|Institutional Source||Beutler Lab|
|Gene Name||interleukin 1 family, member 6|
|Synonyms||Fil1, IL-1H1, Fil1epsilon|
|Is this an essential gene?||Probably non essential (E-score: 0.055)|
|Stock #||R6555 (G1)|
|Chromosomal Location||24215418-24225702 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (1 bp from exon)|
|DNA Base Change (assembly)||G to A at 24224599 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000028361 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000028361]|
|Predicted Effect||probably null
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
|Validation Efficiency||98% (40/41)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il1f6||
(F):5'- AAGGAACCTGTAAAAGCCTCTCTC -3'
(R):5'- AGCTTTGCTACGCATCACC -3'
(F):5'- TAAAAGCCTCTCTCTTCTATCACAAG -3'
(R):5'- CTTCCAAGTACCAGTTAACAGTTGGG -3'