Incidental Mutation 'IGL01141:Olfr805'
ID52155
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr805
Ensembl Gene ENSMUSG00000096858
Gene Nameolfactory receptor 805
SynonymsGA_x6K02T2PULF-11402237-11401278, MOR110-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.093) question?
Stock #IGL01141
Quality Score
Status
Chromosome10
Chromosomal Location129721221-129729375 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 129722945 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Leucine at position 200 (I200L)
Ref Sequence ENSEMBL: ENSMUSP00000149493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078876] [ENSMUST00000204717] [ENSMUST00000216794] [ENSMUST00000217219]
Predicted Effect probably benign
Transcript: ENSMUST00000078876
AA Change: I200L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000092874
Gene: ENSMUSG00000096858
AA Change: I200L

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 3.9e-52 PFAM
Pfam:7tm_1 39 288 5.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203573
AA Change: I200L
SMART Domains Protein: ENSMUSP00000144843
Gene: ENSMUSG00000096858
AA Change: I200L

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 3.9e-52 PFAM
Pfam:7tm_1 39 288 5.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204717
Predicted Effect probably benign
Transcript: ENSMUST00000216794
AA Change: I200L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217219
AA Change: I200L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A T 11: 109,937,730 D1447E probably damaging Het
Atp2a3 T C 11: 72,982,665 I788T probably damaging Het
Axin1 G A 17: 26,190,041 E672K probably damaging Het
Ccno A G 13: 112,989,027 D175G probably damaging Het
Cep83 C A 10: 94,788,757 T632K probably benign Het
Ckmt1 A T 2: 121,362,993 I345F probably benign Het
Cntnap1 G A 11: 101,178,807 probably benign Het
Edem2 A G 2: 155,709,028 Y340H probably benign Het
Erich3 A G 3: 154,714,016 K249R probably benign Het
Fndc9 T C 11: 46,237,699 I15T probably benign Het
Gm4758 A G 16: 36,308,064 E7G probably benign Het
Grip2 G T 6: 91,782,897 Q300K probably benign Het
Herc2 T C 7: 56,212,841 V4050A possibly damaging Het
Jup A T 11: 100,386,249 D44E probably benign Het
Lingo3 G T 10: 80,835,313 P261Q probably damaging Het
Lrrfip2 C T 9: 111,219,715 R311W probably damaging Het
Mansc1 C A 6: 134,621,785 L56F probably benign Het
Map1b A G 13: 99,434,761 I484T probably damaging Het
Mpeg1 T A 19: 12,462,785 F536I probably damaging Het
Mrgprb1 T G 7: 48,448,027 T46P probably benign Het
Mug1 A G 6: 121,870,499 N612S probably benign Het
Olfr477 T C 7: 107,990,551 F62S probably damaging Het
Pax8 A G 2: 24,441,150 S178P probably damaging Het
Peak1 A G 9: 56,258,527 F706L probably benign Het
Prkdc A G 16: 15,726,704 T1853A probably damaging Het
Reln A C 5: 21,969,033 F2024C probably damaging Het
Reln G T 5: 21,919,069 P2813Q probably damaging Het
Riox1 A G 12: 83,951,794 Q368R probably damaging Het
Rspry1 T C 8: 94,649,855 V335A probably benign Het
Scn3a T C 2: 65,495,113 N1020S possibly damaging Het
Scyl2 A G 10: 89,640,635 V876A probably benign Het
Sdhaf3 T A 6: 6,956,141 F39I probably damaging Het
Sfxn4 T C 19: 60,851,014 E202G possibly damaging Het
Slc1a4 A T 11: 20,308,644 probably benign Het
Sln A G 9: 53,853,500 I10V probably benign Het
Ssh2 A G 11: 77,449,726 E568G probably damaging Het
Supt7l G A 5: 31,518,435 P270S probably benign Het
Tanc2 A G 11: 105,886,474 probably benign Het
Tatdn1 A T 15: 58,909,567 probably benign Het
Tfip11 C T 5: 112,329,503 P117L possibly damaging Het
Vpreb1 T C 16: 16,869,087 M9V probably benign Het
Other mutations in Olfr805
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01341:Olfr805 APN 10 129722878 missense possibly damaging 0.87
IGL01960:Olfr805 APN 10 129722887 missense probably damaging 1.00
IGL02729:Olfr805 APN 10 129723521 missense probably benign 0.01
IGL02969:Olfr805 APN 10 129723196 missense probably damaging 0.99
R0116:Olfr805 UTSW 10 129722977 missense probably damaging 1.00
R1236:Olfr805 UTSW 10 129722806 missense probably damaging 0.98
R1332:Olfr805 UTSW 10 129723247 missense probably damaging 1.00
R2428:Olfr805 UTSW 10 129722783 missense probably benign 0.05
R3725:Olfr805 UTSW 10 129723115 missense probably damaging 1.00
R3726:Olfr805 UTSW 10 129723115 missense probably damaging 1.00
R3804:Olfr805 UTSW 10 129723049 missense possibly damaging 0.93
R4365:Olfr805 UTSW 10 129723412 missense probably damaging 0.99
R4630:Olfr805 UTSW 10 129723481 missense probably damaging 1.00
R4735:Olfr805 UTSW 10 129722923 missense probably benign 0.06
R4923:Olfr805 UTSW 10 129722812 missense probably benign 0.03
R4962:Olfr805 UTSW 10 129722723 missense probably damaging 1.00
R5324:Olfr805 UTSW 10 129722945 missense probably benign
R5406:Olfr805 UTSW 10 129722930 missense probably damaging 1.00
R7705:Olfr805 UTSW 10 129723149 missense probably benign 0.01
Posted On2013-06-21