Incidental Mutation 'R6520:Zfp804b'
ID 521101
Institutional Source Beutler Lab
Gene Symbol Zfp804b
Ensembl Gene ENSMUSG00000092094
Gene Name zinc finger protein 804B
Synonyms LOC207618
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R6520 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 6819030-7394378 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 6819283 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 1260 (H1260L)
Ref Sequence ENSEMBL: ENSMUSP00000143568 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164784] [ENSMUST00000200317]
AlphaFold A0A0G2JGH6
Predicted Effect probably damaging
Transcript: ENSMUST00000164784
AA Change: H1224L

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000130571
Gene: ENSMUSG00000092094
AA Change: H1224L

DomainStartEndE-ValueType
ZnF_C2H2 20 44 4.81e0 SMART
low complexity region 922 934 N/A INTRINSIC
low complexity region 1119 1143 N/A INTRINSIC
low complexity region 1160 1171 N/A INTRINSIC
low complexity region 1179 1198 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000200317
AA Change: H1260L

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000143568
Gene: ENSMUSG00000092094
AA Change: H1260L

DomainStartEndE-ValueType
ZnF_C2H2 56 80 2e-2 SMART
low complexity region 958 970 N/A INTRINSIC
low complexity region 1155 1179 N/A INTRINSIC
low complexity region 1196 1207 N/A INTRINSIC
low complexity region 1215 1234 N/A INTRINSIC
Meta Mutation Damage Score 0.2284 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 89 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700093K21Rik T C 11: 23,467,285 (GRCm39) D116G possibly damaging Het
Adam22 C T 5: 8,166,635 (GRCm39) V699M probably damaging Het
Adh7 A G 3: 137,929,771 (GRCm39) Y149C probably damaging Het
Adissp G T 2: 130,989,174 (GRCm39) H111N probably damaging Het
Angptl3 A C 4: 98,926,085 (GRCm39) N405T probably benign Het
Ank3 A G 10: 69,824,217 (GRCm39) H180R probably damaging Het
Apob T A 12: 8,033,124 (GRCm39) I159N probably damaging Het
Arhgap24 T C 5: 103,028,659 (GRCm39) V185A probably benign Het
Atf6 A T 1: 170,695,238 (GRCm39) H11Q probably benign Het
Atxn3 C A 12: 101,900,660 (GRCm39) D208Y probably damaging Het
Brd9 G A 13: 74,090,913 (GRCm39) R273K probably benign Het
Cbfa2t3 T A 8: 123,362,540 (GRCm39) R302W probably benign Het
Ccdc175 C A 12: 72,186,804 (GRCm39) G347C probably damaging Het
Ccdc87 A G 19: 4,891,817 (GRCm39) K770E probably damaging Het
Ccl17 T C 8: 95,537,178 (GRCm39) F27L probably benign Het
Cd3g A T 9: 44,882,613 (GRCm39) probably null Het
Cep350 A G 1: 155,809,082 (GRCm39) V498A probably benign Het
Cfap45 A G 1: 172,368,151 (GRCm39) D381G probably damaging Het
Cfap46 A G 7: 139,194,321 (GRCm39) probably null Het
Cnrip1 T A 11: 17,028,536 (GRCm39) M156K probably damaging Het
Col23a1 T C 11: 51,440,552 (GRCm39) probably null Het
Col4a1 C T 8: 11,269,152 (GRCm39) G933S probably damaging Het
Col5a3 C T 9: 20,685,348 (GRCm39) V1443I unknown Het
Col6a6 T C 9: 105,663,024 (GRCm39) E171G possibly damaging Het
Dennd1a A T 2: 37,851,759 (GRCm39) probably null Het
Dlk2 C T 17: 46,613,438 (GRCm39) T188I probably damaging Het
Dusp8 A G 7: 141,637,418 (GRCm39) I203T probably damaging Het
Eno2 C T 6: 124,744,678 (GRCm39) R56H probably damaging Het
