Mutagenetix > Incidental Mutation

Incidental Mutation 'R6552:Or2ag13'

521700

Institutional Source

Beutler Lab

Gene Symbol

Or2ag13

Ensembl Gene

ENSMUSG00000108948

Gene Name

olfactory receptor family 2 subfamily AG member 13

Synonyms

Olfr695, GA_x6K02T2PBJ9-9092181-9091234, MOR283-6

MMRRC Submission

044677-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.121) question?

Stock #

R6552 (G1)

Quality Score

217.468

Status

Not validated

Chromosome

Chromosomal Location

106312939-106315552 bp(-) (GRCm39)

Type of Mutation

small deletion (2 aa in frame mutation)

DNA Base Change (assembly)

TGAAGCC to T at 106313850 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149773 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000216868]

AlphaFold

Q8VFM3

Predicted Effect

probably benign
Transcript: ENSMUST00000216868

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 98.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ang5	A	T	14: 44,200,254 (GRCm39)	H106L	probably benign	Het
Arsk	A	G	13: 76,220,315 (GRCm39)	Y260H	probably damaging	Het
Atxn2l	C	T	7: 126,092,993 (GRCm39)	V833M	possibly damaging	Het
Bpifa6	G	A	2: 153,829,078 (GRCm39)	D202N	probably damaging	Het
Ccdc103	A	G	11: 102,774,970 (GRCm39)	S190G	probably benign	Het
Col6a6	C	T	9: 105,576,112 (GRCm39)	V2083I	probably damaging	Het
Creb5	A	G	6: 53,662,369 (GRCm39)	D222G	probably damaging	Het
Cyp7a1	C	T	4: 6,272,361 (GRCm39)	W284*	probably null	Het
Dnmt3a	T	C	12: 3,957,623 (GRCm39)	V868A	probably damaging	Het
Efr3a	A	G	15: 65,729,339 (GRCm39)	D680G	possibly damaging	Het
Eml2	G	A	7: 18,935,088 (GRCm39)	V432I	probably damaging	Het
Epb41l4a	A	G	18: 34,012,032 (GRCm39)	Y163H	probably damaging	Het
Gabra1	A	T	11: 42,037,926 (GRCm39)	S231T	probably damaging	Het
Golga4	T	A	9: 118,343,299 (GRCm39)	F42I	probably damaging	Het
Greb1l	G	A	18: 10,541,814 (GRCm39)	S1187N	probably benign	Het
Haspin	A	G	11: 73,028,390 (GRCm39)	V233A	probably benign	Het
Il34	T	A	8: 111,469,059 (GRCm39)	K187I	probably benign	Het
Kcnn2	A	G	18: 45,693,165 (GRCm39)	H247R	probably benign	Het
Klf5	T	C	14: 99,539,078 (GRCm39)	S84P	probably benign	Het
Lama5	G	T	2: 179,822,947 (GRCm39)	P2773Q	probably damaging	Het
Lcat	T	C	8: 106,666,311 (GRCm39)	M404V	possibly damaging	Het
Lrp6	A	T	6: 134,431,692 (GRCm39)	S1473T	probably benign	Het
Lsm3	GATATATA	GATATATATA	6: 91,496,617 (GRCm39)		probably null	Het
Mn1	T	C	5: 111,568,753 (GRCm39)	S908P	possibly damaging	Het
Or1o1	G	A	17: 37,716,796 (GRCm39)	R119H	probably benign	Het
Pcdhb2	A	T	18: 37,429,046 (GRCm39)	M340L	probably benign	Het
Pex1	G	A	5: 3,673,953 (GRCm39)	E748K	probably damaging	Het
Qrich1	T	C	9: 108,411,504 (GRCm39)	V343A	possibly damaging	Het
Rho	A	G	6: 115,908,709 (GRCm39)		probably null	Het
Sdhaf4	C	A	1: 24,044,687 (GRCm39)		probably benign	Het
Sec24d	A	G	3: 123,084,201 (GRCm39)	I127V	probably benign	Het
Siae	T	C	9: 37,557,696 (GRCm39)	V501A	possibly damaging	Het
Skint3	T	C	4: 112,147,482 (GRCm39)	Y402H	possibly damaging	Het
Skint6	A	C	4: 112,924,687 (GRCm39)	V515G	possibly damaging	Het
Slc23a1	C	A	18: 35,755,391 (GRCm39)	G475C	probably damaging	Het
Smad9	A	G	3: 54,690,167 (GRCm39)	Y129C	probably damaging	Het
Snw1	A	G	12: 87,506,189 (GRCm39)		probably null	Het
Spice1	A	G	16: 44,199,396 (GRCm39)	D616G	possibly damaging	Het
Stam2	T	C	2: 52,598,239 (GRCm39)		probably null	Het
Sumo3	G	T	10: 77,442,091 (GRCm39)		probably benign	Het
Syne2	T	G	12: 75,937,015 (GRCm39)	N204K	possibly damaging	Het
Tmem200a	T	C	10: 25,869,381 (GRCm39)	N296S	probably damaging	Het
Ttbk1	G	T	17: 46,789,888 (GRCm39)	T125N	probably benign	Het
Ubr2	G	T	17: 47,277,194 (GRCm39)		probably null	Het
Vmn1r80	C	T	7: 11,927,684 (GRCm39)	L265F	probably damaging	Het
Vwa8	A	T	14: 79,435,662 (GRCm39)	T1791S	possibly damaging	Het

