Incidental Mutation 'R6553:Gpr155'
ID |
521764 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gpr155
|
Ensembl Gene |
ENSMUSG00000041762 |
Gene Name |
G protein-coupled receptor 155 |
Synonyms |
DEPDC3, 1110017O10Rik, PGR22, F730029F15Rik |
MMRRC Submission |
044678-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R6553 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
2 |
Chromosomal Location |
73171850-73216842 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 73179989 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Asparagine
at position 157
(I157N)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076463]
[ENSMUST00000112043]
[ENSMUST00000112044]
|
AlphaFold |
A2AWR3 |
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000048504
|
SMART Domains |
Protein: ENSMUSP00000037772 Gene: ENSMUSG00000041762
Domain | Start | End | E-Value | Type |
Pfam:Mem_trans
|
40 |
205 |
1.9e-16 |
PFAM |
Pfam:Mem_trans
|
187 |
360 |
4.9e-12 |
PFAM |
transmembrane domain
|
380 |
402 |
N/A |
INTRINSIC |
transmembrane domain
|
415 |
432 |
N/A |
INTRINSIC |
transmembrane domain
|
442 |
464 |
N/A |
INTRINSIC |
transmembrane domain
|
477 |
499 |
N/A |
INTRINSIC |
transmembrane domain
|
519 |
538 |
N/A |
INTRINSIC |
transmembrane domain
|
657 |
679 |
N/A |
INTRINSIC |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000076463
AA Change: I717N
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000075788 Gene: ENSMUSG00000041762 AA Change: I717N
Domain | Start | End | E-Value | Type |
Pfam:Mem_trans
|
40 |
205 |
3.3e-15 |
PFAM |
transmembrane domain
|
209 |
231 |
N/A |
INTRINSIC |
transmembrane domain
|
241 |
260 |
N/A |
INTRINSIC |
transmembrane domain
|
272 |
291 |
N/A |
INTRINSIC |
transmembrane domain
|
311 |
330 |
N/A |
INTRINSIC |
transmembrane domain
|
343 |
365 |
N/A |
INTRINSIC |
transmembrane domain
|
380 |
402 |
N/A |
INTRINSIC |
transmembrane domain
|
415 |
432 |
N/A |
INTRINSIC |
transmembrane domain
|
442 |
464 |
N/A |
INTRINSIC |
transmembrane domain
|
477 |
499 |
N/A |
INTRINSIC |
transmembrane domain
|
519 |
538 |
N/A |
INTRINSIC |
transmembrane domain
|
657 |
679 |
N/A |
INTRINSIC |
transmembrane domain
|
689 |
711 |
N/A |
INTRINSIC |
DEP
|
759 |
833 |
8.28e-12 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000112043
AA Change: I717N
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000107674 Gene: ENSMUSG00000041762 AA Change: I717N
Domain | Start | End | E-Value | Type |
Pfam:Mem_trans
|
40 |
205 |
3.3e-15 |
PFAM |
transmembrane domain
|
209 |
231 |
N/A |
INTRINSIC |
transmembrane domain
|
241 |
260 |
N/A |
INTRINSIC |
transmembrane domain
|
272 |
291 |
N/A |
INTRINSIC |
transmembrane domain
|
311 |
330 |
N/A |
INTRINSIC |
transmembrane domain
|
343 |
365 |
N/A |
INTRINSIC |
transmembrane domain
|
380 |
402 |
N/A |
INTRINSIC |
transmembrane domain
|
415 |
432 |
N/A |
INTRINSIC |
transmembrane domain
|
442 |
464 |
N/A |
INTRINSIC |
transmembrane domain
|
477 |
499 |
N/A |
INTRINSIC |
transmembrane domain
|
519 |
538 |
N/A |
INTRINSIC |
transmembrane domain
|
657 |
679 |
N/A |
INTRINSIC |
transmembrane domain
|
689 |
711 |
N/A |
INTRINSIC |
DEP
|
759 |
833 |
8.28e-12 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000112044
AA Change: I689N
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000107675 Gene: ENSMUSG00000041762 AA Change: I689N
Domain | Start | End | E-Value | Type |
Pfam:Mem_trans
|
40 |
205 |
3.3e-15 |
PFAM |
Pfam:Mem_trans
|
187 |
360 |
8.3e-11 |
PFAM |
transmembrane domain
|
382 |
404 |
N/A |
INTRINSIC |
