Incidental Mutation 'R6523:Zfp616'
ID 521522
Institutional Source Beutler Lab
Gene Symbol Zfp616
Ensembl Gene ENSMUSG00000069476
Gene Name zinc finger protein 616
Synonyms Gm12330
MMRRC Submission 044649-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6523 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 73960781-73978118 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 73973968 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 79 (Q79L)
Ref Sequence ENSEMBL: ENSMUSP00000136549 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074813] [ENSMUST00000108463] [ENSMUST00000116546] [ENSMUST00000178159]
AlphaFold J3QN14
Predicted Effect probably benign
Transcript: ENSMUST00000074813
SMART Domains Protein: ENSMUSP00000074365
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108463
AA Change: Q170L

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000104103
Gene: ENSMUSG00000069476
AA Change: Q170L

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
low complexity region 249 258 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116546
SMART Domains Protein: ENSMUSP00000112245
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137407
Predicted Effect possibly damaging
Transcript: ENSMUST00000178159
AA Change: Q79L

PolyPhen 2 Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000136549
Gene: ENSMUSG00000069476
AA Change: Q79L

DomainStartEndE-ValueType
internal_repeat_1 125 447 7.61e-6 PROSPERO
ZnF_C2H2 452 474 3.11e-2 SMART
ZnF_C2H2 509 531 2.61e-4 SMART
ZnF_C2H2 537 559 1.47e-3 SMART
ZnF_C2H2 565 587 5.21e-4 SMART
ZnF_C2H2 593 615 1.22e-4 SMART
ZnF_C2H2 621 643 2.57e-3 SMART
ZnF_C2H2 649 671 9.22e-5 SMART
ZnF_C2H2 677 699 5.9e-3 SMART
ZnF_C2H2 705 727 4.94e-5 SMART
ZnF_C2H2 733 755 8.34e-3 SMART
ZnF_C2H2 761 783 1.6e-4 SMART
ZnF_C2H2 789 811 6.88e-4 SMART
ZnF_C2H2 817 839 1.6e-4 SMART
ZnF_C2H2 845 867 1.3e-4 SMART
ZnF_C2H2 873 895 7.37e-4 SMART
ZnF_C2H2 901 923 1.6e-4 SMART
ZnF_C2H2 929 951 1.3e-4 SMART
ZnF_C2H2 957 979 3.95e-4 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.3%
Validation Efficiency 97% (68/70)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ackr1 A G 1: 173,160,120 (GRCm39) probably null Het
Alg2 A T 4: 47,472,071 (GRCm39) S246T possibly damaging Het
Ankfy1 G A 11: 72,621,308 (GRCm39) R198Q possibly damaging Het
Arid4a A G 12: 71,114,115 (GRCm39) probably null Het
AU040320 G A 4: 126,762,553 (GRCm39) probably null Het
B430306N03Rik A G 17: 48,626,193 (GRCm39) T129A possibly damaging Het
Blvrb C A 7: 27,165,142 (GRCm39) probably null Het
Ccdc175 T C 12: 72,191,565 (GRCm39) N337S probably benign Het
Ccdc28b A C 4: 129,514,780 (GRCm39) F110V probably damaging Het
Cd200 A G 16: 45,220,633 (GRCm39) Y16H probably benign Het
Cfh T G 1: 140,029,445 (GRCm39) E950A possibly damaging Het
Clec3a A T 8: 115,152,345 (GRCm39) Y117F probably damaging Het
CN725425 A G 15: 91,115,784 (GRCm39) S9G probably benign Het
Coasy T A 11: 100,976,944 (GRCm39) W535R probably damaging Het
Cox4i1 T A 8: 121,399,480 (GRCm39) S30R probably benign Het
Csnk1a1 G A 18: 61,688,829 (GRCm39) S3N probably benign Het
Dcst2 C G 3: 89,280,808 (GRCm39) L669V probably benign Het