Other mutations in Or2ag13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01010:Or2ag13	APN	7	106,473,460 (GRCm39)	utr 5 prime	probably benign
IGL02143:Or2ag13	APN	7	106,473,180 (GRCm39)	missense	probably benign	0.02
R0492:Or2ag13	UTSW	7	106,473,084 (GRCm39)	missense	probably damaging	1.00
R1816:Or2ag13	UTSW	7	106,472,695 (GRCm39)	nonsense	probably null
R1834:Or2ag13	UTSW	7	106,473,348 (GRCm39)	missense	probably damaging	1.00
R2011:Or2ag13	UTSW	7	106,472,634 (GRCm39)	missense	probably benign	0.03
R3434:Or2ag13	UTSW	7	106,472,976 (GRCm39)	missense	probably benign	0.01
R3842:Or2ag13	UTSW	7	106,473,302 (GRCm39)	missense	probably benign	0.07
R4405:Or2ag13	UTSW	7	106,472,580 (GRCm39)	missense	probably damaging	1.00
R4742:Or2ag13	UTSW	7	106,472,635 (GRCm39)	missense	probably damaging	0.99
R4815:Or2ag13	UTSW	7	106,473,444 (GRCm39)	missense	probably benign
R4851:Or2ag13	UTSW	7	106,473,221 (GRCm39)	missense	probably damaging	1.00
R4856:Or2ag13	UTSW	7	106,473,177 (GRCm39)	missense	probably damaging	1.00
R5663:Or2ag13	UTSW	7	106,472,877 (GRCm39)	missense	probably benign	0.43
R5783:Or2ag13	UTSW	7	106,472,541 (GRCm39)	missense	probably damaging	0.97
R6640:Or2ag13	UTSW	7	106,313,247 (GRCm39)	missense	probably damaging	1.00
R6798:Or2ag13	UTSW	7	106,313,402 (GRCm39)	missense	probably damaging	1.00
R7365:Or2ag13	UTSW	7	106,313,171 (GRCm39)	missense	probably benign	0.03
R7496:Or2ag13	UTSW	7	106,313,435 (GRCm39)	missense	probably benign	0.23
R7923:Or2ag13	UTSW	7	106,313,649 (GRCm39)	nonsense	probably null
R9012:Or2ag13	UTSW	7	106,313,115 (GRCm39)	missense	probably benign	0.10
R9572:Or2ag13	UTSW	7	106,313,546 (GRCm39)	missense	probably damaging	1.00
R9596:Or2ag13	UTSW	7	106,313,412 (GRCm39)	missense	probably benign	0.01
R9756:Or2ag13	UTSW	7	106,313,002 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TCAGTGCCAGAAACATCTGAAAGG -3'
(R):5'- GGAAAGTTCCCATGTTGTTAGAG -3'

Sequencing Primer
(F):5'- TCTAGTACGGCCTTGGGAATGATAAC -3'
(R):5'- AAGTTCCCATGTTGTTAGAGTCATGC -3'

Posted On

2018-06-06