Incidental Mutation 'IGL01098:Gpr6'
ID52093
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr6
Ensembl Gene ENSMUSG00000046922
Gene NameG protein-coupled receptor 6
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01098
Quality Score
Status
Chromosome10
Chromosomal Location41069977-41072285 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 41070743 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 281 (T281I)
Ref Sequence ENSEMBL: ENSMUSP00000057323 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061796]
Predicted Effect probably damaging
Transcript: ENSMUST00000061796
AA Change: T281I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000057323
Gene: ENSMUSG00000046922
AA Change: T281I

DomainStartEndE-ValueType
low complexity region 13 30 N/A INTRINSIC
low complexity region 37 59 N/A INTRINSIC
Pfam:7tm_1 90 330 2.5e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213704
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik T C 2: 151,473,533 D75G possibly damaging Het
Brip1 G T 11: 86,108,862 R765S possibly damaging Het
Btbd16 T C 7: 130,823,245 I452T probably damaging Het
Cdc42ep4 T G 11: 113,729,502 D21A probably damaging Het
Cdx2 T A 5: 147,306,982 M1L possibly damaging Het
Cfap206 C T 4: 34,721,562 S162N probably damaging Het
Csmd2 C T 4: 128,059,052 T98M probably damaging Het
Cyp26a1 A T 19: 37,700,002 Q324L probably benign Het
Etaa1 A G 11: 17,946,059 V686A probably damaging Het
Herc1 T A 9: 66,461,922 probably null Het
Lama2 A T 10: 27,031,112 I2351N possibly damaging Het
Lman1 A G 18: 65,991,640 F343L probably damaging Het
Lmo1 A G 7: 109,143,450 probably benign Het
Lrrc17 T A 5: 21,575,271 F414L probably benign Het
Man2b2 A T 5: 36,815,556 L538Q probably damaging Het
Map3k9 A G 12: 81,724,154 S910P probably damaging Het
Mapk1ip1 G A 7: 138,836,462 P80S probably damaging Het
Mindy4 G T 6: 55,284,742 probably benign Het
Msh4 A T 3: 153,877,982 probably benign Het
Mta2 A G 19: 8,946,717 D187G probably damaging Het
Olfml2a A G 2: 38,947,214 probably null Het
Pink1 A T 4: 138,320,097 probably null Het
Plekha6 T C 1: 133,282,165 F575L possibly damaging Het
Rpe C A 1: 66,706,515 D71E probably benign Het
Slc5a7 C T 17: 54,292,960 A142T probably benign Het
Sptbn1 C T 11: 30,159,385 R70K probably damaging Het
Taf1c G T 8: 119,602,841 Q159K probably damaging Het
Tgfb1i1 T C 7: 128,252,521 F311S probably damaging Het
Tmc8 T C 11: 117,792,563 V648A possibly damaging Het
Tmed8 G T 12: 87,176,671 A98E probably benign Het
Tmem200a A G 10: 25,994,143 I76T probably damaging Het
Vmn2r104 T C 17: 20,048,096 E37G probably benign Het
Vmn2r18 A T 5: 151,572,831 V474E probably damaging Het
Vps52 C T 17: 33,962,730 T510I possibly damaging Het
Wwox G T 8: 114,445,378 G71* probably null Het
Zer1 C T 2: 30,108,220 probably null Het
Zfp296 A T 7: 19,577,920 K117N possibly damaging Het
Other mutations in Gpr6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Gpr6 APN 10 41070816 missense probably damaging 0.99
IGL01010:Gpr6 APN 10 41071151 missense probably benign
IGL01323:Gpr6 APN 10 41071559 missense possibly damaging 0.96
R1153:Gpr6 UTSW 10 41070837 missense probably damaging 1.00
R1154:Gpr6 UTSW 10 41070837 missense probably damaging 1.00
R1622:Gpr6 UTSW 10 41071292 missense probably damaging 1.00
R1628:Gpr6 UTSW 10 41071548 missense possibly damaging 0.96
R1638:Gpr6 UTSW 10 41070534 missense probably benign 0.02
R1935:Gpr6 UTSW 10 41071481 missense probably benign 0.02
R1936:Gpr6 UTSW 10 41071481 missense probably benign 0.02
R2108:Gpr6 UTSW 10 41070653 missense possibly damaging 0.79
R2129:Gpr6 UTSW 10 41071172 missense possibly damaging 0.50
R4024:Gpr6 UTSW 10 41071268 missense probably damaging 1.00
R4237:Gpr6 UTSW 10 41070608 missense probably damaging 1.00
R4418:Gpr6 UTSW 10 41070608 missense probably damaging 1.00
R4703:Gpr6 UTSW 10 41071041 missense probably damaging 1.00
R4814:Gpr6 UTSW 10 41071262 missense possibly damaging 0.94
R6821:Gpr6 UTSW 10 41071008 missense probably benign 0.04
R7190:Gpr6 UTSW 10 41070960 missense probably damaging 1.00
R7573:Gpr6 UTSW 10 41070872 missense probably damaging 0.99
R7574:Gpr6 UTSW 10 41070656 missense possibly damaging 0.47
R7611:Gpr6 UTSW 10 41070879 missense probably benign 0.02
R8011:Gpr6 UTSW 10 41070915 missense not run
Posted On2013-06-21