transmembrane domain
|
414 |
436 |
N/A |
INTRINSIC |
transmembrane domain
|
449 |
471 |
N/A |
INTRINSIC |
transmembrane domain
|
491 |
510 |
N/A |
INTRINSIC |
transmembrane domain
|
629 |
651 |
N/A |
INTRINSIC |
transmembrane domain
|
661 |
683 |
N/A |
INTRINSIC |
DEP
|
731 |
805 |
8.28e-12 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000131430
AA Change: I157N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000114294 Gene: ENSMUSG00000041762 AA Change: I157N
Domain | Start | End | E-Value | Type |
transmembrane domain
|
98 |
120 |
N/A |
INTRINSIC |
transmembrane domain
|
130 |
152 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184503
|
Meta Mutation Damage Score |
0.5703 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.6%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 26 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam1b |
G |
T |
5: 121,639,250 (GRCm39) |
D598E |
probably benign |
Het |
Ascc3 |
A |
G |
10: 50,718,273 (GRCm39) |
K1989E |
probably benign |
Het |
Asic5 |
A |
T |
3: 81,916,773 (GRCm39) |
T288S |
possibly damaging |
Het |
Chd1 |
A |
G |
17: 15,945,692 (GRCm39) |
N72S |
probably benign |
Het |
Ciita |
T |
A |
16: 10,329,609 (GRCm39) |
V628E |
probably benign |
Het |
Cyp2c50 |
A |
G |
19: 40,079,046 (GRCm39) |
T130A |
probably benign |
Het |
Dapk1 |
T |
A |
13: 60,908,975 (GRCm39) |
V1196E |
probably damaging |
Het |
Dis3l2 |
T |
A |
1: 86,673,216 (GRCm39) |
I69N |
probably damaging |
Het |
Exph5 |
A |
G |
9: 53,213,012 (GRCm39) |
|
probably benign |
Het |
Fcgbp |
A |
T |
7: 27,813,404 (GRCm39) |
Q2313L |
possibly damaging |
Het |
Gm2888 |
A |
G |
14: 3,037,722 (GRCm38) |
H238R |
possibly damaging |
Het |
Gm5622 |
A |
G |
14: 51,895,200 (GRCm39) |
K120E |
probably damaging |
Het |
Hltf |
T |
C |
3: 20,126,558 (GRCm39) |
V245A |
probably damaging |
Het |
Kmt2e |
G |
A |
5: 23,668,024 (GRCm39) |
V28I |
probably damaging |
Het |
Lsm3 |
GATATATA |
GATATATATA |
6: 91,496,617 (GRCm39) |
|
probably null |
Het |
Nprl3 |
C |
T |
11: 32,184,812 (GRCm39) |
R399Q |
probably benign |
Het |
Or6c6c |
C |
T |
10: 129,540,932 (GRCm39) |
R62C |
probably benign |
Het |
Ptgs2 |
T |
C |
1: 149,979,738 (GRCm39) |
V281A |
possibly damaging |
Het |
Speer4f2 |
A |
G |
5: 17,579,420 (GRCm39) |
E73G |
probably damaging |
Het |
Tmem161b |
C |
A |
13: 84,370,537 (GRCm39) |
|
probably benign |
Het |
Trav13n-3 |
A |
G |
14: 53,574,618 (GRCm39) |
T14A |
probably benign |
Het |
Trav9d-4 |
A |
T |
14: 53,221,198 (GRCm39) |
Q63L |
probably benign |
Het |
Vmn2r75 |
T |
A |
7: 85,813,453 (GRCm39) |
N450Y |
probably benign |
Het |
Vmn2r97 |
G |
A |
17: 19,150,566 (GRCm39) |
W471* |
probably null |
Het |
Zfp27 |
G |
A |
7: 29,595,818 (GRCm39) |
T49I |
possibly damaging |
Het |
Zpld2 |
A |
G |
4: 133,929,367 (GRCm39) |
S313P |
probably damaging |
Het |
|
Other mutations in Gpr155 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00731:Gpr155
|
APN |
2 |
73,192,957 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01432:Gpr155
|
APN |
2 |
73,182,229 (GRCm39) |
missense |
possibly damaging |
0.51 |
IGL01528:Gpr155
|
APN |
2 |
73,192,767 (GRCm39) |
critical splice donor site |
probably null |
|
IGL01718:Gpr155
|
APN |
2 |
73,212,576 (GRCm39) |
missense |
probably benign |
|
IGL01733:Gpr155
|
APN |
2 |
73,183,956 (GRCm39) |
splice site |
probably null |
|
IGL03342:Gpr155
|
APN |
2 |
73,180,022 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT1430001:Gpr155
|
UTSW |
2 |
73,200,482 (GRCm39) |
missense |
probably benign |
0.08 |
PIT4810001:Gpr155
|
UTSW |
