2'
ID 520187
Institutional Source Beutler Lab
Gene Symbol Ceacam2
Ensembl Gene ENSMUSG00000054385
Gene Name CEA cell adhesion molecule 2
Synonyms Bgp2
MMRRC Submission 044659-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R6533 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 25215467-25239282 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 25230136 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 157 (V157L)
Ref Sequence ENSEMBL: ENSMUSP00000048118 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044547] [ENSMUST00000064862] [ENSMUST00000066503]
AlphaFold Q925P2
Predicted Effect probably benign
Transcript: ENSMUST00000044547
AA Change: V157L

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000048118
Gene: ENSMUSG00000054385
AA Change: V157L

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
IG 40 143 4.15e0 SMART
IGc2 158 224 1.99e-7 SMART
IGc2 252 308 5.04e-9 SMART
IGc2 337 401 3.28e-8 SMART
transmembrane domain 422 444 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000064862
SMART Domains Protein: ENSMUSP00000068540
Gene: ENSMUSG00000054385

DomainStartEndE-ValueType
low complexity region 18 27 N/A INTRINSIC
IG_like 40 143 6.69e0 SMART
IGc2 157 221 3.28e-8 SMART
transmembrane domain 244 266 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000066503
SMART Domains Protein: ENSMUSP00000064255
Gene: ENSMUSG00000054385

