Incidental Mutation 'IGL01128:Rexo1'
| ID |
52139 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Rexo1
|
| Ensembl Gene |
ENSMUSG00000047417 |
| Gene Name |
REX1, RNA exonuclease 1 |
| Synonyms |
Rex1, Tceb3bp1, 2610511M11Rik, 1700021P10Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.413)
|
| Stock # |
IGL01128
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
80376756-80397394 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 80385573 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 495
(D495G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000049705
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057910]
|
| AlphaFold |
Q7TT28 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057910
AA Change: D495G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000049705
Gene: ENSMUSG00000047417
AA Change: D495G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
53 |
N/A |
INTRINSIC |
|
coiled coil region
|
83 |
113 |
N/A |
INTRINSIC |
|
low complexity region
|
180 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
381 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
396 |
N/A |
INTRINSIC |
|
low complexity region
|
440 |
453 |
N/A |
INTRINSIC |
|
low complexity region
|
468 |
479 |
N/A |
INTRINSIC |
|
low complexity region
|
507 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
533 |
551 |
N/A |
INTRINSIC |
|
low complexity region
|
561 |
583 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
682 |
N/A |
INTRINSIC |
|
Pfam:EloA-BP1
|
794 |
954 |
3.8e-72 |
PFAM |
|
EXOIII
|
1051 |
1210 |
2.36e-38 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182260
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000182604
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000182682
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183073
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183139
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183233
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110038F14Rik |
G |
A |
15: 76,834,475 (GRCm39) |
V124I |
probably damaging |
Het |
| Adgrf5 |
G |
T |
17: 43,733,400 (GRCm39) |
D75Y |
possibly damaging |
Het |
| Aen |
G |
A |
7: 78,557,050 (GRCm39) |
M299I |
probably damaging |
Het |
| Ahi1 |
A |
G |
10: 20,950,332 (GRCm39) |
T128A |
probably benign |
Het |
| Bves |
T |
A |
10: 45,229,944 (GRCm39) |
F249L |
probably damaging |
Het |
| Capns1 |
T |
C |
7: 29,889,558 (GRCm39) |
I214V |
probably benign |
Het |
| Cgnl1 |
G |
T |
9: 71,631,843 (GRCm39) |
Q503K |
possibly damaging |
Het |
| Ep300 |
A |
G |
15: 81,514,207 (GRCm39) |
|
probably benign |
Het |
| Fam117b |
T |
A |
1: 60,008,177 (GRCm39) |
F337Y |
probably damaging |
Het |
| Fam178b |
A |
T |
1: 36,683,435 (GRCm39) |
V95E |
probably damaging |
Het |
| Gak |
T |
A |
5: 108,740,236 (GRCm39) |
M560L |
probably damaging |
Het |
| Gna11 |
C |
A |
10: 81,366,718 (GRCm39) |
A331S |
probably damaging |
Het |
| Gtf3c3 |
A |
C |
1: 54,468,035 (GRCm39) |
F201V |
possibly damaging |
Het |
| Kat6b |
G |
A |
14: 21,710,928 (GRCm39) |
R734H |
probably benign |
Het |
| Lag3 |
T |
C |
6: 124,886,380 (GRCm39) |
D191G |
probably damaging |
Het |
| Mttp |
T |
A |
3: 137,839,758 (GRCm39) |
|
probably null |
Het |
| Nlgn3 |
A |
T |
X: 100,363,698 (GRCm39) |
T790S |
probably benign |
Het |
| Or11g27 |
A |
G |
14: 50,771,406 (GRCm39) |
D179G |
probably damaging |
Het |
| Or5b123 |
G |
A |
19: 13,597,110 (GRCm39) |
E195K |
probably damaging |
Het |
| Pkd2l2 |
T |
A |
18: 34,550,068 (GRCm39) |
Y238N |
probably damaging |
Het |
| Plg |
A |
T |
17: 12,615,586 (GRCm39) |
|
probably benign |
Het |
| Ptprm |
A |
T |
17: 67,349,096 (GRCm39) |
C376S |
probably damaging |
Het |
| Rims1 |
A |
T |
1: 22,573,256 (GRCm39) |
V315D |
probably damaging |
Het |
| Ros1 |
G |
A |
10: 52,018,424 (GRCm39) |
Q745* |
probably null |
Het |
| Satb1 |
A |
G |
17: 52,112,317 (GRCm39) |
V99A |
probably damaging |
Het |
| Sema3e |
C |
T |
