Incidental Mutation 'IGL01096:Ifng'
ID 52089
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifng
Ensembl Gene ENSMUSG00000055170
Gene Name interferon gamma
Synonyms Ifg, IFN-gamma
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.399) question?
Stock # IGL01096
Quality Score
Status
Chromosome 10
Chromosomal Location 118276951-118281797 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) T to A at 118281174 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000063800 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068592]
AlphaFold P01580
Predicted Effect probably benign
Transcript: ENSMUST00000068592
SMART Domains Protein: ENSMUSP00000063800
Gene: ENSMUSG00000055170

DomainStartEndE-ValueType
Pfam:IFN-gamma 14 150 8.2e-57 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219775
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220309
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mutants show immune system abnormalities including decreased inflammatory response in one line, and uncontrolled splenocyte proliferation and susceptibility to intracellular pathogens in another. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg3 A T 8: 95,766,221 (GRCm39) M351L possibly damaging Het
Alk T C 17: 72,228,891 (GRCm39) K725E possibly damaging Het
Castor1 A C 11: 4,171,850 (GRCm39) E309A probably damaging Het
Dspp T A 5: 104,323,233 (GRCm39) H125Q possibly damaging Het
Elmo2 A T 2: 165,138,907 (GRCm39) probably benign Het
Erg A G 16: 95,190,912 (GRCm39) probably benign Het
Fam20c A G 5: 138,794,910 (GRCm39) E513G possibly damaging Het
Gm9839 G T 1: 32,559,917 (GRCm39) T55N possibly damaging Het
Gpd2 A T 2: 57,228,879 (GRCm39) M228L probably damaging Het
Hp A T 8: 110,302,033 (GRCm39) M305K probably benign Het
Igkv9-123 T C 6: 67,931,449 (GRCm39) D39G possibly damaging Het
Melk T A 4: 44,347,262 (GRCm39) F431I probably benign Het
Or10ak12 A G 4: 118,666,653 (GRCm39) V136A probably damaging Het
Or12j5 A T 7: 140,084,097 (GRCm39) S92T probably damaging Het
Or4p19 A G 2: 88,242,135 (GRCm39) M289T probably damaging Het
Or51k1 A C 7: 103,661,321 (GRCm39) L196W probably damaging Het
Or8g27 G A 9: 39,129,412 (GRCm39) G253D probably damaging Het
Pappa T C 4: 65,107,553 (GRCm39) Y655H probably damaging Het
Prss58 A T 6: 40,872,399 (GRCm39) I208N probably damaging Het
Ryr2 T A 13: 11,718,430 (GRCm39) I2720F probably damaging Het
Slc13a1 G T 6: 24,104,076 (GRCm39) T322K probably damaging Het
Spag17 T C 3: 99,970,691 (GRCm39) F1292L probably benign Het
Tbx5 A G 5: 120,021,091 (GRCm39) T366A probably benign Het
Tmeff2 G A 1: 50,969,705 (GRCm39) probably benign Het
Tmem101 C A 11: 102,045,378 (GRCm39) probably null Het
Tpp2 C A 1: 44,000,048 (GRCm39) P389T probably damaging Het
Tyk2 A G 9: 21,020,159 (GRCm39) Y1000H probably damaging Het
Ush2a C A 1: 188,410,574 (GRCm39) N2407K probably damaging Het
Vmn1r94 C T 7: 19,901,561 (GRCm39) V248I probably damaging Het
Vmn2r12 T A 5: 109,234,125 (GRCm39) I696F probably damaging Het
Vmn2r83 A G 10: 79,313,662 (GRCm39) E90G probably damaging Het
Washc5 T C 15: 59,222,060 (GRCm39) probably benign Het
Wee2 A G 6: 40,440,187 (GRCm39) E445G probably benign Het
Zfp518b T C 5: 38,830,131 (GRCm39) T625A probably benign Het
Other mutations in Ifng
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02351:Ifng APN 10 118,278,410 (GRCm39) missense possibly damaging 0.94
IGL02358:Ifng APN 10 118,278,410 (GRCm39) missense possibly damaging 0.94
IGL02428:Ifng APN 10 118,281,159 (GRCm39) missense probably damaging 0.99
IGL02864:Ifng APN 10 118,278,561 (GRCm39) missense probably damaging 1.00
R0295:Ifng UTSW 10 118,277,154 (GRCm39) missense possibly damaging 0.47
R5949:Ifng UTSW 10 118,278,529 (GRCm39) missense probably benign
R9315:Ifng UTSW 10 118,278,588 (GRCm39) missense probably damaging 0.99
R9548:Ifng UTSW 10 118,277,128 (GRCm39) missense probably benign
Posted On 2013-06-21