Incidental Mutation 'R6538:Gm7298'
ID 520528
Institutional Source Beutler Lab
Gene Symbol Gm7298
Ensembl Gene ENSMUSG00000108022
Gene Name predicted gene 7298
Synonyms
MMRRC Submission 044664-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.235) question?
Stock # R6538 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 121711454-121761598 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 121753132 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 870 (V870L)
Ref Sequence ENSEMBL: ENSMUSP00000145242 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000204124]
AlphaFold A0A0N4SVU1
Predicted Effect probably damaging
Transcript: ENSMUST00000204124
AA Change: V870L

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000145242
Gene: ENSMUSG00000108022
AA Change: V870L

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:A2M_N 128 221 4e-18 PFAM
A2M_N_2 449 599 1e-45 SMART
A2M 740 830 2.1e-39 SMART
Pfam:Thiol-ester_cl 963 992 1.9e-15 PFAM
Pfam:A2M_comp 1012 1268 1.6e-90 PFAM
A2M_recep 1378 1465 4.3e-42 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930009A15Rik A G 10: 115,406,104 (GRCm39) probably benign Het
Abcd4 T A 12: 84,658,535 (GRCm39) M223L probably benign Het
Adat1 T C 8: 112,695,094 (GRCm39) I482V probably benign Het
Adrm1b C T 3: 92,336,562 (GRCm39) V47M possibly damaging Het
Arfgef2 A G 2: 166,735,541 (GRCm39) probably null Het
Atn1 A G 6: 124,723,512 (GRCm39) probably benign Het
Cyb561d2 C A 9: 107,417,216 (GRCm39) M178I possibly damaging Het
Dnah14 A T 1: 181,412,550 (GRCm39) H30L unknown Het
Dnah2 T C 11: 69,328,023 (GRCm39) I3367V possibly damaging Het
Fcmr A G 1: 130,802,762 (GRCm39) Y125C possibly damaging Het
Grin3a T C 4: 49,770,856 (GRCm39) S639G probably damaging Het
H1f6 A G 13: 23,879,904 (GRCm39) E19G probably benign Het
Ighv9-1 T A 12: 114,057,685 (GRCm39) T72S possibly damaging Het
Klra2 T A 6: 131,219,953 (GRCm39) H76L probably damaging Het
Lamp1 A G 8: 13,221,285 (GRCm39) T209A probably benign Het
Lrrc9 T A 12: 72,547,703 (GRCm39) Y1294N probably benign Het
Or2b11 C T 11: 59,462,411 (GRCm39) V52I probably benign Het
Or5t9 A T 2: 86,659,869 (GRCm39) T258S possibly damaging Het
Peg10 GAT GATCAT 6: 4,756,449 (GRCm39) probably benign Het
Pik3ca T C 3: 32,493,853 (GRCm39) Y272H probably damaging Het
Spindoc T C 19: 7,360,064 (GRCm39) I35V probably benign Het
St6galnac4 A C 2: 32,487,090 (GRCm39) M262L possibly damaging Het
Szt2 C T 4: 118,247,674 (GRCm39) probably null Het
Tcstv7b T C 13: 120,702,468 (GRCm39) V88A possibly damaging Het
Trem1 T C 17: 48,544,118 (GRCm39) Y48H possibly damaging Het
Trim38 A T 13: 23,969,932 (GRCm39) T164S probably damaging Het
Zfp715 A T 7: 42,948,573 (GRCm39) H462Q possibly damaging Het
Zfyve16 C T 13: 92,641,024 (GRCm39) G1240E probably damaging Het
Other mutations in Gm7298
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0030:Gm7298 UTSW 6 121,751,009 (GRCm39) missense probably benign
R4978:Gm7298 UTSW 6 121,710,076 (GRCm39) critical splice donor site probably null
R4980:Gm7298 UTSW 6 121,736,198 (GRCm39) splice site probably null
R6000:Gm7298 UTSW 6 121,742,038 (GRCm39) missense possibly damaging 0.91