DomainStartEndE-ValueType
low complexity region 18 27 N/A INTRINSIC
IG_like 40 143 6.69e0 SMART
IGc2 157 221 3.28e-8 SMART
transmembrane domain 242 264 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145681
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206300
Meta Mutation Damage Score 0.1477 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (44/44)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit female-specific obesity, disruption in glucose homeostasis, hyperphagia, hyperinsulinemia and decreased energy expenditure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010B08Rik C T 2: 173,561,628 (GRCm39) probably benign Het
4932414N04Rik G T 2: 68,546,662 (GRCm39) E115* probably null Het
Abhd16a G A 17: 35,317,785 (GRCm39) probably null Het
Ankrd28 T A 14: 31,454,041 (GRCm39) I244L possibly damaging Het
Barx2 T C 9: 31,824,275 (GRCm39) Y38C probably damaging Het
Btn2a2 C A 13: 23,665,951 (GRCm39) E294* probably null Het
Ces2c T A 8: 105,578,725 (GRCm39) F334L possibly damaging Het
Col7a1 T C 9: 108,790,426 (GRCm39) I958T unknown Het
Dcp2 T A 18: 44,532,731 (GRCm39) D82E probably benign Het
Dnah8 T C 17: 30,965,964 (GRCm39) L2432S probably damaging Het
Dst A G 1: 34,342,590 (GRCm39) D7582G probably benign Het
Fat3 T A 9: 15,910,195 (GRCm39) I1936L probably benign Het
Gsdmc4 T A 15: 63,763,909 (GRCm39) N396I probably damaging Het
Lonrf2 A C 1: 38,852,349 (GRCm39) D167E probably benign Het
Marf1 T C 16: 13,933,663 (GRCm39) D1575G probably benign Het
Med23 T C 10: 24,769,518 (GRCm39) L101P probably damaging Het
Myh3 A G 11: 66,981,245 (GRCm39) I703V probably damaging Het
Ncan G A 8: 70,549,007 (GRCm39) A1257V probably benign Het
Nipal4 A T 11: 46,041,234 (GRCm39) Y320* probably null Het
Obox5 A T 7: 15,491,532 (GRCm39) Q24L probably benign Het
Orc1 T C 4: 108,454,644 (GRCm39) S345P probably benign Het
P4hb A T 11: 120,462,469 (GRCm39) I79N probably damaging Het
Phf3 A T 1: 30,845,399 (GRCm39) I1262N probably damaging Het
Pigo A T 4: 43,022,697 (GRCm39) N291K probably benign Het
Ppargc1b C T 18: 61,440,845 (GRCm39) R691H possibly damaging Het
Ppm1m T C 9: 106,074,069 (GRCm39) probably benign Het
Ptprd A T 4: 76,046,765 (GRCm39) D500E probably damaging Het
Rab3gap2 T A 1: 184,965,151 (GRCm39) probably null Het
Rnf214 A G 9: 45,811,361 (GRCm39) S101P probably benign Het
Sdhc A G 1: 170,957,396 (GRCm39) S162P possibly damaging Het
Spta1 C T 1: 174,071,713 (GRCm39) T2231I probably damaging Het
Stxbp2 T A 8: 3,692,683 (GRCm39) D578E probably benign Het
Tacc2 A T 7: 130,224,567 (GRCm39) E417D possibly damaging Het
Tas2r144 A T 6: 42,192,280 (GRCm39) N7Y probably benign Het
Tasp1 A G 2: 139,676,277 (GRCm39) *421R probably null Het
Tigd5 A G 15: 75,782,039 (GRCm39) I134V possibly damaging Het
Tmem95 A T 11: 69,768,843 (GRCm39) M1K probably null Het
Trappc10 T C 10: 78,024,728 (GRCm39) M1134V probably damaging Het
Unc45a T G 7: 79,983,817 (GRCm39) K326N probably damaging Het
Vmn1r59 A G 7: 5,457,463 (GRCm39) V99A probably benign Het
Vmn2r4 T C 3: 64,322,519 (GRCm39) T67A probably benign Het
Vmn2r85 A T 10: 130,262,529 (GRCm39) M70K probably benign Het
Zftraf1 C A 15: 76,531,930 (GRCm39) E283* probably null Het
Zkscan8 A G 13: 21,704,748 (GRCm39) F325S probably damaging Het
Other mutations in Ceacam2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00788:Ceacam2 APN 7 25,237,998 (GRCm39) critical splice donor site probably null
IGL01606:Ceacam2 APN 7 25,230,132 (GRCm39) missense possibly damaging 0.95
IGL02106:Ceacam2 APN 7 25,230,166 (GRCm39) missense probably benign
IGL02506:Ceacam2 APN 7 25,227,379 (GRCm39) missense probably benign 0.34
IGL02820:Ceacam2 APN 7 25,219,411 (GRCm39) missense probably damaging 1.00
R0514:Ceacam2 UTSW 7 25,220,356 (GRCm39) missense probably benign 0.43
R2146:Ceacam2 UTSW 7 25,227,368 (GRCm39) nonsense probably null
R3854:Ceacam2 UTSW 7 25,238,227 (GRCm39) missense probably benign 0.06
R4887:Ceacam2 UTSW 7 25,220,257 (GRCm39) missense probably benign 0.00
R6480:Ceacam2 UTSW 7 25,219,414 (GRCm39) missense probably damaging 1.00
R6709:Ceacam2 UTSW 7 25,229,262 (GRCm39) missense possibly damaging 0.95
R6711:Ceacam2 UTSW 7 25,238,295 (GRCm39) missense probably benign
R6853:Ceacam2 UTSW 7 25,217,561 (GRCm39) missense possibly damaging 0.54
R7177:Ceacam2 UTSW 7 25,220,341 (GRCm39) missense probably benign 0.11
R7548:Ceacam2 UTSW 7 25,229,958 (GRCm39) missense probably benign 0.00
R7567:Ceacam2 UTSW 7 25,227,333 (GRCm39) missense probably benign 0.12
R7709:Ceacam2 UTSW 7 25,238,076 (GRCm39) missense probably damaging 0.97
R8378:Ceacam2 UTSW 7 25,217,597 (GRCm39) missense probably damaging 0.99
R8527:Ceacam2 UTSW 7 25,238,155 (GRCm39) missense probably benign 0.03
R8878:Ceacam2 UTSW 7 25,227,351 (GRCm39) missense probably benign 0.06
R9186:Ceacam2 UTSW 7 25,227,213 (GRCm39) missense probably damaging 1.00
R9321:Ceacam2 UTSW 7 25,230,089 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- TCAGGCTGAATGGGTCACTTC -3'
(R):5'- AACCAGTCAGTGAGCACCAG -3'

Sequencing Primer
(F):5'- GGTTTCACACACATAGGGTCCTG -3'
(R):5'- CCAGTCAGTGAGCACCAGGATATAAG -3'
Posted On 2018-06-06