Incidental Mutation 'R6536:Zfp775'
ID520409
Institutional Source Beutler Lab
Gene Symbol Zfp775
Ensembl Gene ENSMUSG00000007216
Gene Namezinc finger protein 775
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.128) question?
Stock #R6536 (G1)
Quality Score225.009
Status Validated
Chromosome6
Chromosomal Location48602063-48623227 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 48619609 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Arginine at position 139 (K139R)
Ref Sequence ENSEMBL: ENSMUSP00000145192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061720] [ENSMUST00000204042] [ENSMUST00000204095] [ENSMUST00000204121]
Predicted Effect probably damaging
Transcript: ENSMUST00000061720
AA Change: K139R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000056290
Gene: ENSMUSG00000007216
AA Change: K139R

DomainStartEndE-ValueType
low complexity region 86 102 N/A INTRINSIC
ZnF_C2H2 104 126 7.9e-4 SMART
ZnF_C2H2 132 154 1.69e-3 SMART
ZnF_C2H2 160 182 2.36e-2 SMART
ZnF_C2H2 188 210 4.11e-2 SMART
ZnF_C2H2 279 301 1.84e-4 SMART
ZnF_C2H2 307 329 4.94e-5 SMART
ZnF_C2H2 335 357 2.95e-3 SMART
ZnF_C2H2 364 386 1.36e-2 SMART
ZnF_C2H2 446 468 1.3e-4 SMART
ZnF_C2H2 474 496 2.12e-4 SMART
ZnF_C2H2 502 524 5.5e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203998
Predicted Effect possibly damaging
Transcript: ENSMUST00000204042
AA Change: K139R

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000145369
Gene: ENSMUSG00000007216
AA Change: K139R

DomainStartEndE-ValueType
low complexity region 86 102 N/A INTRINSIC
ZnF_C2H2 104 126 3.3e-6 SMART
ZnF_C2H2 132 154 7.3e-6 SMART
ZnF_C2H2 160 182 9.9e-5 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000204095
AA Change: K139R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145192
Gene: ENSMUSG00000007216
AA Change: K139R

DomainStartEndE-ValueType
low complexity region 86 102 N/A INTRINSIC
ZnF_C2H2 104 126 7.9e-4 SMART
ZnF_C2H2 132 154 1.69e-3 SMART
ZnF_C2H2 160 182 2.36e-2 SMART
ZnF_C2H2 188 210 4.11e-2 SMART
ZnF_C2H2 279 301 1.84e-4 SMART
ZnF_C2H2 307 329 4.94e-5 SMART
ZnF_C2H2 335 357 2.95e-3 SMART
ZnF_C2H2 364 386 1.36e-2 SMART
ZnF_C2H2 446 468 1.3e-4 SMART
ZnF_C2H2 474 496 2.12e-4 SMART
ZnF_C2H2 502 524 5.5e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000204121
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (36/36)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik2 G T 11: 49,019,723 H628N probably benign Het
Abcb1a T A 5: 8,719,030 F751I probably benign Het
Adamts13 G A 2: 26,975,750 V106M probably damaging Het
Add1 C A 5: 34,601,436 N31K possibly damaging Het
Adgrf5 G T 17: 43,422,661 probably benign Het
Akap11 T G 14: 78,511,314 D1211A possibly damaging Het
Atp5c1 G A 2: 10,080,316 probably benign Het
Cd320 T C 17: 33,847,503 S72P probably benign Het
Clca4b C A 3: 144,916,729 W525L possibly damaging Het
Csmd3 G A 15: 47,838,467 T1740I probably damaging Het
Dnah7c T G 1: 46,658,290 S2122A probably benign Het
Enpp2 T C 15: 54,862,631 N583S probably damaging Het
Fuk A G 8: 110,883,879 V964A possibly damaging Het
Gpd2 A T 2: 57,345,355 I366F probably benign Het
Hsd17b2 G A 8: 117,702,182 V63M possibly damaging Het
Hsdl2 A T 4: 59,610,508 probably null Het
Idh3b AG AGCACCACAACTG 2: 130,279,673 probably null Het
Ifi44 A G 3: 151,732,489 V387A probably benign Het
Kcnc4 T C 3: 107,448,196 D312G possibly damaging Het
Kif1b T C 4: 149,192,596 M1337V probably benign Het
Klra6 C T 6: 130,023,719 V41I probably benign Het
Lrp1 A G 10: 127,558,068 probably null Het
Mpdz T C 4: 81,383,417 E257G probably damaging Het
Olfr1306 T C 2: 111,912,774 D52G possibly damaging Het
Olfr1420 T C 19: 11,896,396 V125A probably benign Het
Papln A G 12: 83,781,887 Y789C probably damaging Het
Pcdh15 T C 10: 74,631,389 L1680P probably damaging Het
Pcdhac1 A G 18: 37,090,314 N60S probably benign Het
Polr3g T C 13: 81,678,216 N162S unknown Het
Pou3f3 A G 1: 42,698,214 I357V probably damaging Het
Sycp2 A G 2: 178,351,648 S1235P probably damaging Het
Tdgf1 A T 9: 110,944,189 probably null Het
Tns3 A T 11: 8,434,531 V1429E probably damaging Het
Trim67 T C 8: 124,794,342 S148P possibly damaging Het
Usp49 A T 17: 47,679,692 I348F probably damaging Het
Wac A T 18: 7,905,189 probably null Het
Other mutations in Zfp775
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0051:Zfp775 UTSW 6 48620772 missense probably benign
R1694:Zfp775 UTSW 6 48619455 missense possibly damaging 0.53
R4178:Zfp775 UTSW 6 48613253 splice site probably null
R5992:Zfp775 UTSW 6 48619816 missense probably damaging 1.00
R6924:Zfp775 UTSW 6 48619655 missense probably damaging 1.00
R7200:Zfp775 UTSW 6 48620481 missense possibly damaging 0.47
R7784:Zfp775 UTSW 6 48619249 missense possibly damaging 0.94
R7872:Zfp775 UTSW 6 48620470 missense probably benign
R8406:Zfp775 UTSW 6 48620703 missense probably damaging 1.00
R8766:Zfp775 UTSW 6 48620179 missense probably damaging 1.00
R8771:Zfp775 UTSW 6 48619972 missense probably benign 0.34
Z1088:Zfp775 UTSW 6 48620688 missense probably damaging 1.00
Z1177:Zfp775 UTSW 6 48620311 missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- TTCAGCAGCAGAGTGGTCTC -3'
(R):5'- GCGCTCACATTCTGGACATG -3'

Sequencing Primer
(F):5'- TAGGGCTCTGGGGTCACAAG -3'
(R):5'- CTCACATTCTGGACATGTGTGAG -3'
Posted On2018-06-06