Erich3 A T 3: 154,469,102 (GRCm39) T1185S probably damaging Het
Evi5l A T 8: 4,255,906 (GRCm39) Q575L possibly damaging Het
Fam187a T A 11: 102,776,701 (GRCm39) H168Q possibly damaging Het
Fat2 T A 11: 55,175,814 (GRCm39) E1633V probably damaging Het
Fbln2 G A 6: 91,236,641 (GRCm39) D719N probably damaging Het
Fbn2 A T 18: 58,235,462 (GRCm39) S672T probably damaging Het
Gas8 C G 8: 124,253,213 (GRCm39) A187G probably benign Het
Gm2696 G A 10: 77,672,332 (GRCm39) probably benign Het
Gnl1 A T 17: 36,293,845 (GRCm39) K272M probably benign Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
Hemgn T G 4: 46,396,466 (GRCm39) K257Q probably damaging Het
Hgsnat T C 8: 26,443,328 (GRCm39) Y474C probably damaging Het
Hoxc4 T C 15: 102,943,380 (GRCm39) S78P probably benign Het
Igkv14-100 T A 6: 68,496,218 (GRCm39) L37Q probably damaging Het
Iqck A T 7: 118,540,854 (GRCm39) K251M probably damaging Het
Itgal A T 7: 126,929,503 (GRCm39) Q1140L probably benign Het
Itpka A G 2: 119,581,259 (GRCm39) R431G probably benign Het
Jade1 A G 3: 41,558,917 (GRCm39) N333D possibly damaging Het
Jmjd7 A G 2: 119,861,800 (GRCm39) H181R probably damaging Het
Jmy A G 13: 93,590,547 (GRCm39) S519P probably benign Het
Klra10 T A 6: 130,252,755 (GRCm39) H173L probably benign Het
Krt72 T G 15: 101,689,481 (GRCm39) I284L probably benign Het
Krt78 C A 15: 101,860,206 (GRCm39) V237F probably benign Het
Mapkapk3 G A 9: 107,134,648 (GRCm39) T296M probably damaging Het
Mcmbp A C 7: 128,314,451 (GRCm39) V255G possibly damaging Het
Mcoln1 T G 8: 3,555,855 (GRCm39) M50R probably damaging Het
Mocos T A 18: 24,799,447 (GRCm39) V227E probably benign Het
Mpeg1 A G 19: 12,439,322 (GRCm39) E260G probably benign Het
Mrc1 A T 2: 14,312,760 (GRCm39) N894I probably damaging Het
Mroh7 A G 4: 106,578,460 (GRCm39) S73P probably benign Het
Myo3a A T 2: 22,404,737 (GRCm39) I690L possibly damaging Het
Naa50 T G 16: 43,979,872 (GRCm39) F87V probably damaging Het
Ndufs6 G T 13: 73,476,471 (GRCm39) T32K probably damaging Het
Nfe2l2 A G 2: 75,506,912 (GRCm39) V396A probably benign Het
Nptn A G 9: 58,551,017 (GRCm39) E348G probably damaging Het
Nsun4 A T 4: 115,901,935 (GRCm39) L177Q probably damaging Het
Or56b1b A G 7: 108,164,046 (GRCm39) *319Q probably null Het
Or8d6 T C 9: 39,853,658 (GRCm39) I34T possibly damaging Het
Or8k36-ps1 A G 2: 86,437,462 (GRCm39) L151P unknown Het
Plekha7 A G 7: 115,763,717 (GRCm39) V233A probably benign Het
Polq C A 16: 36,880,739 (GRCm39) Q968K possibly damaging Het
Prmt7 C T 8: 106,961,516 (GRCm39) T143M probably damaging Het
Ptprc G A 1: 138,007,881 (GRCm39) Q886* probably null Het
Rbp7 C A 4: 149,537,371 (GRCm39) V36L possibly damaging Het
Rev3l A T 10: 39,698,698 (GRCm39) N1065I probably benign Het
Scamp5 A T 9: 57,354,489 (GRCm39) probably null Het
Sec16a A G 2: 26,316,118 (GRCm39) S1698P probably damaging Het
Spr C A 6: 85,114,474 (GRCm39) R85L probably benign Het
Sptlc2 A C 12: 87,402,436 (GRCm39) N163K probably benign Het
Stk10 C T 11: 32,538,839 (GRCm39) T226M probably damaging Het
Sv2c A G 13: 96,123,229 (GRCm39) Y415H probably benign Het
Tet1 A G 10: 62,715,792 (GRCm39) M1T probably null Het
Tnnt1 T A 7: 4,512,060 (GRCm39) K150* probably null Het
Trappc10 C T 10: 78,037,287 (GRCm39) V839M probably benign Het
Ubap2 T C 4: 41,195,155 (GRCm39) N1131S probably damaging Het
