Incidental Mutation 'R6519:Zranb1'
ID 521001
Institutional Source Beutler Lab
Gene Symbol Zranb1
Ensembl Gene ENSMUSG00000030967
Gene Name zinc finger, RAN-binding domain containing 1
Synonyms 9330160G10Rik, D7Wsu87e
MMRRC Submission 044646-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.915) question?
Stock # R6519 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 132532905-132588127 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 132551857 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 195 (C195*)
Ref Sequence ENSEMBL: ENSMUSP00000148867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033265] [ENSMUST00000106157] [ENSMUST00000124096] [ENSMUST00000210507] [ENSMUST00000215716]
AlphaFold Q7M760
Predicted Effect probably null
Transcript: ENSMUST00000033265
AA Change: C169*
SMART Domains Protein: ENSMUSP00000033265
Gene: ENSMUSG00000030967
AA Change: C169*

DomainStartEndE-ValueType
ZnF_RBZ 6 30 9.14e-5 SMART
ZnF_RBZ 86 110 6.56e-6 SMART
ZnF_RBZ 151 175 1.69e-8 SMART
low complexity region 180 195 N/A INTRINSIC
Pfam:OTU 438 586 9.8e-35 PFAM
low complexity region 698 708 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106157
AA Change: C169*
SMART Domains Protein: ENSMUSP00000101763
Gene: ENSMUSG00000030967
AA Change: C169*

DomainStartEndE-ValueType
ZnF_RBZ 6 30 9.14e-5 SMART
ZnF_RBZ 86 110 6.56e-6 SMART
ZnF_RBZ 151 175 1.69e-8 SMART
low complexity region 180 195 N/A INTRINSIC
Pfam:OTU 438 586 1.5e-40 PFAM
low complexity region 698 708 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124096
SMART Domains Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

DomainStartEndE-ValueType
Pfam:Pkinase 1 118 4.8e-19 PFAM
Pfam:Pkinase_Tyr 1 118 1.7e-50 PFAM
low complexity region 146 160 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000210507
AA Change: C169*
Predicted Effect probably null
Transcript: ENSMUST00000215716
AA Change: C195*
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 91.7%
Validation Efficiency 97% (58/60)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased CD4+ T cells and decreased susceptibility to experimental autoimmune encephalomyelitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt T C 9: 99,495,723 (GRCm39) I53T probably damaging Het
Adgrv1 C T 13: 81,715,462 (GRCm39) D909N probably benign Het
Ahdc1 T C 4: 132,792,079 (GRCm39) Y1107H possibly damaging Het
Aldob A T 4: 49,543,835 (GRCm39) V49E probably damaging Het
Apol6 T A 15: 76,935,476 (GRCm39) Y248* probably null Het
Apol7b T A 15: 77,307,548 (GRCm39) T316S probably benign Het
Atp13a2 G C 4: 140,728,165 (GRCm39) R503P possibly damaging Het
Brca2 A C 5: 150,464,444 (GRCm39) T1403P probably damaging Het
Cblc T C 7: 19,526,788 (GRCm39) Y148C probably damaging Het
Cct7 C A 6: 85,439,132 (GRCm39) Q149K probably benign Het
Cd53 T A 3: 106,669,461 (GRCm39) H179L probably benign Het
Cyp2b19 A G 7: 26,458,536 (GRCm39) T84A probably benign Het
Cyp3a41a A G 5: 145,652,308 (GRCm39) C64R probably damaging Het
Dclre1c T C 2: 3,430,366 (GRCm39) Y75H probably damaging Het
