Incidental Mutation 'R6523:Fbxw24'
ID 521508
Institutional Source Beutler Lab
Gene Symbol Fbxw24
Ensembl Gene ENSMUSG00000062275
Gene Name F-box and WD-40 domain protein 24
Synonyms Gm5162
MMRRC Submission 044649-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R6523 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 109430184-109455125 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 109434048 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 421 (R421*)
Ref Sequence ENSEMBL: ENSMUSP00000073617 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073962]
AlphaFold E9PXM9
Predicted Effect probably null
Transcript: ENSMUST00000073962
AA Change: R421*
SMART Domains Protein: ENSMUSP00000073617
Gene: ENSMUSG00000062275
AA Change: R421*

DomainStartEndE-ValueType
FBOX 8 45 3.25e-4 SMART
SCOP:d1gxra_ 87 227 8e-7 SMART
Blast:WD40 137 176 1e-6 BLAST
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.3%
Validation Efficiency 97% (68/70)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ackr1 A G 1: 173,160,120 (GRCm39) probably null Het
Alg2 A T 4: 47,472,071 (GRCm39) S246T possibly damaging Het
Ankfy1 G A 11: 72,621,308 (GRCm39) R198Q possibly damaging Het
Arid4a A G 12: 71,114,115 (GRCm39) probably null Het
AU040320 G A 4: 126,762,553 (GRCm39) probably null Het
B430306N03Rik A G 17: 48,626,193 (GRCm39) T129A possibly damaging Het
Blvrb C A 7: 27,165,142 (GRCm39) probably null Het
Ccdc175 T C 12: 72,191,565 (GRCm39) N337S probably benign Het
Ccdc28b A C 4: 129,514,780 (GRCm39) F110V probably damaging Het
Cd200 A G 16: 45,220,633 (GRCm39) Y16H probably benign Het
Cfh T G 1: 140,029,445 (GRCm39) E950A possibly damaging Het
Clec3a A T 8: 115,152,345 (GRCm39) Y117F probably damaging Het
CN725425 A G 15: 91,115,784 (GRCm39) S9G probably benign Het
Coasy T A 11: 100,976,944 (GRCm39) W535R probably damaging Het
Cox4i1 T A 8: 121,399,480 (GRCm39) S30R probably benign Het
Csnk1a1 G A 18: 61,688,829 (GRCm39) S3N probably benign Het
Dcst2 C G 3: 89,280,808 (GRCm39) L669V probably benign Het
Dnah14 A G 1: 181,471,186 (GRCm39) I1346V probably benign Het
Fstl5 G A 3: 76,443,641 (GRCm39) V329I probably benign Het
Gli3 T C 13: 15,888,235 (GRCm39) probably null Het
Gna11 A T 10: 81,380,688 (GRCm39) I25N probably damaging Het
Greb1 C T 12: 16,734,374 (GRCm39) V1539I possibly damaging Het
Hipk3 T A 2: 104,269,753 (GRCm39) T479S possibly damaging Het
Hspa1b A G 17: 35,176,167 (GRCm39) I606T probably benign Het
Idnk T A 13: 58,311,457 (GRCm39) F141L probably damaging Het
Ifit3 A G 19: 34,565,555 (GRCm39) N367S probably benign Het
Kcnn1 A T 8: 71,299,169 (GRCm39) D448E possibly damaging Het
Krt14 T C 11: 100,095,923 (GRCm39) T212A possibly damaging Het
Ldlr G A 9: 21,648,549 (GRCm39) C285Y probably damaging Het
Mark3 G A 12: 111,593,669 (GRCm39) V234I probably damaging Het
Meikin T A 11: 54,289,327 (GRCm39) Y233* probably null Het
Mtcl2 G A 2: 156,902,263 (GRCm39) Q251* probably null Het
Muc20 T C 16: 32,613,820 (GRCm39) D519G possibly damaging Het
Nalcn T A 14: 123,555,255 (GRCm39) H876L probably benign Het
Ncaph A T 2: 126,947,809 (GRCm39) I698K probably damaging Het
Nipal1 A T 5: 72,824,951 (GRCm39) I215F probably damaging Het
Nrde2 A T 12: 100,100,664 (GRCm39) D607E possibly damaging Het
Nt5dc2 T C 14: 30,857,662 (GRCm39) F217S probably damaging Het
Ntsr2 T A 12: 16,706,697 (GRCm39) S156T probably benign Het
Or13c9 A T 4: 52,935,500 (GRCm39) I261N probably damaging Het
Or5b110-ps1 A C 19: 13,259,728 (GRCm39) D231E probably benign Het
Or5p4 A C 7: 107,680,762 (GRCm39) T254P probably benign Het
Pfas A T 11: 68,881,283 (GRCm39) I1028K probably benign Het
Pnpla5 C A 15: 83,999,912 (GRCm39) R329L possibly damaging Het
Pramel30 T C 4: 144,058,218 (GRCm39) V275A probably benign Het
Rhot2 A G 17: 26,058,394 (GRCm39) V393A possibly damaging Het
Rigi T A 4: 40,205,947 (GRCm39) T882S probably benign Het
Rnase9 T A 14: 51,276,684 (GRCm39) Y98F possibly damaging Het
Sacs C A 14: 61,440,410 (GRCm39) L819I probably damaging Het
