Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01084:Vmn2r80'

52073

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r80

Ensembl Gene

ENSMUSG00000091888

Gene Name

vomeronasal 2, receptor 80

Synonyms

EG624765

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

IGL01084

Quality Score

Status

Chromosome

Chromosomal Location

78984650-79030767 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 79030433 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 753 (Y753C)

Ref Sequence

ENSEMBL: ENSMUSP00000132299 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165834]

AlphaFold

E9Q1L0

Predicted Effect

probably damaging
Transcript: ENSMUST00000165834
AA Change: Y753C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000132299
Gene: ENSMUSG00000091888
AA Change: Y753C

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	79	474	1.5e-36	PFAM
Pfam:NCD3G	517	570	7.9e-22	PFAM
Pfam:7tm_3	603	838	6.2e-49	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aagab	C	A	9: 63,546,901 (GRCm39)	Q284K	probably damaging	Het
Adgrd1	A	T	5: 129,216,656 (GRCm39)	N341I	probably benign	Het
Arhgap40	T	C	2: 158,385,138 (GRCm39)	F457S	probably damaging	Het
Cacng5	C	T	11: 107,772,531 (GRCm39)	V106I	probably benign	Het
Catsper1	G	A	19: 5,387,800 (GRCm39)	V360M	probably damaging	Het
Cdc42bpa	T	A	1: 179,969,839 (GRCm39)		probably benign	Het
Cep250	C	T	2: 155,840,313 (GRCm39)	H2424Y	probably benign	Het
Cln3	T	C	7: 126,174,426 (GRCm39)	E304G	probably damaging	Het
Eml2	T	A	7: 18,924,663 (GRCm39)	C177*	probably null	Het
Epha5	G	A	5: 84,218,946 (GRCm39)	R917*	probably null	Het
Gabra2	A	G	5: 71,163,576 (GRCm39)	F244L	probably damaging	Het
Gars1	C	A	6: 55,032,812 (GRCm39)	D261E	probably benign	Het
Gata3os	A	G	2: 9,887,884 (GRCm39)		probably benign	Het
Keg1	A	G	19: 12,691,976 (GRCm39)	K98E	probably damaging	Het
Kif13a	A	G	13: 46,904,110 (GRCm39)		probably benign	Het
Matn1	A	G	4: 130,679,245 (GRCm39)	K300E	probably benign	Het
Mesp1	A	G	7: 79,442,831 (GRCm39)	S149P	probably benign	Het
Mmp10	T	C	9: 7,505,651 (GRCm39)	V305A	possibly damaging	Het
Muc5b	T	C	7: 141,397,186 (GRCm39)		probably benign	Het
Myof	T	C	19: 37,924,884 (GRCm39)	T1181A	probably damaging	Het
Or1r1	A	T	11: 73,875,353 (GRCm39)	L27Q	probably damaging	Het
Or5d35	T	C	2: 87,855,347 (GRCm39)	S94P	probably benign	Het
Or9i16	G	T	19: 13,864,866 (GRCm39)	T236N	probably damaging	Het
Osbpl11	T	C	16: 33,047,221 (GRCm39)		probably benign	Het
Prune2	T	C	19: 17,095,573 (GRCm39)	V359A	probably benign	Het
Ptch1	T	A	13: 63,691,451 (GRCm39)	E267D	probably damaging	Het
Rbl2	A	G	8: 91,848,941 (GRCm39)	E1049G	probably damaging	Het
Ruvbl2	A	T	7: 45,071,947 (GRCm39)		probably null	Het
Sec23b	A	G	2: 144,406,509 (GRCm39)	I101M	possibly damaging	Het
Srms	A	C	2: 180,848,177 (GRCm39)		probably null	Het
Svep1	T	A	4: 58,111,419 (GRCm39)	T1067S	possibly damaging	Het
Tedc1	C	T	12: 113,126,808 (GRCm39)	R357*	probably null	Het
Tmem127	T	C	2: 127,099,006 (GRCm39)	V180A	probably damaging	Het
Trpm7	A	G	2: 126,687,992 (GRCm39)		probably null	Het
Trpv3	G	A	11: 73,184,826 (GRCm39)		probably null	Het
Tti1	C	T	2: 157,824,379 (GRCm39)	V1025I	probably damaging	Het
Vps13d	A	G	4: 144,881,525 (GRCm39)	L1350S	probably benign	Het
Zfp287	G	T	11: 62,604,716 (GRCm39)	Y730*	probably null	Het
Zfp583	A	G	7: 6,320,184 (GRCm39)	F276S	probably damaging	Het
Zfp638	T	C	6: 83,921,780 (GRCm39)	Y636H	probably benign	Het

