Incidental Mutation 'R6560:Dnai3'
ID 521988
Institutional Source Beutler Lab
Gene Symbol Dnai3
Ensembl Gene ENSMUSG00000043020
Gene Name dynein axonemal intermediate chain 3
Synonyms 4931433A13Rik, Wdr63, Ida7, IC140
MMRRC Submission 044684-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R6560 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 145746281-145813855 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 145801161 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 99 (E99G)
Ref Sequence ENSEMBL: ENSMUSP00000124475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160285]
AlphaFold B2RY71
Predicted Effect possibly damaging
Transcript: ENSMUST00000160285
AA Change: E99G

PolyPhen 2 Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000124475
Gene: ENSMUSG00000043020
AA Change: E99G

DomainStartEndE-ValueType
low complexity region 3 22 N/A INTRINSIC
low complexity region 26 35 N/A INTRINSIC
low complexity region 133 150 N/A INTRINSIC
low complexity region 165 180 N/A INTRINSIC
Blast:WD40 321 367 6e-19 BLAST
low complexity region 375 383 N/A INTRINSIC
WD40 390 429 6.34e-2 SMART
WD40 470 527 1.15e-4 SMART
low complexity region 536 553 N/A INTRINSIC
WD40 693 732 1.07e1 SMART
WD40 737 776 1.1e2 SMART
coiled coil region 867 902 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 T A 10: 79,843,230 (GRCm39) L1235Q probably damaging Het
Acin1 T C 14: 54,916,290 (GRCm39) T174A probably benign Het
Adamtsl1 G A 4: 86,255,130 (GRCm39) R733H probably damaging Het
Akr1b1 C T 6: 34,286,939 (GRCm39) V206M possibly damaging Het
Arsk A T 13: 76,223,105 (GRCm39) I164N probably benign Het
Bbs5 T A 2: 69,487,300 (GRCm39) N194K probably damaging Het
Bicra T C 7: 15,723,119 (GRCm39) T133A possibly damaging Het
Card6 G A 15: 5,128,367 (GRCm39) P1010S probably damaging Het
Ccdc18 T A 5: 108,339,790 (GRCm39) N778K probably benign Het
Cept1 T C 3: 106,412,594 (GRCm39) I240V possibly damaging Het
Crip3 A G 17: 46,741,962 (GRCm39) R150G probably damaging Het
Cyp2c50 A G 19: 40,085,299 (GRCm39) T320A probably benign Het
Dio2 G C 12: 90,696,607 (GRCm39) S127* probably null Het
Dscam T C 16: 96,626,935 (GRCm39) S325G probably benign Het
Exosc4 A G 15: 76,211,813 (GRCm39) I41V probably benign Het
Glb1l3 C T 9: 26,739,720 (GRCm39) probably null Het
Gm10801 C CGTG 2: 98,494,152 (GRCm39) probably null Het
Gm3072 T A 14: 41,345,510 (GRCm39) D89V unknown Het
Gosr2 T C 11: 103,577,508 (GRCm39) H79R probably damaging Het
Has2 T A 15: 56,531,660 (GRCm39) T352S probably damaging Het
Insig1 T A 5: 28,276,531 (GRCm39) C32* probably null Het
Klf9 A G 19: 23,119,314 (GRCm39) S66G probably damaging Het
Mfn1 T C 3: 32,623,665 (GRCm39) I263T probably damaging Het
Myl2 G A 5: 122,240,834 (GRCm39) G38R probably null Het
Negr1 A G 3: 157,018,494 (GRCm39) T332A probably benign Het
Neo1 A G 9: 58,787,884 (GRCm39) S1417P possibly damaging Het
Or52ab4 T C 7: 102,987,945 (GRCm39) F228S probably benign Het
Or7e168 G A 9: 19,720,412 (GRCm39) S266N probably benign Het
Pcgf3 C A 5: 108,621,768 (GRCm39) H35Q probably damaging Het
Plppr5 A G 3: 117,465,639 (GRCm39) I297V probably benign Het
Plxna4 C T 6: 32,192,613 (GRCm39) V783M probably damaging Het
Prx A T 7: 27,214,746 (GRCm39) Q85H probably damaging Het
Tex14 T G 11: 87,388,688 (GRCm39) M305R possibly damaging Het
Ythdc1 T C 5: 86,964,467 (GRCm39) V92A probably benign Het
Zfp619 G A 7: 39,186,954 (GRCm39) E995K probably damaging Het
Zfp90 A G 8: 107,142,379 (GRCm39) R4G probably damaging Het
Other mutations in Dnai3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Dnai3 APN 3 145,788,759 (GRCm39) missense probably benign
