Incidental Mutation 'IGL01082:Myb'
ID 52070
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Myb
Ensembl Gene ENSMUSG00000019982
Gene Name myeloblastosis oncogene
Synonyms c-myb
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01082
Quality Score
Status
Chromosome 10
Chromosomal Location 21000834-21036883 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21028843 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 85 (V85A)
Ref Sequence ENSEMBL: ENSMUSP00000139699 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020158] [ENSMUST00000188495]
AlphaFold P06876
Predicted Effect possibly damaging
Transcript: ENSMUST00000020158
AA Change: V85A

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000020158
Gene: ENSMUSG00000019982
AA Change: V85A

DomainStartEndE-ValueType
low complexity region 7 27 N/A INTRINSIC
SANT 39 88 9.52e-20 SMART
SANT 91 140 2.04e-19 SMART
SANT 143 191 1.75e-18 SMART
low complexity region 227 239 N/A INTRINSIC
Pfam:LMSTEN 267 313 4e-29 PFAM
Pfam:Cmyb_C 399 559 1.5e-64 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180680
Predicted Effect noncoding transcript
Transcript: ENSMUST00000186446
Predicted Effect probably damaging
Transcript: ENSMUST00000188495
AA Change: V85A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000139699
Gene: ENSMUSG00000019982
AA Change: V85A