Dhx35 A T 2: 158,673,630 (GRCm39) I354F probably damaging Het
Diaph3 T C 14: 87,203,771 (GRCm39) N629S probably damaging Het
Dnase1 A T 16: 3,856,453 (GRCm39) S132C probably damaging Het
Dnttip2 T C 3: 122,069,120 (GRCm39) S112P probably benign Het
Eif4g3 C A 4: 137,721,319 (GRCm39) P48T probably benign Het
Fat4 A T 3: 39,057,020 (GRCm39) T4239S probably benign Het
Fbn2 A G 18: 58,196,647 (GRCm39) V1419A possibly damaging Het
Ghitm A C 14: 36,847,204 (GRCm39) M290R probably damaging Het
Glb1l T C 1: 75,177,700 (GRCm39) D406G probably benign Het
Glipr1l1 C A 10: 111,898,153 (GRCm39) A86D probably benign Het
Golm2 T C 2: 121,737,218 (GRCm39) V141A probably benign Het
Grm7 C T 6: 111,184,713 (GRCm39) A348V probably benign Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
Hdac2 T A 10: 36,865,252 (GRCm39) N155K probably damaging Het
Hus1b A G 13: 31,130,930 (GRCm39) I243T probably benign Het
Kcnab2 T C 4: 152,496,450 (GRCm39) T65A probably damaging Het
Lasp1 T A 11: 97,706,383 (GRCm39) probably null Het
Lrch3 G A 16: 32,815,367 (GRCm39) probably benign Het
Ltb4r2 C T 14: 56,000,438 (GRCm39) T353M probably benign Het
Macf1 A G 4: 123,366,118 (GRCm39) M1316T probably benign Het
Msr1 G A 8: 40,077,262 (GRCm39) T116I probably benign Het
Nlrp5 A G 7: 23,117,343 (GRCm39) I356V probably benign Het
Npy C T 6: 49,800,669 (GRCm39) S31F possibly damaging Het
Nsd3 C T 8: 26,152,955 (GRCm39) P432S probably damaging Het
Nup160 A C 2: 90,548,561 (GRCm39) R1037S probably damaging Het
Or12j4 T A 7: 140,046,458 (GRCm39) S115T probably benign Het
Or4b1d A T 2: 89,969,156 (GRCm39) I109N possibly damaging Het
Or8s5 C T 15: 98,237,929 (GRCm39) G314R probably benign Het
Pcx A G 19: 4,652,239 (GRCm39) E108G possibly damaging Het
Pecam1 A T 11: 106,590,468 (GRCm39) M102K probably benign Het
Pgd G T 4: 149,235,343 (GRCm39) Y433* probably null Het
Pkd1l3 A G 8: 110,355,404 (GRCm39) E744G probably benign Het
Rb1 A G 14: 73,535,503 (GRCm39) I118T probably benign Het
Rdh11 T A 12: 79,229,589 (GRCm39) H228L probably damaging Het
Rnf44 C T 13: 54,829,599 (GRCm39) R340Q probably damaging Het
Rtraf A G 14: 19,869,998 (GRCm39) V88A possibly damaging Het
Sigmar1 T C 4: 41,739,380 (GRCm39) T185A possibly damaging Het
Thsd1 A G 8: 22,749,081 (GRCm39) R590G probably damaging Het
Trappc14 A G 5: 138,260,110 (GRCm39) S344P probably damaging Het
Trbv19 T C 6: 41,155,573 (GRCm39) probably benign Het
Txnrd3 T C 6: 89,631,405 (GRCm39) probably null Het
Wwc1 C T 11: 35,744,264 (GRCm39) E853K probably benign Het
Xpnpep1 T C 19: 53,000,275 (GRCm39) N192D possibly damaging Het
Zfp955b T A 17: 33,521,051 (GRCm39) S173R possibly damaging Het
Other mutations in Zranb1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00499:Zranb1 APN 7 132,584,233 (GRCm39) splice site probably benign
IGL00843:Zranb1 APN 7 132,551,622 (GRCm39) missense probably benign 0.26
IGL01727:Zranb1 APN 7 132,568,349 (GRCm39) missense probably damaging 1.00
IGL02087:Zranb1 APN 7 132,575,146 (GRCm39) splice site probably benign
IGL02676:Zranb1 APN 7 132,568,410 (GRCm39) missense probably benign 0.16
