Incidental Mutation 'IGL01060:Trim16'
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ID52186
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim16
Ensembl Gene ENSMUSG00000047821
Gene Nametripartite motif-containing 16
SynonymsEBBP, 9130006M08Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01060
Quality Score
Status
Chromosome11
Chromosomal Location62820231-62850808 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 62820704 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 67 (I67T)
Ref Sequence ENSEMBL: ENSMUSP00000072432 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055006] [ENSMUST00000072639] [ENSMUST00000108703]
Predicted Effect probably benign
Transcript: ENSMUST00000055006
AA Change: I67T

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000055542
Gene: ENSMUSG00000047821
AA Change: I67T

DomainStartEndE-ValueType
Blast:BBOX 64 113 6e-24 BLAST
BBOX 117 157 3.24e-4 SMART
coiled coil region 171 196 N/A INTRINSIC
coiled coil region 237 265 N/A INTRINSIC
PRY 364 417 1.41e-22 SMART
SPRY 418 543 6.4e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000072639
AA Change: I67T

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000072432
Gene: ENSMUSG00000047821
AA Change: I67T

DomainStartEndE-ValueType
Blast:BBOX 64 113 5e-24 BLAST
BBOX 117 157 3.24e-4 SMART
coiled coil region 171 196 N/A INTRINSIC
coiled coil region 237 265 N/A INTRINSIC
PRY 364 417 1.41e-22 SMART
Pfam:SPRY 418 483 1.4e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108703
SMART Domains Protein: ENSMUSP00000104343
Gene: ENSMUSG00000047821