Other mutations in Vmn2r80

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01325:Vmn2r80	APN	10	79,030,081 (GRCm39)	missense	possibly damaging	0.62
IGL01611:Vmn2r80	APN	10	79,007,488 (GRCm39)	missense	probably damaging	1.00
IGL01799:Vmn2r80	APN	10	79,007,385 (GRCm39)	missense	possibly damaging	0.95
IGL01877:Vmn2r80	APN	10	79,007,334 (GRCm39)	splice site	probably null
IGL02673:Vmn2r80	APN	10	79,005,318 (GRCm39)	missense	probably benign	0.02
IGL02756:Vmn2r80	APN	10	79,030,145 (GRCm39)	missense	probably damaging	1.00
IGL02820:Vmn2r80	APN	10	79,007,439 (GRCm39)	missense	probably benign	0.04
IGL03382:Vmn2r80	APN	10	79,005,362 (GRCm39)	missense	probably damaging	1.00
R0071:Vmn2r80	UTSW	10	79,007,566 (GRCm39)	missense	possibly damaging	0.83
R0071:Vmn2r80	UTSW	10	79,007,566 (GRCm39)	missense	possibly damaging	0.83
R0129:Vmn2r80	UTSW	10	79,005,330 (GRCm39)	missense	probably damaging	1.00
R0325:Vmn2r80	UTSW	10	78,984,773 (GRCm39)	missense	possibly damaging	0.89
R0567:Vmn2r80	UTSW	10	79,030,665 (GRCm39)	missense	possibly damaging	0.89
R1510:Vmn2r80	UTSW	10	79,005,553 (GRCm39)	missense	possibly damaging	0.69
R1519:Vmn2r80	UTSW	10	79,030,053 (GRCm39)	missense	probably damaging	1.00
R1520:Vmn2r80	UTSW	10	79,030,594 (GRCm39)	missense	probably damaging	1.00
R1627:Vmn2r80	UTSW	10	79,030,249 (GRCm39)	missense	probably damaging	1.00
R1709:Vmn2r80	UTSW	10	79,030,223 (GRCm39)	missense	probably benign	0.04
R2116:Vmn2r80	UTSW	10	79,030,558 (GRCm39)	missense	probably benign	0.09
R2237:Vmn2r80	UTSW	10	79,004,104 (GRCm39)	missense	probably damaging	1.00
R2308:Vmn2r80	UTSW	10	79,007,455 (GRCm39)	missense	probably damaging	1.00
R2893:Vmn2r80	UTSW	10	78,984,699 (GRCm39)	missense	possibly damaging	0.63
R3408:Vmn2r80	UTSW	10	79,004,227 (GRCm39)	missense	possibly damaging	0.95
R4502:Vmn2r80	UTSW	10	78,984,764 (GRCm39)	missense	probably benign	0.00
R4685:Vmn2r80	UTSW	10	79,030,162 (GRCm39)	missense	possibly damaging	0.95
R4851:Vmn2r80	UTSW	10	79,030,156 (GRCm39)	missense	possibly damaging	0.68
R4947:Vmn2r80	UTSW	10	79,030,532 (GRCm39)	missense	probably damaging	1.00
R5112:Vmn2r80	UTSW	10	79,030,292 (GRCm39)	missense	possibly damaging	0.61
R5217:Vmn2r80	UTSW	10	79,004,980 (GRCm39)	missense	possibly damaging	0.62
R5226:Vmn2r80	UTSW	10	79,029,874 (GRCm39)	missense	probably benign	0.36
R5512:Vmn2r80	UTSW	10	79,004,066 (GRCm39)	missense	probably benign	0.00
R5618:Vmn2r80	UTSW	10	78,984,755 (GRCm39)	missense	probably benign
