Incidental Mutation 'IGL01124:Trpm2'
ID 52133
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trpm2
Ensembl Gene ENSMUSG00000009292
Gene Name transient receptor potential cation channel, subfamily M, member 2
Synonyms LTRPC2, 9830168K16Rik, TRPC7, Trrp7
Accession Numbers
Essential gene? Probably non essential (E-score: 0.172) question?
Stock # IGL01124
Quality Score
Status
Chromosome 10
Chromosomal Location 77907722-77970563 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 77945825 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000101040 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105401]
AlphaFold Q91YD4
Predicted Effect noncoding transcript
Transcript: ENSMUST00000105400
Predicted Effect probably benign
Transcript: ENSMUST00000105401
SMART Domains Protein: ENSMUSP00000101040
Gene: ENSMUSG00000009292

DomainStartEndE-ValueType
low complexity region 654 672 N/A INTRINSIC
transmembrane domain 750 772 N/A INTRINSIC
Pfam:Ion_trans 794 1057 3.7e-21 PFAM
low complexity region 1078 1090 N/A INTRINSIC
low complexity region 1106 1115 N/A INTRINSIC
low complexity region 1123 1146 N/A INTRINSIC
PDB:1QVJ|A 1236 1506 3e-37 PDB
SCOP:d1k2ea_ 1369 1502 9e-10 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a knock-out allele display impaired reactive oxygen species (ROS)-induced chemokine production in monocytes, and reduced neutrophil infiltration and ulceration in a dextran sulfate sodium-induced colitis inflammation model. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ascc3 T C 10: 50,732,473 (GRCm38) I1477T probably damaging Het
Baat A G 4: 49,490,391 (GRCm38) I231T possibly damaging Het
Cactin T C 10: 81,324,350 (GRCm38) S426P possibly damaging Het
Cfh A T 1: 140,183,261 (GRCm38) F6I probably benign Het
Clec4a2 C T 6: 123,139,078 (GRCm38) probably benign Het
Col12a1 A G 9: 79,703,847 (GRCm38) S148P probably damaging Het
Cubn G T 2: 13,478,093 (GRCm38) Q281K possibly damaging Het
Cyp2c65 T A 19: 39,093,510 (GRCm38) probably benign Het
Dennd4b A T 3: 90,269,074 (GRCm38) T243S possibly damaging Het
Epha8 C T 4: 136,936,083 (GRCm38) G518D probably damaging Het
Fmo3 G A 1: 162,958,261 (GRCm38) R387C probably damaging Het
Foxo6 T C 4: 120,269,152 (GRCm38) T149A probably benign Het
Fthl17d T C X: 8,986,588 (GRCm38) E3G probably benign Het
Gm10521 A G 1: 171,896,443 (GRCm38) Y107C unknown Het
Ipo8 T A 6: 148,777,376 (GRCm38) E908V probably benign Het
Kcnd2 T C 6: 21,217,217 (GRCm38) S307P probably damaging Het
Klf3 A G 5: 64,816,780 (GRCm38) M3V possibly damaging Het
Ldb3 T A 14: 34,544,200 (GRCm38) E417D probably damaging Het
Lrch1 A T 14: 74,757,063 (GRCm38) D673E probably benign Het
Map3k4 T C 17: 12,255,200 (GRCm38) K865E probably benign Het
Muc4 G A 16: 32,768,730 (GRCm38) V754I possibly damaging Het
Nek4 A G 14: 30,970,262 (GRCm38) N223D probably benign Het
Nell2 G A 15: 95,296,179 (GRCm38) T551M probably damaging Het
Nup155 T A 15: 8,153,679 (GRCm38) M1241K probably damaging Het
Olfr152 T C 2: 87,783,376 (GRCm38) F279L probably benign Het
Olfr331 A T 11: 58,502,194 (GRCm38) S121T possibly damaging Het