IGL03081:Zranb1 APN 7 132,552,126 (GRCm39) missense probably damaging 0.99
IGL03095:Zranb1 APN 7 132,551,635 (GRCm39) nonsense probably null
IGL03186:Zranb1 APN 7 132,551,932 (GRCm39) missense possibly damaging 0.68
PIT4151001:Zranb1 UTSW 7 132,551,723 (GRCm39) missense probably benign
R0207:Zranb1 UTSW 7 132,552,114 (GRCm39) missense probably damaging 1.00
R0470:Zranb1 UTSW 7 132,584,500 (GRCm39) missense probably damaging 1.00
R0854:Zranb1 UTSW 7 132,551,577 (GRCm39) missense possibly damaging 0.78
R1318:Zranb1 UTSW 7 132,568,281 (GRCm39) nonsense probably null
R1389:Zranb1 UTSW 7 132,573,062 (GRCm39) missense probably damaging 1.00
R1480:Zranb1 UTSW 7 132,551,745 (GRCm39) missense probably benign 0.39
R1656:Zranb1 UTSW 7 132,551,496 (GRCm39) missense probably benign 0.31
R1956:Zranb1 UTSW 7 132,584,458 (GRCm39) missense probably damaging 1.00
R1958:Zranb1 UTSW 7 132,584,458 (GRCm39) missense probably damaging 1.00
R2010:Zranb1 UTSW 7 132,568,425 (GRCm39) critical splice donor site probably null
R2289:Zranb1 UTSW 7 132,551,768 (GRCm39) missense probably damaging 1.00
R3831:Zranb1 UTSW 7 132,584,505 (GRCm39) missense probably damaging 0.98
R4128:Zranb1 UTSW 7 132,568,281 (GRCm39) nonsense probably null
R4745:Zranb1 UTSW 7 132,574,443 (GRCm39) missense probably damaging 0.97
R5121:Zranb1 UTSW 7 132,551,916 (GRCm39) missense probably benign 0.06
R5262:Zranb1 UTSW 7 132,584,556 (GRCm39) small insertion probably benign
R5263:Zranb1 UTSW 7 132,584,556 (GRCm39) small insertion probably benign
R5264:Zranb1 UTSW 7 132,584,556 (GRCm39) small insertion probably benign
R5522:Zranb1 UTSW 7 132,585,678 (GRCm39) makesense probably null
R6252:Zranb1 UTSW 7 132,585,633 (GRCm39) missense probably benign 0.00
R6671:Zranb1 UTSW 7 132,573,042 (GRCm39) missense probably damaging 1.00
R6827:Zranb1 UTSW 7 132,551,474 (GRCm39) missense probably benign 0.17
R6928:Zranb1 UTSW 7 132,568,323 (GRCm39) missense possibly damaging 0.65
R7313:Zranb1 UTSW 7 132,584,481 (GRCm39) missense probably damaging 1.00
R7583:Zranb1 UTSW 7 132,585,625 (GRCm39) missense probably benign 0.00
R8181:Zranb1 UTSW 7 132,585,508 (GRCm39) missense probably damaging 1.00
R8236:Zranb1 UTSW 7 132,551,393 (GRCm39) missense probably damaging 0.99
R8463:Zranb1 UTSW 7 132,551,810 (GRCm39) missense possibly damaging 0.68
R9006:Zranb1 UTSW 7 132,572,909 (GRCm39) splice site probably benign
R9103:Zranb1 UTSW 7 132,584,167 (GRCm39) missense probably damaging 0.96
R9134:Zranb1 UTSW 7 132,551,886 (GRCm39) missense probably benign 0.00
R9229:Zranb1 UTSW 7 132,583,117 (GRCm39) missense probably damaging 0.98
R9244:Zranb1 UTSW 7 132,585,640 (GRCm39) missense probably damaging 1.00
R9417:Zranb1 UTSW 7 132,585,466 (GRCm39) missense probably damaging 1.00
R9596:Zranb1 UTSW 7 132,552,146 (GRCm39) missense probably benign 0.32
R9708:Zranb1 UTSW 7 132,584,600 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GATGTACCCAGTGCTTATCCCAG -3'
(R):5'- CCAGCCAATTCGATCCTCTG -3'

Sequencing Primer
(F):5'- AGTGCTTATCCCAGCGTAGGAC -3'
(R):5'- TGAAAATCCATCTTCACTTCCGAG -3'
Posted On 2018-06-06