Sall3 C T 18: 81,016,403 (GRCm39) M508I possibly damaging Het
Scube3 G A 17: 28,381,362 (GRCm39) C301Y probably damaging Het
Sgo2b G T 8: 64,380,538 (GRCm39) H765N probably benign Het
Sh3gl1 A T 17: 56,324,617 (GRCm39) Y344N possibly damaging Het
Slc15a2 A G 16: 36,572,683 (GRCm39) V635A probably benign Het
Slc1a4 T A 11: 20,282,114 (GRCm39) Y40F probably damaging Het
Slc4a10 A T 2: 62,117,305 (GRCm39) K755* probably null Het
Slco1a5 C T 6: 142,212,121 (GRCm39) G38R probably damaging Het
Snx25 T A 8: 46,508,892 (GRCm39) D564V probably damaging Het
Spon1 T A 7: 113,486,018 (GRCm39) D189E probably benign Het
Sptbn5 T C 2: 119,896,095 (GRCm39) probably null Het
Ssbp2 A G 13: 91,841,170 (GRCm39) I317V probably benign Het
Stil AAGATTTCCAG A 4: 114,889,911 (GRCm39) probably null Het
Strn3 A T 12: 51,689,881 (GRCm39) probably null Het
Tcaf2 A T 6: 42,619,953 (GRCm39) F25I probably benign Het
Themis C T 10: 28,657,894 (GRCm39) T154I possibly damaging Het
Ttn T C 2: 76,626,390 (GRCm39) R13176G probably damaging Het
Utp4 G A 8: 107,625,095 (GRCm39) V125M probably damaging Het
Vmn1r119 T A 7: 20,745,777 (GRCm39) M202L possibly damaging Het
Zfp292 G C 4: 34,816,301 (GRCm39) F329L probably benign Het
Zfp541 C T 7: 15,829,445 (GRCm39) P1281L probably damaging Het
Zfp616 A T 11: 73,973,968 (GRCm39) Q79L possibly damaging Het
Other mutations in Fbxw24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01093:Fbxw24 APN 9 109,434,041 (GRCm39) missense probably benign 0.00
IGL01373:Fbxw24 APN 9 109,452,701 (GRCm39) missense probably damaging 0.98
IGL01996:Fbxw24 APN 9 109,434,440 (GRCm39) missense possibly damaging 0.84
IGL02179:Fbxw24 APN 9 109,438,973 (GRCm39) nonsense probably null
IGL02718:Fbxw24 APN 9 109,453,858 (GRCm39) missense possibly damaging 0.55
IGL02936:Fbxw24 APN 9 109,454,026 (GRCm39) splice site probably null
IGL03010:Fbxw24 APN 9 109,452,678 (GRCm39) missense probably benign 0.07
IGL03350:Fbxw24 APN 9 109,436,081 (GRCm39) missense probably damaging 1.00
IGL03402:Fbxw24 APN 9 109,430,316 (GRCm39) missense probably damaging 1.00
R0140:Fbxw24 UTSW 9 109,434,482 (GRCm39) missense possibly damaging 0.73
R0718:Fbxw24 UTSW 9 109,452,577 (GRCm39) splice site probably benign
R1166:Fbxw24 UTSW 9 109,436,066 (GRCm39) missense probably benign 0.00
R1550:Fbxw24 UTSW 9 109,436,112 (GRCm39) missense probably benign 0.00
R1950:Fbxw24 UTSW 9 109,434,481 (GRCm39) missense probably benign 0.02
R1986:Fbxw24 UTSW 9 109,436,124 (GRCm39) missense probably damaging 0.97
R2244:Fbxw24 UTSW 9 109,434,117 (GRCm39) missense possibly damaging 0.66
R3683:Fbxw24 UTSW 9 109,437,110 (GRCm39) missense possibly damaging 0.51
R4324:Fbxw24 UTSW 9 109,434,013 (GRCm39) critical splice donor site probably null
R4387:Fbxw24 UTSW 9 109,439,053 (GRCm39) missense probably damaging 1.00
R4409:Fbxw24 UTSW 9 109,437,256 (GRCm39) missense probably damaging 1.00
R4410:Fbxw24 UTSW 9 109,437,256 (GRCm39) missense probably damaging 1.00
R4803:Fbxw24 UTSW 9 109,453,910 (GRCm39) missense probably benign 0.02
R5571:Fbxw24 UTSW 9 109,436,066 (GRCm39) missense probably benign 0.00
R6042:Fbxw24 UTSW 9 109,436,079 (GRCm39) missense probably benign 0.09
R6799:Fbxw24 UTSW 9 109,453,998 (GRCm39) missense probably damaging 1.00
R7122:Fbxw24 UTSW 9 109,430,328 (GRCm39) missense probably benign 0.03
R7239:Fbxw24 UTSW 9 109,434,598 (GRCm39) missense possibly damaging 0.71
R7405:Fbxw24 UTSW 9 109,436,136 (GRCm39) missense possibly damaging 0.46
R7705:Fbxw24 UTSW 9 109,437,516 (GRCm39) splice site probably null
R8536:Fbxw24 UTSW 9 109,452,599 (GRCm39) missense probably damaging 1.00
R8873:Fbxw24 UTSW 9 109,453,996 (GRCm39) missense probably damaging 1.00
R9332:Fbxw24 UTSW 9 109,452,681 (GRCm39) missense probably damaging 1.00
R9430:Fbxw24 UTSW 9 109,439,038 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGCTGCCATGTGGATGCTAG -3'
(R):5'- ATCGTTTCTTCTCCAGTGGG -3'

Sequencing Primer
(F):5'- TGTGGATGCTAGGGATGGAACC -3'
(R):5'- TGAGCACTTTCAGAGTCCAG -3'
Posted On 2018-06-06