DomainStartEndE-ValueType
low complexity region 7 27 N/A INTRINSIC
SANT 39 88 9.52e-20 SMART
SANT 91 140 2.04e-19 SMART
SANT 143 191 1.75e-18 SMART
low complexity region 227 239 N/A INTRINSIC
Pfam:LMSTEN 266 313 3.6e-32 PFAM
low complexity region 409 421 N/A INTRINSIC
Pfam:Cmyb_C 516 682 8.5e-66 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214539
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216751
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for deficient alleles of this gene display severe hematopoietic abnormalities. Red and white blood cells and platelets are all affected. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 G A 1: 71,353,273 (GRCm39) S723F probably damaging Het
Cacng5 C T 11: 107,772,531 (GRCm39) V106I probably benign Het
Ccdc116 A G 16: 16,959,856 (GRCm39) S278P probably damaging Het
Cep152 A T 2: 125,411,465 (GRCm39) probably benign Het
Cftr T C 6: 18,226,102 (GRCm39) V350A probably damaging Het
Dsc2 A T 18: 20,176,849 (GRCm39) N399K probably damaging Het
Eif3d T C 15: 77,843,943 (GRCm39) T468A probably damaging Het
Fam110b C T 4: 5,799,461 (GRCm39) A293V possibly damaging Het
Flrt1 T C 19: 7,073,339 (GRCm39) T403A probably benign Het
H3c6 A G 13: 23,746,548 (GRCm39) probably benign Het
Ift140 T A 17: 25,267,429 (GRCm39) V609E possibly damaging Het
Klb G A 5: 65,533,283 (GRCm39) V531I possibly damaging Het
Krt73 T C 15: 101,707,372 (GRCm39) probably null Het
Mcm2 A G 6: 88,864,859 (GRCm39) V539A probably benign Het
Ndufs1 T C 1: 63,203,976 (GRCm39) E102G probably damaging Het
Nr5a2 C A 1: 136,773,206 (GRCm39) A499S probably benign Het
Opa1 A T 16: 29,436,933 (GRCm39) probably benign Het
Or14j5 T A 17: 38,161,514 (GRCm39) S10R probably benign Het
Or4a47 A T 2: 89,674,407 (GRCm39) probably benign Het
Or4c11b T C 2: 88,625,637 (GRCm39) F304L probably benign Het
Pcnx1 G A 12: 82,037,372 (GRCm39) E1877K possibly damaging Het
Sel1l A G 12: 91,778,682 (GRCm39) V711A probably benign Het
Slc22a16 A G 10: 40,449,860 (GRCm39) T120A probably benign Het
Slc26a1 G T 5: 108,819,744 (GRCm39) T485N possibly damaging Het
Sp100 T C 1: 85,597,741 (GRCm39) V201A possibly damaging Het
Spz1 T G 13: 92,712,029 (GRCm39) K149T probably damaging Het
Stxbp5l A G 16: 37,024,940 (GRCm39) S553P possibly damaging Het
Szt2 A G 4: 118,254,821 (GRCm39) S290P probably damaging Het
Tbc1d10c A G 19: 4,239,026 (GRCm39) Y165H probably damaging Het
Tnxb C A 17: 34,933,584 (GRCm39) Q2335K probably damaging Het
Trim33 T C 3: 103,234,175 (GRCm39) I471T possibly damaging Het
Vsig10 A G 5: 117,472,970 (GRCm39) I188V probably benign Het
Zfp109 A T 7: 23,933,784 (GRCm39) L45Q probably damaging Het
Other mutations in Myb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00654:Myb APN 10 21,017,725 (GRCm39) missense probably damaging 0.99
IGL00707:Myb APN 10 21,024,283 (GRCm39) missense probably damaging 1.00
IGL00796:Myb APN 10 21,017,698 (GRCm39) missense probably benign 0.00
IGL01012:Myb APN 10 21,022,159 (GRCm39) missense probably benign 0.03
IGL01365:Myb APN 10 21,028,401 (GRCm39) missense probably benign 0.31
IGL01906:Myb APN 10 21,028,533 (GRCm39) missense probably damaging 1.00
IGL02560:Myb APN 10 21,028,347 (GRCm39) missense probably damaging 1.00
Huang_river UTSW 10 21,028,516 (GRCm39) missense probably damaging 1.00
PIT4495001:Myb UTSW 10 21,028,521 (GRCm39) missense probably damaging 0.98
R0385:Myb UTSW 10 21,030,611 (GRCm39) missense possibly damaging 0.73
R0442:Myb UTSW 10 21,002,095 (GRCm39) missense probably benign 0.05
R0759:Myb UTSW 10 21,020,927 (GRCm39) missense probably benign 0.01
R0882:Myb UTSW 10 21,032,259 (GRCm39) missense possibly damaging 0.75
R0920:Myb UTSW 10 21,002,133 (GRCm39) missense possibly damaging 0.80
R1401:Myb UTSW 10 21,028,844 (GRCm39) missense probably damaging 1.00
R1651:Myb UTSW 10 21,002,097 (GRCm39) missense probably damaging 1.00
R1752:Myb UTSW 10 21,032,336 (GRCm39) missense possibly damaging 0.89
R1879:Myb UTSW 10 21,017,876 (GRCm39) missense probably benign 0.24
R1971:Myb UTSW 10 21,016,555 (GRCm39) missense probably benign 0.00
R4355:Myb UTSW 10 21,028,516 (GRCm39) missense probably damaging 1.00
R4611:Myb UTSW 10 21,021,223 (GRCm39) missense probably damaging 1.00
R4650:Myb UTSW 10 21,028,840 (GRCm39) missense probably damaging 1.00
R4888:Myb UTSW 10 21,002,137 (GRCm39) missense probably benign 0.01
R5121:Myb UTSW 10 21,002,137 (GRCm39) missense probably benign 0.01
R5922:Myb UTSW 10 21,028,826 (GRCm39) missense probably damaging 1.00
R5955:Myb UTSW 10 21,028,398 (GRCm39) missense probably damaging 1.00
R6116:Myb UTSW 10 21,030,653 (GRCm39) missense probably damaging 1.00
R6150:Myb UTSW 10 21,017,668 (GRCm39) missense probably damaging 1.00
R6207:Myb UTSW 10 21,021,221 (GRCm39) missense probably benign
R6656:Myb UTSW 10 21,028,844 (GRCm39) missense probably damaging 1.00
R6801:Myb UTSW 10 21,020,865 (GRCm39) splice site probably null
R6824:Myb UTSW 10 21,021,019 (GRCm39) missense probably benign 0.00
R6884:Myb UTSW 10 21,028,431 (GRCm39) missense probably damaging 1.00
R6977:Myb UTSW 10 21,028,551 (GRCm39) missense probably damaging 0.96
R7562:Myb UTSW 10 21,017,653 (GRCm39) splice site probably null
R7651:Myb UTSW 10 21,032,273 (GRCm39) missense probably damaging 1.00
R7747:Myb UTSW 10 21,032,324 (GRCm39) missense possibly damaging 0.89
R8346:Myb UTSW 10 21,002,136 (GRCm39) missense probably benign 0.00
R8683:Myb UTSW 10 21,026,405 (GRCm39) missense possibly damaging 0.53
R8829:Myb UTSW 10 21,021,130 (GRCm39) missense probably damaging 0.96
R9227:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9228:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9240:Myb UTSW 10 21,016,500 (GRCm39) missense probably damaging 1.00
R9304:Myb UTSW 10 21,028,516 (GRCm39) missense probably damaging 1.00
R9408:Myb UTSW 10 21,026,275 (GRCm39) missense probably benign 0.21
R9517:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9576:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9577:Myb UTSW 10 21,030,612 (GRCm39) missense probably benign 0.03
R9610:Myb UTSW 10 21,030,627 (GRCm39) nonsense probably null
Posted On 2013-06-21