Incidental Mutation 'R6540:Or2l5'
ID 520718
Institutional Source Beutler Lab
Gene Symbol Or2l5
Ensembl Gene ENSMUSG00000045341
Gene Name olfactory receptor family 2 subfamily L member 5
Synonyms MOR272-1, GA_x54KRFPKG5P-15963726-15962788, Olfr167
MMRRC Submission 044666-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.248) question?
Stock # R6540 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 19333446-19334384 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19333571 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 272 (I272V)
Ref Sequence ENSEMBL: ENSMUSP00000150102 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054606] [ENSMUST00000214315]
AlphaFold Q8VGJ5
Predicted Effect probably benign
Transcript: ENSMUST00000054606
AA Change: I272V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000055344
Gene: ENSMUSG00000045341
AA Change: I272V

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 4.8e-46 PFAM
Pfam:7TM_GPCR_Srsx 33 295 1.2e-6 PFAM
Pfam:7tm_1 40 289 1.8e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214315
AA Change: I272V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217566
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A3galt2 T C 4: 128,660,779 (GRCm39) Y143H possibly damaging Het
Aco1 G A 4: 40,186,367 (GRCm39) R593Q probably benign Het
Adamts2 T C 11: 50,679,567 (GRCm39) V849A possibly damaging Het
Ash1l A T 3: 88,892,368 (GRCm39) T1416S probably damaging Het
Cdc5l A G 17: 45,737,570 (GRCm39) W63R probably damaging Het
Cep95 T A 11: 106,692,328 (GRCm39) D169E probably damaging Het
Col14a1 A C 15: 55,235,977 (GRCm39) N297T unknown Het
Cp T C 3: 20,018,693 (GRCm39) probably null Het
Fbxl19 G T 7: 127,347,525 (GRCm39) probably benign Het
Flnc T C 6: 29,446,376 (GRCm39) V931A possibly damaging Het
Foxj2 A G 6: 122,810,202 (GRCm39) H187R probably benign Het
Hectd4 G A 5: 121,441,634 (GRCm39) V1199I probably benign Het
Ighv7-4 A G 12: 114,186,470 (GRCm39) Y101H possibly damaging Het
Igkv10-94 T A 6: 68,681,507 (GRCm39) Y111F probably benign Het
Lin28a C T 4: 133,745,372 (GRCm39) V74M possibly damaging Het
Lrrc49 T C 9: 60,592,335 (GRCm39) N53S possibly damaging Het
Mroh9 T G 1: 162,866,541 (GRCm39) T701P possibly damaging Het
Ndst4 A T 3: 125,515,801 (GRCm39) K309* probably null Het
Nlrp9a T C 7: 26,256,817 (GRCm39) V145A possibly damaging Het
Ovgp1 A T 3: 105,893,897 (GRCm39) K557* probably null Het
Pde4b T C 4: 102,459,073 (GRCm39) L546P probably damaging Het
Pkd1 G A 17: 24,794,951 (GRCm39) V2213M probably damaging Het
Plekhh1 A G 12: 79,111,263 (GRCm39) I542V probably benign Het
Ppan A G 9: 20,802,506 (GRCm39) probably null Het
Prdm15 A T 16: 97,637,005 (GRCm39) V104E probably benign Het
Semp2l2a A C 8: 13,887,573 (GRCm39) S173A probably benign Het
Sik3 A G 9: 46,123,351 (GRCm39) H1050R probably benign Het
Slc35d3 A G 10: 19,725,086 (GRCm39) F257L possibly damaging Het
Tfip11 A G 5: 112,482,263 (GRCm39) probably null Het
Tmem132d A G 5: 128,345,596 (GRCm39) S309P possibly damaging Het
Tmem87a T C 2: 120,234,400 (GRCm39) I48V probably benign Het
V1rd19 T A 7: 23,703,056 (GRCm39) L174* probably null Het
Zfp729a A G 13: 67,767,767 (GRCm39) C821R possibly damaging Het
Zfp970 C A 2: 177,167,388 (GRCm39) H321N probably damaging Het
Zzef1 T C 11: 72,804,055 (GRCm39) L2599P probably damaging Het
Other mutations in Or2l5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01535:Or2l5 APN 16 19,334,228 (GRCm39) missense probably benign 0.01
IGL02115:Or2l5 APN 16 19,333,853 (GRCm39) missense probably damaging 1.00
IGL02562:Or2l5 APN 16 19,333,714 (GRCm39) missense possibly damaging 0.74
BB008:Or2l5 UTSW 16 19,334,258 (GRCm39) missense possibly damaging 0.94
BB018:Or2l5 UTSW 16 19,334,258 (GRCm39) missense possibly damaging 0.94
R0366:Or2l5 UTSW 16 19,333,598 (GRCm39) missense probably benign 0.13
R0673:Or2l5 UTSW 16 19,334,146 (GRCm39) missense probably damaging 1.00
R1187:Or2l5 UTSW 16 19,333,796 (GRCm39) missense probably benign 0.01
R1237:Or2l5 UTSW 16 19,334,375 (GRCm39) missense probably benign 0.01
R1975:Or2l5 UTSW 16 19,333,586 (GRCm39) missense probably damaging 0.99
R1977:Or2l5 UTSW 16 19,333,586 (GRCm39) missense probably damaging 0.99
R1997:Or2l5 UTSW 16 19,333,792 (GRCm39) missense probably damaging 1.00
R2225:Or2l5 UTSW 16 19,333,996 (GRCm39) missense probably benign 0.05
R2226:Or2l5 UTSW 16 19,333,996 (GRCm39) missense probably benign 0.05
R4078:Or2l5 UTSW 16 19,333,982 (GRCm39) missense possibly damaging 0.76
R5019:Or2l5 UTSW 16 19,334,285 (GRCm39) missense probably damaging 0.99
R5071:Or2l5 UTSW 16 19,333,777 (GRCm39) missense probably benign 0.00
R5278:Or2l5 UTSW 16 19,334,128 (GRCm39) nonsense probably null
R5415:Or2l5 UTSW 16 19,333,996 (GRCm39) missense possibly damaging 0.94
R5744:Or2l5 UTSW 16 19,334,086 (GRCm39) missense probably benign 0.00
R5991:Or2l5 UTSW 16 19,333,507 (GRCm39) missense probably damaging 0.99
R6151:Or2l5 UTSW 16 19,334,281 (GRCm39) missense probably damaging 1.00
R7014:Or2l5 UTSW 16 19,334,206 (GRCm39) missense probably benign 0.20
R7145:Or2l5 UTSW 16 19,333,649 (GRCm39) missense probably damaging 0.99
R7535:Or2l5 UTSW 16 19,333,544 (GRCm39) missense probably damaging 1.00
R7677:Or2l5 UTSW 16 19,333,678 (GRCm39) missense probably benign 0.42
R7715:Or2l5 UTSW 16 19,333,480 (GRCm39) missense probably benign 0.00
R7931:Or2l5 UTSW 16 19,334,258 (GRCm39) missense possibly damaging 0.94
R8137:Or2l5 UTSW 16 19,333,846 (GRCm39) missense possibly damaging 0.89
R8671:Or2l5 UTSW 16 19,333,804 (GRCm39) missense possibly damaging 0.63
Predicted Primers PCR Primer
(F):5'- GAGATCGATCCGAGTACTTAACC -3'
(R):5'- TGTGAGTACAATCCTCTTTCTTGTG -3'

Sequencing Primer
(F):5'- TCTGGATTCACGGAAGCA -3'
(R):5'- CATTGGAATAGTGTGTTCCTATGGTC -3'
Posted On 2018-06-06