Incidental Mutation 'R6554:Wdr97'
ID 521872
Institutional Source Beutler Lab
Gene Symbol Wdr97
Ensembl Gene ENSMUSG00000109179
Gene Name WD repeat domain 97
Synonyms Gm35339
MMRRC Submission 044679-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # R6554 (G1)
Quality Score 210.009
Status Validated
Chromosome 15
Chromosomal Location 76238649-76249141 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 76239178 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 85 (D85G)
Ref Sequence ENSEMBL: ENSMUSP00000146420 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023211] [ENSMUST00000023212] [ENSMUST00000160172] [ENSMUST00000160914] [ENSMUST00000160853] [ENSMUST00000160560] [ENSMUST00000208833] [ENSMUST00000230314] [ENSMUST00000161527]
AlphaFold A0A140LHH9
Predicted Effect probably benign
Transcript: ENSMUST00000023211
SMART Domains Protein: ENSMUSP00000023211
Gene: ENSMUSG00000022552

DomainStartEndE-ValueType
Pfam:Sharpin_PH 13 125 1.2e-44 PFAM
low complexity region 187 202 N/A INTRINSIC
PDB:4DBG|A 203 299 1e-17 PDB
SCOP:d1euvb_ 212 301 2e-5 SMART
Blast:UBQ 218 299 2e-26 BLAST
ZnF_RBZ 343 367 9.65e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000023212
SMART Domains Protein: ENSMUSP00000023212
Gene: ENSMUSG00000022553

DomainStartEndE-ValueType
Pfam:Maf1 24 202 2.8e-69 PFAM
low complexity region 215 244 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123112
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133993
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137106
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144816
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152151
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160069
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161391
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160857
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160875
Predicted Effect probably benign
Transcript: ENSMUST00000160172
SMART Domains Protein: ENSMUSP00000124242
Gene: ENSMUSG00000022553

DomainStartEndE-ValueType
Pfam:Maf1 24 202 2.7e-70 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160914
SMART Domains Protein: ENSMUSP00000124110
Gene: ENSMUSG00000022553

DomainStartEndE-ValueType
low complexity region 33 48 N/A INTRINSIC
Pfam:Maf1 84 202 4.3e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161072
SMART Domains Protein: ENSMUSP00000125332
Gene: ENSMUSG00000022553

DomainStartEndE-ValueType
low complexity region 24 53 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000160853
SMART Domains Protein: ENSMUSP00000124893
Gene: ENSMUSG00000022553

DomainStartEndE-ValueType
Pfam:Maf1 25 202 4.6e-67 PFAM
low complexity region 215 244 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154477
Predicted Effect probably benign
Transcript: ENSMUST00000160560
SMART Domains Protein: ENSMUSP00000125382
Gene: ENSMUSG00000022552

DomainStartEndE-ValueType
low complexity region 2 23 N/A INTRINSIC
PDB:4EMO|D 24 62 2e-13 PDB
low complexity region 64 81 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160097
Predicted Effect possibly damaging
Transcript: ENSMUST00000208833
AA Change: D85G

PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162865
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162871
Predicted Effect probably benign
Transcript: ENSMUST00000230314
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161786
Predicted Effect probably benign
Transcript: ENSMUST00000161527
SMART Domains Protein: ENSMUSP00000125387
Gene: ENSMUSG00000022553