Upk2 T C 9: 44,364,803 (GRCm39) E132G probably damaging Het
Vmn2r117 A T 17: 23,679,193 (GRCm39) V677D probably damaging Het
Vps13a A T 19: 16,702,943 (GRCm39) L670H probably damaging Het
Wwc1 C T 11: 35,744,264 (GRCm39) E853K probably benign Het
Zfp512 G A 5: 31,623,984 (GRCm39) R67H probably damaging Het
Zzef1 C A 11: 72,716,891 (GRCm39) N360K probably damaging Het
Other mutations in Zfp804b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01085:Zfp804b APN 5 6,820,931 (GRCm39) missense probably damaging 1.00
IGL01726:Zfp804b APN 5 7,230,707 (GRCm39) intron probably benign
IGL02020:Zfp804b APN 5 6,819,118 (GRCm39) missense probably damaging 1.00
IGL02567:Zfp804b APN 5 6,819,989 (GRCm39) missense probably benign 0.02
IGL02679:Zfp804b APN 5 6,821,392 (GRCm39) missense possibly damaging 0.50
IGL03245:Zfp804b APN 5 6,822,253 (GRCm39) missense possibly damaging 0.92
IGL03352:Zfp804b APN 5 6,820,039 (GRCm39) missense probably benign 0.45
Flush UTSW 5 6,820,217 (GRCm39) missense probably benign 0.27
gozinta UTSW 5 6,820,153 (GRCm39) missense possibly damaging 0.90
healthy UTSW 5 6,820,013 (GRCm39) missense probably benign 0.04
Paluka UTSW 5 6,820,534 (GRCm39) missense probably benign
PIT4142001:Zfp804b UTSW 5 6,819,422 (GRCm39) missense probably damaging 0.99
R0025:Zfp804b UTSW 5 6,821,665 (GRCm39) missense probably damaging 1.00
R0044:Zfp804b UTSW 5 6,819,655 (GRCm39) missense probably damaging 1.00
R0137:Zfp804b UTSW 5 6,820,534 (GRCm39) missense probably benign
R0330:Zfp804b UTSW 5 6,821,994 (GRCm39) missense possibly damaging 0.63
R0330:Zfp804b UTSW 5 6,821,029 (GRCm39) missense possibly damaging 0.83
R0522:Zfp804b UTSW 5 6,822,014 (GRCm39) missense probably benign 0.05
R1463:Zfp804b UTSW 5 7,229,372 (GRCm39) intron probably benign
R1497:Zfp804b UTSW 5 6,821,105 (GRCm39) missense probably damaging 0.97
R1511:Zfp804b UTSW 5 6,819,771 (GRCm39) missense possibly damaging 0.87
R1633:Zfp804b UTSW 5 7,229,513 (GRCm39) intron probably benign
R1666:Zfp804b UTSW 5 6,821,323 (GRCm39) missense possibly damaging 0.93
R1668:Zfp804b UTSW 5 6,821,323 (GRCm39) missense possibly damaging 0.93
R1677:Zfp804b UTSW 5 7,229,533 (GRCm39) intron probably benign
R1698:Zfp804b UTSW 5 6,819,509 (GRCm39) missense probably damaging 1.00
R1716:Zfp804b UTSW 5 6,819,673 (GRCm39) missense probably benign 0.00
R1730:Zfp804b UTSW 5 6,821,938 (GRCm39) missense probably damaging 0.99
R1747:Zfp804b UTSW 5 6,820,217 (GRCm39) missense probably benign 0.27
R1776:Zfp804b UTSW 5 6,819,806 (GRCm39) missense probably damaging 1.00
R1783:Zfp804b UTSW 5 6,821,938 (GRCm39) missense probably damaging 0.99
R1804:Zfp804b UTSW 5 6,821,756 (GRCm39) missense possibly damaging 0.78
R1885:Zfp804b UTSW 5 6,820,376 (GRCm39) missense probably damaging 0.97
R1887:Zfp804b UTSW 5 6,820,376 (GRCm39) missense probably damaging 0.97
R1900:Zfp804b UTSW 5 6,819,283 (GRCm39) missense probably damaging 0.99
R1929:Zfp804b UTSW 5 6,819,748 (GRCm39) missense probably benign 0.05
R2141:Zfp804b UTSW 5 6,822,583 (GRCm39) missense probably benign 0.11
R2181:Zfp804b UTSW 5 6,821,674 (GRCm39) missense probably damaging 1.00
R2401:Zfp804b UTSW 5 6,819,445 (GRCm39) missense probably damaging 1.00
R2408:Zfp804b UTSW 5 7,229,410 (GRCm39) intron probably benign
R3237:Zfp804b UTSW 5 6,819,239 (GRCm39) missense probably benign
