Incidental Mutation 'R6557:Cxcl15'
ID521893
Institutional Source Beutler Lab
Gene Symbol Cxcl15
Ensembl Gene ENSMUSG00000029375
Gene Namechemokine (C-X-C motif) ligand 15
Synonymsweche, lungkine, Scyb15, Il8
MMRRC Submission
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R6557 (G1)
Quality Score225.009
Status Not validated
Chromosome5
Chromosomal Location90794534-90803067 bp(+) (GRCm38)
Type of Mutationstart gained
DNA Base Change (assembly) C to T at 90794566 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000031322 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031322]
Predicted Effect probably benign
Transcript: ENSMUST00000031322
SMART Domains Protein: ENSMUSP00000031322
Gene: ENSMUSG00000029375

DomainStartEndE-ValueType
SCY 27 88 2.97e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175341
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201840
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation are viable and fertile but display reduced host defense against the pulmonary pathogen Klebsiella pneumoniae. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Dysf A G 6: 84,186,384 D1580G probably damaging Het
Gpc5 A T 14: 115,092,534 probably benign Het
Greb1 T C 12: 16,710,383 I575V probably benign Het
Hecw1 T C 13: 14,316,646 E174G possibly damaging Het
Hip1 T C 5: 135,428,719 D300G possibly damaging Het
Ica1l T C 1: 59,997,625 T336A probably benign Het
Ikzf3 C T 11: 98,516,881 A45T probably benign Het
Krtap16-1 T C 11: 99,985,130 S483G possibly damaging Het
Lamb2 T C 9: 108,488,400 L1394P probably damaging Het
Liph T A 16: 21,983,920 E133V possibly damaging Het
Mamdc2 A G 19: 23,310,845 S610P possibly damaging Het
Map10 T C 8: 125,670,252 V128A probably damaging Het
Mon2 C A 10: 123,016,402 C1022F probably damaging Het
Nfatc3 T C 8: 106,119,354 S1039P probably benign Het
Nov A T 15: 54,747,927 R153* probably null Het
Olfr1275 T C 2: 111,231,631 H54R probably benign Het
Scaper T C 9: 55,550,850 N879S probably benign Het
Sec24d T C 3: 123,343,087 Y490H probably damaging Het
Tdrd5 T C 1: 156,300,721 K137R probably benign Het
Topaz1 A G 9: 122,748,895 N290S probably benign Het
Vmn2r111 T C 17: 22,559,051 N549S possibly damaging Het
Zfp638 C A 6: 83,930,110 P419Q probably damaging Het
Zzz3 T A 3: 152,428,460 L385Q probably damaging Het
Other mutations in Cxcl15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01995:Cxcl15 APN 5 90794608 missense possibly damaging 0.83
R0511:Cxcl15 UTSW 5 90798038 splice site probably benign
R0735:Cxcl15 UTSW 5 90801294 missense probably benign 0.01
R1709:Cxcl15 UTSW 5 90801416 missense unknown
R1758:Cxcl15 UTSW 5 90801464 missense unknown
R3768:Cxcl15 UTSW 5 90801444 missense unknown
R4950:Cxcl15 UTSW 5 90795245 missense possibly damaging 0.93
R5168:Cxcl15 UTSW 5 90795283 missense probably damaging 1.00
R5938:Cxcl15 UTSW 5 90801366 missense unknown
R6479:Cxcl15 UTSW 5 90795245 missense possibly damaging 0.93
X0064:Cxcl15 UTSW 5 90801341 missense unknown
Predicted Primers
Posted On2018-06-06