IGL00565:Dnai3 APN 3 145,750,674 (GRCm39) splice site probably benign
IGL01339:Dnai3 APN 3 145,748,591 (GRCm39) missense probably benign 0.14
IGL01952:Dnai3 APN 3 145,802,918 (GRCm39) missense probably damaging 0.96
IGL02663:Dnai3 APN 3 145,760,312 (GRCm39) missense possibly damaging 0.53
IGL02710:Dnai3 APN 3 145,753,903 (GRCm39) missense possibly damaging 0.96
P0041:Dnai3 UTSW 3 145,786,997 (GRCm39) missense possibly damaging 0.96
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0498:Dnai3 UTSW 3 145,787,119 (GRCm39) missense possibly damaging 0.54
R0589:Dnai3 UTSW 3 145,768,086 (GRCm39) missense probably benign 0.01
R1484:Dnai3 UTSW 3 145,802,996 (GRCm39) missense probably benign 0.02
R1537:Dnai3 UTSW 3 145,748,504 (GRCm39) missense probably damaging 0.98
R1611:Dnai3 UTSW 3 145,801,113 (GRCm39) missense probably damaging 1.00
R1743:Dnai3 UTSW 3 145,803,017 (GRCm39) missense possibly damaging 0.81
R1861:Dnai3 UTSW 3 145,788,801 (GRCm39) missense probably damaging 1.00
R1991:Dnai3 UTSW 3 145,769,235 (GRCm39) missense possibly damaging 0.82
R2185:Dnai3 UTSW 3 145,772,619 (GRCm39) missense possibly damaging 0.76
R4299:Dnai3 UTSW 3 145,774,561 (GRCm39) missense probably damaging 1.00
R4620:Dnai3 UTSW 3 145,748,564 (GRCm39) missense probably damaging 1.00
R4649:Dnai3 UTSW 3 145,753,922 (GRCm39) missense probably damaging 1.00
R4914:Dnai3 UTSW 3 145,772,582 (GRCm39) missense probably damaging 0.98
R4948:Dnai3 UTSW 3 145,788,820 (GRCm39) nonsense probably null
R5578:Dnai3 UTSW 3 145,802,983 (GRCm39) nonsense probably null
R6130:Dnai3 UTSW 3 145,748,559 (GRCm39) missense probably benign 0.25
R6162:Dnai3 UTSW 3 145,750,617 (GRCm39) missense probably damaging 1.00
R6291:Dnai3 UTSW 3 145,772,648 (GRCm39) missense probably benign 0.00
R6390:Dnai3 UTSW 3 145,801,143 (GRCm39) missense probably damaging 1.00
R6893:Dnai3 UTSW 3 145,786,184 (GRCm39) missense probably damaging 1.00
R7090:Dnai3 UTSW 3 145,746,582 (GRCm39) missense possibly damaging 0.80
R7102:Dnai3 UTSW 3 145,761,459 (GRCm39) missense possibly damaging 0.49
R7111:Dnai3 UTSW 3 145,803,028 (GRCm39) missense probably damaging 0.99
R7260:Dnai3 UTSW 3 145,752,295 (GRCm39) missense probably benign 0.01
R7288:Dnai3 UTSW 3 145,787,007 (GRCm39) missense probably damaging 0.97
R7411:Dnai3 UTSW 3 145,802,900 (GRCm39) missense probably damaging 0.98
R7417:Dnai3 UTSW 3 145,798,835 (GRCm39) splice site probably null
R7466:Dnai3 UTSW 3 145,761,373 (GRCm39) missense probably benign 0.01
R7860:Dnai3 UTSW 3 145,772,675 (GRCm39) missense probably damaging 0.99
R7964:Dnai3 UTSW 3 145,774,531 (GRCm39) missense probably benign 0.09
R8013:Dnai3 UTSW 3 145,787,040 (GRCm39) missense probably damaging 1.00
R8059:Dnai3 UTSW 3 145,752,428 (GRCm39) missense possibly damaging 0.75
R8191:Dnai3 UTSW 3 145,800,066 (GRCm39) missense probably damaging 1.00
R8354:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8454:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8770:Dnai3 UTSW 3 145,752,298 (GRCm39) missense probably benign 0.01
R8967:Dnai3 UTSW 3 145,761,395 (GRCm39) missense possibly damaging 0.95
R9135:Dnai3 UTSW 3 145,772,589 (GRCm39) missense probably benign 0.39
R9310:Dnai3 UTSW 3 145,802,895 (GRCm39) critical splice donor site probably null
R9664:Dnai3 UTSW 3 145,748,594 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGATTCAGGACGAGCACAC -3'
(R):5'- GAACCATTTTCCTCAAACCTCATG -3'

Sequencing Primer
(F):5'- ATCCAGATGCTGCGCTGAG -3'
(R):5'- TAACTCCAGTTCCAGGGGATC -3'
Posted On 2018-06-06