Incidental Mutation 'R6514:Fer1l5'
ID 520487
Institutional Source Beutler Lab
Gene Symbol Fer1l5
Ensembl Gene ENSMUSG00000037432
Gene Name fer-1 like family member 5
Synonyms 4930533C12Rik
MMRRC Submission 044641-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R6514 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 36411372-36461191 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36442697 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 739 (I739V)
Ref Sequence ENSEMBL: ENSMUSP00000142130 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000179162]
AlphaFold P0DM40
Predicted Effect probably benign
Transcript: ENSMUST00000179162
AA Change: I739V

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000142130
Gene: ENSMUSG00000037432
AA Change: I739V

DomainStartEndE-ValueType
C2 1 98 2.74e-4 SMART
C2 168 264 4.29e-6 SMART
FerI 250 323 1.59e-19 SMART
C2 325 422 1.06e-5 SMART
FerA 602 669 6.26e-18 SMART
FerB 691 764 1.38e-37 SMART
internal_repeat_1 781 836 1.77e-5 PROSPERO
internal_repeat_1 852 904 1.77e-5 PROSPERO
DysFC 913 951 1.61e-3 SMART
DysFC 981 1013 4.81e-2 SMART
C2 1078 1222 1.56e0 SMART
Pfam:C2 1248 1329 1e-1 PFAM
low complexity region 1376 1387 N/A INTRINSIC
low complexity region 1459 1470 N/A INTRINSIC
C2 1487 1586 2.21e-8 SMART
C2 1659 1851 5.32e-2 SMART
transmembrane domain 1964 1986 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000202030
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.2%
Validation Efficiency 95% (35/37)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933414I15Rik G A 11: 50,833,569 (GRCm39) A11V unknown Het
Add1 T A 5: 34,763,317 (GRCm39) H168Q probably damaging Het
Apol7b C T 15: 77,308,126 (GRCm39) R123Q probably benign Het
Arrdc3 A G 13: 81,037,309 (GRCm39) E155G probably damaging Het
Capn7 T G 14: 31,066,511 (GRCm39) D108E probably benign Het
Cdc6 A G 11: 98,810,118 (GRCm39) T476A probably benign Het
Cntnap5c A G 17: 58,637,165 (GRCm39) E1014G probably damaging Het
Crybg1 A T 10: 43,873,211 (GRCm39) L1299H probably damaging Het
Duoxa1 A G 2: 122,135,194 (GRCm39) S184P probably benign Het
Ech1 A G 7: 28,525,440 (GRCm39) H65R possibly damaging Het
Egr3 T C 14: 70,316,366 (GRCm39) L59P probably damaging Het
Eif4enif1 T A 11: 3,190,996 (GRCm39) D724E probably null Het
Erbb2 A G 11: 98,310,972 (GRCm39) D44G probably benign Het
Gfm1 T C 3: 67,380,879 (GRCm39) F665L probably benign Het
Gm10801 T A 2: 98,494,214 (GRCm39) W119R probably benign Het
H2-M11 A T 17: 36,859,839 (GRCm39) E277D probably damaging Het
Ighv1-66 T C 12: 115,556,740 (GRCm39) Y114C possibly damaging Het
Irf1 C G 11: 53,662,148 (GRCm39) L12V probably damaging Het
Itpr3 C T 17: 27,310,344 (GRCm39) A403V probably benign Het
Ly6g C T 15: 75,028,581 (GRCm39) P14S probably benign Het
Mfsd13a T C 19: 46,363,064 (GRCm39) probably null Het
Mme T A 3: 63,272,265 (GRCm39) C621* probably null Het
Mmp16 T C 4: 18,116,123 (GRCm39) C576R probably damaging Het
Ngp A T 9: 110,249,017 (GRCm39) I30F probably damaging Het
Or2q1 T A 6: 42,794,930 (GRCm39) I175N probably damaging Het
Pdcd6ip G A 9: 113,518,762 (GRCm39) T166I probably benign Het
Pgd C T 4: 149,245,209 (GRCm39) probably null Het
Plcb4 T A 2: 135,796,916 (GRCm39) H440Q probably benign Het