DomainStartEndE-ValueType
Pfam:Maf1 24 202 2.8e-69 PFAM
low complexity region 215 244 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m C T 6: 121,618,246 (GRCm39) R180C probably damaging Het
B3galt9 C A 2: 34,729,276 (GRCm39) S358R probably benign Het
Ces1b C A 8: 93,791,619 (GRCm39) V327L probably benign Het
Cps1 C T 1: 67,213,628 (GRCm39) R787* probably null Het
Dmrt2 C T 19: 25,655,312 (GRCm39) P304S probably damaging Het
Dop1b A G 16: 93,557,346 (GRCm39) D429G probably benign Het
Dync1h1 T A 12: 110,616,282 (GRCm39) M3111K probably benign Het
Dync2h1 A G 9: 7,037,699 (GRCm39) V3393A probably benign Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Fam184a T C 10: 53,517,063 (GRCm39) D1007G possibly damaging Het
Flt3 A C 5: 147,312,545 (GRCm39) L132W probably damaging Het
Gm14322 G A 2: 177,410,220 (GRCm39) S60N possibly damaging Het
Katnip C T 7: 125,449,914 (GRCm39) R993C probably damaging Het
Kcnj16 T A 11: 110,916,131 (GRCm39) Y264* probably null Het
Klkb1 T A 8: 45,726,591 (GRCm39) I471F probably damaging Het
Lrfn4 T C 19: 4,663,914 (GRCm39) T207A probably damaging Het
Mfsd4b5 T A 10: 39,862,428 (GRCm39) T32S probably benign Het
Mtbp A G 15: 55,430,645 (GRCm39) D234G probably damaging Het
Nfix T C 8: 85,454,279 (GRCm39) T218A possibly damaging Het
Nsd3 A T 8: 26,152,891 (GRCm39) E410D probably damaging Het
Or4g17 C T 2: 111,209,504 (GRCm39) S53F possibly damaging Het
Or5aq7 A T 2: 86,937,970 (GRCm39) S254T probably benign Het
Reln T C 5: 22,101,838 (GRCm39) Y3364C probably damaging Het
Selplg G A 5: 113,958,210 (GRCm39) P32L probably benign Het
Serpina1d A T 12: 103,731,062 (GRCm39) H305Q probably benign Het
Skic8 A T 9: 54,634,929 (GRCm39) I88N probably damaging Het
Skint8 G A 4: 111,784,413 (GRCm39) C13Y probably benign Het
Smc4 G A 3: 68,936,848 (GRCm39) V863I probably benign Het
Spdl1 T G 11: 34,713,397 (GRCm39) N224T possibly damaging Het
Sprr1b T G 3: 92,344,420 (GRCm39) Q152P possibly damaging Het
St6gal1 A G 16: 23,140,405 (GRCm39) N192S probably benign Het
Tbc1d8 T C 1: 39,445,903 (GRCm39) N96S probably damaging Het
Tbccd1 A T 16: 22,640,874 (GRCm39) I501K probably damaging Het
Tmem161b C A 13: 84,370,537 (GRCm39) probably benign Het
Unk T C 11: 115,942,285 (GRCm39) I293T probably damaging Het
Vmn2r61 A G 7: 41,926,139 (GRCm39) E548G probably damaging Het
Zeb2 A T 2: 44,887,524 (GRCm39) V496E probably damaging Het
Other mutations in Wdr97
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6006:Wdr97 UTSW 15 76,241,372 (GRCm39) missense probably damaging 1.00
R6258:Wdr97 UTSW 15 76,239,895 (GRCm39) nonsense probably null
R6464:Wdr97 UTSW 15 76,246,977 (GRCm39) missense probably benign 0.01
R6544:Wdr97 UTSW 15 76,242,478 (GRCm39) missense probably benign 0.00
R6545:Wdr97 UTSW 15 76,247,578 (GRCm39) missense probably damaging 1.00
R6803:Wdr97 UTSW 15 76,240,776 (GRCm39) missense probably damaging 1.00
R6850:Wdr97 UTSW 15 76,241,996 (GRCm39) missense probably damaging 1.00
R7574:Wdr97 UTSW 15 76,241,949 (GRCm39) nonsense probably null
R7793:Wdr97 UTSW 15 76,243,307 (GRCm39) missense
R7985:Wdr97 UTSW 15 76,245,687 (GRCm39) missense
R8008:Wdr97 UTSW 15 76,244,832 (GRCm39) missense
R8170:Wdr97 UTSW 15 76,247,819 (GRCm39) missense
R8171:Wdr97 UTSW 15 76,247,819 (GRCm39) missense
R8267:Wdr97 UTSW 15 76,240,794 (GRCm39) missense
R8337:Wdr97 UTSW 15 76,245,684 (GRCm39) missense
R8478:Wdr97 UTSW 15 76,247,629 (GRCm39) splice site probably null
R8735:Wdr97 UTSW 15 76,240,775 (GRCm39) missense
R8958:Wdr97 UTSW 15 76,245,694 (GRCm39) missense
R9385:Wdr97 UTSW 15 76,240,367 (GRCm39) missense
R9440:Wdr97 UTSW 15 76,245,064 (GRCm39) missense
R9657:Wdr97 UTSW 15 76,245,476 (GRCm39) missense
R9672:Wdr97 UTSW 15 76,240,377 (GRCm39) missense
R9778:Wdr97 UTSW 15 76,241,125 (GRCm39) missense
RF004:Wdr97 UTSW 15 76,247,373 (GRCm39) frame shift probably null
RF009:Wdr97 UTSW 15 76,247,367 (GRCm39) frame shift probably null
RF016:Wdr97 UTSW 15 76,240,172 (GRCm39) missense
RF030:Wdr97 UTSW 15 76,247,365 (GRCm39) frame shift probably null
Z1177:Wdr97 UTSW 15 76,247,330 (GRCm39) missense
Z1177:Wdr97 UTSW 15 76,239,130 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- AGTCCTTGACCCAGCATGAC -3'
(R):5'- TAGTACCATGAAGCGTTCACC -3'

Sequencing Primer
(F):5'- CAGCATGACCCTCAGAGGAG -3'
(R):5'- TGAAGCGTTCACCCACTGGATC -3'
Posted On 2018-06-06