R3429:Zfp804b UTSW 5 7,230,625 (GRCm39) intron probably benign
R3785:Zfp804b UTSW 5 6,820,153 (GRCm39) missense possibly damaging 0.90
R4459:Zfp804b UTSW 5 6,821,481 (GRCm39) missense probably damaging 0.99
R4460:Zfp804b UTSW 5 6,821,481 (GRCm39) missense probably damaging 0.99
R4608:Zfp804b UTSW 5 6,822,584 (GRCm39) missense probably benign 0.04
R4762:Zfp804b UTSW 5 6,822,250 (GRCm39) missense probably benign 0.00
R4871:Zfp804b UTSW 5 6,926,479 (GRCm39) missense probably damaging 1.00
R4910:Zfp804b UTSW 5 6,820,540 (GRCm39) missense possibly damaging 0.69
R4973:Zfp804b UTSW 5 6,821,198 (GRCm39) missense probably damaging 0.99
R5199:Zfp804b UTSW 5 6,820,013 (GRCm39) missense probably benign 0.04
R5219:Zfp804b UTSW 5 6,820,703 (GRCm39) missense probably benign 0.01
R5411:Zfp804b UTSW 5 6,820,071 (GRCm39) missense probably benign 0.00
R6001:Zfp804b UTSW 5 6,819,043 (GRCm39) missense probably benign 0.00
R6041:Zfp804b UTSW 5 6,821,231 (GRCm39) missense probably benign 0.08
R6151:Zfp804b UTSW 5 6,819,910 (GRCm39) missense probably benign
R6252:Zfp804b UTSW 5 6,819,478 (GRCm39) missense probably damaging 0.99
R6283:Zfp804b UTSW 5 6,819,908 (GRCm39) missense probably benign 0.01
R6346:Zfp804b UTSW 5 6,820,534 (GRCm39) missense probably benign
R6714:Zfp804b UTSW 5 6,819,239 (GRCm39) missense probably benign 0.00
R6924:Zfp804b UTSW 5 6,819,902 (GRCm39) missense probably benign 0.09
R6966:Zfp804b UTSW 5 6,821,615 (GRCm39) missense probably damaging 1.00
R7027:Zfp804b UTSW 5 6,820,372 (GRCm39) missense probably benign
R7042:Zfp804b UTSW 5 6,820,042 (GRCm39) missense probably benign 0.00
R7076:Zfp804b UTSW 5 6,819,751 (GRCm39) missense probably benign 0.02
R7099:Zfp804b UTSW 5 6,822,161 (GRCm39) missense probably benign 0.37
R7574:Zfp804b UTSW 5 6,822,301 (GRCm39) missense possibly damaging 0.74
R7609:Zfp804b UTSW 5 6,820,066 (GRCm39) missense possibly damaging 0.90
R7654:Zfp804b UTSW 5 6,819,458 (GRCm39) missense probably damaging 0.97
R7669:Zfp804b UTSW 5 6,819,362 (GRCm39) missense probably damaging 1.00
R7717:Zfp804b UTSW 5 6,821,293 (GRCm39) missense possibly damaging 0.50
R7721:Zfp804b UTSW 5 6,821,263 (GRCm39) missense possibly damaging 0.55
R7830:Zfp804b UTSW 5 6,821,124 (GRCm39) missense probably benign
R7937:Zfp804b UTSW 5 6,821,866 (GRCm39) missense possibly damaging 0.49
R7941:Zfp804b UTSW 5 6,820,042 (GRCm39) missense probably benign 0.00
R8093:Zfp804b UTSW 5 6,820,082 (GRCm39) missense probably benign 0.02
R8275:Zfp804b UTSW 5 6,822,289 (GRCm39) missense probably benign 0.00
R8714:Zfp804b UTSW 5 6,822,378 (GRCm39) nonsense probably null
R8788:Zfp804b UTSW 5 6,822,635 (GRCm39) missense probably benign 0.00
R9206:Zfp804b UTSW 5 6,822,154 (GRCm39) missense probably benign 0.37
R9223:Zfp804b UTSW 5 6,821,496 (GRCm39) missense probably benign 0.02
R9276:Zfp804b UTSW 5 6,821,398 (GRCm39) missense probably damaging 0.96
R9285:Zfp804b UTSW 5 6,820,723 (GRCm39) missense probably benign 0.02
R9534:Zfp804b UTSW 5 6,819,115 (GRCm39) missense probably damaging 1.00
X0027:Zfp804b UTSW 5 6,821,257 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AACTGTTGCATCTGGCTGG -3'
(R):5'- TGTGCAGACAGTTCCAGTG -3'

Sequencing Primer
(F):5'- CAAGAGTGATGGTAAAGATCTTGAC -3'
(R):5'- GACAGTTCCAGTGCACCAG -3'
Posted On 2018-06-06