Incidental Mutation 'R6559:Fcrl1'
ID 521935
Institutional Source Beutler Lab
Gene Symbol Fcrl1
Ensembl Gene ENSMUSG00000059994
Gene Name Fc receptor-like 1
Synonyms mBXMH1, A230020G22Rik, IFGP1, moFcRH1L, moFcRH1, Fcrh1, BXMAS1-like, moFcRH1S, mIFGP1
MMRRC Submission 044683-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6559 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 87283694-87310241 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87298560 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 352 (I352V)
Ref Sequence ENSEMBL: ENSMUSP00000130936 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072480] [ENSMUST00000163661] [ENSMUST00000167200] [ENSMUST00000191666] [ENSMUST00000194786]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000072480
AA Change: I332V

PolyPhen 2 Score 0.197 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000072300
Gene: ENSMUSG00000059994
AA Change: I332V

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
IG 28 113 4.03e-8 SMART
IG 123 204 1.35e0 SMART
transmembrane domain 221 243 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163661
AA Change: I352V

PolyPhen 2 Score 0.331 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000130936
Gene: ENSMUSG00000059994
AA Change: I352V

DomainStartEndE-ValueType
IG 48 133 4.03e-8 SMART
IG 143 224 1.35e0 SMART
transmembrane domain 241 263 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000167200
AA Change: I289V

PolyPhen 2 Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000128235
Gene: ENSMUSG00000059994
AA Change: I289V

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
IG 28 113 4.03e-8 SMART
IG 123 204 1.35e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191666
SMART Domains Protein: ENSMUSP00000141916
Gene: ENSMUSG00000059994

DomainStartEndE-ValueType
IG_like 9 94 4.5e-2 SMART
IG 28 113 1.7e-10 SMART
IG 123 204 5.5e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193854
Predicted Effect probably benign
Transcript: ENSMUST00000194786
SMART Domains Protein: ENSMUSP00000142286
Gene: ENSMUSG00000059994

DomainStartEndE-ValueType
IG_like 9 94 4.5e-2 SMART
IG 28 113 1.7e-10 SMART
IG 123 204 5.5e-3 SMART
transmembrane domain 221 243 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522H14Rik C T 4: 109,363,002 (GRCm39) V106I possibly damaging Het
Actn4 T C 7: 28,606,461 (GRCm39) K284R possibly damaging Het
Adam20 G C 8: 41,249,329 (GRCm39) E480Q probably benign Het
Cdkl3 A G 11: 51,916,696 (GRCm39) T275A probably benign Het
Dync2h1 A G 9: 7,139,501 (GRCm39) I1378T possibly damaging Het
Fam186a A G 15: 99,842,356 (GRCm39) I1296T possibly damaging Het
Fbf1 G A 11: 116,046,272 (GRCm39) T193M probably benign Het
Ifit3 T C 19: 34,564,514 (GRCm39) F20S probably damaging Het
Klhl3 G A 13: 58,164,290 (GRCm39) R431W probably damaging Het
Lipi A G 16: 75,337,982 (GRCm39) V464A probably benign Het
Lrp6 T C 6: 134,490,217 (GRCm39) I120M probably damaging Het
Mst1r A G 9: 107,785,470 (GRCm39) N376S possibly damaging Het
Myo1c C T 11: 75,562,461 (GRCm39) P918S probably benign Het
Ncoa2 G A 1: 13,220,841 (GRCm39) probably null Het
Odad2 T C 18: 7,223,664 (GRCm39) T460A probably damaging Het
Or6c215 A T 10: 129,637,533 (GRCm39) I287N probably damaging Het
Or8c10 A G 9: 38,279,052 (GRCm39) Y60C probably damaging Het
Teddm1a A T 1: 153,768,111 (GRCm39) I192F probably benign Het
Tnfaip3 A G 10: 18,882,996 (GRCm39) S190P probably damaging Het
Ttc3 T C 16: 94,223,208 (GRCm39) probably null Het
Zfp112 C T 7: 23,825,888 (GRCm39) Q619* probably null Het
Zscan4-ps3 A G 7: 11,344,339 (GRCm39) E99G probably damaging Het
Other mutations in Fcrl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00321:Fcrl1 APN 3 87,296,942 (GRCm39) missense probably damaging 0.99
IGL01884:Fcrl1 APN 3 87,292,044 (GRCm39) missense probably damaging 1.00
IGL02029:Fcrl1 APN 3 87,283,794 (GRCm39) utr 5 prime probably benign
IGL02231:Fcrl1 APN 3 87,292,470 (GRCm39) missense probably damaging 1.00
IGL02231:Fcrl1 APN 3 87,292,469 (GRCm39) missense possibly damaging 0.94
IGL02405:Fcrl1 APN 3 87,293,074 (GRCm39) missense probably damaging 0.99
IGL02858:Fcrl1 APN 3 87,292,012 (GRCm39) missense probably damaging 1.00
IGL03133:Fcrl1 APN 3 87,296,699 (GRCm39) missense probably benign 0.00
IGL03176:Fcrl1 APN 3 87,298,564 (GRCm39) missense probably damaging 1.00
IGL03352:Fcrl1 APN 3 87,292,398 (GRCm39) missense probably benign 0.01
R1497:Fcrl1 UTSW 3 87,292,109 (GRCm39) missense probably damaging 1.00
R1569:Fcrl1 UTSW 3 87,292,012 (GRCm39) missense probably damaging 1.00
R1581:Fcrl1 UTSW 3 87,293,030 (GRCm39) missense possibly damaging 0.94
R1778:Fcrl1 UTSW 3 87,292,626 (GRCm39) splice site probably benign
R1959:Fcrl1 UTSW 3 87,283,827 (GRCm39) missense possibly damaging 0.92
R2928:Fcrl1 UTSW 3 87,298,564 (GRCm39) missense probably benign 0.19
R4677:Fcrl1 UTSW 3 87,297,563 (GRCm39) missense possibly damaging 0.61
R5122:Fcrl1 UTSW 3 87,293,081 (GRCm39) missense probably benign 0.35
R5507:Fcrl1 UTSW 3 87,298,549 (GRCm39) missense probably benign 0.16
R6363:Fcrl1 UTSW 3 87,292,475 (GRCm39) missense probably damaging 0.96
R6478:Fcrl1 UTSW 3 87,296,946 (GRCm39) missense probably benign 0.41
R6985:Fcrl1 UTSW 3 87,296,957 (GRCm39) missense probably benign
R7291:Fcrl1 UTSW 3 87,293,088 (GRCm39) critical splice donor site probably null
R9649:Fcrl1 UTSW 3 87,291,918 (GRCm39) missense possibly damaging 0.68
Z1177:Fcrl1 UTSW 3 87,296,670 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCTTCCAGAGTCACAGGCTC -3'
(R):5'- GACTTGCTCCAGCTTCACAC -3'

Sequencing Primer
(F):5'- GAGTCACAGGCTCTTTTGATAATGC -3'
(R):5'- TCCAGCTTCACACAGGGTAG -3'
Posted On 2018-06-06