R5959:Vmn2r80	UTSW	10	79,005,313 (GRCm39)	missense	probably benign	0.00
R6104:Vmn2r80	UTSW	10	78,984,854 (GRCm39)	missense	probably benign	0.00
R6110:Vmn2r80	UTSW	10	79,017,837 (GRCm39)	missense	probably damaging	1.00
R6270:Vmn2r80	UTSW	10	79,030,159 (GRCm39)	missense	probably benign	0.00
R6508:Vmn2r80	UTSW	10	79,030,290 (GRCm39)	missense	probably benign	0.03
R6843:Vmn2r80	UTSW	10	79,005,502 (GRCm39)	missense	probably benign	0.08
R6894:Vmn2r80	UTSW	10	79,005,438 (GRCm39)	missense	probably benign	0.06
R7048:Vmn2r80	UTSW	10	79,030,153 (GRCm39)	missense	probably damaging	1.00
R7149:Vmn2r80	UTSW	10	79,030,654 (GRCm39)	missense	probably benign	0.00
R7262:Vmn2r80	UTSW	10	79,005,579 (GRCm39)	missense	probably damaging	0.98
R7559:Vmn2r80	UTSW	10	79,030,459 (GRCm39)	missense	probably benign	0.00
R7622:Vmn2r80	UTSW	10	79,030,097 (GRCm39)	missense	probably damaging	1.00
R8003:Vmn2r80	UTSW	10	78,984,711 (GRCm39)	missense	probably benign	0.16
R8207:Vmn2r80	UTSW	10	79,030,150 (GRCm39)	nonsense	probably null
R8330:Vmn2r80	UTSW	10	79,007,550 (GRCm39)	missense	probably damaging	1.00
R8337:Vmn2r80	UTSW	10	78,984,707 (GRCm39)	missense	probably benign	0.00
R8354:Vmn2r80	UTSW	10	78,984,710 (GRCm39)	missense	probably benign
R8688:Vmn2r80	UTSW	10	79,004,069 (GRCm39)	missense	probably damaging	1.00
R8903:Vmn2r80	UTSW	10	79,017,928 (GRCm39)	missense	probably damaging	1.00
R9088:Vmn2r80	UTSW	10	79,005,378 (GRCm39)	missense	probably benign	0.05
R9125:Vmn2r80	UTSW	10	78,984,760 (GRCm39)	missense	probably benign	0.12
R9147:Vmn2r80	UTSW	10	79,030,687 (GRCm39)	missense	probably damaging	0.98
R9148:Vmn2r80	UTSW	10	79,030,687 (GRCm39)	missense	probably damaging	0.98
R9187:Vmn2r80	UTSW	10	79,030,438 (GRCm39)	missense	probably benign	0.20
R9218:Vmn2r80	UTSW	10	79,030,270 (GRCm39)	missense	possibly damaging	0.61
R9553:Vmn2r80	UTSW	10	78,984,743 (GRCm39)	missense	probably benign
R9612:Vmn2r80	UTSW	10	79,030,712 (GRCm39)	missense	probably damaging	1.00
R9677:Vmn2r80	UTSW	10	78,984,672 (GRCm39)	missense	probably benign	0.15
R9769:Vmn2r80	UTSW	10	79,005,443 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r80	UTSW	10	79,030,441 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r80	UTSW	10	79,030,232 (GRCm39)	missense	possibly damaging	0.65
Z1176:Vmn2r80	UTSW	10	79,005,311 (GRCm39)	missense	not run
Z1176:Vmn2r80	UTSW	10	79,030,605 (GRCm39)	missense	probably damaging	1.00
Z1177:Vmn2r80	UTSW	10	79,005,311 (GRCm39)	missense	not run

Posted On

2013-06-21