Orc1 T C 4: 108,588,787 (GRCm38) probably benign Het
Pclo T C 5: 14,714,329 (GRCm38) I4272T unknown Het
Ppp1r12c A G 7: 4,497,345 (GRCm38) probably benign Het
Prcp A G 7: 92,910,208 (GRCm38) E160G probably benign Het
Prl3d3 G A 13: 27,159,107 (GRCm38) R92Q possibly damaging Het
Prl6a1 T A 13: 27,316,364 (GRCm38) M106K possibly damaging Het
Slc22a1 T A 17: 12,650,862 (GRCm38) probably benign Het
Slco3a1 A G 7: 74,284,547 (GRCm38) Y626H probably damaging Het
Smtn A G 11: 3,526,326 (GRCm38) probably null Het
Snx30 T C 4: 59,886,404 (GRCm38) probably benign Het
Spock2 A G 10: 60,131,387 (GRCm38) D393G unknown Het
Trem3 T G 17: 48,249,801 (GRCm38) L100R probably damaging Het
Ubr1 T C 2: 120,914,905 (GRCm38) M901V probably benign Het
Usp28 T A 9: 49,037,213 (GRCm38) S873T probably damaging Het
Vmn1r86 T C 7: 13,102,929 (GRCm38) I7V probably benign Het
Xirp2 T C 2: 67,508,615 (GRCm38) L400P probably damaging Het
Other mutations in Trpm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00730:Trpm2 APN 10 77,942,915 (GRCm38) splice site probably null
IGL00773:Trpm2 APN 10 77,949,214 (GRCm38) nonsense probably null
IGL00962:Trpm2 APN 10 77,943,916 (GRCm38) splice site probably benign
IGL01093:Trpm2 APN 10 77,932,280 (GRCm38) missense probably benign 0.04
IGL01301:Trpm2 APN 10 77,923,984 (GRCm38) missense probably damaging 1.00
IGL02094:Trpm2 APN 10 77,942,996 (GRCm38) nonsense probably null
IGL02175:Trpm2 APN 10 77,937,907 (GRCm38) missense probably benign 0.07
IGL02653:Trpm2 APN 10 77,912,669 (GRCm38) missense probably benign 0.19
IGL02667:Trpm2 APN 10 77,935,942 (GRCm38) missense probably damaging 1.00
IGL02668:Trpm2 APN 10 77,935,942 (GRCm38) missense probably damaging 1.00
IGL02828:Trpm2 APN 10 77,918,986 (GRCm38) missense probably benign 0.16
IGL02951:Trpm2 APN 10 77,929,278 (GRCm38) missense possibly damaging 0.95
IGL03188:Trpm2 APN 10 77,918,909 (GRCm38) missense probably benign 0.18
IGL03242:Trpm2 APN 10 77,917,734 (GRCm38) missense probably benign
IGL03405:Trpm2 APN 10 77,966,072 (GRCm38) splice site probably benign
Fugit UTSW 10 77,938,368 (GRCm38) missense probably damaging 1.00
scusate UTSW 10 77,966,994 (GRCm38) nonsense probably null
temporal UTSW 10 77,925,682 (GRCm38) missense probably benign 0.30
ANU18:Trpm2 UTSW 10 77,923,984 (GRCm38) missense probably damaging 1.00
R0147:Trpm2 UTSW 10 77,925,825 (GRCm38) missense probably damaging 1.00
R0148:Trpm2 UTSW 10 77,925,825 (GRCm38) missense probably damaging 1.00
R0302:Trpm2 UTSW 10 77,943,990 (GRCm38) splice site probably benign
R0332:Trpm2 UTSW 10 77,947,988 (GRCm38) missense probably damaging 1.00
R0586:Trpm2 UTSW 10 77,923,516 (GRCm38) missense probably damaging 0.99
R0847:Trpm2 UTSW 10 77,929,288 (GRCm38) missense possibly damaging 0.94
R1183:Trpm2 UTSW 10 77,923,564 (GRCm38) missense probably damaging 1.00
R1472:Trpm2 UTSW 10 77,966,007 (GRCm38) missense probably damaging 1.00
R1510:Trpm2 UTSW 10 77,966,994 (GRCm38) nonsense probably null
R1518:Trpm2 UTSW 10 77,943,005 (GRCm38) missense possibly damaging 0.67
R1564:Trpm2 UTSW 10 77,942,999 (GRCm38) missense probably benign 0.14