R6160:Gm7298 UTSW 6 121,741,886 (GRCm39) missense probably benign 0.28
R6180:Gm7298 UTSW 6 121,737,782 (GRCm39) missense probably benign 0.01
R6243:Gm7298 UTSW 6 121,756,096 (GRCm39) missense possibly damaging 0.88
R6266:Gm7298 UTSW 6 121,759,663 (GRCm39) missense probably damaging 1.00
R6268:Gm7298 UTSW 6 121,756,032 (GRCm39) missense possibly damaging 0.83
R6363:Gm7298 UTSW 6 121,765,565 (GRCm39) missense probably damaging 1.00
R6364:Gm7298 UTSW 6 121,756,402 (GRCm39) missense possibly damaging 0.90
R6527:Gm7298 UTSW 6 121,746,669 (GRCm39) missense probably benign 0.01
R6801:Gm7298 UTSW 6 121,752,768 (GRCm39) missense probably benign 0.03
R6884:Gm7298 UTSW 6 121,737,480 (GRCm39) missense possibly damaging 0.74
R6935:Gm7298 UTSW 6 121,744,653 (GRCm39) missense probably benign 0.02
R7051:Gm7298 UTSW 6 121,751,993 (GRCm39) critical splice donor site probably null
R7144:Gm7298 UTSW 6 121,738,546 (GRCm39) missense probably damaging 0.99
R7178:Gm7298 UTSW 6 121,762,855 (GRCm39) missense probably damaging 0.98
R7398:Gm7298 UTSW 6 121,758,912 (GRCm39) missense probably benign 0.02
R7706:Gm7298 UTSW 6 121,712,570 (GRCm39) missense probably damaging 0.96
R7793:Gm7298 UTSW 6 121,737,563 (GRCm39) critical splice donor site probably null
R7829:Gm7298 UTSW 6 121,742,297 (GRCm39) missense probably damaging 1.00
R7877:Gm7298 UTSW 6 121,759,741 (GRCm39) nonsense probably null
R8010:Gm7298 UTSW 6 121,712,542 (GRCm39) missense probably benign
R8167:Gm7298 UTSW 6 121,761,414 (GRCm39) nonsense probably null
R8188:Gm7298 UTSW 6 121,763,537 (GRCm39) critical splice acceptor site probably null
R8248:Gm7298 UTSW 6 121,764,402 (GRCm39) missense probably benign 0.02
R8669:Gm7298 UTSW 6 121,742,002 (GRCm39) missense probably benign
R8806:Gm7298 UTSW 6 121,761,641 (GRCm39) synonymous silent
R8867:Gm7298 UTSW 6 121,748,788 (GRCm39) missense probably benign
R8907:Gm7298 UTSW 6 121,741,817 (GRCm39) missense probably benign 0.10
R8930:Gm7298 UTSW 6 121,742,030 (GRCm39) missense probably benign 0.01
R8932:Gm7298 UTSW 6 121,742,030 (GRCm39) missense probably benign 0.01
R8947:Gm7298 UTSW 6 121,757,553 (GRCm39) missense possibly damaging 0.62
R9016:Gm7298 UTSW 6 121,758,800 (GRCm39) missense possibly damaging 0.96
R9040:Gm7298 UTSW 6 121,764,438 (GRCm39) missense probably benign 0.20
R9069:Gm7298 UTSW 6 121,761,393 (GRCm39) missense probably benign
R9154:Gm7298 UTSW 6 121,756,436 (GRCm39) missense probably damaging 1.00
R9273:Gm7298 UTSW 6 121,756,604 (GRCm39) intron probably benign
R9371:Gm7298 UTSW 6 121,744,541 (GRCm39) missense probably benign 0.02
R9372:Gm7298 UTSW 6 121,748,746 (GRCm39) missense probably benign 0.21
R9490:Gm7298 UTSW 6 121,751,083 (GRCm39) missense probably benign 0.00
R9649:Gm7298 UTSW 6 121,764,491 (GRCm39) missense probably damaging 1.00
Z1176:Gm7298 UTSW 6 121,741,834 (GRCm39) missense possibly damaging 0.48
Z1176:Gm7298 UTSW 6 121,741,829 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GCTCCCAGTCATTATTGTATCTGG -3'
(R):5'- CCAGCTATGAACTATCTCATGGTC -3'

Sequencing Primer
(F):5'- TGCAGATCTAGGGGCTTT -3'
(R):5'- CATCTAAATATAGTCAACACTGCTCC -3'
Posted On 2018-06-06