Dnah14 A G 1: 181,471,186 (GRCm39) I1346V probably benign Het
Fbxw24 G A 9: 109,434,048 (GRCm39) R421* probably null Het
Fstl5 G A 3: 76,443,641 (GRCm39) V329I probably benign Het
Gli3 T C 13: 15,888,235 (GRCm39) probably null Het
Gna11 A T 10: 81,380,688 (GRCm39) I25N probably damaging Het
Greb1 C T 12: 16,734,374 (GRCm39) V1539I possibly damaging Het
Hipk3 T A 2: 104,269,753 (GRCm39) T479S possibly damaging Het
Hspa1b A G 17: 35,176,167 (GRCm39) I606T probably benign Het
Idnk T A 13: 58,311,457 (GRCm39) F141L probably damaging Het
Ifit3 A G 19: 34,565,555 (GRCm39) N367S probably benign Het
Kcnn1 A T 8: 71,299,169 (GRCm39) D448E possibly damaging Het
Krt14 T C 11: 100,095,923 (GRCm39) T212A possibly damaging Het
Ldlr G A 9: 21,648,549 (GRCm39) C285Y probably damaging Het
Mark3 G A 12: 111,593,669 (GRCm39) V234I probably damaging Het
Meikin T A 11: 54,289,327 (GRCm39) Y233* probably null Het
Mtcl2 G A 2: 156,902,263 (GRCm39) Q251* probably null Het
Muc20 T C 16: 32,613,820 (GRCm39) D519G possibly damaging Het
Nalcn T A 14: 123,555,255 (GRCm39) H876L probably benign Het
Ncaph A T 2: 126,947,809 (GRCm39) I698K probably damaging Het
Nipal1 A T 5: 72,824,951 (GRCm39) I215F probably damaging Het
Nrde2 A T 12: 100,100,664 (GRCm39) D607E possibly damaging Het
Nt5dc2 T C 14: 30,857,662 (GRCm39) F217S probably damaging Het
Ntsr2 T A 12: 16,706,697 (GRCm39) S156T probably benign Het
Or13c9 A T 4: 52,935,500 (GRCm39) I261N probably damaging Het
Or5b110-ps1 A C 19: 13,259,728 (GRCm39) D231E probably benign Het
Or5p4 A C 7: 107,680,762 (GRCm39) T254P probably benign Het
Pfas A T 11: 68,881,283 (GRCm39) I1028K probably benign Het
Pnpla5 C A 15: 83,999,912 (GRCm39) R329L possibly damaging Het
Pramel30 T C 4: 144,058,218 (GRCm39) V275A probably benign Het
Rhot2 A G 17: 26,058,394 (GRCm39) V393A possibly damaging Het
Rigi T A 4: 40,205,947 (GRCm39) T882S probably benign Het
Rnase9 T A 14: 51,276,684 (GRCm39) Y98F possibly damaging Het
Sacs C A 14: 61,440,410 (GRCm39) L819I probably damaging Het
Sall3 C T 18: 81,016,403 (GRCm39) M508I possibly damaging Het
Scube3 G A 17: 28,381,362 (GRCm39) C301Y probably damaging Het
Sgo2b G T 8: 64,380,538 (GRCm39) H765N probably benign Het
Sh3gl1 A T 17: 56,324,617 (GRCm39) Y344N possibly damaging Het
Slc15a2 A G 16: 36,572,683 (GRCm39) V635A probably benign Het
Slc1a4 T A 11: 20,282,114 (GRCm39) Y40F probably damaging Het
Slc4a10 A T 2: 62,117,305 (GRCm39) K755* probably null Het
Slco1a5 C T 6: 142,212,121 (GRCm39) G38R probably damaging Het
Snx25 T A 8: 46,508,892 (GRCm39) D564V probably damaging Het
Spon1 T A 7: 113,486,018 (GRCm39) D189E probably benign Het
Sptbn5 T C 2: 119,896,095 (GRCm39) probably null Het
Ssbp2 A G 13: 91,841,170 (GRCm39) I317V probably benign Het
Stil AAGATTTCCAG A 4: 114,889,911 (GRCm39) probably null Het
Strn3 A T 12: 51,689,881 (GRCm39) probably null Het
Tcaf2 A T 6: 42,619,953 (GRCm39) F25I probably benign Het
Themis C T 10: 28,657,894 (GRCm39) T154I possibly damaging Het
Ttn T C 2: 76,626,390 (GRCm39) R13176G probably damaging Het
Utp4 G A 8: 107,625,095 (GRCm39) V125M probably damaging Het
Vmn1r119 T A 7: 20,745,777 (GRCm39) M202L possibly damaging Het