R1593:Trpm2 UTSW 10 77,943,076 (GRCm38) missense possibly damaging 0.71
R1617:Trpm2 UTSW 10 77,935,875 (GRCm38) splice site probably null
R1673:Trpm2 UTSW 10 77,942,944 (GRCm38) missense probably benign
R1912:Trpm2 UTSW 10 77,945,876 (GRCm38) missense probably benign 0.10
R1932:Trpm2 UTSW 10 77,941,158 (GRCm38) missense probably damaging 1.00
R1993:Trpm2 UTSW 10 77,947,989 (GRCm38) missense probably damaging 1.00
R2013:Trpm2 UTSW 10 77,925,766 (GRCm38) missense probably damaging 1.00
R2151:Trpm2 UTSW 10 77,932,179 (GRCm38) missense probably benign 0.01
R2201:Trpm2 UTSW 10 77,920,471 (GRCm38) nonsense probably null
R2217:Trpm2 UTSW 10 77,941,182 (GRCm38) missense probably damaging 1.00
R2312:Trpm2 UTSW 10 77,918,964 (GRCm38) missense probably benign 0.04
R2339:Trpm2 UTSW 10 77,914,806 (GRCm38) splice site probably benign
R2395:Trpm2 UTSW 10 77,947,880 (GRCm38) missense possibly damaging 0.69
R2396:Trpm2 UTSW 10 77,930,637 (GRCm38) missense probably benign 0.14
R2405:Trpm2 UTSW 10 77,934,724 (GRCm38) missense probably damaging 1.00
R2567:Trpm2 UTSW 10 77,941,174 (GRCm38) missense probably damaging 0.99
R3001:Trpm2 UTSW 10 77,930,534 (GRCm38) critical splice donor site probably null
R3002:Trpm2 UTSW 10 77,930,534 (GRCm38) critical splice donor site probably null
R3125:Trpm2 UTSW 10 77,911,374 (GRCm38) missense probably damaging 1.00
R3500:Trpm2 UTSW 10 77,932,302 (GRCm38) missense probably benign 0.03
R3777:Trpm2 UTSW 10 77,935,990 (GRCm38) missense probably benign 0.13
R3778:Trpm2 UTSW 10 77,935,990 (GRCm38) missense probably benign 0.13
R4272:Trpm2 UTSW 10 77,933,642 (GRCm38) missense probably damaging 1.00
R4384:Trpm2 UTSW 10 77,917,725 (GRCm38) missense probably benign 0.44
R4395:Trpm2 UTSW 10 77,929,219 (GRCm38) missense probably benign 0.01
R4423:Trpm2 UTSW 10 77,935,068 (GRCm38) missense probably benign 0.00
R4452:Trpm2 UTSW 10 77,923,593 (GRCm38) missense probably damaging 1.00
R4612:Trpm2 UTSW 10 77,945,916 (GRCm38) missense probably damaging 0.99
R4662:Trpm2 UTSW 10 77,938,138 (GRCm38) missense probably benign 0.05
R4825:Trpm2 UTSW 10 77,941,173 (GRCm38) missense probably damaging 0.98
R4906:Trpm2 UTSW 10 77,932,189 (GRCm38) nonsense probably null
R4943:Trpm2 UTSW 10 77,966,007 (GRCm38) missense probably damaging 1.00
R4948:Trpm2 UTSW 10 77,917,792 (GRCm38) missense probably benign 0.34
R5046:Trpm2 UTSW 10 77,966,018 (GRCm38) missense probably damaging 1.00
R5320:Trpm2 UTSW 10 77,923,521 (GRCm38) missense probably benign 0.06
R5523:Trpm2 UTSW 10 77,935,961 (GRCm38) missense probably benign 0.04
R5562:Trpm2 UTSW 10 77,959,939 (GRCm38) missense possibly damaging 0.71
R5623:Trpm2 UTSW 10 77,932,139 (GRCm38) missense probably damaging 0.96
R5628:Trpm2 UTSW 10 77,912,636 (GRCm38) missense probably benign 0.00
R5633:Trpm2 UTSW 10 77,938,353 (GRCm38) missense possibly damaging 0.71
R5817:Trpm2 UTSW 10 77,965,980 (GRCm38) missense probably damaging 1.00
R5989:Trpm2 UTSW 10 77,959,900 (GRCm38) missense probably damaging 1.00
R6018:Trpm2 UTSW 10 77,917,713 (GRCm38) missense probably benign 0.00
