Mutagenetix > Incidental Mutations

Incidental Mutation 'R6529:Zfp664'

522171

Institutional Source

Beutler Lab

Gene Symbol

Zfp664

Ensembl Gene

ENSMUSG00000079215

Gene Name

zinc finger protein 664

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6529 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

124862691-124902693 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 124886288 bp

Zygosity

Heterozygous

Amino Acid Change

Histidine to Tyrosine at position 249 (H249Y)

Ref Sequence

ENSEMBL: ENSMUSP00000107048 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000111417]

Predicted Effect

probably damaging
Transcript: ENSMUST00000111417
AA Change: H249Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000107048
Gene: ENSMUSG00000079215
AA Change: H249Y

Domain	Start	End	E-Value	Type
ZnF_C2H2	3	25	2.57e-3	SMART
ZnF_C2H2	31	53	7.55e-1	SMART
ZnF_C2H2	59	81	5.99e-4	SMART
ZnF_C2H2	87	109	3.21e-4	SMART
ZnF_C2H2	115	137	4.54e-4	SMART
ZnF_C2H2	143	165	4.79e-3	SMART
ZnF_C2H2	171	193	8.34e-3	SMART
ZnF_C2H2	199	221	6.23e-2	SMART
ZnF_C2H2	227	249	7.9e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130616

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134463

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134473

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141533

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.4%
20x: 91.6%

Validation Efficiency

98% (41/42)

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acan	A	T	7: 79,089,731	M296L	probably benign	Het
Atxn2	T	C	5: 121,811,614		probably null	Het
B3galnt2	G	T	13: 13,995,792	R242S	probably benign	Het
Casz1	G	A	4: 148,938,189	E571K	probably damaging	Het
Ccdc163	A	G	4: 116,708,924		probably null	Het
Cd109	A	G	9: 78,712,625	D1383G	probably damaging	Het
Cd200r1	A	G	16: 44,789,702	T95A	possibly damaging	Het
Chd2	T	C	7: 73,503,443	E219G	possibly damaging	Het
Dnah14	T	A	1: 181,666,469	V1730D	probably damaging	Het
Eps8	G	A	6: 137,514,337	H348Y	possibly damaging	Het
Fam92a	A	G	4: 12,168,978	V175A	probably damaging	Het
Fbxo2	A	T	4: 148,165,054	D187V	probably damaging	Het
Fsip2	A	T	2: 82,982,313	Y2992F	probably benign	Het
Gle1	A	T	2: 29,935,527	T10S	possibly damaging	Het
Got2	T	C	8: 95,888,385		probably benign	Het
Gtf3c6	T	C	10: 40,251,255	T34A	probably benign	Het
Hist1h4j	G	T	13: 21,735,306	V71F	possibly damaging	Het
Klf15	C	T	6: 90,467,412	T323I	probably damaging	Het
Krtap5-3	C	A	7: 142,202,342	C305*	probably null	Het
Map2k6	A	T	11: 110,492,562	D99V	probably damaging	Het
Nckap5l	G	T	15: 99,426,594	P676Q	probably benign	Het
Nup188	A	T	2: 30,326,454	T757S	possibly damaging	Het
Olfr1337	C	T	4: 118,781,710	V292I	probably benign	Het
Olfr638	T	C	7: 104,003,926	V217A	probably benign	Het
Peg3	C	A	7: 6,708,072	A1384S	probably damaging	Het
Plekho2	C	T	9: 65,573,101	R14H	probably benign	Het
Qsox2	A	T	2: 26,217,741	C247S	probably damaging	Het
Slc25a13	A	G	6: 6,073,451	V469A	probably benign	Het
Slitrk3	T	C	3: 73,051,218	T74A	probably benign	Het
Spata48	T	C	11: 11,515,009	F120S	possibly damaging	Het
Sult1a1	T	C	7: 126,675,138	T91A	probably benign	Het
Sult3a2	T	C	10: 33,779,737	Y82C	probably damaging	Het
Taf1b	A	T	12: 24,556,651	H490L	possibly damaging	Het
Trrap	T	A	5: 144,834,204	H2804Q	probably benign	Het
Uhrf1bp1	A	G	17: 27,879,776	I218M	possibly damaging	Het
Usp8	A	G	2: 126,725,378	I106V	probably benign	Het
Wdcp	T	A	12: 4,851,143	V333D	probably damaging	Het
Wdr46	T	A	17: 33,949,146	L564Q	possibly damaging	Het
Wrn	T	C	8: 33,335,976		probably null	Het
Zfp975	A	C	7: 42,661,901	H429Q	possibly damaging	Het

Other mutations in Zfp664

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01556:Zfp664	APN	5	124886188	nonsense	probably null
IGL02683:Zfp664	APN	5	124886322	missense	probably benign	0.03
R0394:Zfp664	UTSW	5	124886065	nonsense	probably null
R0629:Zfp664	UTSW	5	124885595	missense	probably damaging	0.99
R1400:Zfp664	UTSW	5	124886153	missense	unknown
R6052:Zfp664	UTSW	5	124886186	missense	unknown
R6058:Zfp664	UTSW	5	124885978	nonsense	probably null
R7031:Zfp664	UTSW	5	124886006	missense	probably benign	0.06
R7752:Zfp664	UTSW	5	124885775	nonsense	probably null
R7901:Zfp664	UTSW	5	124885775	nonsense	probably null
R8434:Zfp664	UTSW	5	124885763	missense	possibly damaging	0.90
R8686:Zfp664	UTSW	5	124886069	missense	possibly damaging	0.61

Predicted Primers

PCR Primer
(F):5'- TCTGCATCCACCAGAGAGTG -3'
(R):5'- TCCATCCTGGGCAAATACAG -3'

Sequencing Primer
(F):5'- CACCAGAGAGTGCACACAGG -3'
(R):5'- TCCATCCTGGGCAAATACAGAGAAG -3'

Posted On

2018-06-06