Zfp292 G C 4: 34,816,301 (GRCm39) F329L probably benign Het
Zfp541 C T 7: 15,829,445 (GRCm39) P1281L probably damaging Het
Other mutations in Zfp616
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00530:Zfp616 APN 11 73,974,439 (GRCm39) missense probably damaging 0.98
IGL00570:Zfp616 APN 11 73,976,631 (GRCm39) missense probably benign 0.03
IGL00594:Zfp616 APN 11 73,973,789 (GRCm39) missense possibly damaging 0.72
IGL01861:Zfp616 APN 11 73,973,742 (GRCm39) missense possibly damaging 0.53
IGL03022:Zfp616 APN 11 73,973,800 (GRCm39) missense possibly damaging 0.85
R0197:Zfp616 UTSW 11 73,976,500 (GRCm39) missense probably damaging 1.00
R0442:Zfp616 UTSW 11 73,975,321 (GRCm39) missense possibly damaging 0.92
R0497:Zfp616 UTSW 11 73,974,306 (GRCm39) missense probably benign 0.00
R0651:Zfp616 UTSW 11 73,974,555 (GRCm39) nonsense probably null
R0730:Zfp616 UTSW 11 73,975,648 (GRCm39) missense probably damaging 1.00
R0883:Zfp616 UTSW 11 73,976,500 (GRCm39) missense probably damaging 1.00
R0926:Zfp616 UTSW 11 73,976,644 (GRCm39) missense probably benign 0.04
R0940:Zfp616 UTSW 11 73,975,850 (GRCm39) missense probably damaging 1.00
R1068:Zfp616 UTSW 11 73,973,767 (GRCm39) makesense probably null
R1272:Zfp616 UTSW 11 73,976,062 (GRCm39) missense probably benign 0.08
R1446:Zfp616 UTSW 11 73,974,064 (GRCm39) splice site probably null
R1482:Zfp616 UTSW 11 73,974,803 (GRCm39) missense possibly damaging 0.72
R1553:Zfp616 UTSW 11 73,974,744 (GRCm39) missense possibly damaging 0.53
R1564:Zfp616 UTSW 11 73,975,548 (GRCm39) missense probably damaging 1.00
R1728:Zfp616 UTSW 11 73,976,597 (GRCm39) missense probably damaging 0.99
R1796:Zfp616 UTSW 11 73,976,671 (GRCm39) missense probably damaging 0.98
R1797:Zfp616 UTSW 11 73,976,105 (GRCm39) nonsense probably null
R1993:Zfp616 UTSW 11 73,975,795 (GRCm39) missense probably benign 0.08
R2026:Zfp616 UTSW 11 73,974,413 (GRCm39) missense possibly damaging 0.86
R2124:Zfp616 UTSW 11 73,973,869 (GRCm39) splice site probably null
R2126:Zfp616 UTSW 11 73,976,229 (GRCm39) missense probably benign 0.08
R2199:Zfp616 UTSW 11 73,975,456 (GRCm39) missense possibly damaging 0.58
R2265:Zfp616 UTSW 11 73,976,289 (GRCm39) missense possibly damaging 0.89
R2404:Zfp616 UTSW 11 73,975,682 (GRCm39) missense probably damaging 1.00
R2508:Zfp616 UTSW 11 73,974,121 (GRCm39) missense probably benign 0.01
R2519:Zfp616 UTSW 11 73,975,094 (GRCm39) nonsense probably null
R3103:Zfp616 UTSW 11 73,962,561 (GRCm39) missense probably benign 0.01
R3611:Zfp616 UTSW 11 73,974,268 (GRCm39) missense possibly damaging 0.53
R3703:Zfp616 UTSW 11 73,974,145 (GRCm39) nonsense probably null
R3744:Zfp616 UTSW 11 73,974,813 (GRCm39) missense probably benign 0.01
R4043:Zfp616 UTSW 11 73,976,108 (GRCm39) missense possibly damaging 0.50
R4273:Zfp616 UTSW 11 73,974,526 (GRCm39) missense probably benign 0.00
R4384:Zfp616 UTSW 11 73,974,005 (GRCm39) missense possibly damaging 0.94
R4469:Zfp616 UTSW 11 73,961,950 (GRCm39) missense probably damaging 0.98
R4560:Zfp616 UTSW 11 73,973,860 (GRCm39) missense probably benign 0.00
R4821:Zfp616 UTSW 11 73,975,033 (GRCm39) missense probably benign 0.41
R4844:Zfp616 UTSW 11 73,975,225 (GRCm39) missense probably benign 0.10