R6075:Trpm2 UTSW 10 77,935,043 (GRCm38) critical splice donor site probably null
R6092:Trpm2 UTSW 10 77,925,682 (GRCm38) missense probably benign 0.30
R6309:Trpm2 UTSW 10 77,938,368 (GRCm38) missense probably damaging 1.00
R6327:Trpm2 UTSW 10 77,932,227 (GRCm38) missense probably damaging 1.00
R6568:Trpm2 UTSW 10 77,937,826 (GRCm38) missense probably benign 0.01
R6579:Trpm2 UTSW 10 77,937,826 (GRCm38) missense probably benign 0.01
R6640:Trpm2 UTSW 10 77,937,826 (GRCm38) missense probably benign 0.01
R6642:Trpm2 UTSW 10 77,937,826 (GRCm38) missense probably benign 0.01
R6798:Trpm2 UTSW 10 77,914,740 (GRCm38) missense probably damaging 0.99
R6999:Trpm2 UTSW 10 77,935,891 (GRCm38) missense probably damaging 1.00
R7034:Trpm2 UTSW 10 77,912,592 (GRCm38) missense probably benign
R7036:Trpm2 UTSW 10 77,912,592 (GRCm38) missense probably benign
R7113:Trpm2 UTSW 10 77,947,931 (GRCm38) missense probably damaging 0.96
R7171:Trpm2 UTSW 10 77,924,014 (GRCm38) missense probably damaging 1.00
R7240:Trpm2 UTSW 10 77,935,876 (GRCm38) critical splice donor site probably null
R7274:Trpm2 UTSW 10 77,923,555 (GRCm38) missense probably benign 0.00
R7379:Trpm2 UTSW 10 77,914,734 (GRCm38) missense probably benign
R7527:Trpm2 UTSW 10 77,966,060 (GRCm38) missense probably benign 0.01
R7571:Trpm2 UTSW 10 77,937,950 (GRCm38) missense probably benign 0.21
R7600:Trpm2 UTSW 10 77,938,051 (GRCm38) missense probably benign 0.02
R7727:Trpm2 UTSW 10 77,925,789 (GRCm38) missense probably benign 0.34
R7771:Trpm2 UTSW 10 77,932,179 (GRCm38) missense probably benign 0.01
R7844:Trpm2 UTSW 10 77,923,506 (GRCm38) missense probably benign 0.00
R8158:Trpm2 UTSW 10 77,947,897 (GRCm38) missense probably damaging 0.99
R8225:Trpm2 UTSW 10 77,947,973 (GRCm38) missense probably damaging 1.00
R8226:Trpm2 UTSW 10 77,947,973 (GRCm38) missense probably damaging 1.00
R8239:Trpm2 UTSW 10 77,936,002 (GRCm38) missense probably benign 0.06
R8275:Trpm2 UTSW 10 77,966,025 (GRCm38) nonsense probably null
R8340:Trpm2 UTSW 10 77,923,624 (GRCm38) nonsense probably null
R8354:Trpm2 UTSW 10 77,933,649 (GRCm38) missense probably damaging 1.00
R8427:Trpm2 UTSW 10 77,911,402 (GRCm38) missense possibly damaging 0.93
R8445:Trpm2 UTSW 10 77,910,252 (GRCm38) missense probably damaging 1.00
R8769:Trpm2 UTSW 10 77,932,294 (GRCm38) missense probably benign 0.00
R9144:Trpm2 UTSW 10 77,929,288 (GRCm38) missense probably benign 0.01
R9286:Trpm2 UTSW 10 77,941,180 (GRCm38) missense probably benign 0.06
R9319:Trpm2 UTSW 10 77,949,198 (GRCm38) missense probably damaging 1.00
R9319:Trpm2 UTSW 10 77,942,942 (GRCm38) nonsense probably null
R9381:Trpm2 UTSW 10 77,911,357 (GRCm38) missense possibly damaging 0.90
R9457:Trpm2 UTSW 10 77,911,392 (GRCm38) missense possibly damaging 0.82
R9477:Trpm2 UTSW 10 77,911,390 (GRCm38) missense probably benign 0.12
R9547:Trpm2 UTSW 10 77,912,633 (GRCm38) missense probably benign 0.33
R9660:Trpm2 UTSW 10 77,930,555 (GRCm38) missense probably benign 0.00
R9663:Trpm2 UTSW 10 77,920,486 (GRCm38) missense probably benign 0.01
Z1177:Trpm2 UTSW 10 77,937,868 (GRCm38) missense possibly damaging 0.94
Posted On 2013-06-21