5: 14,282,129 (GRCm39) |
P422S |
probably damaging |
Het |
| Stkld1 |
G |
T |
2: 26,841,483 (GRCm39) |
W476L |
probably benign |
Het |
| Syna |
T |
C |
5: 134,588,334 (GRCm39) |
D205G |
probably damaging |
Het |
| Tas2r134 |
G |
T |
2: 51,517,671 (GRCm39) |
C50F |
probably damaging |
Het |
| Togaram1 |
A |
G |
12: 65,027,650 (GRCm39) |
T880A |
probably benign |
Het |
| Uckl1 |
T |
C |
2: 181,212,130 (GRCm39) |
E363G |
probably damaging |
Het |
| Yeats2 |
T |
A |
16: 19,980,718 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Rexo1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00970:Rexo1
|
APN |
10 |
80,386,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01890:Rexo1
|
APN |
10 |
80,378,845 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
PIT4453001:Rexo1
|
UTSW |
10 |
80,386,231 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0044:Rexo1
|
UTSW |
10 |
80,380,212 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0365:Rexo1
|
UTSW |
10 |
80,378,410 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0573:Rexo1
|
UTSW |
10 |
80,380,684 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1146:Rexo1
|
UTSW |
10 |
80,380,239 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1146:Rexo1
|
UTSW |
10 |
80,380,239 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1511:Rexo1
|
UTSW |
10 |
80,385,884 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1523:Rexo1
|
UTSW |
10 |
80,378,585 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1807:Rexo1
|
UTSW |
10 |
80,378,413 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1868:Rexo1
|
UTSW |
10 |
80,378,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1935:Rexo1
|
UTSW |
10 |
80,386,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1936:Rexo1
|
UTSW |
10 |
80,386,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1957:Rexo1
|
UTSW |
10 |
80,379,200 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2084:Rexo1
|
UTSW |
10 |
80,397,100 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2153:Rexo1
|
UTSW |
10 |
80,379,943 (GRCm39) |
nonsense |
probably null |
|
|
R2262:Rexo1
|
UTSW |
10 |
80,385,403 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4471:Rexo1
|
UTSW |
10 |
80,378,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Rexo1
|
UTSW |
10 |
80,378,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4690:Rexo1
|
UTSW |
10 |
80,382,255 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4972:Rexo1
|
UTSW |
10 |
80,385,527 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6335:Rexo1
|
UTSW |
10 |
80,379,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6505:Rexo1
|
UTSW |
10 |
80,378,845 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6615:Rexo1
|
UTSW |
10 |
80,379,848 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6949:Rexo1
|
UTSW |
10 |
80,386,470 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7612:Rexo1
|
UTSW |
10 |
80,385,497 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7807:Rexo1
|
UTSW |
10 |
80,385,970 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7840:Rexo1
|
UTSW |
10 |
80,386,572 (GRCm39) |
missense |
probably benign |
|
|
R8779:Rexo1
|
UTSW |
10 |
80,384,292 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8897:Rexo1
|
UTSW |
10 |
80,378,437 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8995:Rexo1
|
UTSW |
10 |
80,386,095 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9094:Rexo1
|
UTSW |
10 |
80,378,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9411:Rexo1
|
UTSW |
10 |
80,397,248 (GRCm39) |
missense |
|
|
|
R9438:Rexo1
|
UTSW |
10 |
80,378,848 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9524:Rexo1
|
UTSW |
10 |
80,386,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9648:Rexo1
|
UTSW |
10 |
80,385,540 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1177:Rexo1
|
UTSW |
10 |
80,385,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-06-21 |
Incidental Mutation