Incidental Mutation 'R6540:V1rd19'
| ID |
520688 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
V1rd19
|
| Ensembl Gene |
ENSMUSG00000092456 |
| Gene Name |
vomeronasal 1 receptor, D19 |
| Synonyms |
|
| MMRRC Submission |
044666-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.061)
|
| Stock # |
R6540 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
23702536-23703453 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 23703056 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 174
(L174*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133284
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000173571]
|
| AlphaFold |
Q3KNP5 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000173571
AA Change: L174*
|
| SMART Domains |
Protein: ENSMUSP00000133284
Gene: ENSMUSG00000092456
AA Change: L174*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
296 |
1e-9 |
PFAM |
|
Pfam:V1R
|
42 |
295 |
5.9e-13 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A3galt2 |
T |
C |
4: 128,660,779 (GRCm39) |
Y143H |
possibly damaging |
Het |
| Aco1 |
G |
A |
4: 40,186,367 (GRCm39) |
R593Q |
probably benign |
Het |
| Adamts2 |
T |
C |
11: 50,679,567 (GRCm39) |
V849A |
possibly damaging |
Het |
| Ash1l |
A |
T |
3: 88,892,368 (GRCm39) |
T1416S |
probably damaging |
Het |
| Cdc5l |
A |
G |
17: 45,737,570 (GRCm39) |
W63R |
probably damaging |
Het |
| Cep95 |
T |
A |
11: 106,692,328 (GRCm39) |
D169E |
probably damaging |
Het |
| Col14a1 |
A |
C |
15: 55,235,977 (GRCm39) |
N297T |
unknown |
Het |
| Cp |
T |
C |
3: 20,018,693 (GRCm39) |
|
probably null |
Het |
| Fbxl19 |
G |
T |
7: 127,347,525 (GRCm39) |
|
probably benign |
Het |
| Flnc |
T |
C |
6: 29,446,376 (GRCm39) |
V931A |
possibly damaging |
Het |
| Foxj2 |
A |
G |
6: 122,810,202 (GRCm39) |
H187R |
probably benign |
Het |
| Hectd4 |
G |
A |
5: 121,441,634 (GRCm39) |
V1199I |
probably benign |
Het |
| Ighv7-4 |
A |
G |
12: 114,186,470 (GRCm39) |
Y101H |
possibly damaging |
Het |
| Igkv10-94 |
T |
A |
6: 68,681,507 (GRCm39) |
Y111F |
probably benign |
Het |
| Lin28a |
C |
T |
4: 133,745,372 (GRCm39) |
V74M |
possibly damaging |
Het |
| Lrrc49 |
T |
C |
9: 60,592,335 (GRCm39) |
N53S |
possibly damaging |
Het |
| Mroh9 |
T |
G |
1: 162,866,541 (GRCm39) |
T701P |
possibly damaging |
Het |
| Ndst4 |
A |
T |
3: 125,515,801 (GRCm39) |
K309* |
probably null |
Het |
| Nlrp9a |
T |
C |
7: 26,256,817 (GRCm39) |
V145A |
possibly damaging |
Het |
| Or2l5 |
T |
C |
16: 19,333,571 (GRCm39) |
I272V |
probably benign |
Het |
| Ovgp1 |
A |
T |
3: 105,893,897 (GRCm39) |
K557* |
probably null |
Het |
| Pde4b |
T |
C |
4: 102,459,073 (GRCm39) |
L546P |
probably damaging |
Het |
| Pkd1 |
G |
A |
17: 24,794,951 (GRCm39) |
V2213M |
probably damaging |
Het |
| Plekhh1 |
A |
G |
12: 79,111,263 (GRCm39) |
I542V |
probably benign |
Het |
| Ppan |
A |
G |
9: 20,802,506 (GRCm39) |
|
probably null |
Het |
| Prdm15 |
A |
T |
16: 97,637,005 (GRCm39) |
V104E |
probably benign |
Het |
| Semp2l2a |
A |
C |
8: 13,887,573 (GRCm39) |
S173A |
probably benign |
Het |
| Sik3 |
A |
G |
9: 46,123,351 (GRCm39) |
H1050R |
probably benign |
Het |
| Slc35d3 |
A |
G |
10: 19,725,086 (GRCm39) |
F257L |
possibly damaging |
Het |
| Tfip11 |
A |
G |
5: 112,482,263 (GRCm39) |
|
probably null |
Het |
| Tmem132d |
A |
G |
5: 128,345,596 (GRCm39) |
S309P |
possibly damaging |
Het |
| Tmem87a |
T |
C |
2: 120,234,400 (GRCm39) |
I48V |
probably benign |
Het |
| Zfp729a |
A |
G |
13: 67,767,767 (GRCm39) |
C821R |
possibly damaging |
Het |
| Zfp970 |
C |
A |
2: 177,167,388 (GRCm39) |
H321N |
probably damaging |
Het |
| Zzef1 |
T |
C |
11: 72,804,055 (GRCm39) |
L2599P |
probably damaging |
Het |
|
| Other mutations in V1rd19 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02631:V1rd19
|
APN |
7 |
23,702,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02898:V1rd19
|
APN |
7 |
23,702,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03231:V1rd19
|
APN |
7 |
23,703,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0021:V1rd19
|
UTSW |
7 |
23,703,029 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0184:V1rd19
|
UTSW |
7 |
23,702,632 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0391:V1rd19
|
UTSW |
7 |
23,703,010 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1520:V1rd19
|
UTSW |
7 |
23,702,623 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1635:V1rd19
|
UTSW |
7 |
23,702,812 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1861:V1rd19
|
UTSW |
7 |
23,703,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1889:V1rd19
|
UTSW |
7 |
23,702,632 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2008:V1rd19
|
UTSW |
7 |
23,702,726 (GRCm39) |
nonsense |
probably null |
|
|
R2059:V1rd19
|
UTSW |
7 |
23,703,259 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2098:V1rd19
|
UTSW |
7 |
23,703,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:V1rd19
|
UTSW |
7 |
23,703,310 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3002:V1rd19
|
UTSW |
7 |
23,703,310 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4271:V1rd19
|
UTSW |
7 |
23,702,839 (GRCm39) |
missense |
probably benign |
0.36 |
|
R5130:V1rd19
|
UTSW |
7 |
23,702,537 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R5169:V1rd19
|
UTSW |
7 |
23,703,209 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5297:V1rd19
|
UTSW |
7 |
23,702,714 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5924:V1rd19
|
UTSW |
7 |
23,703,374 (GRCm39) |
missense |
probably benign |
|
|
R6181:V1rd19
|
UTSW |
7 |
23,702,640 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7331:V1rd19
|
UTSW |
7 |
23,703,308 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7332:V1rd19
|
UTSW |
7 |
23,702,743 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8338:V1rd19
|
UTSW |
7 |
23,702,674 (GRCm39) |
nonsense |
probably null |
|
|
R8398:V1rd19
|
UTSW |
7 |
23,703,374 (GRCm39) |
nonsense |
probably null |
|
|
R8881:V1rd19
|
UTSW |
7 |
23,703,081 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9536:V1rd19
|
UTSW |
7 |
23,703,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0065:V1rd19
|
UTSW |
7 |
23,702,761 (GRCm39) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGAGTATCCATCAGTTTGTCACAC -3'
(R):5'- GCATCAGGATAGTATGGGTTGC -3'
Sequencing Primer
(F):5'- GTCACACTTGTTCCTGTTAATTCAG -3'
(R):5'- GTGGTCTCTGCTTGGCCC -3'
|
| Posted On |
2018-06-06 |
Incidental Mutation