DomainStartEndE-ValueType
Blast:BBOX 1 26 9e-10 BLAST
BBOX 30 70 3.24e-4 SMART
coiled coil region 84 109 N/A INTRINSIC
coiled coil region 150 178 N/A INTRINSIC
PRY 277 330 1.41e-22 SMART
SPRY 331 456 6.4e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147942
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,950,275 V124I probably damaging Het
Anks4b A G 7: 120,173,925 T3A possibly damaging Het
Arhgef26 T A 3: 62,340,121 S209T probably benign Het
Ccdc78 A G 17: 25,788,832 D281G probably damaging Het
Ccnb3 A T X: 6,980,274 N1362K probably benign Het
Dnah2 T C 11: 69,478,092 N1662S possibly damaging Het
Ern2 T A 7: 122,170,092 R904W probably damaging Het
Fam120c C T X: 151,469,587 P1045S probably benign Het
Gm12887 C T 4: 121,616,413 probably benign Het
Gpld1 G A 13: 24,982,566 G627S probably damaging Het
Ikbkap C T 4: 56,784,537 probably null Het
Krt77 T A 15: 101,860,880 probably benign Het
Ltf A T 9: 111,022,882 probably null Het
Map3k6 G T 4: 133,247,302 probably null Het
Nsd1 G A 13: 55,263,429 G1431D probably damaging Het
Plekhm2 C T 4: 141,642,645 probably null Het
Popdc2 T A 16: 38,373,965 N249K probably damaging Het
Ppm1h A G 10: 122,907,571 D400G possibly damaging Het
Rps6ka1 A T 4: 133,860,870 S320T probably damaging Het
Rsph6a C T 7: 19,054,868 R42* probably null Het
Sap130 T C 18: 31,715,443 L967P probably damaging Het
Smyd2 T C 1: 189,897,470 E121G possibly damaging Het
Sspo G A 6: 48,449,479 W144* probably null Het
Taar6 A G 10: 23,985,072 V192A probably benign Het
Tbc1d24 A T 17: 24,185,828 V114E probably damaging Het
Ttll7 A G 3: 146,909,582 D267G possibly damaging Het
Ttn T C 2: 76,889,729 probably benign Het
Vmn2r56 T A 7: 12,713,089 I379F probably damaging Het
Zfp14 T C 7: 30,038,085 T492A probably damaging Het
Other mutations in Trim16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00661:Trim16 APN 11 62837232 splice site probably benign
IGL01568:Trim16 APN 11 62820858 missense probably benign 0.05
IGL01659:Trim16 APN 11 62820695 missense probably benign 0.00
IGL02519:Trim16 APN 11 62834079 missense possibly damaging 0.49
IGL02662:Trim16 APN 11 62840557 missense possibly damaging 0.91
FR4589:Trim16 UTSW 11 62820695 intron probably benign
FR4976:Trim16 UTSW 11 62820689 intron probably benign
R0007:Trim16 UTSW 11 62829118 missense probably benign 0.00
R0007:Trim16 UTSW 11 62829118 missense probably benign 0.00
R0346:Trim16 UTSW 11 62840694 missense probably benign 0.00
R0410:Trim16 UTSW 11 62820471 start gained probably benign
R1725:Trim16 UTSW 11 62820505 start codon destroyed possibly damaging 0.91
R3845:Trim16 UTSW 11 62836672 splice site probably benign
R3879:Trim16 UTSW 11 62840607 missense probably damaging 1.00
R5023:Trim16 UTSW 11 62836812 missense probably benign 0.36
R5344:Trim16 UTSW 11 62820925 missense probably damaging 1.00
R6919:Trim16 UTSW 11 62840869 missense possibly damaging 0.86
R7490:Trim16 UTSW 11 62834123 missense probably damaging 1.00
R7525:Trim16 UTSW 11 62820754 missense probably damaging 1.00
R8354:Trim16 UTSW 11 62836761 missense probably benign 0.01
R8439:Trim16 UTSW 11 62850588 missense probably benign 0.10
R8754:Trim16 UTSW 11 62840937 missense probably benign 0.01
X0026:Trim16 UTSW 11 62829137 missense probably benign 0.02
Z1186:Trim16 UTSW 11 62820602 missense probably benign
Z1186:Trim16 UTSW 11 62820676 missense probably benign
Z1186:Trim16 UTSW 11 62820690 intron probably benign
Z1186:Trim16 UTSW 11 62820692 intron probably benign
Z1186:Trim16 UTSW 11 62836817 missense probably benign 0.00
Z1186:Trim16 UTSW 11 62840746 missense probably benign
Z1186:Trim16 UTSW 11 62840849 missense probably benign 0.00
Z1187:Trim16 UTSW 11 62820602 missense probably benign
Z1187:Trim16 UTSW 11 62820676 missense probably benign
Z1187:Trim16 UTSW 11 62820690 intron probably benign
Z1187:Trim16 UTSW 11 62820694 intron probably benign
Z1187:Trim16 UTSW 11 62820695 intron probably benign
Z1187:Trim16 UTSW 11 62836817 missense probably benign 0.00
Z1187:Trim16 UTSW 11 62840746 missense probably benign
Z1187:Trim16 UTSW 11 62840849 missense probably benign 0.00
Z1188:Trim16 UTSW 11 62820602 missense probably benign
Z1188:Trim16 UTSW 11 62820676 missense probably benign
Z1188:Trim16 UTSW 11 62820690 intron probably benign
Z1188:Trim16 UTSW 11 62820695 intron probably benign
Z1188:Trim16 UTSW 11 62836817 missense probably benign 0.00
Z1188:Trim16 UTSW 11 62840746 missense probably benign
Z1188:Trim16 UTSW 11 62840849 missense probably benign 0.00
Z1189:Trim16 UTSW 11 62820602 missense probably benign
Z1189:Trim16 UTSW 11 62820676 missense probably benign
Z1189:Trim16 UTSW 11 62820690 intron probably benign
Z1189:Trim16 UTSW 11 62820691 intron probably benign
Z1189:Trim16 UTSW 11 62820694 intron probably benign
Z1189:Trim16 UTSW 11 62836817 missense probably benign 0.00
Z1189:Trim16 UTSW 11 62840746 missense probably benign
Z1189:Trim16 UTSW 11 62840849 missense probably benign 0.00
Z1190:Trim16 UTSW 11 62820602 missense probably benign
Z1190:Trim16 UTSW 11 62820676 missense probably benign
Z1190:Trim16 UTSW 11 62820690 intron probably benign
Z1190:Trim16 UTSW 11 62820693 intron probably benign
Z1190:Trim16 UTSW 11 62820695 intron probably benign
Z1190:Trim16 UTSW 11 62836817 missense probably benign 0.00
Z1190:Trim16 UTSW 11 62840746 missense probably benign
Z1190:Trim16 UTSW 11 62840849 missense probably benign 0.00
Z1191:Trim16 UTSW 11 62820602 missense probably benign
Z1191:Trim16 UTSW 11 62820676 missense probably benign
Z1191:Trim16 UTSW 11 62820690 intron probably benign
Z1191:Trim16 UTSW 11 62836817 missense probably benign 0.00
Z1191:Trim16 UTSW 11 62840746 missense probably benign
Z1191:Trim16 UTSW 11 62840849 missense probably benign 0.00
Z1192:Trim16 UTSW 11 62820602 missense probably benign
Z1192:Trim16 UTSW 11 62820676 missense probably benign
Z1192:Trim16 UTSW 11 62820690 intron probably benign
Z1192:Trim16 UTSW 11 62820695 intron probably benign
Z1192:Trim16 UTSW 11 62836817 missense probably benign 0.00
Z1192:Trim16 UTSW 11 62840746 missense probably benign
Z1192:Trim16 UTSW 11 62840849 missense probably benign 0.00
Posted On2013-06-21