2 |
73,178,607 (GRCm39) |
missense |
probably benign |
0.08 |
R0226:Gpr155
|
UTSW |
2 |
73,197,936 (GRCm39) |
missense |
probably benign |
0.02 |
R0399:Gpr155
|
UTSW |
2 |
73,200,346 (GRCm39) |
missense |
possibly damaging |
0.91 |
R0445:Gpr155
|
UTSW |
2 |
73,200,488 (GRCm39) |
splice site |
probably benign |
|
R1570:Gpr155
|
UTSW |
2 |
73,200,382 (GRCm39) |
missense |
possibly damaging |
0.87 |
R1598:Gpr155
|
UTSW |
2 |
73,200,434 (GRCm39) |
missense |
probably damaging |
0.98 |
R1647:Gpr155
|
UTSW |
2 |
73,194,508 (GRCm39) |
splice site |
probably null |
|
R1648:Gpr155
|
UTSW |
2 |
73,194,508 (GRCm39) |
splice site |
probably null |
|
R1756:Gpr155
|
UTSW |
2 |
73,197,921 (GRCm39) |
missense |
probably benign |
0.00 |
R1760:Gpr155
|
UTSW |
2 |
73,212,279 (GRCm39) |
missense |
probably damaging |
1.00 |
R2033:Gpr155
|
UTSW |
2 |
73,178,526 (GRCm39) |
missense |
probably benign |
0.18 |
R2044:Gpr155
|
UTSW |
2 |
73,203,977 (GRCm39) |
missense |
probably damaging |
1.00 |
R2145:Gpr155
|
UTSW |
2 |
73,187,002 (GRCm39) |
missense |
probably benign |
0.01 |
R2172:Gpr155
|
UTSW |
2 |
73,212,471 (GRCm39) |
missense |
probably benign |
0.00 |
R2274:Gpr155
|
UTSW |
2 |
73,178,479 (GRCm39) |
critical splice donor site |
probably null |
|
R3878:Gpr155
|
UTSW |
2 |
73,198,736 (GRCm39) |
nonsense |
probably null |
|
R3924:Gpr155
|
UTSW |
2 |
73,200,420 (GRCm39) |
missense |
probably damaging |
1.00 |
R4910:Gpr155
|
UTSW |
2 |
73,197,882 (GRCm39) |
nonsense |
probably null |
|
R4950:Gpr155
|
UTSW |
2 |
73,212,529 (GRCm39) |
missense |
probably benign |
|
R5337:Gpr155
|
UTSW |
2 |
73,178,592 (GRCm39) |
missense |
probably benign |
0.32 |
R5830:Gpr155
|
UTSW |
2 |
73,200,433 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5887:Gpr155
|
UTSW |
2 |
73,174,062 (GRCm39) |
nonsense |
probably null |
|
R5929:Gpr155
|
UTSW |
2 |
73,204,011 (GRCm39) |
nonsense |
probably null |
|
R6293:Gpr155
|
UTSW |
2 |
73,204,341 (GRCm39) |
missense |
possibly damaging |
0.47 |
R6585:Gpr155
|
UTSW |
2 |
73,179,989 (GRCm39) |
missense |
probably damaging |
1.00 |
R7003:Gpr155
|
UTSW |
2 |
73,173,961 (GRCm39) |
missense |
probably damaging |
0.99 |
R7353:Gpr155
|
UTSW |
2 |
73,197,835 (GRCm39) |
nonsense |
probably null |
|
R7506:Gpr155
|
UTSW |
2 |
73,198,683 (GRCm39) |
missense |
probably damaging |
0.97 |
R7631:Gpr155
|
UTSW |
2 |
73,213,291 (GRCm39) |
intron |
probably benign |
|
R7753:Gpr155
|
UTSW |
2 |
73,212,550 (GRCm39) |
missense |
probably benign |
0.27 |
R7810:Gpr155
|
UTSW |
2 |
73,212,296 (GRCm39) |
missense |
probably damaging |
0.99 |
R7813:Gpr155
|
UTSW |
2 |
73,212,329 (GRCm39) |
nonsense |
probably null |
|
R7815:Gpr155
|
UTSW |
2 |
73,192,904 (GRCm39) |
missense |
probably benign |
|
R7873:Gpr155
|
UTSW |
2 |
73,173,934 (GRCm39) |
missense |
possibly damaging |
0.51 |
R8506:Gpr155
|
UTSW |
2 |
73,173,806 (GRCm39) |
missense |
probably damaging |
0.99 |
R8680:Gpr155
|
UTSW |
2 |
73,174,039 (GRCm39) |
missense |
probably damaging |
0.99 |
R8856:Gpr155
|
UTSW |
2 |
73,203,993 (GRCm39) |
missense |
probably benign |
0.27 |
R8872:Gpr155
|
UTSW |
2 |
73,197,936 (GRCm39) |
missense |
probably benign |
0.02 |
R9116:Gpr155
|
UTSW |
2 |
73,204,109 (GRCm39) |
missense |
possibly damaging |
0.78 |
R9683:Gpr155
|
UTSW |
2 |
73,192,780 (GRCm39) |
missense |
probably benign |
|
|
Predicted Primers |
PCR Primer
(F):5'- TGCCTGTCAGCTCTTGTTAAAATG -3'
(R):5'- GTCTACCCTGGATGCTGAATTTC -3'
Sequencing Primer
(F):5'- GCTGGATTTATAATACCACTTCCG -3'
(R):5'- CTCGCTCACTAAGCATCT -3'
|
Posted On |
2018-06-06 |