R4948:Zfp616 UTSW 11 73,974,830 (GRCm39) missense possibly damaging 0.72
R5007:Zfp616 UTSW 11 73,974,643 (GRCm39) missense possibly damaging 0.96
R5198:Zfp616 UTSW 11 73,974,336 (GRCm39) missense probably benign 0.33
R5344:Zfp616 UTSW 11 73,975,321 (GRCm39) missense possibly damaging 0.92
R5918:Zfp616 UTSW 11 73,974,086 (GRCm39) missense possibly damaging 0.70
R5933:Zfp616 UTSW 11 73,973,952 (GRCm39) missense probably damaging 0.96
R6084:Zfp616 UTSW 11 73,974,672 (GRCm39) nonsense probably null
R6421:Zfp616 UTSW 11 73,974,696 (GRCm39) missense possibly damaging 0.53
R6494:Zfp616 UTSW 11 73,976,018 (GRCm39) missense probably damaging 1.00
R6849:Zfp616 UTSW 11 73,976,276 (GRCm39) missense possibly damaging 0.70
R6910:Zfp616 UTSW 11 73,975,828 (GRCm39) missense probably damaging 1.00
R7146:Zfp616 UTSW 11 73,976,087 (GRCm39) missense possibly damaging 0.61
R7213:Zfp616 UTSW 11 73,976,689 (GRCm39) missense probably benign 0.05
R7302:Zfp616 UTSW 11 73,976,205 (GRCm39) missense probably benign 0.08
R7391:Zfp616 UTSW 11 73,976,155 (GRCm39) missense probably benign 0.08
R7654:Zfp616 UTSW 11 73,974,013 (GRCm39) missense possibly damaging 0.53
R7877:Zfp616 UTSW 11 73,975,188 (GRCm39) missense probably damaging 1.00
R7889:Zfp616 UTSW 11 73,976,271 (GRCm39) missense probably damaging 1.00
R8022:Zfp616 UTSW 11 73,974,894 (GRCm39) missense probably benign
R8061:Zfp616 UTSW 11 73,974,340 (GRCm39) missense possibly damaging 0.96
R8212:Zfp616 UTSW 11 73,976,569 (GRCm39) missense probably damaging 0.96
R8335:Zfp616 UTSW 11 73,974,726 (GRCm39) nonsense probably null
R8361:Zfp616 UTSW 11 73,975,476 (GRCm39) missense probably damaging 0.98
R8486:Zfp616 UTSW 11 73,974,909 (GRCm39) missense probably benign 0.18
R8695:Zfp616 UTSW 11 73,975,710 (GRCm39) missense probably benign 0.45
R8808:Zfp616 UTSW 11 73,976,523 (GRCm39) missense probably damaging 1.00
R9022:Zfp616 UTSW 11 73,976,539 (GRCm39) missense probably damaging 1.00
R9126:Zfp616 UTSW 11 73,976,280 (GRCm39) missense probably damaging 1.00
R9164:Zfp616 UTSW 11 73,975,825 (GRCm39) missense probably damaging 1.00
R9293:Zfp616 UTSW 11 73,974,744 (GRCm39) missense possibly damaging 0.53
R9421:Zfp616 UTSW 11 73,974,331 (GRCm39) missense possibly damaging 0.72
R9512:Zfp616 UTSW 11 73,975,936 (GRCm39) missense probably damaging 1.00
R9529:Zfp616 UTSW 11 73,976,596 (GRCm39) missense possibly damaging 0.90
R9529:Zfp616 UTSW 11 73,975,660 (GRCm39) missense probably damaging 1.00
R9606:Zfp616 UTSW 11 73,976,220 (GRCm39) missense probably damaging 1.00
R9708:Zfp616 UTSW 11 73,976,283 (GRCm39) missense probably damaging 1.00
R9788:Zfp616 UTSW 11 73,975,276 (GRCm39) missense probably damaging 0.99
Z1176:Zfp616 UTSW 11 73,976,467 (GRCm39) missense possibly damaging 0.90
Z1176:Zfp616 UTSW 11 73,974,045 (GRCm39) missense possibly damaging 0.72
Z1176:Zfp616 UTSW 11 73,973,859 (GRCm39) missense probably benign
Z1177:Zfp616 UTSW 11 73,975,878 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- CTGAGAATCTACTACAAATGGTGTG -3'
(R):5'- CCTACATGGTAGAACTTGTCACAGAG -3'

Sequencing Primer
(F):5'- GAATCTACTACAAATGGTGTGTACAC -3'
(R):5'- AGTAGATTTAATTGTTGAGGAAGCTG -3'
Posted On 2018-06-06