Ppl A G 16: 4,905,181 (GRCm39) S1705P probably damaging Het
Ryr1 A G 7: 28,746,266 (GRCm39) F3831S probably damaging Het
Serpine2 A C 1: 79,799,287 (GRCm39) probably null Het
Skor2 T A 18: 76,950,389 (GRCm39) W906R probably damaging Het
Tle6 G A 10: 81,427,810 (GRCm39) H482Y probably damaging Het
Ufl1 T A 4: 25,262,238 (GRCm39) D336V probably damaging Het
Vav1 T C 17: 57,634,660 (GRCm39) F832L probably damaging Het
Other mutations in Fer1l5
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4151001:Fer1l5 UTSW 1 36,450,728 (GRCm39) missense probably benign 0.27
R5580:Fer1l5 UTSW 1 36,424,539 (GRCm39) nonsense probably null
R5848:Fer1l5 UTSW 1 36,428,016 (GRCm39) missense probably benign 0.39
R5930:Fer1l5 UTSW 1 36,424,254 (GRCm39) nonsense probably null
R6193:Fer1l5 UTSW 1 36,448,517 (GRCm39) missense probably benign 0.20
R6195:Fer1l5 UTSW 1 36,414,367 (GRCm39) splice site probably null
R6207:Fer1l5 UTSW 1 36,424,241 (GRCm39) missense probably damaging 1.00
R6233:Fer1l5 UTSW 1 36,414,367 (GRCm39) splice site probably null
R6349:Fer1l5 UTSW 1 36,450,355 (GRCm39) missense probably damaging 0.96
R6478:Fer1l5 UTSW 1 36,441,612 (GRCm39) missense probably damaging 1.00
R6611:Fer1l5 UTSW 1 36,445,735 (GRCm39) missense probably benign 0.01
R6634:Fer1l5 UTSW 1 36,450,466 (GRCm39) missense probably damaging 0.99
R6733:Fer1l5 UTSW 1 36,447,753 (GRCm39) critical splice donor site probably null
R6816:Fer1l5 UTSW 1 36,445,591 (GRCm39) missense possibly damaging 0.60
R7225:Fer1l5 UTSW 1 36,460,033 (GRCm39) missense possibly damaging 0.90
R7316:Fer1l5 UTSW 1 36,457,197 (GRCm39) missense probably benign 0.41
R7455:Fer1l5 UTSW 1 36,428,064 (GRCm39) missense probably benign 0.00
R7473:Fer1l5 UTSW 1 36,460,689 (GRCm39) missense possibly damaging 0.53
R7702:Fer1l5 UTSW 1 36,459,775 (GRCm39) nonsense probably null
R7714:Fer1l5 UTSW 1 36,440,558 (GRCm39) missense probably damaging 1.00
R7872:Fer1l5 UTSW 1 36,460,967 (GRCm39) missense probably benign 0.00
R7881:Fer1l5 UTSW 1 36,446,117 (GRCm39) missense not run
R7984:Fer1l5 UTSW 1 36,447,702 (GRCm39) missense possibly damaging 0.68
R8326:Fer1l5 UTSW 1 36,415,841 (GRCm39) missense probably benign 0.04
R8523:Fer1l5 UTSW 1 36,426,271 (GRCm39) missense probably benign 0.27
R8528:Fer1l5 UTSW 1 36,456,855 (GRCm39) missense possibly damaging 0.91
R8975:Fer1l5 UTSW 1 36,456,897 (GRCm39) missense probably benign 0.13
R9011:Fer1l5 UTSW 1 36,441,601 (GRCm39) missense probably damaging 0.96
R9084:Fer1l5 UTSW 1 36,429,619 (GRCm39) missense probably benign 0.00
R9140:Fer1l5 UTSW 1 36,460,047 (GRCm39) intron probably benign
R9180:Fer1l5 UTSW 1 36,449,999 (GRCm39) missense probably null 1.00
R9312:Fer1l5 UTSW 1 36,460,248 (GRCm39) missense probably damaging 1.00
R9510:Fer1l5 UTSW 1 36,442,662 (GRCm39) missense probably damaging 0.97
R9655:Fer1l5 UTSW 1 36,460,696 (GRCm39) missense probably benign 0.40
Z1176:Fer1l5 UTSW 1 36,429,644 (GRCm39) nonsense probably null
Z1177:Fer1l5 UTSW 1 36,448,275 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TCAACGCTGTGATCCCTGAG -3'
(R):5'- CTGTGTGAGCTCAGTTCTACTTAATAC -3'

Sequencing Primer
(F):5'- TGATCCCTGAGGTAGGCACTG -3'
(R):5'- CAGTTCTACTTAATACAGAAGCAGGG -3'
Posted On 2018-06-06